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Bone marrow derived cells in the experimental mouse pancreatic cancer.

Research Project

Project/Area Number 21590871
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

HIROTA Morihisa  東北大学, 病院, 助教 (70400364)

Co-Investigator(Kenkyū-buntansha) HAMADA Shin  東北大学, 病院, 医員 (20451560)
KANNO Atsushi  東北大学, 病院, 助教 (70509190)
佐藤 賢一  東北大学, 病院, 講師 (10282055)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords胆道学 / 膵臓学 / 膵癌 / 骨髄由来細胞 / 慢性膵炎 / グリーンマウス / 骨髄由来幹細包
Research Abstract

7, 12-Dimethylbenz(a)anthracene (DMBA)induced murine pancreatic cancer model was established, which mimicked undifferentiated human pancreatic cancer. Bone marrow derived cells were incorporated in tumor tissue in this model. Almost half of cells in the tumor tissue were derived from bone marrow, which were spindle like morphology resembling cancer cells in this model. By the immunohistochemical analysis, CK19, α-smooth muscle actin (α-SMA)and vimentin were negative in these cells, whereas vascular endothelial marker CD31 and macrophage marker CD68 were positive in a part of these cells. Because the bone marrow derived cells were found in abundant in the invasive edge of cancer, it is possible that these cells play an important role to facilitate the invasion of the cancer cells into the host pancreas.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG22012

    • Author(s)
      濱田晋, 佐藤賢一, 廣田衛久, 他
    • Journal Title

      Journal of Cellular Physiology

      Volume: 227巻 Pages: 729-738

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perfusion computed tomography findings of autoimmune pancreas2011

    • Author(s)
      廣田衛久, 他
    • Journal Title

      Pancreas

      Volume: 49巻 Pages: 1295-1301

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The homepbox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of the transporter gene ABCG22011

    • Author(s)
      濱田晋、佐藤賢一、廣田衛久, 他
    • Journal Title

      Journal of Cellular Physiology

      Volume: 227 Pages: 729-738

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed

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Published: 2009-04-01   Modified: 2018-02-02  

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