| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
In order to establish novel diagnostic and therapeutic approaches aiming at avoidance of severe hypoglycemia in pancreatic diabetes, we studied daily glycemic profiles using the continuous glucose monitoring system, measured plasma levels of adiponectin, insuin and C-peptide and analyzed relevant factors in glycemic control and diabetic complications. The mean glucose concentration, the standard deviation in blood glucose values and the slope of glycemic variability per 5 minutes calculated based on the data from CGMS were predictive factors of hypoglycemia. Furthermore, increased insulin dose and the shortage of pancreatic enzyme supplementation as well as drinking alcohol were associated with a high incidence of hypoglycemia. Abstinence from alcohol and careful insulin treatment with enough digestive enzyme supplements are reconfirmed as one of the appropriate approaches to prevent severe hypoglycemia in pancreatic diabetes.
|
