Investigation of conduction abnormality in right ventricular outflow tract in Brugada syndrome.

• Project/Area Number: 21590889
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Niigata University
• Principal Investigator: FURUSHIMA Hiroshi 新潟大学, 医歯学総合病院, 助教 (10377161)
• Co-Investigator(Renkei-kenkyūsha): CHINUSHI Masaomi 新潟大学, 医歯学系, 准教授 (40303151)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
• Keywords: 臨床血管病態学 / Brugada症候群 / 加算平均心電図 / 右室流出路 / 伝導遅延 / 抗不整脈薬

Research Abstract

Patients with Brugada syndrome had greater circadian variation in signal averaged ECG in contrast to patients with arrhythmogenic right ventricular cardiomyopathy, whose late potential may caused by the conduction delay due to fibro fatty replacement in the right ventricle. Late potential in Brugada syndrome might be caused by different mechanism from scar-related late potential.
Conduction delay during premature stimulation, especially in the outflow tract of the right ventricle, might suggest electrophysiological arrhythmogenic substrate in Brugada syndrome.

Research Products

• [Journal Article] Is the coexistence of sustained ST-segment elevation and abnormal Q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases? (2012)
  • Author(s): Furushima H, Chinushi M, Iijima K, Hasegawa K, Sato A, Izumi D, Watanabe H, Aizawa Y
  • Journal Title: Europace Volume: 14(5) Pages: 675-681
  • Peer Reviewed
• [Journal Article] The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval (2012)
  • Author(s): Izumi D, Chinushi M, Iijima K, Furushima H, Hosaka Y, Hasegawa K, Aizawa Y
  • Journal Title: Heart Rhythm Volume: 9(5) Pages: 796-803
  • Peer Reviewed
• [Journal Article] Epicardial scar in a patient with no apparent heart disease (2012)
  • Author(s): Chinushi M, Izumi D, Furushima H, Sato A, Iijima K, Hasegawa K, Aizawa Y
  • Journal Title: Pacing Clinical of Electrophysiology Volume: 35(5) Pages: 136-139
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Furushima H, Shimohata T, Nakayama H, Ozawa T, Chinushi M, Aizawa Y, Nishizawa M
  • Journal Title: Movement Disorders Volume: 27(4) Pages: 570-574
  • Peer Reviewed
• [Journal Article] Relationship between electroanatomical voltage mapping characteristics and breakout site of ventricular activation in idiopathic ventricular tachyarrhythmia originating from the right ventricular outflow tract septum (2012)
  • Author(s): Furushima H, Chinushi M, Iijima K, Izumi D, Hosaka Y, Aizawa Y
  • Journal Title: Journal of Interventional Cardiac Electrophysiology Volume: 33(2) Pages: 135-141
  • Peer Reviewed
• [Journal Article] Relationship between electroanatomical voltage mapping characteristics and breakout site of ventricular activation in idiopathic ventricular tachyarrhythmia originating from the right ventricular outflow tract septum (2012)
  • Author(s): Hiroshi Furushima
  • Journal Title: Journal of Interventional Cardiac Electrophysiology Volume: 33 Pages: 135-141
  • Peer Reviewed
• [Journal Article] Is the coexistence of sustained ST-segment elevation and abnormal Q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases? (2012)
  • Author(s): Hiroshi Furushima
  • Journal Title: Europace Volume: (In press)
  • Peer Reviewed
• [Journal Article] Significance and usefulness of heart rate variability in patients with multiple system atrophy (2012)
  • Author(s): Hiroshi Furushima
  • Journal Title: Movement Disorders Volume: (In press)
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Sato A, Chinushi M, Iijima K, Watanabe H, Izumi D, Furushima H, Sonoda K, Hasegawa K, Yagihara N, Aizawa Y
  • Journal Title: Internal Medicine Volume: 50(22) Pages: 2615-2818
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Iijima K, Chinushi M, Hasegawa K, Izumi D, Hosaka Y, Furushima H, Aizawa Y
  • Journal Title: Interval Medicine Volume: 50(9) Pages: 1021-1024
  • Peer Reviewed
• [Journal Article] Catheter ablation of ventricular tachycardias due to forward and reverse propagation across a reentrant circuit inside a nonischemic biventricular aneurysm (2011)
  • Author(s): Chinushi M, Izumi D, Furushima H, Aizawa Y
  • Journal Title: Journal of Cardiovascular Electrophysiology Volume: 22(4) Pages: 467-471
  • Peer Reviewed
• [Journal Article] Ventricular fibrillation and ventricular tachycardia triggered by late-coupled ventricular extrasystoles in a Brugada syndrome patient (2011)
  • Author(s): Chinushi M, Furushima H, Hosaka Y, Izumi D, Aizawa Y
  • Journal Title: Pacing Clinical of Electrophysiology Volume: 34(1) Pages: 1-5
  • Peer Reviewed
• [Journal Article] Fetal atrioventricular block and postpartum augmentative QT prolongation in a patient with long QT syndrome with KCNQ1 mutaion (2010)
  • Author(s): Furushima H, Chinushi M, Sato A, Aizawa Y, Kikuchi A, Takakuwa K, Tanaka K
  • Journal Title: Journal of Cardiovascular Electrophysiology Volume: 21(10) Pages: 1170-1173
  • Peer Reviewed
• [Journal Article] Ventricular tachyarrhythmia associated with hypertrophic cardiomyopathy : incidence, prognosis, and relation to type of hypertrophy (2010)
  • Author(s): Furushima H, Chinushi M, Iijima K, Sanada A, Izumi D, Hosaka Y, Aizawa Y
  • Journal Title: Journal of Cardiovascular Electrophysiology Volume: 21(9) Pages: 991-999
  • Peer Reviewed
• [Journal Article] Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog (2010)
  • Author(s): Izumi D, Chinushi M, Iijima K, Ahara S, Komura S, Furushima H, Hosaka Y, Sanada A, Yagihara N, Aizawa Y
  • Journal Title: Pacing Clinical of Electrphysiology Volume: 33(8) Pages: 950-959
  • Peer Reviewed
• [Journal Article] Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation-prevention of vagal nerve activation-induced shortening of the atrial action potential duration- (2010)
  • Author(s): Iijima K, Chinushi M, Izumi D, Ahara S, Furushima H, Komura S, Hosaka Y, Sanada A, Sasto A, Aizawa Y
  • Journal Title: Circulation Journal Volume: 74(5) Pages: 895-902
  • NAID: 10026473475
  • Peer Reviewed
• [Journal Article] Ventricular tachyarrhythmia associated with hypertrophic cardiomyopathy incidence, prognosis, and relation of type of hypertrophy (2010)
  • Author(s): Hiroshi Furushima
  • Journal Title: Journal of Cardiovascular Electrophysiology Volume: 21 Pages: 991-999
  • Peer Reviewed
• [Journal Article] Fetal atrioventricular block and postpartum augmentative QT Prolongation in a patient with longQT syndrome with KCNQ1 mutation (2010)
  • Author(s): Hiroshi Furushima
  • Journal Title: Journal of Cardiovascular Electrophysiology Volume: 21 Pages: 1170-1173
  • Peer Reviewed
• [Journal Article] Significance of early onset and progressive increase of activation delay during premature stimulation in Brugada syndrome (2009)
  • Author(s): Furushima H, Chinushi M, Iijima K, Izumi D, Hosaka Y, Aizawa Y
  • Journal Title: Circulation Journal Volume: 73(8) Pages: 1408-1415
  • NAID: 10025933443
  • Peer Reviewed
• [Journal Article] Focal atrial tachycardia refractory to radiofrequency catheter ablation originating from right atrial appendage (2009)
  • Author(s): Furushima H, Chinushi M, Hosaka Y, Aizawa Y
  • Journal Title: Europace Volume: 11(4) Pages: 521-522
  • Peer Reviewed
• [Journal Article] Significance of early onset and progressive increase of activation delay during premature stimulation in Brugada syndrome (2009)
  • Author(s): Hiroshi Furushima
  • Journal Title: Circulation Journal 73
  • NAID: 10025933443
  • Peer Reviewed
• [Journal Article] Nifekalant enlarged the transmural activation. recovery interval difference as well as the peak-to-end interval on surface ECG in a patient with short-QT syndrome
  • Author(s): Chinushi M, Sato A, Izumi D, Furushima H
  • Journal Title: Journal of Cardiovascular Electrophysiology Volume: (掲載決定印刷中)
  • Peer Reviewed
• [Journal Article] Ealry repolarization and its modification by preexcitation in two patients with intermittent Wolff-Parkinsion-White syndrome
  • Author(s): Hasegawa K, Sato A, Watanabe H, Furushima H, Chinushi M, Aizawa Y
  • Journal Title: Pacing Clinical of Electrophysiology Volume: (掲載決定印刷中)
  • Peer Reviewed
• [Journal Article] Epicardial and endocardial mapping determine most successful site of ablation for ventricular tachyarrhythmias originating from left ventricular summit
  • Author(s): Iijima K, Chinushi M, Furushima H, Aizawa Y
  • Journal Title: Europace Volume: (掲載決定印刷中)
  • Peer Reviewed
• [Journal Article]
  • Author(s): Chinushi M, Hasegawa K, Iijima K, Furushima H, Izumi D, Sato A, Aizawa Y
  • Journal Title: Pacing Clinical of Electrophysiology Volume: (掲載決定印刷中)
  • Peer Reviewed
• [Journal Article]
  • Author(s): Chinushi M, Iijima K, Furushima H, Izumi D, Sato A, Yagihara N, Hasegawa K, Watanabe H, Soejima K, Aizawa Y
  • Journal Title: Pacing Clinical of Electrophysiology Volume: (掲載決定印刷中)
  • Peer Reviewed
• [Presentation] Different characteristics of circadian variation of the signal-averaged ECG between Brugada syndrome and right venricular cardiomyopathy (2012)
  • Author(s): 古嶋博司、池主雅臣、和泉大輔、八木原伸江、園田桂子、渡部裕、佐藤光希、相澤義房
  • Organizer: 第76回日本循環器学会
  • Year and Date: 2012-03-18
• [Presentation] Different Characteristics of Circadian Variation of the Signal-averaged ECG between Brugada Syndrome and Right Ventricular Cardiomyopathy (2012)
  • Author(s): 古嶋博司
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-18
• [Presentation] Charecteristics of ventricular tachycardia in drug-refractory electrical storm in ICD patients with structural disease (2011)
  • Author(s): 古嶋博司、池主雅臣、飯嶋賢一、和泉大輔、八木原伸江、園田桂子、渡部裕、佐藤光希、相澤義房
  • Organizer: APHRS/JHRS/JSE合同学会
  • Year and Date: 2011-09-19
• [Presentation] Is coexistence of ST elevation and abnormal Q wave risk factor of electrical storm of ICD patients with structural heart disease? (2011)
  • Author(s): 古嶋博司、池主雅臣、佐藤光希、保坂幸男、八木原伸江、飯嶋賢一、和泉大輔、渡部裕、相澤義房
  • Organizer: 第75回日本循環器病学会
  • Year and Date: 2011-08-03
• [Presentation] Relationship between His-Purkinje conduction and conduction delay in the RVOT in Brugada syndrome-investigation of activity delay during premature stimulation and signal averaged ECG (2010)
  • Author(s): Hiroshi Furushima
  • Organizer: 7^<th> Tawara-Aschoff symposion
  • Place of Presentation: Tokyo
  • Year and Date: 2010-11-27
• [Presentation] (2010)
  • Author(s): 古嶋博司、池主雅臣、長谷川奏恵、八木原伸江、飯嶋賢一、和泉大輔、真田明子、渡部裕、保坂幸男、相澤義房
  • Organizer: 第25回日本不整脈学会
  • Year and Date: 2010-06-11
• [Presentation] 洞調律と類似する心房波を有し、右房前側壁の低電位領域にて異なる頻拍回路からなる2種類の心房頻拍を併発したEbstein奇形の症例 (2010)
  • Author(s): 古嶋博司、池主雅臣、佐藤光希、長谷川奏恵、八木原伸江、飯嶋賢一、和泉大輔、渡部裕、相澤義房
  • Organizer: 第40回臨床心臓電気生理研究会
  • Year and Date: 2010-05-29
• [Presentation] Postoperative atrial fibrillation in coronary artery bypass graft surgery : surface P wave morphology as predictor and preventive effect of statin (2010)
  • Author(s): 古嶋博司、池主雅臣、飯嶋賢一、和泉大輔、真田明子、八木原伸江、保坂幸男、長谷川奏恵、相澤義房、林純一
  • Organizer: 第74回日本循環器病学会
  • Year and Date: 2010-03-05