Pancreatic diseases in metabolic syndrome

• Project/Area Number: 21590877
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya University of Arts and Sciences
• Principal Investigator: KITAGAWA Motoji 名古屋学芸大学, 管理栄養学部, 教授 (80262898)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: メタボリックシンドローム / 内臓脂肪型肥満 / 膵脂肪置換 / アディポネクチン / 膵障害 / 膵萎縮 / 血中アミラーゼ

Research Abstract

Pancreatic diseases in subjects with excess visceral adipose tissue were evaluated by pancreatic images by abdominal computed tomography(CT) and serum markers. Fat deposition or pancreatic atrophy was detected in 19% of subjects with the amount of visceral fat area(VFA)≧100cm^<2>, and in only 2% of subjects with VFA<100cm^<2>. Excess visceral adipose tissue may cause pancreatic fat deposition. Subjects with VFA≧100cm^<2> had significant lower levels of serum amylase and adiponectin than subjects with VFA<100cm<2>. Exocrine and endocrine pancreatic damages should be elucidated in subjects with excess visceral adipose tissue.