| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Biliary transport maximum of taurocholate, a substrate of bile salt export pump was increased by 4-phenylbutyrate in rats, suggesting further increase of the amount of bile salt export pump at the canalicular membrane. In contrast, biliary transport maximum of sulfobromophthalein, a substrate of multidrug resistance protein 2 was not increased by 4-phenylbutyrate. Bile flow and biliary taurocholate excretion inhibited by lipopolysaccharide was relieved by 4-phenylbutyrate. These data suggest that 4-phenylbutyrate is effective in the treatment of intrahepatic cholestasis.
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