Mechanism of Ventricular Fibrillation : Establishment of Novel Technique for Predicting Sudden Cardiac Death

• Project/Area Number: 21590909
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Toho University (2011); Kyorin University (2009-2010)
• Principal Investigator: IKEDA Takanori 東邦大学, 医学部, 教授 (80256734)
• Co-Investigator(Kenkyū-buntansha): NAKAZAWA Kazuo 国立循環器病研究センター, 研究情報基盤管理室, 室長 (50198058)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 臨床心血管病態学 / 不整脈学 / 心電図学 / 心臓突然死 / 心室細動 / コンピュータシミュレーション / マッピング解析 / 予知指標 / 電気生理学的異常 / コンピュータシムレーション / 脱分極異常 / 再分極異常

Research Abstract

Sudden cardiac death(SCD) remains one of the major challenges of contemporary cardiology. Major clinical trials have demonstrated that primary prophylaxis of implantable cardioverter-defibrillators(ICD) is effective in saving lives. It is well known that SCD is caused by mainly ventricular fibrillation(VF). In this study, we seek to clarify the mechanism of VF and to establish techniques for predicting SCD. At the first year(2009), we assessed electrophysiological indices that are related to the generation of VF with computer simulation using super computer and mapping analysis from animal models. As a result, the generation of VF is more associated with repolarization abnormality than depolarization abnormality. At the second year(2010), we reanalyzed data that obtained at the first year, then, assessed which electrophysiological marker is useful to detect repolarization abnormality. T-wave alternans(TWA), i. e., alternation of T wave on the electrocardiogram appears to be the best marker to detect the abnormality. At the last year, we evaluated clinical utility of TWA and other electrophysiological makers such as late potentials by signal-averaged electrocardiography and heart rate turbulence in some settings(myocardial infarction, cardiomyopathy, etc). Our data support that TWA is the most useful technique to detect patients at risk for SCD.

Research Products

• [Journal Article] For the PREVENT-SCD Investigators : Prognostic utility of T-wave alternans in a real-world population of patients with left ventricular dysfunction : the PREVENT-SCD study (2012)
  • Author(s): Shizuta S, Ando K, Nobuyoshi M, Ikeda T, Yoshino H, Hiramatsu S, Kazatani Y, Yamashiro K, Okajima K, Kajiya T, Kobayashi Y, Kato T, Fujii S, Mitsudo K, Inoue K, Ito H, Haruna Y, Doi T, Nishio Y, Ozasa N, Nishiyama K, Kita T, Morimoto T, Kimura T
  • Journal Title: Clin Res Cardiol Volume: 101 Pages: 89-99
  • Peer Reviewed
• [Journal Article] The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation : implications for electrogram-based cather ablation (2012)
  • Author(s): Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Ito M, Horie M, Trayanova NA
  • Journal Title: Circ Res Volume: 110 Pages: 275-284
  • Peer Reviewed
• [Journal Article] Selective site pacing from the right ventricular mid-septum : Follow up of lead performance and procedure technique (2012)
  • Author(s): Yusu S, Mera H, Hoshida K, Miyakoshi M, Miwa Y, Tsukada T, Yoshino H, Ikeda T
  • Journal Title: Int Heart J Volume: 53 Pages: 113-116
  • Peer Reviewed
• [Journal Article] Prognostic utility of T-wave altemans in a real-world population of patients with left ventricular dysfunction : the PREVENT-SCD study (2012)
  • Author(s): Shizuta S, et al
  • Journal Title: Clin Res Cardiol Volume: 101 Issue: 2 Pages: 89-99
  • DOI: 10.1007/s00392-011-0368-2
  • Peer Reviewed
• [Journal Article] Transmural dispersion of repolarization determines scroll wave behaivior during ventricular tachyarrhythmias : A simulation study (2011)
  • Author(s): Haraguchi R, Ashihara T, Namba T, Tsumoto K, Murakami S, Kurachi Y, Ikeda T, Nakazawa K
  • Journal Title: Circ J Volume: 75 Pages: 80-88
  • Peer Reviewed
• [Journal Article] Microvolt T-wave alternans : Physiologic basis, methods of measurement, and clinical utility : Consensus statement by the International Society for Holter and Noninvasive Electrocardiology (2011)
  • Author(s): Verrier, RL, Klingenheben T, Malik M, El-Sherif N, Exner DV, Hohnloser SH, Ikeda T, Martinez JP, Narayan SM, Nieminen T, Rosenbaum DS
  • Journal Title: J Am Coll Cardiol Volume: 58 Pages: 1309-1324
  • Peer Reviewed
• [Journal Article] Heart rate turbulence can predict cardiac mortality following myocardial infarction in patients with diabetes mellitus (2011)
  • Author(s): Miwa Y, Miyakoshi M, Hoshida K, Yanagisawa R, Abe A, Tsukada T, Ishiguro H, Mera H, Yusu S, Yoshino H, Ikeda T
  • Journal Title: J Cardiovasc Electrophysiol Volume: 22 Pages: 1135-1140
  • Peer Reviewed
• [Journal Article] Usefulness of heart rate turbulence for predicting cardiac events in patients with nonischemic dilated cardiomyopathy (2011)
  • Author(s): Ikeda T, Miwa Y, Abe A, Nakazawa K
  • Journal Title: J Electrocardiol Volume: 44 Pages: 669-672
  • Peer Reviewed
• [Journal Article] Effects of landiolol, an ultra-short-acting β1-selective blocker, on electrical storm refractory to class III antiarrhythmic drugs (2010)
  • Author(s): Miwa Y, Ikeda T, Mera H, Miyakoshi M, Hoshida K, Yanagisawa K, Ishiguro H, Tsukada T, Abe A, Yusu S, Yoshino H
  • Journal Title: Circ J Volume: 74 Pages: 856-863
  • Peer Reviewed
• [Journal Article] Circadian variation of late potentials in idiopathic ventricular fibrillation associated with J waves : Insights into pathophysiology and risk stratification (2010)
  • Author(s): Abe A, Ikeda T, Tsukada T, Ishiguro H, Miwa Y, Miyakoshi M, Mera H, Yusu S, Yoshino H
  • Journal Title: Heart Rhythm Volume: 7 Pages: 675-82
  • Peer Reviewed
• [Journal Article] Circadian variation in out-of-hospital cardiac arrests due to cardiac cause in a Japanese patient population (2010)
  • Author(s): Tsukada T, Ikeda T, Ishiguro H, Abe A, Miyakoshi M, Miwa Y, Mera H, Yusu S, Yamaguchi Y, Yoshino H
  • Journal Title: Circ J Volume: 74 Pages: 1880-1887
  • NAID: 10026971398
  • Peer Reviewed
• [Journal Article] Effects of landiolol, an ultra-short-acting β1-selective blocker, on electrical storm refractory to class III antiarrhythmic drug. (2010)
  • Author(s): Miwa Y, et al.
  • Journal Title: Circ J Volume: 74 Pages: 856-863
  • Peer Reviewed
• [Journal Article] Circadian variation of late potentials in idiopathic ventricular fibrillation associated with J waves : Insights into pathophysiology and risk stratification. (2010)
  • Author(s): Abe A, et al.
  • Journal Title: Heart Rhythm Volume: 7 Pages: 675-82
  • Peer Reviewed
• [Journal Article] Circadian variation in out-of-hospital cardiac arrests due to cardiac cause in a Japanese patient population. (2010)
  • Author(s): Tsukada T, et al.
  • Journal Title: Circ J Volume: 74 Pages: 1880-1887
  • Peer Reviewed
• [Journal Article] Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction : A prospective study (2009)
  • Author(s): Sakaki K, Ikeda T, Miwa Y, Miyakoshi M, Abe A, Tsukada T, Ishiguro H, Mera H, Yusu S, Yoshino H
  • Journal Title: Heart Rhythm Volume: 6 Pages: 332-337
  • Peer Reviewed
• [Journal Article] Evidence regarding clinical use of microvolt T-wave alternans (2009)
  • Author(s): Hohnloser SH, Ikeda T, Cohen RJ
  • Journal Title: Heart Rhythm Volume: 6
  • Peer Reviewed
• [Journal Article] Heart rate turbulence as a predictor of cardiac mortality and arrhythmic events in patients with dilated cardiomyopathy : A prospective study (2009)
  • Author(s): Miwa Y, Ikeda T, Sakaki K, Miyakoshi M, Ishiguro H, Tsukada T, Abe A, Mera H, Yusu S, Yoshino H
  • Journal Title: J Cardiovasc Electrophysiol Volume: 20 Pages: 788-795
  • Peer Reviewed
• [Journal Article] Quantitative assessment of cibenzoline treatment for vagally mediated paroxysmal atrial fibrillation using frequency-domain heart rate variability analysis (2009)
  • Author(s): Miyakoshi M, Ikeda T, Miwa Y, Sakaki K, Ishiguro H, Abe A, Tsukada T, Mera H, Yusu S, Yoshino H
  • Journal Title: J Cardiol Volume: 54 Pages: 86-92
  • Peer Reviewed
• [Journal Article] Effects of intravenous nifekalant as a lifesaving drug for severe ventricular tachyarrhythmias complicating acute coronary syndrome (2009)
  • Author(s): Yusu S, Ikeda T, Mera H, Miyakoshi M, Miwa Y, Abe A, Tsukada T, Ishiguro H, Shimizu H, Yoshino H
  • Journal Title: Circ J Volume: 73 Pages: 2021-2028
  • NAID: 10025937099
  • Peer Reviewed
• [Journal Article] Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction. (2009)
  • Author(s): Sakaki K, et al.
  • Journal Title: Heart Rhythm 6 Pages: 332-337
  • Peer Reviewed
• [Journal Article] Evidence regarding clinical use of microvolt T-wave alternans. (2009)
  • Author(s): Hohnloser SH, et al.
  • Journal Title: Heart Rhythm 6
  • Peer Reviewed
• [Journal Article] Heart rate turbulence as a predictor of cardiac mortality and arrhyth-mic events in patients with dilated cardiomyopathy. (2009)
  • Author(s): Miwa Y, et al.
  • Journal Title: J Cardiovasc Electrophysiol 20 Pages: 788-795
  • Peer Reviewed
• [Journal Article] Quantitative assessment of CBZ treatment for vagally mediated paroxysmal AF using frequency-domain heart rate variability analysis. (2009)
  • Author(s): Miyakoshi M, et al.
  • Journal Title: J Cardiol 54 Pages: 86-92
  • Peer Reviewed
• [Journal Article] Effects of intravenous nifekalant as a lifesaving drug for severe ventricular tachy-arrhythmias complicating acute coronary syndrome. (2009)
  • Author(s): Yusu S, et al.
  • Journal Title: Circ J 73 Pages: 2021-2028
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 池田隆徳(分担)
  • Journal Title: 不整脈クリニカルプラクティス(南江堂)
• [Journal Article] (2009)
  • Author(s): 池田隆徳(分担)
  • Journal Title: 内科確定診断完全マスター(メジカルビュー) Pages: 101-110
• [Journal Article] (2009)
  • Author(s): 池田隆徳(編集・分担)
  • Journal Title: 失神を極める-循環器診療に活かすために(西村書店) Pages: 225-237
• [Journal Article] (2009)
  • Author(s): 池田隆徳(分担)
  • Journal Title: 心臓リズムマネージメントを究める(メディカルレビュー) Pages: 80-89
• [Journal Article] (2009)
  • Author(s): 池田隆徳(分担)
  • Journal Title: 新しい診断と治療のABC 64:心臓突然死(最新医学社) Pages: 162-171
• [Journal Article] (2009)
  • Author(s): 池田隆徳(分担)
  • Journal Title: 循環器疾患のグノーティ・セアウトン(シナジー) Pages: 172-175
• [Journal Article] (2009)
  • Author(s): 池田隆徳(分担)
  • Journal Title: 循環器臨床サピア(3)ICDとCRT-Dの臨床(中山書店) Pages: 30-35
• [Presentation] Antiarrhythmia Drug Therapy for Atrial Fibrillation : Lessons from the JCS Guidelines (2011)
  • Author(s): Ikeda T
  • Organizer: 4th Asia-Pacific Heart Rhythm Society & 7th Asia-Pacific Atrial Fibrillation Symposium & 26th Japanese Heart Rhythm Society & 28th Japanese Society of Electrocardiology
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-09-20
• [Presentation] Noninvasive Risk Stratification for Sudden Death in Patients with Asymptomatic Brugada-Type Electrocardiograms (2011)
  • Author(s): Ikeda T
  • Organizer: 4th Asia-Pacific Heart Rhythm Society & 7th Asia-Pacific Atrial Fibrillation Symposium & 26th Japanese Heart Rhythm Society & 28th Japanese Society of Electrocardiology
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-09-20
• [Presentation] Noninvasive Risk Stratification for Sudden Death in Patients with Asymptomatic Brugada-Type Electrocardiograms (2011)
  • Author(s): Ikeda T
  • Organizer: 4th APHRS (Asia-Pacific Heart Rhythm Society)
  • Place of Presentation: Hilton Fukuoka Sea Hawk Hotel, Fukuoka
  • Year and Date: 2011-09-20
• [Presentation] Drug Therapy for Atrial Fibrillation : Lessons from the JCS Guidelines (2011)
  • Author(s): Ikeda T
  • Organizer: 4th APHRS (Asia-Pacific Heart Rhythm Society)
  • Place of Presentation: Hilton Fukuoka Sea Hawk Hotel, Fukuoka
  • Year and Date: 2011-09-20
• [Presentation] Relationship between Hypertension and Atrial Fibrillation : Epidemiology and Clinical Outcome (2011)
  • Author(s): Ikeda T
  • Organizer: 4th Asia-Pacific Heart Rhythm Society & 7th Asia-Pacific Atrial Fibrillation Symposium & 26th Japanese Heart Rhythm Society & 28th Japanese Society of Electrocardiology
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-09-19
• [Presentation] Relationship between Hypertension and Atrial Fibrillation : Epidemiology and Clinical Outcome (2011)
  • Author(s): Ikeda T
  • Organizer: 4th APHRS (Asia-Pacific Heart Rhythm Society)
  • Place of Presentation: Hilton Fukuoka Sea Hawk Hotel, Fukuoka
  • Year and Date: 2011-09-19
• [Presentation] Autonomic Nerve System and Electrophysiological Risk Stratification Indices : Overview (2011)
  • Author(s): Ikeda T
  • Organizer: 36th International Society of Computerized Electrocardiography
  • Place of Presentation: San Jose(U. S. A.)
  • Year and Date: 2011-04-15
• [Presentation] Heart Rate Turbulence and Late Potentials Related to Autonomic Nerve System (2011)
  • Author(s): Ikeda T
  • Organizer: 36th International Society of Computerized Electrocardiography
  • Place of Presentation: San Jose(U. S. A.)
  • Year and Date: 2011-04-15
• [Presentation] Autonomic Nerve System and Electrophysiological Risk Stratification Indices : Overview (2011)
  • Author(s): Ikeda T
  • Organizer: 36th ISCE (International Society of Computerized Electrocardiography)
  • Place of Presentation: San Jose, USA
  • Year and Date: 2011-04-15
• [Presentation] Heart Rate Turbulence and Late Potentials Related to Autonomic Nerve System (2011)
  • Author(s): Ikeda T
  • Organizer: 36th ISCE (International Society of Computerized Electrocardiography)
  • Place of Presentation: San Jose, USA
  • Year and Date: 2011-04-15
• [Presentation] QT measures and T wave alternans (2011)
  • Author(s): Ikeda T
  • Organizer: 60th American College of Cardiology
  • Place of Presentation: New Orleans(U. S. A.)
  • Year and Date: 2011-04-05
• [Presentation] Ikeda T : QT measures and T wave altemans (2011)
  • Author(s): Ikeda T
  • Organizer: 60th ACC (American College of Cardiology)
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2011-04-04
• [Presentation] Circadian Variation in Out-of-Hospital Cardiac Arrests in a Japanese Patient Population : Analysis of a Nationwide Population-Based Registry 2005-2008. (2010)
  • Author(s): Tsukada T, et al.
  • Organizer: American Heart Association
  • Place of Presentation: Chicago
  • Year and Date: 2010-11-20
• [Presentation] Roles of fibroblasts in the mechanisms of complex fractionated atrial electrograms and catheter ablation during chronic atrial fibrillation. (2010)
  • Author(s): Ashihara T, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-30
• [Presentation] Deceleration capacity of heart rate are associated with cardiac mortality in Japanese patients after myocardial infarction. (2010)
  • Author(s): Miwa Y, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-30
• [Presentation] Assessment of time-domain T-wave alternans measured from Holter electro-cardiogram for predicting serious cardiac events in patients with reduced left ventricular function after myocardial infarction. (2010)
  • Author(s): Yanagisawa R, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-30
• [Presentation] Prevalence of J Waves on 12-Lead electrocardiogram in patients with syncope and no organic disorder (2010)
  • Author(s): Abe A, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-30
• [Presentation] Evaluation of the CHADS2 Score in Japanese patients with cerebral embolism due to non-valvular atrial fibrillation. (2010)
  • Author(s): Miyakoshi M, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-30
• [Presentation] Waveform similarity between unipolar and bipolar electrical potential at QRS complex and P wave in precordial leads of electrocardiogram. (2010)
  • Author(s): Namba T, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-30
• [Presentation] Heart rate turbulencefor stratifying patients at risk (2010)
  • Author(s): Ikeda T
  • Organizer: 3nd Asia-Pacific Heart Rhythm Society & 6th Asia-Pacific Atrial Fibrillation Symposium
  • Place of Presentation: Jeju(Korea)
  • Year and Date: 2010-10-29
• [Presentation] Heart rate turbulence for stratifying patients at risk. (2010)
  • Author(s): Ikeda T
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-29
• [Presentation] Prognostic Value of Heart Rate Turbulence in Post-Myocardial Infarction Patients with Beta-Blocker Treatment. (2010)
  • Author(s): Hoshida K, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-29
• [Presentation] Risk stratification markers for sudden cardiac death (2010)
  • Author(s): Ikeda T
  • Organizer: 3nd Asia-Pacific Heart Rhythm Society & 6th Asia-Pacific Atrial Fibrillation Symposium
  • Place of Presentation: Jeju(Korea)
  • Year and Date: 2010-10-28
• [Presentation] T-wave alternans for stratifying patients at risk (2010)
  • Author(s): Ikeda T
  • Organizer: 3nd Asia-Pacific Heart Rhythm Society & 6th Asia-Pacific Atrial Fibrillation Symposium
  • Place of Presentation: Jeju(Korea)
  • Year and Date: 2010-10-28
• [Presentation] Risk stratification markers for sudden cardiac death. (2010)
  • Author(s): Ikeda T
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-28
• [Presentation] T-wave alternans for stratifying patients at risk. (2010)
  • Author(s): Ikeda T
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Jeju
  • Year and Date: 2010-10-28
• [Presentation] Who needs an ICD after AMI? Identification and management of high risk post AMI patients : T-wave alternans for early detection (2010)
  • Author(s): Ikeda T
  • Organizer: World Congress of Cardiology 2010
  • Place of Presentation: Beijing(China)
  • Year and Date: 2010-06-17
• [Presentation] Who needs an ICD after AMI? Identification and management of high risk post AMI patients : T-wave alternans for early detection. (2010)
  • Author(s): Ikeda T
  • Organizer: World Congress of Cardiology
  • Place of Presentation: Beijing
  • Year and Date: 2010-06-17
• [Presentation] Roles of fibroblasts in the mechanism of complex fractionated atrial electrograms during chronic atrial fibrillation. (2010)
  • Author(s): Ashihara T, et al.
  • Organizer: Heart Rhythm Society
  • Place of Presentation: Denver
  • Year and Date: 2010-05-14
• [Presentation] Circadian variation of late potentials in idiopathic ventricular fibrillation associated with J waves : Insights into pathophysiology and risk stratification. (2010)
  • Author(s): Abe A, et al.
  • Organizer: Heart Rhythm Society
  • Place of Presentation: Denver
  • Year and Date: 2010-05-13
• [Presentation] T-wave alternans and cardiac mortality risk. (2009)
  • Author(s): Ikeda T, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Beijing
  • Year and Date: 2009-11-24
• [Presentation] Time-domain T-wave alternans measured from Holter electrocardiograms for predicting cardiac mortality in patients with ischemic cardiomyopathy. (2009)
  • Author(s): Miwa Y, et al.
  • Organizer: Asia-Pacific Heart Rhythm Society
  • Place of Presentation: Beijing
  • Year and Date: 2009-11-24
• [Presentation] Efficacy of combined use of T-wave alternans and late potentials in predicting lethal ventricular tachyarrhythmia among patients with left ventricular dysfunction. (2009)
  • Author(s): Shizuta S, et al.
  • Organizer: American Heart Association
  • Place of Presentation: Chicago
  • Year and Date: 2009-11-16
• [Presentation] Prognostic utility of T-wave alternans in a real world population of patients with left ventricular dysfunction. (2009)
  • Author(s): Shizuta S, et al.
  • Organizer: American Heart Association
  • Place of Presentation: Chicago
  • Year and Date: 2009-11-15
• [Presentation] T-wave alternans and cardiac mortality risk (2009)
  • Author(s): Ikeda T
  • Organizer: 2nd Asia-Pacific Heart Rhythm Society & 5th Asia-Pacific Atrial Fibrillation Symposium
  • Place of Presentation: Beijing(China)
  • Year and Date: 2009-10-24
• [Presentation] Current concept of pharmacological therapy for atrial fibrillation in Japan (2009)
  • Author(s): Ikeda T
  • Organizer: 3rd Asia Pacific Heart Rhythm Management Fellowship Program 2009
  • Place of Presentation: Sapporo
  • Year and Date: 2009-09-12
• [Presentation] Mechanisms of atrial fibrillation using mapping analyses (2009)
  • Author(s): Ikeda T
  • Organizer: 3rd Asia Pacific Heart Rhythm Management Fellowship Program 2009
  • Place of Presentation: Sapporo
  • Year and Date: 2009-09-12
• [Presentation] Antiarrhythmic drug therapy in atrial fibrillation with cardiac disease. (2009)
  • Author(s): Ikeda T, et al.
  • Organizer: European Society of Cardiology
  • Place of Presentation: Barcelona
  • Year and Date: 2009-08-30
• [Presentation] Conduction disturbances as the mechanism of J waves on electrocardio-gram in patients with idiopathic ventricular fibrillation. (2009)
  • Author(s): Abe A, et al.
  • Organizer: International Symposium of Holter and Non-invasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-06
• [Presentation] Time-domain T-wave alternans measured from Holter electrocardiograms for predicting cardiac mortality in patients with ischemic cardiomyopathy. (2009)
  • Author(s): Sakaki K, et al.
  • Organizer: International Symposium of Holter and Non-invasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-06
• [Presentation] Analogy of QRS complex between precordial unipolar(used in standard 12-lead electrocardiograph)and precordial bipolar potential. (2009)
  • Author(s): Namba T, et al.
  • Organizer: International Symposium of Holter and Non-invasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-06
• [Presentation] Current risk stratification techniques for sudden cardiac death : Which markers should we use? (2009)
  • Author(s): Ikeda T
  • Organizer: 13th International Symposium of Holter and Noninvasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-04
• [Presentation] Clinical aspects of time-domain T-wave alternans for cardiac mortality (2009)
  • Author(s): Ikeda T
  • Organizer: 13th ISHNE(International Symposium of Holter and Noninvasive Electrocardiology)
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-04
• [Presentation] Current risk stratification techniques for sudden sardiac death : Which markers should we use? (2009)
  • Author(s): Ikeda T, et al.
  • Organizer: International Symposium of Holter and Non-invasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-04
• [Presentation] Clinical aspects of time-domain T-wave alternans for cardiac mortality. (2009)
  • Author(s): Ikeda T, et al.
  • Organizer: International Symposium of Holter and Non-invasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-04
• [Presentation] Usefulness of heart rate turbulence as a risk stratification marker in patients with ischemic cardiomyopathy. (2009)
  • Author(s): Miwa Y, et al.
  • Organizer: International Symposium of Holter and Non-invasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-04
• [Presentation] Scroll wave dynamics in a simulated ventricular wall model : Role of transmural dispersion of repolarization. (2009)
  • Author(s): Haraguchi R, et al.
  • Organizer: International Symposium of Holter and Non-invasive Electrocardiology
  • Place of Presentation: Yokohama
  • Year and Date: 2009-06-04
• [Presentation] Usefulness of time-domain T-wave alternans measured from Holter electrocardiograms to predict cardiac mortality. (2009)
  • Author(s): Sakaki K, et al.
  • Organizer: Heart Rhythm Society
  • Place of Presentation: Boston
  • Year and Date: 2009-05-15
• [Presentation] Mechanisms of J waves on electrocardiograms in patients with idiopathic ventricular fibrillation. (2009)
  • Author(s): Abe A, et al.
  • Organizer: Heart Rhythm Society
  • Place of Presentation: Boston
  • Year and Date: 2009-05-14
• [Presentation] Heart rate turbulence predicts cardiac mortality and arrhythmic events in patients with dilated cardiomyopathy. (2009)
  • Author(s): Miwa Y, et al.
  • Organizer: Heart Rhythm Society
  • Place of Presentation: Boston
  • Year and Date: 2009-05-14
• [Presentation] Assessment of circadian variation in the occurrence of out-of-hospital cardiopulmonary arrest with a large number of Japanese patients. (2009)
  • Author(s): Tsukada T, et al.
  • Organizer: Heart Rhythm Society
  • Place of Presentation: Boston
  • Year and Date: 2009-05-14
• [Book] 不整脈のアブレーション・デバイス治療マニュアル (2012)
  • Author(s): 池田隆徳
  • Publisher: メディカ出版
• [Book] 循環器疾患最新の治療2012-2013 (2012)
  • Author(s): 池田隆徳
  • Publisher: 南江堂
• [Book] EBM循環器疾患の治療2012-2013 (2012)
  • Author(s): 池田隆徳
  • Publisher: 中外医学社
• [Book] 第2章成人の二次救命処置(ALS)。JRC蘇生ガイドライン2010 (2011)
  • Author(s): 池田隆徳
  • Publisher: へるす出版
• [Book] T波交互現象(T-wave alternans)。Medical Topics Series不整脈2011 (2011)
  • Author(s): 池田隆徳
  • Publisher: メディカルレビュー社
• [Book] 心臓突然死の予知。新名医の最新治療 (2011)
  • Author(s): 池田隆徳
  • Publisher: 朝日新聞出版
• [Book] ステップアップのためのベースライン:不整脈の分類と発生メカニズム。ステップアップのための不整脈診療ガイドブック (2011)
  • Author(s): 池田隆徳
  • Publisher: メジカルビュー社
• [Book] 非侵襲的検査指標による心事故の予知。医学のあゆみ:ここまで進んだ不整脈研究の最新動向 (2011)
  • Author(s): 池田隆徳
  • Publisher: 医歯薬出版
• [Book] 不整脈関連の様々な検査法。不整脈治療のThe Basics :臨床に役立つ電気生理学 (2011)
  • Author(s): 阿部敦子、池田隆徳
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] すべてがわかる不整脈診療エッセンス (2011)
  • Author(s): 池田隆徳
  • Publisher: 南江堂
• [Book] そうだったのか!絶対読める心電図 (2011)
  • Author(s): 池田隆徳
  • Publisher: 羊土社
• [Book] ここまで進んだ不整脈研究の最新動向 (2011)
  • Author(s): 池田隆徳
  • Publisher: 医歯薬出版
• [Book] ステップアップのための不整脈診療ガイドブック (2011)
  • Author(s): 池田隆徳
  • Publisher: メジカルビュー社
• [Book] そこが知りたい抗血栓療法 (2011)
  • Author(s): 池田隆徳
  • Publisher: メジカルビュー社
• [Book] 外科医のための循環器必須知識 (2011)
  • Author(s): 池田隆徳
  • Publisher: メジカルビュー社
• [Book] ファーマナビゲーターβ遮断薬編改訂版 (2011)
  • Author(s): 池田隆徳
  • Publisher: メジカルビュー社
• [Book] 不整脈診療のトラブルシューティング (2011)
  • Author(s): 池田隆徳
  • Publisher: 南江堂
• [Book] 症状からアプローチするプライマリケア (2011)
  • Author(s): 池田隆徳
  • Publisher: 医師薬出版社
• [Book] JRC蘇生ガイドライン2010 (2011)
  • Author(s): 池田隆徳
  • Publisher: へるす出版
• [Book] Medical Topics Series不整脈2011 (2011)
  • Author(s): 池田隆徳
  • Publisher: メディカルレビュー社
• [Book] QRS波終末部にみられるJ波と原因不明の失神→特発性心室細動。レジデントノート:心電図の読み方、診かた、考え方 (2010)
  • Author(s): 池田隆徳
  • Publisher: 羊土社
• [Book] T-wave alternans(TWA)。心臓突然死を予知するための不整脈ノンインベイシブ検査 (2010)
  • Author(s): 池田隆徳
  • Publisher: 医学書院
• [Book] マンガで学ぶ心電図と不整脈 (2010)
  • Author(s): 池田隆徳
  • Publisher: 中外医学社
• [Book] 循環器臨床サピア(4)心臓リハビリテーションと運動負荷試験 (2010)
  • Author(s): 池田隆徳(分担)
  • Publisher: 中山書店
• [Book] 循環器疾患 最新の治療 2010-2011 (2010)
  • Author(s): 池田隆徳(分担)
  • Publisher: 南江堂
• [Book] 患者抄録で究める循環器病シリーズ2 不整脈 (2010)
  • Author(s): 池田隆徳(分担)
  • Publisher: 羊土社
• [Book] ガイドラインに準じた循環器治療薬ファーストブック (2010)
  • Author(s): 池田隆徳(編集・分担)
  • Publisher: 南江堂
• [Book] 1冊でわかる不整脈のカテーテル・デバイス治療 (2010)
  • Author(s): 池田隆徳(編集・分担)
  • Publisher: 南江堂
• [Book] 循環器研修ノート (2010)
  • Author(s): 池田隆徳(分担)
  • Publisher: 診断と治療社
• [Book] レジデントノート:心電図の読み方、診かた、考え方 (2010)
  • Author(s): 池田隆徳(編集・分担)
  • Publisher: 羊土社
• [Book] 心電図チェックリスト120 (2010)
  • Author(s): 池田隆徳(編集・分担)
  • Publisher: 中外医学社
• [Book] マンガで学ぶ心電図と不整脈 (2010)
  • Author(s): 池田隆徳(単著)
  • Publisher: 中外医学社
• [Book] 今さら聞けない心電図-これで心電図の基本がわかる- (2010)
  • Author(s): 池田隆徳(編集・分担)
  • Publisher: メジカルビュー社
• [Book] 心臓突然死を予知するための不整脈ノンインベイシブ検査 (2010)
  • Author(s): 池田隆徳(分担)
  • Publisher: 医学書院
• [Book] 循環器病学:基礎と臨床 (2010)
  • Author(s): 池田隆徳(分担)
  • Publisher: 西村書店
• [Book] 加算平均心電図・T派交互脈(T-wave alternans)。不整脈クリニカルプラクティス (2009)
  • Author(s): 池田隆徳
  • Publisher: 南江堂
• [Book] その他のBrugada型心電図誘発試験。Brugada症候群-病態解明から診断・治療指針の決定 (2009)
  • Author(s): 池田隆徳
  • Publisher: メジカルビュー
• [Book] デバイス治療に必要な検査と解釈法-心臓電気生理検査(EPS)。心臓リズムマネージメントを究める (2009)
  • Author(s): 池田隆徳
  • Publisher: メディカルレビュー社
• [Book] その他の心電学的指標(TWA、LP、HRV、BRS、HRT)。新しい診断と治療のABC 64 :心臓突然死 (2009)
  • Author(s): 池田隆徳
  • Publisher: 最新医学社
• [Book] 心電図の新しい評価法:遅延電位。循環器臨床サピア(3) ICDとCRT-Dの臨床 (2009)
  • Author(s): 池田隆徳
  • Publisher: 中山書店