Intestinal environmental control by using a newly-produced biopolymer during the progression of acute pancreatitis.
| Project/Area Number |
21590876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Hiroaki 京都府立医科大学, 医学研究科, 助教 (40363973)
KATAOKA Keisho 京都府立医科大学, 医学研究科, 教授 (70185792)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 急性膵炎 / 微生物 / バイオテクノロジー / バイオポリマー / 腸管内環境 / バクテリアルトランスロケーション |
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| Research Abstract |
We investigated if Poly-(R)-3-hydroxybutyrate(PHB), a newly-developed biopolymer, had a preventive effect against the progression of acute pancreatitis with regard to intra-and extra-intestinal environment. PHB showed significant protective activity toward the bacterial translocation in rats with severe acute pancreatitis. PHB affected both bowel flora and bowel amount without altering fecal organic acid composition. The precise mechanism remains unknown, but the intestinal fermentation of oral PHB might become a novel treatment for invasive intestinal involvement in acute pancreatitis.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Early-stage blocking of Notch signaling inhibits the depletion of gobletcells in dextran sodium sulfate-induced colitis in mice.2010
Author(s)
Shinoda M, Shin-ya M, Naito Y, Kishida T, Ito R, Suzuki N, Yasuda H, Sakagami J, Imanishi J, Kataoka K, Mazda O, Yoshikawa T.
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Journal Title
J Gastroenterol
Volume: 45
Pages: 608-617
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Peer Reviewed
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[Presentation] Identification of new genetic biomarkers predicting the blood concentration of azathioprine administrated with 5-aminosalicylic acid as combination therapy for inflammatory bowel disease2011
Author(s)
Uchiyama K, Naito Y, Takagi T, Kondo N, Iwamoto Y, Ishikawa S, Yoshida N, Handa O, Ishikawa T, Yasuda H, Sakagami J, Konishi H, Wakabayashi N, Yagi N, Kokura S, Yoshikawa T
Organizer
DDW2011
Place of Presentation
米国・イリノイ州・シカゴ
Year and Date
2011-05-07
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