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Role of innate immunity and influence of smoking in the Pathogenesis of alcoholic pancreatitis

Research Project

Project/Area Number 21590878
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKansai Medical University

Principal Investigator

NISHIO Akiyoshi  関西医科大学, 医学部, 准教授 (50362463)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords慢性膵炎 / アルコール / エンドトキシン / 自然免疫 / toll-like receptor / サイトカイン / toll-like / receptor
Research Abstract

To clarify the pathogenesis of alcoholic pancreatitis, we created a murine model induced by administration of ethanol and lipopolysaccharide and analyzed the role of innate and acquired immunity in the disease. Participation of acquired immunity was indispensable for the development of ethanol-induced pancreatitis. Smoking aggravated the disease. Induction of endogenous antioxidants ameliorated pancreatitis, suggesting the usefulness of antioxidant therapy for the treatment of alcoholic pancreatitis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (47 results)

All 2012 2011 2010 2009

All Journal Article (23 results) (of which Peer Reviewed: 22 results) Presentation (24 results)

  • [Journal Article] Regulatory T cells in type 1 autoimmune pancreatitis2012

    • Author(s)
      Uchida K, Kusuda T, Nishio A
    • Journal Title

      Int J Rheumatol

      Pages: 795026-795026

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin2012

    • Author(s)
      Nakajima A, Fukui T, Nishio A
    • Journal Title

      J Gastroenterol

      Volume: (in press)

    • NAID

      10031122084

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells2011

    • Author(s)
      Hoshino S, Kurishima A, Nishio A
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 1368-81

    • NAID

      10030295176

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent Concepts of Autoimmune Pancreatitis and IgG4-Related Disease2011

    • Author(s)
      Okazaki K, Uchida K, Nishio A
    • Journal Title

      Clin Rev Allergy Immunol

      Volume: 41 Pages: 126-38

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of steroid pulse therapy and conventional oral steroid therapy as initial treatment for autoimmune pancreatitis2011

    • Author(s)
      Tomiyama T, Uchida K, Nishio A
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 696-704

    • NAID

      10029029366

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis2011

    • Author(s)
      Fukui T, Kishimoto M, Nishio A
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 456-68

    • NAID

      10029028438

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of innate immunity in the pathogenesis of experimental autoimmune pancreatitis in mice2011

    • Author(s)
      Nishio A, Asada M, Uchida K
    • Journal Title

      Pancreas

      Volume: 40 Pages: 95-102

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis2011

    • Author(s)
      Toshiro Fukui
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Issue: 4 Pages: 456-168

    • DOI

      10.1007/s00535-010-0364-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of steroid pulse therapy and conventional oral steroid therapy as initial treatment for autoimmune pancreatitis2011

    • Author(s)
      Takashi Tomiyama
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Issue: 5 Pages: 696-704

    • DOI

      10.1007/s00535-010-0361-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent concepts of autoimmune pancreatitis and IgG4-related disease2011

    • Author(s)
      Kazuichi Okazaki
    • Journal Title

      Clin Rev Allergy Immunol

      Volume: 41 Issue: 2 Pages: 126-138

    • DOI

      10.1007/s12016-010-8214-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells2011

    • Author(s)
      Shoichi Hoshino
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Issue: 12 Pages: 1368-1381

    • DOI

      10.1007/s00535-011-0460-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of innate immunity in the pathogenesis of marine autoimmune pancreatitis2011

    • Author(s)
      Akiyoshi Nishio
    • Journal Title

      Pancreas

      Volume: 40 Pages: 95-102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Idiopathic duct-centric pancreatitis(IDCP) with immunological studies2010

    • Author(s)
      Kusuda T, Uchida K, Nishio A
    • Journal Title

      Intern Med

      Volume: 49 Pages: 2569-75

    • NAID

      130000413401

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune pancreatitis-a new evolving pancreatic disease?2010

    • Author(s)
      Okazaki K, Uchida K, Nishio A
    • Journal Title

      Langenbecks Arch Surg

      Volume: 395 Pages: 989-1000

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases2010

    • Author(s)
      Koyabu M, Uchida K, Nishio A
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 732-41

    • NAID

      10026707041

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells2010

    • Author(s)
      Koyabu M, Uchida K, Nishio A
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 122-9

    • NAID

      10027214145

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases.2010

    • Author(s)
      Masanori Koyabu
    • Journal Title

      Journal of Gastrocnleology

      Volume: 45 Pages: 732-741

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune pancreatitis--a new evolving pancreatic disease?2010

    • Author(s)
      Kazuichi Okazaki
    • Journal Title

      Langenbeck's Archives of Surgery

      Volume: 395 Pages: 989-1000

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Idiopathic duct-centric pancreatitis (IDCP) with immunological studies.2010

    • Author(s)
      Takeo Kusuda
    • Journal Title

      Internal Medicine

      Volume: 49 Pages: 2569-2575

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases.2010

    • Author(s)
      Masaki Koyabu
    • Journal Title

      Journal of Gastroenterology (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells.2010

    • Author(s)
      Masaki Koyabu
    • Journal Title

      Journal of Gastroenterology 45

      Pages: 122-129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical retroperitoneal fibrosis associated with biliary stricture : IgG4-related sclerosing disease?2009

    • Author(s)
      Matsushita M, Fukui T, Nishio A
    • Journal Title

      Scand J Gastroenterol

      Volume: 44 Pages: 1146-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atypical retroperitoneal fibrosis associated with biliary stricture : IgG4-related sclerosing disease?2009

    • Author(s)
      Mitsunobu Matsushita
    • Journal Title

      Scandinavian Journal of Gastroenterology 44

      Pages: 1146-1147

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of innate immunity in the pathogenesis of alcoholic pancreatitis in mice2011

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      42nd Annual Meeting of the American Pancreatic Association
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2011-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] The Role of Innate Immunity in the Pathogenesis of Alcoholic Pancreatitis in Mice2011

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      42nd Annual Meeting of the American Pancreatic Association
    • Place of Presentation
      Northwestern Memorial Hospital Conference Center(米国シカゴ)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] The participation of innate and acquired immunity of alcoholic chronic pancreatitis2011

    • Author(s)
      Shinji Nakayama
    • Organizer
      6th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] The participation of innate and acquired immunity of alcoholic chronic pancreatitis2011

    • Author(s)
      Shinji Nakayama
    • Organizer
      6th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of ICOS and IL-10 positive regulatory T cells in the development of IgG4-related autoimmune pancreatitis2011

    • Author(s)
      Takeo Kusuda
    • Organizer
      112th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2011-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of ICOS and IL-10 Positive Regulatory T Cells in the Development of IgG4-related Autoimmune Pancreatitis2011

    • Author(s)
      Takeo Kusuda
    • Organizer
      111th Annual Meeting of the America Gastroenterological Association
    • Place of Presentation
      McCormick Place(米国シカゴ)
    • Year and Date
      2011-05-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] The participation of innate and acquired immunity of alcoholic chronic pancreatitis2011

    • Author(s)
      Shinji Nakayama
    • Organizer
      112th Annual Meeting of the America Gastroenterological Association
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2011-05-08
    • Related Report
      2011 Final Research Report
  • [Presentation] The participation of innate and acquired immunity of alcoholic chronic pancreatitis2011

    • Author(s)
      Shinji Nakayama
    • Organizer
      111th Annual Meeting of the America Gastroenterological Association
    • Place of Presentation
      McCormick Place(米国シカゴ)
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cytokine imbalance induces autoimmune pancreatitis in mice2011

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      Joint Conference of the International Association of Pancreatology & the Indian Pancreas Club
    • Place of Presentation
      インドコチン
    • Year and Date
      2011-02-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytokine imbalance induces autoimmune pancreatitis in mice2011

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      Joint Conference of the International Association of Pancreatology & the Indian Pancreas Club
    • Place of Presentation
      International Convention Center(インド コチン)
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of innate immunity in the pathogenesis of experimental autoimmune pancreatitis in mice2010

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      2010 American Pancreatic Association Meeting
    • Place of Presentation
      米国ボストン
    • Year and Date
      2010-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] The Role of Innate Immunity in the Pathogenesis of Experimental Autoimmune Pancreatitis in Mice2010

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      2010 American Pancreatic Association Meeting
    • Place of Presentation
      Wyndham Hotel(米国ボストン)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of extrapancreatic lesions associated with murine autoimmune pancreatitis2010

    • Author(s)
      Masao Yamashina
    • Organizer
      18th United European Gastroenterology Week
    • Place of Presentation
      スペインバルセロナ
    • Year and Date
      2010-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of extrapancreatic lesions associated with murine autoimmune pancreatitis2010

    • Author(s)
      Masao Yamashina
    • Organizer
      18th United European Gastroenterology Week
    • Place of Presentation
      Centre Convencions Internacional Barcelona(スペイン バルセロナ)
    • Year and Date
      2010-10-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of ICOS and IL-10 positive regulatory T cells in the development of autoimmune pancreatitis2010

    • Author(s)
      Kazushige Uchida
    • Organizer
      Joint meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      福岡
    • Year and Date
      2010-07-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of ICOS and IL-10 positive regulatory T cells in the development of autoimmune pancreatitis2010

    • Author(s)
      Kazushige Uchida
    • Organizer
      Joint meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of cholangitis associated with experimental autoimmune pancreatitis in mice2010

    • Author(s)
      Masao Yamashina
    • Organizer
      111th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      米国ニューオーリンズ
    • Year and Date
      2010-05-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of cholangitis associated with experimental autoimmune pancreatitis in mice2010

    • Author(s)
      Masao Yamashina
    • Organizer
      111th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      Emest N.Morial Convention Center(米国ニューオーリンズ)
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of cholangitis associated with experimental autoimmune pancreatitis in mice2009

    • Author(s)
      Akiyoshi Nishio
    • Organizer
      United European Gastroenterology Week/World Congress Gastroenterology Gastro 2009
    • Place of Presentation
      英国ロンドン
    • Year and Date
      2009-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of cholangitis associated with experimental autoimmune pancreatitis in mice2009

    • Author(s)
      西尾彰功
    • Organizer
      United European Gastroenterology Week/World Congress Gastroenterology Gastro 2009
    • Place of Presentation
      英国 ロンドン
    • Year and Date
      2009-11-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスモデルを用いた自己免疫性膵炎発症における自然免疫の関与2009

    • Author(s)
      西尾彰功
    • Organizer
      第51回日本消化器病学会大会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-15
    • Related Report
      2011 Final Research Report
  • [Presentation] マウスモデルを用いた自己免疫性膵炎発症における自然免疫の関与2009

    • Author(s)
      西尾彰功
    • Organizer
      第51回日本消化器病学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自己免疫性膵炎における制御性T細胞とIgG4に関する研究2009

    • Author(s)
      内田一茂
    • Organizer
      第46回日本消化器免疫学会総会
    • Place of Presentation
      松山
    • Year and Date
      2009-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己免疫性膵炎における制御性T細胞とIgG4に関する研究2009

    • Author(s)
      内田一茂
    • Organizer
      第46回日本消化器免疫学会総会
    • Place of Presentation
      松山全日空ホテル
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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