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The new biomarker to diagnose heart failure

Research Project

Project/Area Number 21590886
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionChiba University

Principal Investigator

HASEGAWA Hiroshi  千葉大学, 大学院・医学研究院, 助教 (50375656)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords心不全 / 虚血性心疾患 / 心腎連関 / 左室リモデリング / 血中マーカー
Research Abstract

To evaluate the factors to detect the prognosis of the patients with heart failure, blood samples, clinical factors and medicine were screened. The anti-p53 antibody was not related to the severity of the heart failure. The prescription of telmisartan was related to the inhibitory effects on the progression of intima-media thickness of the carotid artery wall. The prescription of candesartan was related to the inhibitory effects on the morning hypertension, which was one of the risk factors of cardiovascular mortality.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (40 results)

All 2012 2011 2010 2009

All Journal Article (22 results) (of which Peer Reviewed: 6 results) Presentation (16 results) Book (2 results)

  • [Journal Article] Effects of Pitavastatin on Pressure Overload-Induced Heart Failure in Mice2012

    • Author(s)
      Kameda Y, Hasegawa H, Kubota A, Tadokoro H, Kobayashi Y, Komuro I, Takano H
    • Journal Title

      Circ J

      Volume: 76 Pages: 1159-1168

    • NAID

      10030132534

    • Related Report
      2011 Final Research Report
  • [Journal Article] Role of regulatory T cells in atheroprotective effects of granulocyte colony-stimulating factor2012

    • Author(s)
      Uchiyama R, Hasegawa H, Kameda Y, Ueda K, Kobayashi Y, Komuro I, Takano H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 52 Pages: 1038-1047

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of Switching from Telmisartan, Valsartan, Olmesartan, or Losartan to Candesartan on Morning Hypertension2012

    • Author(s)
      Hasegawa H, Takano H, Kameda Y, Kubota A, Kobayashi Y, Komuro I
    • Journal Title

      Clin Exp Hypertens

      Volume: 34 Pages: 86-91

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 高野博之PPAR2012

    • Author(s)
      長谷川洋
    • Journal Title

      血管医学

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of Pitavastatin on Pressure Overload-Induced Heart Failure in Mice2012

    • Author(s)
      Kameda Y, Hasegawa H, Kubota A, Tadokoro H, Kobayashi Y, Komuro I, Takano H
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 1159-1168

    • NAID

      10030132534

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of regulatory T cells in atheroprotective effects of granulocytecolony-stimulating factor2012

    • Author(s)
      Uchiyama R, Hasegawa H, Kameda Y, Ueda K, Kobayashi Y, Komuro I, Takano H
    • Journal Title

      J Mol Cell Cardiol

      Volume: 52 Pages: 1038-1047

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPAR2012

    • Author(s)
      長谷川洋, 高野博之
    • Journal Title

      血管医学

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients : a subanalysis of the VART2011

    • Author(s)
      Takano H, Hasegawa H, Narumi H, Shindo S, Mizuma H, Kuwabara Y, Kobayashi Y, Komuro I
    • Journal Title

      J Hum Hypertens

      Pages: 1-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hyrpertensive patients : a subanalysis of the VAET2011

    • Author(s)
      Takano H, Hasegawa H, Narumi H, Shindo S, Mizuma H, Kuwabara Y, Kobayashi Y, Komuro I
    • Journal Title

      J Hum Hypertens

      Pages: 1-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of telmisartan and losartan on cardiovascular protection in Japanese hypertensive patients2011

    • Author(s)
      Hasegawa H, Takano H, Narumi H, Ohtsuka M, Mizuguchi T, Namiki T, Kobayashi Y, Komuro I
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 1179-84

    • NAID

      10030277278

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Implications of PPARgamma in Cardiovascular Diseases2010

    • Author(s)
      Hasegawa H, Takano H, Komuro I
    • Journal Title

      PPAR Res 2010

    • Related Report
      2011 Final Research Report
  • [Journal Article] Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice2010

    • Author(s)
      Ueda K, Takano H, Niitsuma Y, Hasegawa H, Uchiyama R, Oka T, Miyazaki M, Nakaya H, Komuro I
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 2016-2029

    • Related Report
      2011 Final Research Report
  • [Journal Article] 心不全の新しい発生機序と再生治療2010

    • Author(s)
      長谷川洋, 小室一成
    • Journal Title

      日本臨牀内科医会会誌

      Volume: 24 Pages: 628-634

    • Related Report
      2011 Final Research Report
  • [Journal Article] 細胞老化と炎症2010

    • Author(s)
      長谷川洋, 南野徹
    • Journal Title

      血管医学

      Volume: 12 Pages: 31-39

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 心不全の新しい発生機序と再生治療2010

    • Author(s)
      長谷川洋, 小室一成
    • Journal Title

      日本臨林内科医会会誌

      Volume: 24 Pages: 628-634

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Therapeutic Implications of PPARgamma in Cardiovascular Diseases.2010

    • Author(s)
      Hasegawa H, Takano H, et al.
    • Journal Title

      PPAR Res.

      Volume: 2010(Epub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice.2010

    • Author(s)
      Ueda K, Takano H, et al.
    • Journal Title

      J Clin Invest.

      Volume: 120 Pages: 2016-29

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高血圧性,弁膜症性心不全2009

    • Author(s)
      長谷川洋, 小室一成
    • Journal Title

      医学のあゆみ

      Volume: 232 Pages: 309-315

    • Related Report
      2011 Final Research Report
  • [Journal Article] 拡張障害型心不全2009

    • Author(s)
      長谷川洋, 小室一成
    • Journal Title

      Medical Practice

      Volume: 26 Pages: 1924-1929

    • Related Report
      2011 Final Research Report
  • [Journal Article] 虚血性心疾患に対するG-CSF治療2009

    • Author(s)
      長谷川洋, 小室一成
    • Journal Title

      循環器科 66

      Pages: 417-423

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 高血圧性,弁膜症性心不全2009

    • Author(s)
      長谷川洋, 小室一成
    • Journal Title

      医学のあゆみ 232

      Pages: 309-315

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 拡張障害型心不全2009

    • Author(s)
      長谷川洋, 小室一成
    • Journal Title

      Medical Practice 26

      Pages: 1924-1929

    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Pitavastatin on Pressure2012

    • Author(s)
      Yoshihito Kameda, Hiroshi Hasegawa, Akihiko Kubota, Hiroyuki Tadokoro, Yoshio Kobayashi, Hiroyuki Takano
    • Organizer
      Overload-Induced Heart Failure in Mice American College of Cardiology 2012
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2012-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of Pitavastatin on Pressure Overload-Induced Heart Failure in Mice2012

    • Author(s)
      Yoshihito Kameda, Hiroshi Hasegawa, Akihiko Kubota, Hiroyuki Tadokoro, Yoshio Kobayashi, Hiroyuki Takano
    • Organizer
      American College of Cardiology 2012
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] The roles of regulatory T cells in the atheroprotective effects of granulocyte colony-stimulating factor2012

    • Author(s)
      久保田暁彦, 長谷川洋
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] OE-080 The roles of regulatory T cells in the atheroprotective effects of granulocyte colony-stimulating factor2012

    • Author(s)
      久保田暁彦, 長谷川洋
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of Regulatory T Cells in Atheroprotective Effects of Granulocyte Colony-Stimulating Factor2011

    • Author(s)
      Hiroshi Hasegawa, Hiroyuki Takano, Raita Uchiyama, Kazutaka Ueda, Yoshihito Kameda,Yoshio Kobayashi,Issei Komuro
    • Organizer
      American Heart Association 2011
    • Place of Presentation
      米国オーランド
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] バルサルタンおよびアムロジンの家庭血圧および心血管イベントに対する効果の検討 (VARTサブ解析)2011

    • Author(s)
      長谷川洋
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] CO6-35 バルサルタンおよびアムロジンの家庭血圧および心血管イベントに対する効果の検討(VARTサブ解析)2011

    • Author(s)
      長谷川洋
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of telmisartan and losartan on cardiovascular protection in Japanese hypertensive patients -TALENT study-2011

    • Author(s)
      長谷川洋
    • Organizer
      日本心臓病学会総会
    • Place of Presentation
      神戸ポートピア ホテル
    • Year and Date
      2011-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] P396 Effects of telmisartan and losartan on cardiovascular protection in Japanese hypertensive patients-TALENT study-2011

    • Author(s)
      長谷川洋
    • Organizer
      日本心臓病学会総会
    • Place of Presentation
      神戸ポートピア ホテル
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients2011

    • Author(s)
      H. Hasegawa, H. Takano, H. Narumi, S. Shindo, H. Mizuma, Y. Kuwabara, Y. Kobayashi, I. Komuro
    • Organizer
      a subanalysis of the VART European Society of Cardiology 2011
    • Place of Presentation
      パリ フランス
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 81800「Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients : a subanalysisof the VAET」2011

    • Author(s)
      H.Hasegawa, H.Takano, H.Narumi, S.Shindo, H.Mizuma, Y.Kuwabara, Y.Kobayashi, I.Komuro
    • Organizer
      European Society of Cardiology 2011
    • Place of Presentation
      パリ
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] テルミサルタンとロサルタンの心血管リモデリングに対する効果の比較-TALENT試験-2010

    • Author(s)
      長谷川洋, et al
    • Organizer
      第33回日本高血圧学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-15
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Effects of telmisartan and losartran on cardiovascular remodeling in Japanese hypertensive patients2010

    • Author(s)
      Hiroshi Hasegawa, et al
    • Organizer
      Euroean Society of Cardiology
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-08-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of telmisartan and losartran on cardiovascular remodeling in Japanese hypertensive patients.2010

    • Author(s)
      Hiroshi Hasegawa, et al.
    • Organizer
      Euroean Society of Cardiology
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] G-CSF therapy for acute myocardial infarction : Studies of animal experiments give valuable hints to clinical trials.2009

    • Author(s)
      Hiroshi Hasegawa, Hiroyuki Takano, Issei Komuro
    • Organizer
      The 26th Annual Meetingof ISHR Japanese Section
    • Place of Presentation
      北海道大学,札幌
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report
  • [Presentation] G-CSF therapy for acute myocardial infarction : Studies of animal experiments give valuable hints to clinical trials2009

    • Author(s)
      Hiroshi Hasegawa, Hiroyuki Takano, Issei Komuro
    • Organizer
      The 26^<th> Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      北海道大学,札幌
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Book] 拡張型心筋症循環器疾患最新の治療2010-20112010

    • Author(s)
      長谷川洋, 小室一成
    • Total Pages
      567
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report
  • [Book] 循環器疾患最新の治療2010-2011拡張型心筋症2010

    • Author(s)
      長谷川洋, 小室一成
    • Publisher
      南江堂
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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