| Project/Area Number |
21590873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya University |
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Principal Investigator |
ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385)
KO Shigeru 国立長寿医療研究センター, 病院・内科総合診療部 (90402578)
NAGAO Shizuko 藤田保健衛生大学, 疾患モデル教育研究センター, 准教授 (20183527)
近藤 孝晴 名古屋大学, 総合保健体育科学センター, 教授 (20135388)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵石症 / 膵導管上皮 / カルシウム輸送体 / 単離小葉間膵管 / microperfusion / 多発性嚢胞腎症 / PCKラット / 線毛 / 膵導管細胞 / 細胞内Ca^<2+>濃度 / polycystic kidneyラット / fibrocystin / secretin / 溶液分泌 / 膵石 / Ca^<2+>チャネル / 膵液 / Panc-1細胞 |
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| Research Abstract |
Pancreatic juice is an alkaline fluid that contains digestive enzymes and high concentrations of HCO3-. A little amount of CO32-in the juice binds to acinar cell-derived Ca2+, which leads to the precipitation of CaCO3. Pancreatic ductal epithelium is supposed to absorb luminal Ca2+ to prevent the formation of pancreatic stone. In the present study, we identified the membrane localization of Ca2+ transporters, measured the Ca2+-transport activities, and demonstrated the mechanisms to absorb luminal Ca2+ by pancreatic ductal epithelium.
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