Arrhythmogenic substrate and therapeutic interventions of Tdp induced by class III and IV antiarrhythmic drugs(Tridimentional mapping of the heart)

• Project/Area Number: 21590890
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Niigata University
• Principal Investigator: CHINUSHI Masaomi 新潟大学, 医歯学系, 准教授 (40303151)
• Co-Investigator(Renkei-kenkyūsha): FURUSHIMA Hiroshi 新潟大学, 医歯学総合病院, 助手 (10377161)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: III群 / IV群抗不整脈薬 / 心臓立体マッピング / 不整脈 / 薬物療法 / 心臓電気生理 / マッピング / 催不整脈効果

Research Abstract

A high correlation was found between surface ECG Tp-e(from peak to end interval of T wave) and total left ventricular dispersion. In contrast, pseudo transmural Tp-e correlated with transmural recovery time(RT) dispersion. The shortest RT in the heart roughly corresponded to the peak, as did the longest RT with the end of the T wave on the surface ECG. Pacing treatment was most effective in anthopleurin-A model followed by E-4031, bepridil and amiodarone model. On the other hand, supplemental treatment of potassium showed the greatest therapeutic effect in E-4031 model. Magnesium homogenized the distribution of ventricular repolarization in anthopleurin-A model but not in the other models created by E-4031, bepridil and amiodarone.

Research Products

• [Journal Article] The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval (2012)
  • Author(s): Izumi D, Chinushi M, Iijima K, Furushima H, Hosaka Y, Hasegawa K, Aizawa Y
  • Journal Title: Heart Rhythm Volume: (掲載決定印刷中)
  • Peer Reviewed
• [Journal Article] Rate control is a better initial treatment for patients with atrial fibrillation and heart failure (2011)
  • Author(s): Chinushi M, Iijima K
  • Journal Title: Circ J Volume: 75(4) Pages: 970-8
  • Peer Reviewed
• [Journal Article] ST-T Abnormalities on ECG in relation to cardiovascular risk factors (2011)
  • Author(s): Chinushi Y, Watanabe H, Chinushi M, Aizawa Y
  • Journal Title: Journal of Arrhythmia Volume: 27 Pages: 202-207
  • NAID: 10029599200
  • Peer Reviewed
• [Journal Article] Endocardial arrhythmogenic mechanisms of torsades de pointes in patients with the congenital long QT syndrome (2011)
  • Author(s): Chinushi M, Furushima H, Hosaka Y, Komura S, Sato A, Iijima K, Aizawa Y.
  • Journal Title: Internal Med Volume: 50(16) Pages: 1695-702
  • NAID: 130000969371
  • Peer Reviewed
• [Journal Article] Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats (2011)
  • Author(s): Kimura S, Ito M, Tomita M, Hoyano M, Obata H, Limin D, Chinushi M, Hanawa H, Kodama M, Aizawa Y
  • Journal Title: Hypertens Res. Volume: 34(5) Pages: 584-91
  • NAID: 10031163222
  • Peer Reviewed
• [Journal Article] An appropriate defibrillation threshold obtained by the combined connection between two shock leads and ICD generator (2011)
  • Author(s): Sato A, Chinushi M, Iijima K, Watanabe H, Izumi D, Furushima H, Sonoda K, Hasegawa K, Yagihara N, Aizawa Y
  • Journal Title: Intern Med Volume: 50(22) Pages: 2815-8
  • NAID: 130002130066
  • Peer Reviewed
• [Journal Article] Brugada-type ST-segment elevation influenced by post-esophageal reconstruction (2011)
  • Author(s): Chinushi M, Ohno Y, Sanada A, Aizawa Yoshifusa
  • Journal Title: J Cardiovasc Electrophysiol Volume: 22(11) Pages: 1292-3
  • Peer Reviewed
• [Journal Article] Inappropriate pacing inhibition triggered by QT prolongation due to T wave oversensing in an ICD recipient presenting with long QT syndrome (2011)
  • Author(s): Iijima K, Chinushi M, Hasegawa K, Izumi D, Hosaka Y, Furushima H, Aizawa Y
  • Journal Title: Intern Med Volume: 50(9) Pages: 1021-4
  • NAID: 130000650105
  • Peer Reviewed
• [Journal Article] Ventricular tachycardia due to intramyocardial fibroma. (2011)
  • Author(s): Iijima K, Chinushi M, Izumi D, Aizawa Y.
  • Journal Title: J Cardiovasc Electrophysiol Volume: 22(7) Pages: 825-6
  • Peer Reviewed
• [Journal Article] Preexcitation unmasks J waves (2011)
  • Author(s): Nagao S, Hayashi Y, Yagihara N, Sato A, Watanabe H, Furushima H, Chinushi M, Aizawa Y
  • Journal Title: J Electrocardiol Volume: 44(3) Pages: 359-62
  • Peer Reviewed
• [Journal Article] Catheter ablation of ventricular tachycardias due to forward and reverse propagation across a reentrant circuit inside a nonischemic biventricular aneurysm (2011)
  • Author(s): Chinushi M, Izumi D, Furushima H, Aizawa Y
  • Journal Title: J Cardiovasc Electrophysiol. Volume: 22(4) Pages: 467-71
  • Peer Reviewed
• [Journal Article] Ventricular fibrillation and ventricular tachycardia triggered by late-coupled ventricular extrasystoles in a Brugada syndrome patient (2011)
  • Author(s): Chinushi M, Furushima H, Hosaka Y, Izumi D, Aizawa Y.
  • Journal Title: Pacing Clin Electrophysiol Volume: 34(1) Pages: 1-5
  • Peer Reviewed
• [Journal Article] The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather. than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval (2011)
  • Author(s): Izumi D, Chinushi M, Iijima K, Furushima H, Hosaka Y., et al
  • Journal Title: Heart Rhythm Volume: 26 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats (2011)
  • Author(s): Kimura S, Ito M, Tomita M, Hoyano M, Obata H, Ding L, Chinushi M, et al
  • Journal Title: Hypertens Res. Volume: 34 Pages: 584-591
  • NAID: 10031163222
  • Peer Reviewed
• [Journal Article] Endocardial arrhythmogenic mechanisms of torsades de pointes with the congenital long QT syndrome (2011)
  • Author(s): Chinushi M, Furushima H, Hosaka Y, Komura S, Sato A, Iijima K, Aizawa Y
  • Journal Title: Intern Med. Volume: 50 Pages: 1695-1702
  • Peer Reviewed
• [Journal Article] Ventricular tachyarrhythmia associated with hypertrophic cardiomyopathy (2010)
  • Author(s): Furushima H, Chinushi M, Iijima K ; Sanada A, Izum D, Hosaka Y, Aizawa Y
  • Journal Title: J Cardiovasc Electrophysiol Volume: 21(9) Pages: 991-9
  • Peer Reviewed
• [Journal Article] Effects of bepridil versus e-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog (2010)
  • Author(s): Izumi D, Chinushi M, Iijima K, Ahara S, Komura S, Furushima H, Hosaka Y, Sanada A, Yagihara N, Aizawa Y
  • Journal Title: Pacing Clin Electrophysiol Volume: 33(8) Pages: 950-9
  • Peer Reviewed
• [Journal Article] Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation. Prevention of vagal nerve activation induced shortening of the atrial action potential duration (2010)
  • Author(s): Iijima K, Chinushi M, Izumi D, Ahara S, Furushima H, Komura S, Hosaka Y, Sanada A, Sato A, Aizawa Y
  • Journal Title: Circ J. Volume: 74(5) Pages: 895-902
  • NAID: 10026473475
  • Peer Reviewed
• [Journal Article] Effects of bepridil versus e-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog (2010)
  • Author(s): Izumi D, Chinushi M, Iijima K, Ahara S, Komura S, Furushima H, et al
  • Journal Title: Pacing Clin Electrophysiol Volume: 33 Pages: 950-959
  • Peer Reviewed
• [Journal Article] Efficacy of procainamide and lidocaine in terminating sustained monomorphic ventricular tachycardia (2010)
  • Author(s): Komura S, Chinushi M, Furushima H, Hosaka Y, Izumi D, Iijima K, et al.
  • Journal Title: Circ J Volume: 74 Pages: 864-869
  • Peer Reviewed
• [Journal Article] Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation. (2010)
  • Author(s): Iijima K, Chinushi M, Izumi D, Ahara S, Furushima H, Komura S, et al.
  • Journal Title: Circ J Volume: 74 Pages: 895-902
  • Peer Reviewed
• [Journal Article] Effects of verapamil on anterior ST segment and ventricular fibrillation cycle length in patients with Brugada syndrome (2009)
  • Author(s): Chinushi M, lijima K, Tagawa M, Komura S, Furushima H, Aizawa Y
  • Journal Title: J Electrocardiology 42 Pages: 369-373
  • Peer Reviewed
• [Journal Article] Significance of Early Onset and Progressive Increase of Activation Delay during Premature Stimulation in Brugada Syndrome. (2009)
  • Author(s): Furushima H, Chinushi M, lijima K, Izumi D, Hosaka Y, Aizawa, Y.
  • Journal Title: Circulation Journal 73 Pages: 1408-1415
  • NAID: 10025933443
  • Peer Reviewed
• [Journal Article] Ventricular fibrillation triggered during and after radiofrequency energy delivery to the site of origin of idiopathic right ventricular outflow tract arrhythmia (2009)
  • Author(s): lijima K, Chinushi M, Furushima H, Hosaka Y, Izumi D, Aizawa Y,
  • Journal Title: Pacing Clin Electrophysiol 32 Pages: 406-409
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 池主雅臣、和泉大輔、相澤義戸
  • Journal Title: 分担執筆。ベプリジルの基礎と臨床。心室性不整脈に対する効果(ライフメディコム社) Pages: 79-89
• [Presentation] シンポジウム。不整脈と心不全。心不全の心室性不整脈 (2011)
  • Author(s): 池主雅臣
  • Organizer: 第15回日本心不全学会シンポジウム
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-10-13
• [Presentation] 心不全と心室性不整脈 (2011)
  • Author(s): 池主雅臣
  • Organizer: 第15回日本心不全学会シンポジク
  • Place of Presentation: かごじま県交流センター(鹿児島県)(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] Magnesium treatment for drug-induced QT prolongation (2011)
  • Author(s): Izumi D, Chinushi M, Iijima K, Hasegawa K, Sato A, Furushima H, Aizawa Y
  • Organizer: The 28th Japanese Society of Electrocardiology
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-09-18
• [Presentation] Non-linear radiofrequency catheter ablation for electrical storm due to non-ischemic ventricular tachycardia (2011)
  • Author(s): Chinushi M, Iijima K, Izumi D, Furushima H, Sato A, Hosaka Y, Hasegawa K, Yagihara N, Watanabe H, Sanada A, Aizawa Y.
  • Organizer: The 75th annual scientific meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama
• [Presentation] Correlation between T peak-end interval on surface ECG and distribution of the intracardiac repolarization in steady state and during TWA (2011)
  • Author(s): Izumi1 D, Chinushi M, Iijima K, Furushima H, Komura S, Hosaka Y, Ahara S, Aizawa Y
  • Organizer: The 75th annual scientific meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama
• [Presentation] Activation recovery interval is a useful parameter to assess the intracardiac ventricular repolarization at multiple sites during an electrophysiologic study (2010)
  • Author(s): Chinushi M, Furushima H, Iijima K, Izumi D, Hosaka Y, Sato A, Watanabe H, Yagihara N, Hasegawa K, Aizawa Y
  • Organizer: Asia Pacific Heart Rhythm Society
  • Place of Presentation: Korea
  • Year and Date: 2010-10-30
• [Presentation] 病態に応じた心室性不整脈の薬物療法 (2010)
  • Author(s): 池主雅臣
  • Organizer: 第27回日本心電学会学術集会公開講座
  • Place of Presentation: 大分
  • Year and Date: 2010-10-09
• [Presentation] 心室不整脈に対するハイブリット療法の実践 (2009)
  • Author(s): 池主雅臣
  • Organizer: 日本不整脈学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-04
• [Book] 専門医をめざす!循環器診療のパーフェクトガイド。陳旧性心筋梗塞の心室頻拍。 (2011)
  • Author(s): 池主雅臣・飯嶋賢一
  • Publisher: 中山書店
• [Book] EPS概論。陳旧性心筋梗塞の心室不整脈 (2011)
  • Author(s): 池主雅臣
  • Publisher: 南江堂
• [Book] 分担執筆。EPS概論。陳旧性心筋梗塞の心室不整脈 (2011)
  • Author(s): 池主雅臣
  • Publisher: 南江堂
• [Book] カテーテルアブレーション治療(2010改定版)。基本から最新治療まで。心室頻拍・心室細動 (2010)
  • Author(s): 池主雅臣・和泉大輔
  • Publisher: メジカルビュー社
• [Book] 循環器病ケースアプローチシリーズ 非持続性心室頻拍(分担執筆) (2010)
  • Author(s): 池主雅臣・飯嶋賢一
  • Publisher: 羊土社