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Development of Novel Biomarker to Predict Cardiovascular Diseases

Research Project

Project/Area Number 21590884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTohoku University

Principal Investigator

FUKUMOTO Yoshihiro  東北大学, 大学院・医学系研究科, 准教授 (70363372)

Co-Investigator(Kenkyū-buntansha) HIROAKI Shimokawa  東北大学, 大学院・医学系研究科, 教授 (00235681)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsRhoキナーゼ活性 / 慢性心不全 / 肺高血圧症 / 狭心症 / 急性冠症候群 / 心血管病 / 急性心不全 / 虚血性心疾患
Research Abstract

In the present study, we have examined Rho-kinase activity in organ and peripheral white blood cells in patients with pulmonary hypertension, stable angina pectoris, acute coronary syndrome(acute myocardial infarction, unstable angina), chronic heart failure(Stage C-D), and acute heart failure. These results indicate that Rho-kinase is systemically and locally activated in patients with various cardiovascular diseases, suggesting that inhibition of Rho-kinase could be a new therapeutic strategy for cardiovascular diseases.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (8 results) Book (5 results) Remarks (3 results)

  • [Journal Article] Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension2012

    • Author(s)
      Sugimura K, Fukumoto, Y, et al
    • Journal Title

      Circ J

      Volume: 76 Pages: 485-8

    • NAID

      10030036102

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure2011

    • Author(s)
      Aoki T, Fukumoto Y, Sugimura K, Oikawa M, Satoh K, Nakano M, Nakayama M, Shimokawa H
    • Journal Title

      Circ J

      Volume: 75 Pages: 2605-13

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intensive Intensive immunosuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease2011

    • Author(s)
      Miyamichi-Yamamoto S, Fukumoto Y, Sugimura K, Ishii T, Satoh K, Miura Y, Tatebe S, Nochioka K, Aoki T, Do E Z, Shimokawa H
    • Journal Title

      Circ J

      Volume: 75 Pages: 2668-74

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats -Implication for the pathogenesis of hypertensive vascular disease-2011

    • Author(s)
      Sugimura K, Fukumoto Y, et al
    • Journal Title

      Tohoku J Exp Med

      Volume: 222 Pages: 201-210

    • NAID

      10027459508

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris2010

    • Author(s)
      Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, Yasuda S, Kuriyama S, Tsuji I, Shimokawa H
    • Journal Title

      Circ J

      Volume: 74 Pages: 589-91

    • NAID

      10025943921

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension2010

    • Author(s)
      Fujita H, Fukumoto Y, Saji K, Sugimura K, Demachi J, Nawata J, Shimokawa H
    • Journal Title

      Heart Vessels

      Volume: 25 Pages: 144-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical coherence tomography as a novel diagnostic tool for distal type chronic thromboembolic pulmonary hypertension2010

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Nakano M, Miyamichi S, Satoh K, Oikawa M, Shimokawa H
    • Journal Title

      Circ J

      Volume: 74 Pages: 1742-4

    • NAID

      10026566233

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo2010

    • Author(s)
      Ito Y, Ito K, Shiroto T, Tsuburaya R, Yi GJ, Takeda M, Fukumoto Y, Yasuda S, Shimokawa H
    • Journal Title

      Coron Artery Dis

      Volume: 21 Pages: 304-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of new prognostic factors of pulmonary hypertension2010

    • Author(s)
      Miura Y, Fukumoto Y, Sugimura K, Oikawa M, Nakano M, Tatebe S, Miyamichi S, Satoh K, Shimokawa H
    • Journal Title

      Circ J

      Volume: 74 Pages: 1965-71

    • NAID

      10026971784

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic effects of calcium channel blockers in patients with vasospastic angina2010

    • Author(s)
      Nishigaki K, Inoue Y, Yamanouchi Y, Fukumoto Y, Yasuda S, Sueda S, Urata H, Shimokawa H, Minatoguchi S
    • Journal Title

      Circ J

      Volume: 74 Pages: 1943-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and clinical implication of metabolic syndrome in chronic heart failure2010

    • Author(s)
      Miura Y, Fukumoto Y, Shiba N, Miura T, Shimada K, Iwama Y, Takagi A, Matsusaka H, Tsutsumi T, Yamada A, Kinugawa S, Asakura M, Okamatsu S, Tsutsui H, Daida H, Matsuzaki M, Tomoike H, Shimokawa H
    • Journal Title

      Circ J

      Volume: 74 Pages: 2612-21

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization2010

    • Author(s)
      Nakano M, Fukumoto Y, Satoh K, Ito Y, Kagaya Y, Ishii N, Sugamura K, Shimokawa H
    • Journal Title

      Cardiovasc Res

      Volume: 88 Pages: 539-46

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats-Implication for the pathogenesis of hypertensive vascular disease-2010

    • Author(s)
      Sugimura K, Fukumoto Y, Nawata J, Wang H, Onoue N, Tada T, Shirato K, Shimokawa H
    • Journal Title

      Tohoku J Exp Med

      Volume: 222 Pages: 201-210

    • NAID

      10027459508

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-12009

    • Author(s)
      Satoh K, Fukumoto Y, Nakano M, Sugimura K, Nawata J, Demachi J, Karibe A, Kagaya Y, Ishii N, Sugamura K, Shimokawa H
    • Journal Title

      Cardiovasc Res

      Volume: 81 Pages: 226-34

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors2009

    • Author(s)
      Rashid M, Tawara S, Fukumoto Y, Seto M, Yano K, Shimokawa H
    • Journal Title

      Circ J

      Volume: 73 Pages: 361-70

    • NAID

      110007042186

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats2009

    • Author(s)
      Fukui S, Fukumoto Y, Suzuki J, Saji K, Nawata J, Shinozaki T, Kagaya Y, Watanabe J, Shimokawa H
    • Journal Title

      Hypertens Res

      Volume: 32 Pages: 472-80

    • NAID

      10024831111

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for Rho-Kinase Activation in Patients With Pulmonary Arterial Hypertension2009

    • Author(s)
      Do E Z, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, Tada T, Saji K, Sugimura K, Fujita H, Hoshikawa Y, Nawata J, Kondo T, Shimokawa H
    • Journal Title

      Circ J

      Volume: 73 Pages: 1731-9

    • NAID

      10025935263

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation2009

    • Author(s)
      Toyohara T, Suzuki T, Morimoto R, Akiyama Y, Souma T, Shiwaku HO, Takeuchi Y, Mishima E, Abe M, Tanemoto M, Masuda S, Kawano H, Maemura K, Nakayama M, Sato H, Mikkaichi T, Yamaguchi H, Fukui S, Fukumoto Y, Shimokawa H, Inui K, Terasaki T, Goto J, Ito S, Hishinuma T, Rubera I, Tauc M, Fujii-Kuriyama Y, Yabuuchi H, Moriyama Y, Soga T, Abe T
    • Journal Title

      J Am Soc Nephrol

      Volume: 20 Pages: 2546-55

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for Rho-Kinase Activation in Patients With Pulmonary Arterial Hypertension2009

    • Author(s)
      Do E Z, Fukumoto Y, et al.
    • Journal Title

      Circ J. 73

      Pages: 1731-1739

    • NAID

      10025935263

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rho-kinase Activity in Circulating Leukocytes as a Novel Biomarker in Patients with Chronic Heart Failure2012

    • Author(s)
      YZhulanqiqige Do. e, Yoshihiro Fukumoto, Koichiro Sugimura, Yutaka Miura, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Kotaro Nochioka, Kimio Satoh, Hiroaki Shimokawa
    • Organizer
      第76回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Rho-kinase Activity in Circulating Leukocytes as a Novel Biomarker in Patients with Chronic Heart Failure2012

    • Author(s)
      ジョランチチゴ、福本義弘, 他
    • Organizer
      第76回日本循環器学会学術集会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] (東北大学病院循環器内科)心不全ガイドラインを見直す2011

    • Author(s)
      福本義弘
    • Organizer
      第15回日本心不全学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2011-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] (東北大学病院循環器内科)三浦俊郎、松崎益徳(山口大学)島田和典、岩間義孝、高木篤俊、代田浩之(順天堂大学)朝倉正紀、友池仁暢(国立循環器病センター)堤孝樹、山田明(飯塚病院)絹川真太郎、筒井裕之(北海道大学)わが国の慢性心不全の成因における糖尿病の意義2010

    • Author(s)
      福本義弘、三浦裕、福井重文、柴信行、下川宏明
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] (東北大学病院循環器内科)肺高血圧症における新たな分子治療標的 : Rhoキナーゼの重要性2010

    • Author(s)
      福本義弘下川宏明
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺高血圧症における新たな分子治療標的:Rh0キナーゼの重要性2010

    • Author(s)
      福本義弘、下川宏明
    • Organizer
      第58回 日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Current Status and Future Perspectives of Diastolic Heart Failure in Japan-Rho-kinase as a Possible Therapeutic Target-2010

    • Author(s)
      Yoshihiro Fukumoto, Yutaka Miura, Shigefumi Fukui, Tatsuo Aoki, Toshiro Miura, Masunori Matsuzaki, Kazunori Shimada, Yoshitaka Iwama, atsutoshi Takagi, Hiroyuki Daida, Takaki Tsutsumi, Akira Yamada, Shintaro Kinugawa, Hiroyuki Tsutsui, Masanori Asakura, Hitonobu Tomoike, 1Nobuyuki Shiba, Hiroaki Shimokawa
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] (東北大学病院循環器内科)心不全に期待される新薬:ファスジル(Rhoキナーゼ阻害薬)2010

    • Author(s)
      福本義弘
    • Organizer
      第14回日本心不全学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Book] 心疾患動物モデル。完全版マウス・ラット疾患モデル活用ハンドブック2011

    • Author(s)
      珠蘭其其格、福本義弘
    • Publisher
      羊土社
    • Related Report
      2011 Final Research Report
  • [Book] 肺高血圧症に対するRhoキナーゼ阻害薬の治療効果2011

    • Author(s)
      福本義弘、下川宏明
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] 心不全日常診療Q & A2011

    • Author(s)
      青木竜男、杉村宏一郎、福本義弘
    • Publisher
      南山堂
    • Related Report
      2011 Final Research Report
  • [Book] 薬効群別副作用脂質異常症治療薬, 医薬品副作用ハンドブック第2版2010

    • Author(s)
      福本義弘、下川宏明
    • Publisher
      日本臨床社
    • Related Report
      2011 Final Research Report
  • [Book] 5章重症心不全を予防する10.メタボリックシンドロームを治す。重症心不全の予防と治療2009

    • Author(s)
      福本義弘、下川宏明
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.cardio.med.tohoku.ac.jp/class/research/blood02.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.cardio.med.tohoku.ac.jp/class/research/blood02.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cardio.med.tohoku.ac.jp/class/research/blood02.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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