• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Impact of exercise therapy on regression of coronary atherosclerotic plaque

Research Project

Project/Area Number 21590910
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionJuntendo University

Principal Investigator

DAIDA Hiroyuki  順天堂大学, 医学部, 教授 (40197596)

Research Collaborator MIYAUCHI Katsumi  順天堂大学, 医学部, 先任准教授 (60200119)
SHIMADA Kazunori  順天堂大学, 医学部, 准教授 (60327814)
NISHITANI Miho  順天堂大学, 医学部, 助教 (60407301)
KOBA Shinji  昭和大学, 医学部, 講師 (20276546)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords急性冠症候群 / 血管内超音波 / 冠動脈プラーク / 血管リモデリング / 包括的心臓 / リハビリテーション / 身体活動量 / 急性心筋梗塞 / 包括的心臓リハビリテーション / 包括的リハビリテーション
Research Abstract

We investigated the effects of comprehensive cardiac rehabilitation (CR) on coronary plaque volume changes and vascular remodeling in patients after acute coronary syndrome (ACS). We enrolled 41 consecutive patients after ACS and patients were divided into the CR (16 patients) and the non-CR group (25 patients). Plaque volume and vascular remodeling were not significantly changed in the two groups during 6 months. However, percent change in plaque volume showed a significant negative correlation with daily physical activity. Intensive physical activity may result in coronary plaque regression in patients after ACS.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (14 results) Book (2 results)

  • [Journal Article] Reverse vessel remodeling but not coronary plaque regression could predict future cardiovascular events in ACS patients with intensive statin therapy the extended APAN-ACS study2012

    • Author(s)
      宮内 克己、代田 浩之(以下省略計15名、1・2番目)
    • Journal Title

      Circ J.

      Volume: 76 Pages: 825-32

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Azelnidipine and amlodipine anti-coronary atherosclerosis trial in hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo University (ALPS-J)2011

    • Author(s)
      小島 貴彦、宮内 克己(以下省略計18名、2番目)、代田 浩之(18番目)
    • Journal Title

      Circ J.

      Volume: 75 Pages: 1071-9

    • NAID

      10028147283

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plaque regression determined by intravascular ultrasound predicts long-term outcomes of patients with acute coronary syndrome2011

    • Author(s)
      土肥 智貴、宮内 克己(以下省略計10名、2番目)、代田 浩之(10番目)
    • Journal Title

      J Atheroscler Thromb.

      Volume: 18 Pages: 231-9

    • NAID

      130004444503

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of diabetes on muscle mass, muscle strength, and exercise tolerance in patients after coronary artery bypass grafting2011

    • Author(s)
      Nishitani M., et al
    • Journal Title

      J Cardiol

      Volume: 58 Pages: 173-80

    • NAID

      10031159590

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term effect of metabolic syndrome with and without diabetes mellitus on coronary revascularization in Japanese patients undergoing percutaneous coronary intervention2011

    • Author(s)
      Nishino A., et al
    • Journal Title

      Clin Cardiol

      Volume: 34 Pages: 610-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of angiographic restenosis after bare-metal stent implantation on long-term outcomes in patients with coronary artery disease2011

    • Author(s)
      Ogita M., et al
    • Journal Title

      Circ J

      Volume: 75 Pages: 2566-72

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher baseline LDL-C levels amplify the short-term benefit of early intensive statin treatment in acute coronary syndrome2011

    • Author(s)
      Dohi T, Miyauchi K, Okazaki S, Yokoyama T, Yanagisawa N, Tamura H, Kojima T, Yokoyama K, Kurata T, Daida H.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 18(1) Pages: 42-48

    • NAID

      130004444468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early intensive statin treatment for six months improves long-term clinical outcomes in patients with acute coronary syndrome (extended-ESTABLISH trial) : A follow-up study.2010

    • Author(s)
      Dohi T, Miyauchi K, Okazaki S, Yokoyama T, Yanagisawa N, Tamura H, Kojima T, Yokoyama K, Kurata T, Daida H.
    • Journal Title

      Atherosclerosis

      Volume: 210(2) Pages: 497-502

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of phase III cardiac rehabilitation on mortality and cardiovascular events in elderly patients with stable coronary artery disease2010

    • Author(s)
      Onishi T, Shimada K, Sato H, Seki E, Watanabe Y, Sunayama S, Ohmura H, Masaki Y, Nishitani M, Fukao K, Kume A, Sumide T, Mokuno H, Naito H, Kawai S, Daida H.
    • Journal Title

      Circulation Journal 74(4)

      Pages: 709-714

    • NAID

      10026472427

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early intensive statin treatment for six months improves long-term clinical outcomes in patients with acute coronary syndrome(extended-ESTABLISH trial)2010

    • Author(s)
      Dohi T, Miyauchi K, Okazaki S, Yokoyama T, Yanagisawa N, Tamura H, Kojima T, Yokoyama K, Kurata T, Daida H.
    • Journal Title

      Atherosclerosis (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome : A multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastat in versus atorvastatin(JAPAN-ACS[japan assessment of pitavastatin and atorvastatin in acute coronary syndrome]study)2009

    • Author(s)
      Hiro T, Kimura T, Morimoto T, Miyauchi K, Nakagawa Y, Yamagishi M, Ozaki Y, Kimura K, Saito S, Yamaguchi T, Daida H, Matsuzaki M, JAPAN-ACS Investigators
    • Journal Title

      Journal of the American College of Cardiology 54(4)

      Pages: 293-302

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plaque regression determined by intravascular ultrasound predicts long-term outcomes of patients with acute coronary syndrome

    • Author(s)
      Dohi T, Miyauchi K, Okazaki S, Yokoyama T, Yanagisawa N, Tamura H, Kojima T, Yokoyama K, Kurata T, Daida H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: (in press)

    • NAID

      130004444503

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of cardiac rehabilitation on muscle mass, muscle strength, and exercise tolerance in diabetic patients after coronary artery bypass grafting2012

    • Author(s)
      西谷 美帆
    • Organizer
      第76回日本循環器学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-03-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of cardiac rehabilitation on muscle mass, muscle strength, and exercise tolerance in diabetic patients after coronary artery bypass grafting2012

    • Author(s)
      西谷美帆
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of Aldosterone on coronary plaque volume in hypertensive patients with stable coronary artery disease in ALPS-J subanalysis2012

    • Author(s)
      宮内 克己
    • Organizer
      第76回日本循環器学会総会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of Aldosterone on coronary plaque volume in hypertensive patients with stable coronary artery disease in ALPS-J subanalysis2012

    • Author(s)
      宮内克己
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Azelnidipine and Amlodipine Anti-Coronary Atherosclerosis Trial in Hypertensive Patients Undergoing Coronary Intervention by Serial Volumetric Intravascular Ultrasound in Juntendo (ALPS-J)2011

    • Author(s)
      代田 浩之
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-03-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Relationship Between Advanced Glycation End Products and Plaque Progression in Patients with Acute Coronary Syndrome; The Japan-ACS Sub-study2011

    • Author(s)
      代田 浩之
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-03-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Azelnidipine and Amlodipine Anti-Coronary Atherosclerosis Trial in Hypertensive Patients Undergoing Coronary Intervention by Serial Volumetric Intravascular Ultrasound in Juntendo (ALPS-J)2011

    • Author(s)
      代田浩之
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Relationship Between Advanced Glycation End Products and Plaque Progression in Patients with Acute Coronary Syndrome ; The Japan-ACS Sub-study2011

    • Author(s)
      代田浩之
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impact of Diabetes on Muscle Mass, Muscle Strength, and Exercise Tolerance in Patients after Coronary Artery Bypass Grafting2011

    • Author(s)
      西谷美帆
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Higher Baseline LDL-C Levels Amplify the Long-term Benefit of Early Intensive Statin Treatment in Acute Coronary Syndrome2011

    • Author(s)
      土肥智貴
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Amlodipine Combined with an Angiotension II Blocker versus Increased Angiotension II Blocker Alone in Diabetic Patientswith Hypertension : Three-Year follow-up Results of the ADVANCED-J study2010

    • Author(s)
      代田浩之
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Candesartan with Pioglitazone on Coronary Endothelial Function and Vascular Inflammation in Porcine Coronary Arteries Implanted with Sirolimus-Eluting Stent2010

    • Author(s)
      土肥智貴
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Importance of Total Lipid Management for Prevention of Coronary Events2010

    • Author(s)
      代田浩之
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regression in Diabetie patients ACS Subanalysis of JAPAN-ACS study2010

    • Author(s)
      宮内克己
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-04
    • Related Report
      2009 Annual Research Report
  • [Book] 糖尿病診療ガイド(門脇孝 他編著)2011

    • Author(s)
      松森理枝, 代田浩之
    • Total Pages
      422
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] CT冠動脈造影実践学(木原康樹 他編著)2010

    • Author(s)
      松永江律子, 代田浩之
    • Total Pages
      256
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi