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The development of novel diagnostic and therapeutic approaches aiming at avoidance of severe hypoglycemia in pancreatic diabetes

Research Project

Project/Area Number 21590869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHirosaki University

Principal Investigator

TANDO Yusuke  弘前大学, 医学部・附属病院, 講師 (00332495)

Co-Investigator(Kenkyū-buntansha) YANAGIMACHI Miyuki  弘前大学, 大学院・医学研究科, 助教 (70372282)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords膵性糖尿病 / 重症低血糖 / 持続血糖モニタリング / インスリン / 膵消化酵素 / 低血糖 / 連続血糖測定 / 慢性膵炎 / 膵術後
Research Abstract

In order to establish novel diagnostic and therapeutic approaches aiming at avoidance of severe hypoglycemia in pancreatic diabetes, we studied daily glycemic profiles using the continuous glucose monitoring system, measured plasma levels of adiponectin, insuin and C-peptide and analyzed relevant factors in glycemic control and diabetic complications. The mean glucose concentration, the standard deviation in blood glucose values and the slope of glycemic variability per 5 minutes calculated based on the data from CGMS were predictive factors of hypoglycemia. Furthermore, increased insulin dose and the shortage of pancreatic enzyme supplementation as well as drinking alcohol were associated with a high incidence of hypoglycemia. Abstinence from alcohol and careful insulin treatment with enough digestive enzyme supplements are reconfirmed as one of the appropriate approaches to prevent severe hypoglycemia in pancreatic diabetes.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (10 results) Book (2 results)

  • [Journal Article] Analysis of glycemic variability and in sulin resistance in patients with pancreatic diabetes using a continuous glucose monitoring system2012

    • Author(s)
      Kon A, Tando Y, Yanagimachi M, Tanaka H, Matsuhashi Y, Matsumoto A, Sato E, Chikazwa S, Suda T, Nakamura T
    • Journal Title

      Hirosaki Med J

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膵切除後の合併症とその対策-特に晩期合併症の膵内外分泌障害について2010

    • Author(s)
      丹藤雄介、今昭人、松橋有紀、中村光男
    • Journal Title

      成人病と生活習慣病

      Volume: 40 Pages: 105-109

    • Related Report
      2011 Final Research Report
  • [Journal Article] 膵切除後の合併所とその対策-特に晩期合併症の膵内外分泌障害について-2010

    • Author(s)
      丹藤雄介
    • Journal Title

      成人病と生活習慣病 40

      Pages: 105-109

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 高齢膵機能不全患者の栄養管理と血糖コントロール2009

    • Author(s)
      丹藤雄介、柳町幸、今昭人、近澤真司、松橋有紀、柳町幸、佐藤江里、松本敦史、田中光、中村光男
    • Journal Title

      老年消化器病

      Volume: 21 Pages: 159-164

    • Related Report
      2011 Final Research Report
  • [Journal Article] 高齢膵機能不全患者の栄養管理と血糖コントロール2009

    • Author(s)
      丹藤雄介
    • Journal Title

      老年消化器病 21

      Pages: 159-164

    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵性糖尿病患者の高分子アディポネクチン濃度評価2012

    • Author(s)
      今昭人、丹藤雄介、柳町幸、佐藤江里、近澤真司、中村光男、須田俊宏
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2012-05-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 病態から見たCGMによる血糖変動解析2011

    • Author(s)
      今昭人、丹藤雄介、柳町幸、中村光男、他
    • Organizer
      第11回日本先進糖尿病治療研究会
    • Place of Presentation
      いわて県民情報交流センター(盛岡市)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 膵癌術後膵性糖尿病のCGMによる血糖変動解析2011

    • Author(s)
      今昭人、丹藤雄介、柳町幸、中村光男、他
    • Organizer
      第42回日本膵臓学会
    • Place of Presentation
      ホテルニューキャッスル(弘前市)
    • Year and Date
      2011-07-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] CGMによる2型糖尿病患者のインスリン抵抗性評価の試み2011

    • Author(s)
      今昭人、丹藤雄介、柳町幸、中村光男、他
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌市教育文化会館(札幌市)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Does stopping drinking alcohol even after the onset of overt exocrine and endocrine pancreatic insufficiency improve the prognosis of patients with alcohol-induced chronic pancreatitis?2010

    • Author(s)
      Tando Y, Yanagimachi M, Matsuhashi Y, Tanaka H, Sato E, Matsumoto A, Chikazawa S, Kon A, Suda T, Nakamaura T
    • Organizer
      The 41th Annual Meeting of the American Pancreatic Association
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2010-11-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Glycemic characteristics in continuously monitored patients with pancreatic diabetes treating with pancreatic enzyme replacement therapy2010

    • Author(s)
      Tando Y, Yanagimachi M, Matsuhashi Y, Tanaka H, Sato E, Matsumoto A, Chikazawa S, Kon A, Suda T, Nakamaura T
    • Organizer
      Pancreas Fest 2010
    • Place of Presentation
      Pittsburgh (USA)
    • Year and Date
      2010-07-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Glycemic characteristics in continuously monitored patients with pan-creatic diabetes treating with pancreatic enzyme, replacement therapy.2010

    • Author(s)
      Yusuke Tando
    • Organizer
      Pancreas Fest 2010
    • Place of Presentation
      Pittsburgh, USA
    • Year and Date
      2010-07-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nutritional management and diabetes control in older people with pancreatic insufficiency2010

    • Author(s)
      Tando Y, Kon A, Chikazawa S, Matsuhashi Y, Yanagimachi M, Sato E, Matsumoto A, Tanaka H, Hasegawa N, Nakamura T, Suda T
    • Organizer
      Joint Meeting of the International Association of Pancrea-tology and the Japan Pancreas Society
    • Place of Presentation
      Fukuoka (Japan)
    • Year and Date
      2010-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] CGM連続血糖モニタリングで絶食輸液中の血糖管理を施行した膵性糖尿病の一例2009

    • Author(s)
      丹藤雄介、柳町幸、中村光男、他
    • Organizer
      第24回東北静脈経腸栄養研究会
    • Place of Presentation
      水産ビル(青森市)
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] CGM(連続血糖モニタリング)で絶食輸液中の血糖管理を施行した膵性糖尿病の一例2009

    • Author(s)
      丹藤雄介
    • Organizer
      第24回東北静脈経腸栄養研究会
    • Place of Presentation
      水産ビル(青森県)
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Book] KARGER2011

    • Author(s)
      Tando Y, Matsumoto A, Matsuhashi Y, Tanaka H, Yanagimachi M, Nakamura T
    • Publisher
      Gas Biology Research in Clinical Practice
    • Related Report
      2011 Final Research Report
  • [Book] Gas Biology Research in Clinical Practice2011

    • Author(s)
      Yusuke Tando
    • Publisher
      KARGER
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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