Arrhythmogenic substrate and therapeutic interventions of Tdp induced by class III and IV antiarrhythmic drugs(Tridimentional mapping of the heart)
Project/Area Number |
21590890
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Niigata University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
FURUSHIMA Hiroshi 新潟大学, 医歯学総合病院, 助手 (10377161)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | III群 / IV群抗不整脈薬 / 心臓立体マッピング / 不整脈 / 薬物療法 / 心臓電気生理 / マッピング / 催不整脈効果 |
Research Abstract |
A high correlation was found between surface ECG Tp-e(from peak to end interval of T wave) and total left ventricular dispersion. In contrast, pseudo transmural Tp-e correlated with transmural recovery time(RT) dispersion. The shortest RT in the heart roughly corresponded to the peak, as did the longest RT with the end of the T wave on the surface ECG. Pacing treatment was most effective in anthopleurin-A model followed by E-4031, bepridil and amiodarone model. On the other hand, supplemental treatment of potassium showed the greatest therapeutic effect in E-4031 model. Magnesium homogenized the distribution of ventricular repolarization in anthopleurin-A model but not in the other models created by E-4031, bepridil and amiodarone.
|
Report
(4 results)
Research Products
(38 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article]2009
Author(s)
池主雅臣、和泉大輔、相澤義戸
-
Journal Title
分担執筆。ベプリジルの基礎と臨床。心室性不整脈に対する効果(ライフメディコム社)
Pages: 79-89
Related Report
-
-
[Presentation] 心不全と心室性不整脈2011
Author(s)
池主雅臣
Organizer
第15回日本心不全学会シンポジク
Place of Presentation
かごじま県交流センター(鹿児島県)(招待講演)
Year and Date
2011-10-13
Related Report
-
-
[Presentation] Non-linear radiofrequency catheter ablation for electrical storm due to non-ischemic ventricular tachycardia2011
Author(s)
Chinushi M, Iijima K, Izumi D, Furushima H, Sato A, Hosaka Y, Hasegawa K, Yagihara N, Watanabe H, Sanada A, Aizawa Y.
Organizer
The 75th annual scientific meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Related Report
-
-
-
-
-
-
-
-
-