| Project/Area Number |
21590865
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
SATA Michio 久留米大学, 医学部, 教授 (10162398)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Takumi 久留米大学, 医学部, 講師 (00320177)
TANIGUCHI Eitaro 久留米大学, 医学部, 助教 (50341318)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 酸化型アルブミン / 還元型アルブミン / 肝細胞癌 / 酸化ストレス / グリチルリチン酸製剤 / システイン / C型肝炎ウイルス |
|---|
| Research Abstract |
Albumin exists in both oxidized and reduced forms. Since oxidized albumin shows lower anti-oxidative effects, an increase in oxidized albumin seems to be associated with hepatocarcinogenesis. The aims of this study are 1) to investigate changes in redox state of albumin in patients with chronic liver disease and 2) to develop a reducing method for oxidized albumin. 1) The oxidized albumin rate was significantly increased by the severity(n=79, chronic hepatitis 28.3±1.1%, Child-Pugh A 33.5±1.2%, Child-Pugh B and C 37.8±1.3%). Furthermore, the oxidized albumin rate was significantly correlated with MELD score(R^2=0.336, P<0.001). 2) By treatment with a glycyrrhizin agent, reduced albumin rate was significantly increased(27.7±0.18% vs. 78.7±0.36%; P<0.01). The percentage of reduced albumin reached its peak at 15 min after treatment with a glycyrrhizin agent. This study showed that the oxidized albumin rate was significantly increased by disease progression. In addition, we have developed a reducing method for oxidized albumin by using a glycyrrhizin agent.
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