Development of New Treatment Strategies for Viral Myocarditis and Cardiomyopathy with Lymphangiogenesis factors in the Heart

• Project/Area Number: 21590892
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: NISHIO Ryosuke 京都大学, 医学研究科, 助教 (00335275)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 臨床心血管病態学 / 心不全 / リンパ管 / 心筋症 / 心筋梗塞 / 心筋炎 / 心機能

Research Abstract

We examined the effects of VEGF-C156S, lymphangiogenesis inducer, and VEGFR3-Fc, lymphangiogenesis blocker, in murine models of viral myocarditis and cardiomyopathy with micro-catheters. We developed new treatment strategies for viral myocarditis and cardiomyopathy with limphangiogenesis factors in the heart.

Research Products

• [Journal Article] Guidelines for diagnosis and treatment of myocarditis(JCS 2009): digest version (2011)
  • Author(s): JCS Joint Working Group
  • Journal Title: Circ J. Volume: 75 Pages: 734-743
  • Peer Reviewed
• [Journal Article] Guidelines for diagnosis and treatment of myocarditis (JCS 2009) : digest version. (2011)
  • Author(s): JCS Joint Working Group
  • Journal Title: Circ J. Volume: 75 Pages: 734-743
  • Peer Reviewed
• [Journal Article] Role of substance P in viral myocarditis in mice (2010)
  • Author(s): Wang Y, Shimada M, Xu Y, Hu D, Nishio R, Matsumori A
  • Journal Title: Heart Vessels Volume: 25 Pages: 348-352
  • Peer Reviewed
• [Journal Article] Calcium channel blockers differentially modulate cytokine production by peripheral blood mononuclear cells (2010)
  • Author(s): Matsumori A, Nishio R, Nose Y
  • Journal Title: Circ J Volume: 74 Pages: 567-571
  • NAID: 10025943815
  • Peer Reviewed
• [Journal Article] Role of substance P in viral myocarditis in mice. (2010)
  • Author(s): Wang Y, Shimada M, Xu Y, Hu D, Nishio R, Matsumori A.
  • Journal Title: Heart Vessels Volume: 25 Pages: 348-352
  • Peer Reviewed
• [Journal Article] Calcium channel blockers differentially modulate cytokine production by peripheral blood mononuclear cells. (2010)
  • Author(s): Matsumori A, Nishio R, Nose Y.
  • Journal Title: Circ J. 74 Pages: 567-571
  • NAID: 10025943815
  • Peer Reviewed
• [Journal Article] Reverse remodeling and improved function by antihypertensive treatment in hypertensive patients with coronary artery disease. (2010)
  • Author(s): Yui Y, Kodama K, Hirayama A, Nishio R, Iwanaga Y, Nongi H, Haze K, Sumiyoshi T, Yui N, Hosoda S, Kawai C ; Japan Multicenter Investigation for Cardiovascular Diseases B (JMIC-B) Study Group.
  • Journal Title: J Hypertens. 28 Pages: 178-185
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 西尾亮介、松森昭
  • Journal Title: 「循環器内科」(第67巻第3号)特集/循環器と他臓器疾患 5.循環器と免疫(科学評論社) Pages: 262-272
• [Journal Article] (2010)
  • Author(s): 西尾亮介、松森昭
  • Journal Title: 診療に活かす心機能評価、実際の患者治療に心機能評価を取り入れる §1 収縮機能の低下 4.二次性心筋症(サルコイドーシス、アミロイドーシスなど)(羊土社) Pages: 181-193
• [Journal Article] (2010)
  • Author(s): 西尾亮介、松森昭
  • Journal Title: 「循環器疾患 最新の治療2010-2011」 VI-4拘束型心筋症(南江堂) Pages: 191-194
• [Journal Article] Japan Multicenter Investigation for Cardiovascular Diseases B(JMIC-B) Study Group. Reverse remodeling and improved function by antihypertensive treatment in hypertensive patients with coronary artery disease. (2009)
  • Author(s): Yui Y, Kodama K, Hirayama A, Nishio R, Iwanaga Y, Nonogi H, Haze K, Sumiyoshi T, Yui N, Hosoda S, Kawai C
  • Journal Title: J Hypertens Volume: 28 Pages: 178-185
  • Peer Reviewed
• [Journal Article] Gelsolin and cardiac myocyte apoptosis : a new target in the treatment of postinfarction remodeling (2009)
  • Author(s): Nishio R, Matsumori A
  • Journal Title: Circ Res Volume: 104
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphyin Parkinson disease (2009)
  • Author(s): Sawada H, Oeda T, Yamamoto K, Kitagawa N, Mizuta E, Hosokawa R, Ohba M, Nishio R, Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T
  • Journal Title: Eur J Neurol Volume: 16 Pages: 174-82
  • Peer Reviewed
• [Journal Article] Gelsolin and cardiac myocyte apoptosis : a new target in the treatment of postinfarction remodeling. (2009)
  • Author(s): Nishio R, Matsumori A.
  • Journal Title: Circ Res. 104 Pages: 829-831
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease. (2009)
  • Author(s): Sawada H, Oeda T, Yamamoto K, Kitagawa N, Mizuta E, Hosokawa R, Ohba M, Nishio R, Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T.
  • Journal Title: Eur J Neurol. 16 Pages: 174-182
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 西尾亮介、松森昭
  • Journal Title: 月刊「Mebio」(2009年12月号)心血管病の診断と治療におけるバイオマーカーの有用性 トロポニンI抗体(メジカルビュー社) Pages: 16-23
• [Journal Article] (2009)
  • Author(s): 西尾亮介、松森昭
  • Journal Title: 重症心不全の予防と治療 1章 6.感染症学から(中外医学社) Pages: 43-50
• [Journal Article] (2009)
  • Author(s): 西尾亮介
  • Journal Title: 失神を究める IV-循環器疾患における失神の病態と治療を知る 3.心筋症(メジカルビュー社) Pages: 160-169
• [Presentation] 心疾患におけるリンパ管新生 (2010)
  • Author(s): Ryosuke Nishio, Hajime Kubo, Akira Matsumori
  • Organizer: 第34回リンパ学会総会
  • Place of Presentation: 東京大学山上会館大会議室,東京
  • Year and Date: 2010-06-26
• [Presentation] 心疾患におけるリンパ管新生 (2010)
  • Author(s): Ryosuke Nishio, Hajime Kubo, Akira Matsumori
  • Organizer: 第34回リンパ学会総会
  • Place of Presentation: 東京大学 山上会館 大会議室,東京
  • Year and Date: 2010-06-26
• [Presentation] Role of Lymphangiogenesis Factors in Heart Diseases. (2010)
  • Author(s): Ryosuke Nishio, Hajime Kubo, Akira Matsumori
  • Organizer: World Congress of Cardiology Scientific Sessions 2010
  • Place of Presentation: China National Convention Center, Beijing, China
  • Year and Date: 2010-06-19
• [Presentation] Role of Lymphangiogenesis Factors in Heart Diseases (2010)
  • Author(s): Ryosuke Nishio, Hajime Kubo, Akira Matsumori
  • Organizer: World Congress of Cardiology Scientific Sessions
  • Place of Presentation: China National Convention Center, Beijing, China
  • Year and Date: 2010-06-10
• [Presentation] Effects of Lymphangiogenic Factors on Left Ventricular Function in Heart Diseases. (2009)
  • Author(s): Ryosuke Nishio, Hajime Kubo, Kaoru Koike, Akira Matsumori
  • Organizer: 17^<th> Asian Pacific Congress of Cardiology
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2009-05-21
• [Presentation] Effects of Lymphangiogenic Factors on Left Ventricular Function in Heart Diseases (2009)
  • Author(s): Ryosuke Nishio, Hajime Kubo, Kaoru Koike, Akira Matsumori
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2009-03-21
• [Book] 「ER・ICUでの薬の使い方Q & A～2011・12」VI.循環器疾患の緊急治療26-心筋炎/劇症型心筋炎 (2011)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 総合医学社
• [Book] ER・ICUでの薬の使い方Q&A～2011・12(VI.循環器疾患の緊急治療 26.心筋炎/劇症型心筋炎) (2011)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 総合医学社
• [Book] 性心筋炎の病態生理一とくにウイルス感染症における場合 (2010)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 東京医学社
• [Book] 「循環器診療サピア8心不全の急性期対応」4章:心不全の原因疾患と急性期対応を知るD.(拡張型)心筋症 (2010)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 羊土社
• [Book] 「循環器内科」(第67巻第3号)特集/循環器と他臓器疾患5-循環器と免疫 (2010)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 科学評論社
• [Book] 診療に活かす心機能評価、実際の患者治療に心機能評価を取り入れる§1収縮機能の低下4.二次性心筋症(サルコイドーシス、アミロイドーシスなど) (2010)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 羊土社
• [Book] 「循環器疾患最新の治療2010-2011」VI-4拘束型心筋症 (2010)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 南江堂
• [Book] 小児内科 心筋・心膜疾患のup to date(I.総論急性心筋炎の病態生理-とくにウイルス感染症における場合) (2010)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 東京医学社
• [Book] 循環器診療サピア8 心不全の急性期対応(4章:心不全の原因疾患と急性期対応を知る D.(拡張型)心筋症) (2010)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 羊土社
• [Book] 月刊「Mebio」(2009年12月号)心血管病の診断と治療におけるバイオマーカーの有用性トロポニンI抗体 (2009)
  • Author(s): 西尾亮介、松森昭
  • Publisher: メジカルビュー社
• [Book] 重症心不全の予防と治療1章6-感染症学から (2009)
  • Author(s): 西尾亮介、松森昭
  • Publisher: 中外医学社
• [Book] 失神を究めるIV-循環器疾患における失神の病態と治療を知る3.心筋症 (2009)
  • Author(s): 西尾亮介
  • Publisher: メジカルビュー社
• [Remarks]
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/shinkinsyo/