Mechanisms for Ca2+ absorption by pancreatic ductal epithelium : A study looking for a new strategy to prevent pancreatic stone formation.
| Project/Area Number |
21590873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya University |
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Principal Investigator |
ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385)
KO Shigeru 国立長寿医療研究センター, 病院・内科総合診療部 (90402578)
NAGAO Shizuko 藤田保健衛生大学, 疾患モデル教育研究センター, 准教授 (20183527)
近藤 孝晴 名古屋大学, 総合保健体育科学センター, 教授 (20135388)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵石症 / 膵導管上皮 / カルシウム輸送体 / 単離小葉間膵管 / microperfusion / 多発性嚢胞腎症 / PCKラット / 線毛 / 膵導管細胞 / 細胞内Ca^<2+>濃度 / polycystic kidneyラット / fibrocystin / secretin / 溶液分泌 / 膵石 / Ca^<2+>チャネル / 膵液 / Panc-1細胞 |
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| Research Abstract |
Pancreatic juice is an alkaline fluid that contains digestive enzymes and high concentrations of HCO3-. A little amount of CO32-in the juice binds to acinar cell-derived Ca2+, which leads to the precipitation of CaCO3. Pancreatic ductal epithelium is supposed to absorb luminal Ca2+ to prevent the formation of pancreatic stone. In the present study, we identified the membrane localization of Ca2+ transporters, measured the Ca2+-transport activities, and demonstrated the mechanisms to absorb luminal Ca2+ by pancreatic ductal epithelium.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis2010
Author(s)
Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H
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Journal Title
Gastroenterology
Volume: 138
Issue: 5
Pages: 1988-96
DOI
Related Report
Peer Reviewed
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[Journal Article] High glucose inhibits HCO3-and fluid secretion in rat pancreatic ducts2009
Author(s)
Futakuchi S, Ishiguro H, Naruse S, Ko SB, Fujiki K, Yamamoto A, Nakakuki M, Song Y, Steward MC, Kondo T, Goto H.
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Journal Title
Pflugers Arch
Volume: 459
Issue: 1
Pages: 215-26
DOI
Related Report
Peer Reviewed
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[Journal Article] Structure and function of the pancreas in the polycystic kidney rat
Author(s)
Yi L, Naruse S, Furuya S, Yamamoto A, Nakakuki M, Nagao S, Yoshihara D, Ko SB, Wei M, Kondo T, Ishiguro H.
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Journal Title
Related Report
Peer Reviewed
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