| Project/Area Number |
21590888
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Niigata University |
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Principal Investigator |
OZAWA Takuya 新潟大学, 医歯学総合病院, 特任助教 (70467075)
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| Co-Investigator(Kenkyū-buntansha) |
TOBA Ken 新潟大学, 医歯学総合病院, 講師 (60313540)
HANAWA Haruo 新潟大学, 医歯学系, 講師 (40282983)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Hiroshi 昭和大学, 准教授 (90266106)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 臨床心血管病態学 / 血管再生 / 赤芽球 / 細胞療法 / 体外増幅 |
|---|
| Research Abstract |
We investigated the efficacy of a novel cell therapy by implantation of ex vivo expanded immature erythroblasts cultured from hematopoietic stem/precursor cells. 10 patients with severe chronic limb ischemia accompanied by peripheral artery disease, Burger's disease or collagen arteritis were enrolled in a pilot clinical trial of the novel cell therapy by transplantation of ex-vivo expanded immature erythroid cells. In the clinical trial, most clinical symptoms such as rest pain and skin ulcers improved in 4 weeks, and did not recur in the one-year follow-up. No adverse events were observed in any of the patients.
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