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Clinical significance of HCV core region, to antiviral therapy and clinicopatological features.

Research Project

Project/Area Number 21590866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionOkinaka Memorial Institute for Medical Research

Principal Investigator

AKUTA Norio  財団法人冲中記念成人病研究所, 研究員 (20469638)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords肝臓学 / HCV / Coreアミノ酸置換 / Peginterferon / Ribavirin / 肝発癌 / 脂質代謝 / NS5A-ISDR / 糖代謝 / インスリン抵抗性 / HOMA-IR
Research Abstract

Clinical significance of HCV core region, to antiviral therapy and clinicopatological features, was investigated. Substitutions of amino acid 70 and 91 of HCV genotype 1b could predict the response to peginterferon/ribavirin combination therapy and new therapy with Telaprevir. Furthermore, those also affected clinical outcome, including hepatocarcinogenesis, glucose metabolism, and lipid metabolism.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 2009 2007 2005

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (13 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy2012

    • Author(s)
      Akuta N, Kumada H(他13名, 1番目)
    • Journal Title

      Intervirology

      Volume: 55 Pages: 231-41

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variati on Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy2012

    • Author(s)
      Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
    • Journal Title

      Intervirology

      Volume: 55 Issue: 3 Pages: 231-41

    • DOI

      10.1159/000328327

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy2011

    • Author(s)
      Akuta N, Kumada H(他11名, 1番目)
    • Journal Title

      J Med Virol

      Volume: 83 Pages: 1016-1022

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy2011

    • Author(s)
      芥田憲夫
    • Journal Title

      Journal of Medical Virology

      Volume: VOL.83 Issue: 6 Pages: 1016-1022

    • DOI

      10.1002/jmv.22094

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin2010

    • Author(s)
      Akuta N, Kumada H(他14名, 1番目)
    • Journal Title

      Hepatology

      Volume: 52 Pages: 412-429

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin2010

    • Author(s)
      Akuta N, Kumada H(他12名, 1番目)
    • Journal Title

      J Med Virol

      Volume: 82 Pages: 575-582

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.2010

    • Author(s)
      芥田憲夫
    • Journal Title

      Hepatology

      Volume: VOL.52 Pages: 412-429

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype]b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin.2010

    • Author(s)
      芥田憲夫
    • Journal Title

      Journal of Medical Virology

      Volume: VOL.82 Pages: 575-582

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus2009

    • Author(s)
      Akuta N, Kumada H(他12名, 1番目)
    • Journal Title

      J Med Virol

      Volume: 81 Pages: 1032-1039

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan : amino acid substitutions in HCV core region as predictor of sustained virological response2009

    • Author(s)
      Akuta N, Kumada H(他12名, 1番目)
    • Journal Title

      J Med Virol

      Volume: 81 Pages: 452-458

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy2009

    • Author(s)
      Akuta N, Kumada H(他12名, 1番目)
    • Journal Title

      Intervirology

      Volume: 52 Pages: 301-309

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus2009

    • Author(s)
      芥田憲夫
    • Journal Title

      Journal of Medical Virology VOL.81

      Pages: 1032-1039

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan : amino acid substitutions in HCV core region as predictor of sustained virological response2009

    • Author(s)
      芥田憲夫
    • Journal Title

      Journal of Medical Virology VOL.81

      Pages: 452-458

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy2009

    • Author(s)
      芥田憲夫
    • Journal Title

      Intervirology VOL.52

      Pages: 301-309

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Amino acid substitution in the hepatitis C virus core region of genotype 1b are the important predictor of telaprevir with peginterferon plus ribavirin, and hepatocarcinogenesis2011

    • Author(s)
      芥田憲夫
    • Organizer
      The 62th annual meeting of the American association for the study of liver disease
    • Place of Presentation
      CA(USA)
    • Year and Date
      2011-11-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Amino acid substitution in the hepatitis C virus core region of genotype 1b are the important predictor of telaprevir with peginterferon plus ribavirin, and hepatocarcinogenesis2011

    • Author(s)
      芥田憲夫
    • Organizer
      The 62th annual meeting of the American association for the study of liver disease, 2011
    • Place of Presentation
      CA (USA)
    • Year and Date
      2011-11-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] C型肝炎の治療抵抗性と肝発癌に影響するウイルス・宿主要因の検討2011

    • Author(s)
      芥田憲夫
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡サンパレス(東京都)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] HCV coreアミノ酸置換が肝発癌・代謝要因に及ぼす影響2011

    • Author(s)
      芥田憲夫
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京都)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 新規抗HCV療法を含めた難治要因の検討と代謝要因への影響2011

    • Author(s)
      芥田憲夫
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Amino acid substitutions in HCV core region of genotype 1b are the important viral predictors of treatment resistance and hepatocarcinogenesis2010

    • Author(s)
      芥田憲夫
    • Organizer
      7th APASL Single Topic Conference"Hepatitis C Virus"
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2010-12-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Amino acid substitutions in HCV core region of genotype Ib are the important viral predictors of treatment resistance and hepatocarcinogenesis.2010

    • Author(s)
      芥田憲夫
    • Organizer
      7th APASL Single Topic Conference Hepatitis C Virus
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Coreアミノ酸置換とIL28B遺伝子多型のPEG-IFN/RBV/Telaprevir併用療法における有用性2010

    • Author(s)
      芥田憲夫
    • Organizer
      第38回日本肝臓学会東部会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-12-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Coreアミノ酸置換とIL28B遺伝子多型のPEG-IFN/SBV/Telaprevir併用療法における有用性2010

    • Author(s)
      芥田憲夫
    • Organizer
      第38回日本肝臓学会東部会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] PEG-IFN/RBV/Telaprevir併用療法におけるCore aa70置換とIL28B遺伝子多型の有用性2010

    • Author(s)
      芥田憲夫
    • Organizer
      第14回日本肝臓学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-10-14
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] HCV coreアミノ酸置換の新規抗HCV療法・肝発癌に及ぼす影響2010

    • Author(s)
      芥田憲夫
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟県民会館(新潟県)
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of treatment resistance, insulin resistance, and hepatocarcinogenesis2009

    • Author(s)
      芥田憲夫
    • Organizer
      The 60th annual meeting of the American association for the study of liver disease
    • Place of Presentation
      BOSTON HYNES CONVENTION CENTER(USA)
    • Year and Date
      2009-11-01
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 抗ウイルス療法・肝病態におけるHCV-1b core aa70/91の意義2009

    • Author(s)
      芥田憲夫
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] B型肝炎ウイルス量が低下する可能性を予測する方法2007

    • Inventor(s)
      熊田博光・芥田憲夫
    • Industrial Property Rights Holder
      熊田博光・芥田憲夫
    • Industrial Property Number
      2007-340261
    • Filing Date
      2007-12-28
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] B型肝炎ウイルス量が低下する可能性を予測する方法2007

    • Inventor(s)
      熊田博光, 芥田憲夫
    • Industrial Property Rights Holder
      熊田博光, 芥田憲夫
    • Industrial Property Number
      2007-340261
    • Filing Date
      2007-12-28
    • Related Report
      2011 Annual Research Report 2009 Annual Research Report
  • [Patent(Industrial Property Rights)] C型肝炎に対するインターフェロン/リバビリン併用療法の有効性2005

    • Inventor(s)
      熊田博光・芥田憲夫
    • Industrial Property Rights Holder
      熊田博光・芥田憲夫
    • Patent Publication Number
      2007-043985
    • Filing Date
      2005-08-11
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] C型肝炎に対するインターフェロン/リバビリン併用療法の有効性2005

    • Inventor(s)
      熊田博光, 芥田憲夫
    • Industrial Property Rights Holder
      熊田博光, 芥田憲夫
    • Patent Publication Number
      2007-043985
    • Filing Date
      2005-08-11
    • Related Report
      2011 Annual Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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