| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Research Abstract |
The alteration in the pancreas of IRF2 knock-out mice resulted from the defect of regulated exocytosis. Zymogen granules accumulated throughout the cytoplasm and mild acute pancreatitis was proceeding in the acinar cells of Irf2^<-/-> pancreas. However, IRF2 did not regulate the SNARE proteins directly, which plays a pivotal role in the dock and fusion between zymogen granules and apical plasma membrane. So, it is urgently needed to clarify the target gene of IRF2 and molecular mechanisms regulating the pancreatic exocytosis.
|
