Study of Reendotheliazation after Placing the Drug Eluting Scent.

• Project/Area Number: 21590901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Saga University
• Principal Investigator: NODE Koichi 佐賀大学, 医学部, 教授 (80359950)
• Co-Investigator(Kenkyū-buntansha): SAKUMA Masashi 佐賀大学, 医学部, 医員 (10530199)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 臨床心血管病態学

Research Abstract

Cultured human peripheral blood mononuclear cell indicated that the effects of cilostazol induce the endothelial differentiation. Furthermore, the PKA inhibitor was established to control the cilostazol-inducing activity toward endothelial cell. It is remained unproven that cilostazol improves the delay of vascular endothelial regeneration caused by SES.

Research Products

• [Journal Article] Activation of matrix metalloproteinase-9 is associated with mobilization of bone marrow-derived cells after coronary stent implantation (2011)
  • Author(s): Inoue T, Taguchi I, Abe S, Toyoda S, Nakajima K, Sakuma M, Node K
  • Journal Title: Int J Cardiol Volume: 152(3) Pages: 332-6
  • Peer Reviewed
• [Journal Article] Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice (2011)
  • Author(s): Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata K, Oike Y
  • Journal Title: J Biol Chem Volume: 286(5) Pages: 3992-4002
  • NAID: 120006957387
  • Peer Reviewed
• [Journal Article] The role of vascular failure in coronary artery spasm (2011)
  • Author(s): Kawano H, Node K
  • Journal Title: J Cardiol Volume: 57(1) Pages: 2-7
  • NAID: 10027869014
  • Peer Reviewed
• [Journal Article] Potential benefit of statin therapy for dyslipidemia with chronic kidney disease : Fluvastatin Renal Evaluation Trial(FRET) (2011)
  • Author(s): Taguchi I, Kikuchi M, Toyoda S, Miyazono M, Kishi T, Sanai T, Node K
  • Journal Title: Intern Med Volume: 50(12) Pages: 1273-8
  • NAID: 130000770491
  • Peer Reviewed
• [Journal Article] Inhibition of intestinal cholesterol absorption might explain cholesterol-lowering effect of telmisartan (2011)
  • Author(s): Inoue T, Taguchi I, Abe S, Toyoda S, Sakuma M, Node K
  • Journal Title: J Clin Pharm Ther Volume: 36(1) Pages: 103-10
  • Peer Reviewed
• [Journal Article] Defining Vascular Disease(DVD) Research Group. Risk stratification based on metabolic syndrome as well as non-metabolic risk factors in the assessment of carotid atherosclerosis (2011)
  • Author(s): Noda H, Iso H, Yamashita S, Ueno H, Yokode M, Yamada N, Ouchi Y
  • Journal Title: J Atheroscler Thromb Volume: 18(6) Pages: 504-12
  • Peer Reviewed
• [Journal Article] Vascular inflammation and repair : implications for re-endothelialization, restenosis, and stent thrombosis (2011)
  • Author(s): Inoue T, Croce K, Morooka T, Sakuma M, Node K, Simon DI
  • Journal Title: JACC Cardiovasc Interv Volume: 4(10) Pages: 1057-1066
  • Peer Reviewed
• [Journal Article] Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to Get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria (2011)
  • Author(s): Ando K, Haneda M, Ito S, Kashihara N, Node K, Nangaku M, Shimosawa T, Kishimoto J, Fujita T
  • Journal Title: Cardiovasc Drugs Ther.2011 Volume: 25(4) Pages: 341-734
  • Peer Reviewed
• [Journal Article] Renovascular protective effects of erythropoietin in patients with chronic kidney disease (2011)
  • Author(s): Fujiwara N, Nakamura T, Sato E, Kawagoe Y, Hikichi Y, Ueda Y, Node K
  • Journal Title: Intern Med Volume: 50(18) Pages: 1929-1934
  • NAID: 130000969298
  • Peer Reviewed
• [Journal Article] Effects of aerobic exercise on lipid profiles and high molecular weight adiponectin in Japanese workers (2011)
  • Author(s): Guo W, Kawano H, Piao L, Itoh N, Node K, Sato T
  • Journal Title: Intern Med Volume: 50(5) Pages: 389-395
  • NAID: 130000649848
  • Peer Reviewed
• [Journal Article] Potential benefit of statin therapy for dyslipidemia with chronic kidney disease : Fluvastatin Renal Evaluation Trial (FRET) (2011)
  • Author(s): Inoue T, Ikeda H, Nakamura T, Abe S, Taguchi I, Kikuchi M, Toyoda S, Miyazono M, Kishi T, Sanai T, Node K
  • Journal Title: Intern Med Volume: 50(12) Pages: 1273-8
  • NAID: 130000770491
  • Peer Reviewed
• [Journal Article] Inhibition of intestinal cholesterol absorption might explain cholesterol-1 owering effect of telmisartan (2011)
  • Author(s): Inoue T, Taguchi I, Abe S, Toyoda S, Sakuma M, Node K
  • Journal Title: J Clin Pharm Ther Volume: 36(1) Pages: 103-10
  • Peer Reviewed
• [Journal Article] Antihypertensive treatment using an angiotensin receptor blocker and a thiazide diuretic improves patients' quality of life : the Saga Challenge Antihypertensive Study (S-CATS) (2011)
  • Author(s): Kamura A, Inoue T, Kuroki S, Ishida S, Iimori K, Kato T, Naitoh H, Tamesue S, Ikeda H, Node K
  • Journal Title: Hypertens Res Volume: 34(12) Pages: 1288-94
  • NAID: 10030277951
  • Peer Reviewed
• [Journal Article] Risk stratification based on metabolic syndrome as well as non- metabolie risk factors in the assessment of carotid atherosclerosis (2011)
  • Author(s): Noda H, Iso H, Yamashita S, Ueno H, Yokode M, Yamada N, Ouchi Y; Defining Vascular Disease (DVD) Research Group
  • Journal Title: J Atheroscler Thromb Volume: 18(6) Pages: 504-12
  • Peer Reviewed
• [Journal Article] Relationships among hyperuricemia, metabolic syndrome, and endothelial function (2011)
  • Author(s): Tomiyama H, Higashi Y, Takase B, Node K, Sata M, Inoue T, Ishibashi Y, Ueda S, Shimada K, Yamashina A
  • Journal Title: Am J Hypertens Volume: 24(7) Pages: 770-774
  • Peer Reviewed
• [Journal Article] Pleiotropic effects of ARB on dyslipidemia (2011)
  • Author(s): Taguchi I, Inoue T, Kikuchi M, Toyoda S, Arikawa T, Abe S, Node K
  • Journal Title: Curr Vasc Pharmacol Volume: 9(2):129-35 Pages: 129-135
  • Peer Reviewed
• [Journal Article] Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice. (2011)
  • Author(s): Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata K, Oike Y.
  • Journal Title: J Biol Chem. Volume: 286(5) Pages: 3992-4002
  • NAID: 120006957387
  • Peer Reviewed
• [Journal Article] The role of vascular failure in coronary artery spasm. (2011)
  • Author(s): Kawano H, Node K.
  • Journal Title: J Cardiol. Volume: 57(1) Pages: 2-7
  • NAID: 10027869014
  • Peer Reviewed
• [Journal Article] Rab5a-mediated localization of claudin-1 is regulated by proteasomes in endothelial cells. (2011)
  • Author(s): Asaka M, Hirase T, Hashimoto-Komatsu A, Node K.
  • Journal Title: Am J Physiol CellPhysiol. Volume: 300(1)
  • Peer Reviewed
• [Journal Article] Nobuyoshi M. PCI using a 4-Fr" child" guide catheter in a" mother" guide catheter : Kyushu KIWAMIR ST registry (2010)
  • Author(s): Hiwatashi A, Iwabuchi M, Yokoi H, Tayama S, Sakamoto T, Noda K, Shibata Y, Hikichi Y, Node K, Ueno T
  • Journal Title: Catheter Cardiovasc Interv Volume: 76(7) Pages: 919-23
  • Peer Reviewed
• [Journal Article] PCI using a 4-Fr "child" guide catheter in a "mother" guide catheter : Kyushu KIWAMI[○!R] ST registry. (2010)
  • Author(s): Hiwatashi A, Iwabuchi M, Yokoi H, Tayama S, Sakamoto T, Noda K, Shibata Y, Hikichi Y, Node K, Ueno T, Nobuyoshi M.
  • Journal Title: Catheter Cardiovasc Interv. Volume: 76(7) Pages: 919-23
  • Peer Reviewed
• [Journal Article] Activation of matrix metalloproteinase-9 is associated with mobilization of bone marrow-derived cells after coronary stent implantation. (2010)
  • Author(s): Inoue T, Taguchi I, Abe S, Toyoda S, Nakajima K, Sakuma M, Node K.
  • Journal Title: Int J Cardiol.2010 Aug26. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Molecular Basis of Restenosis and Novel Issues of Drug-Eluting Stents (2009)
  • Author(s): Inoue T, Node K
  • Journal Title: Circulation Journal Volume: 73(4) Pages: 615-621
  • NAID: 10025928943
  • Peer Reviewed
• [Journal Article] Estimated glomerular filtration rate as a predictor of secondary outcomes in Japanese patients with coronary artery disease (2009)
  • Author(s): Matsuo K, Inoue T, Node K
  • Journal Title: Journal of Cardiology Volume: 53(2) Pages: 232-239
  • NAID: 10025183179
  • Peer Reviewed
• [Journal Article] Reversible primary hypothyroidism in Japanese patients undergoing maintenance hemodialysis. (2009)
  • Author(s): Sanai T, Inoue T, Okamura K, Sato K, Yamamoto K, Abe T, Node K, Tsuruya K, Iida M.
  • Journal Title: Clin Nephrol 69(2) Pages: 107-113
  • Peer Reviewed
• [Journal Article] Increased interleukin-13 levels in patients with chronic heart failure. (2009)
  • Author(s): Nishimura Y, Inoue T, Nitto T, Morooka T, Node K.
  • Journal Title: Int J Cardiol. 131(3) Pages: 421-23
  • Peer Reviewed
• [Journal Article] Identification of four novel mutations in F5 associated with congenital factor V deficiency. (2009)
  • Author(s): Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okamura T, Nagumo F, Ohta S, Izuhara K.
  • Journal Title: Int J Hematol. 89(1) Pages: 71-75
  • NAID: 10025159727
  • Peer Reviewed
• [Journal Article] Molecular Basis of Restenosis and Novel Issues of Drug-Eluting Stents (2009)
  • Author(s): Inoue T, Node K.
  • Journal Title: Circulation Journal 73(4) Pages: 615-621
  • NAID: 10025928943
  • Peer Reviewed
• [Journal Article] Estimated glomerular filtration rate as a predictor of secondary outcomes in Japanese patients with coronary artery disease (2009)
  • Author(s): Matsuo K, Inoue T, Node K.
  • Journal Title: Journal of Cardiology 53 Pages: 232-239
  • NAID: 10025183179
  • Peer Reviewed
• [Journal Article]
  • Author(s): Inoue T, Ikeda H, Nakamura T, Abe S
• [Presentation] 心不全における遠隔治療-ITによる在宅管理(HOMES-CHF) (2011)
  • Author(s): 野出孝一
  • Organizer: 第15回日本心不全学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-10-13
• [Presentation] 心不全における遠隔治療-ITによる在宅管理(HOMES-CHF) (2011)
  • Author(s): 野出孝一
  • Organizer: 第15回日本心不全学会学術集会
  • Place of Presentation: 鹿児島県
  • Year and Date: 2011-10-13
• [Presentation] 左冠動脈主幹部におけるKBTステント留置後の一剖検症例" micro focus CTによるKBT後のstent strut評価" (2011)
  • Author(s): 佐久間理吏、挽地裕、下村光洋、兒玉和久、小松愛子、野出孝一
  • Organizer: 第18回CVIT九州地方会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-08-27
• [Presentation] 左冠動脈主幹部におけるKBTステント留置後の一剖検症例"micro focus CTによるKBT後のstent strut評価" (2011)
  • Author(s): 佐久間理吏、挽地裕、下村光洋、兒玉和久、小松愛子、野出孝一
  • Organizer: 第18回CVIT九州地方会
  • Place of Presentation: 沖縄県
  • Year and Date: 2011-08-27
• [Presentation] ステント留置後のLate luminal loss-シロリムス溶出性ステントとパクリタキセル溶出性ステントとの比較 (2011)
  • Author(s): 井上洋平、柴田剛徳、福島裕介、仲間達也、三根大悟、相良秀一郎、西平賢作、野村勝政、足利敬一、栗山根廣、松山明彦、野出孝一
  • Organizer: 第110回日本循環器学会九州地方会
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-25
• [Presentation] ステント留置後のLate luminal loss-シロリムス溶出性ステントとパクリタキセル溶出性ステントとの比較 (2011)
  • Author(s): 井上洋平、柴田剛徳、福島裕介、仲間達也、三根大悟、相良秀一郎、西平賢作、野村勝政、足利敬一、栗山根廣、松山明彦、野出孝一
  • Organizer: 第110回日本循環器学会九州地方会
  • Place of Presentation: 福岡県
  • Year and Date: 2011-06-25
• [Presentation] The regulatory effect of statin on the coronary plaque from the view point of molecular mechanism (2010)
  • Author(s): Node K
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: 京都
  • Year and Date: 2010-06-14
• [Presentation] Role of Carcium Antagonists in Coronary Artery Disease-In view of their vasoprotective action- (2010)
  • Author(s): Node K
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: 京都
  • Year and Date: 2010-06-14
• [Presentation] 血管不全と心腎連関 (2010)
  • Author(s): Node K
  • Organizer: XXth World Congress of the International Society for Heart Research
  • Place of Presentation: 京都
  • Year and Date: 2010-05-16
• [Presentation] Vascular Failure and Vascular Endothelial Function (2009)
  • Author(s): 野出孝一
  • Organizer: 10^<th> International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: 宮城
  • Year and Date: 2009-06-02
• [Book] そこが知りたい抗血栓療法, 糖尿病と抗血栓療法 (2011)
  • Author(s): 福富達也、野出孝一
• [Book] そこが知りたい抗血栓療法糖尿病と抗血栓療法 (2011)
  • Author(s): 福富達也、野出孝一
  • Publisher: メジカルビュー社
• [Book] ステントを用いた左主幹部病変治療の可能性と限界: in vitroからの知見 (2010)
  • Author(s): 挽地裕、野出孝一
  • Publisher: Coronary Intervention
• [Book] 医学のあゆみ (2010)
  • Author(s): 挽地裕、野出孝一
  • Publisher: DESの基本構造Basic Efficiently of Drug-eluting Stent
• [Book] Coronary Intervention (2010)
  • Author(s): 挽地裕、野出孝一
  • Total Pages: 5
  • Publisher: メディファルファ
• [Book] 医学のあゆみ (2010)
  • Author(s): 挽地裕、野出孝一
  • Total Pages: 6
  • Publisher: 医歯薬出版株式会社