| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
DNA damage is one of the major cause of atherosclerotic cardiovascular diseases. We focused on Ape 1, themajor enzyme of base excision repair system. Ape 1 was highly expressed in a damaged cardiovascular lesion, and the transfection of Ape 1 gene effectively prevented cardiovascular remodeling. Thermal treatment at 41 degree Celsius induced heat shock protein (HSP) 72 expression, and reduced oxidative stress. Ape1 and HSP 72 additively show an antiatherosclerotic action and are a potential new strategy for suppression of cardiovascular remodeling.
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