Role of Mitochondria on Platelet Activation Contributing to the Onset of Acute Myocardial Infarction

• Project/Area Number: 21590911
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tokai University
• Principal Investigator: GOTO Shinya 東海大学, 医学部, 教授 (50225653)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 血小板 / ミトコンドリア / 血栓 / アテローム血栓 / 心筋梗塞 / 電子伝達系 / 動脈血栓 / イメージング / カルシウム / コンピューターモ / アテローム血栓症

Research Abstract

Platelets play crucial role in the onset of acute myocardial infarction. Platelets are active cells in view of energetic metabolism with several mitochondria. This study attempts to clarify the role of mitochondria in platelet cells for the onset of acute myocardial infarction.
Mitochondria need oxygen to express their physiological function. Platelets in arterial blood containing high oxygen concentration have higher thrombogenicity than those in venous blood. The number and localization of mitochondria was not influenced by platelet activation. Cyclic increase in intracellular concentration of calcium ion induced by platelet activation was inhibited when the function of mitochondria was blocked.

Research Products

• [Journal Article] Rivaroxaban in patients with a recent acute coronary syndrome (2012)
  • Author(s): Mega JL, Braunwald E, Wiviott SD, Basssand JR, Bhatt DL, Bode C, Burton P, Cohen M, Cook-Bruns N, Fox KA, Goto S, Murphy SA, Plotnikov AN, Schneider D, Sun X, Verheugt FW, Gibson CM; ATLAS ACS 2-TIMI 51 Investigators
  • Journal Title: N Engl J Med Volume: 366 Issue: 1 Pages: 9-19
  • DOI: 10.1056/nejmoa1112277
  • Peer Reviewed
• [Journal Article] International Longitudinal registry of patients with atrial fibrillation at risk of stroke : Global Anticoagulant Registry in the FIELD (GARFIELD) (2012)
  • Author(s): Kakkar AK, Mueller I, Bassand JP, Fitzmaurice DA, Goldhaber SZ, Goto S, Haas S, Hacke W, Lip GYH, Mantovani LG, Verheugt FWA, Jamal W, Misselwith F, Rushton-Smith S, Turpie AGG
  • Journal Title: Am Heart J Volume: 163 Issue: 1 Pages: 13-19
  • DOI: 10.1016/j.ahj.2011.09.011
  • Peer Reviewed
• [Journal Article] The ATLAS ACS 2.TIMI 51 Investigators. Rivaroxaban in Patients with a Recent Acute Coronary Syndrome (2011)
  • Author(s): Mega JL, Braunwald E, Wiviott SD, Bassand JP, Bhatt DL, Bode C, Burton P, Cohen M, Cook-Bruns N, Fox KA, Goto S, Murphy SA, Plotnikov AN, Schneider D, Sun X, Verheugt FW, Gibson CM
  • Journal Title: N Engl J Med Volume: 366(1) Pages: 9-19
  • Peer Reviewed
• [Journal Article] Apixaban versus Warfarin in Patients with Atrial Fibrillation (2011)
  • Author(s): Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L
  • Journal Title: N Engl J Med Volume: 365 Pages: 981-992
  • Peer Reviewed
• [Journal Article] The J-TRACE Investigators. One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction (2011)
  • Author(s): Goto S, Ikeda Y, Shimada K, Uchiyama S, Origasa H, Kobayashi H
  • Journal Title: Circ J Volume: 75(11) Pages: 2598-2604
  • Peer Reviewed
• [Journal Article] Safety and Tolerability of Atopaxar in the Treatment of Patients With Acute Coronary Syndromes (2011)
  • Author(s): O' Donoghue ML, Bhatt DL, Wiviott SD, Goodman SD, Fitzgerald DJ, Angiolillo DJ, Goto S, Montalescot G, Zeymer U, Aylward PE, Guetta V, Dudek D, Ziecina R, Contant CF, Flather MD
  • Journal Title: Circulation Volume: 123 Pages: 1843-53
  • Peer Reviewed
• [Journal Article] Bhatt DL on behalf of the REACH Registry Investigators (2011)
  • Author(s): Goto S, Ikeda Y, Chan JCN, Wilson PWF, Yeo TC, Liau CS, Abola MT, Salette G, Steg PG, Bhatt DL
  • Journal Title: Heart Asia Volume: 3 Pages: 92-98
  • Peer Reviewed
• [Journal Article] Randomized Trial of Atopaxar in the Treatment of Patients With Coronary Artery Disease (2011)
  • Author(s): Wiviott SD, Flather MD, O' Donoghue ML, Goto S. Fitzgerald DJ, Cura F, Aylward P, Guetta V, Dudek D, Contant CF, Angiolillo DJ, Bhatt DL
  • Journal Title: Circulation Volume: 123 Pages: 1854-63
  • Peer Reviewed
• [Journal Article] Ethnic Differences in Cardiovascular Eisks and Mortality in Atherothrombotic Disease : Insighes From the Reduction of Atherothrombosis for Continued Health (REACH) Registry (2011)
  • Author(s): Meadows T.A., Bhatt D.L., Cannon C.P., Gersh B.J., Rother J, Goto S, Liau C, Wilson P.W.F., Salette G, Smith S.C., Steg G, for the REACH Registry Investigators
  • Journal Title: Mayo Clinic Proceedings Volume: 86 Issue: 10 Pages: 960-967
  • DOI: 10.4065/mcp.2011.0010
  • Peer Reviewed
• [Journal Article] Apixaban versus warfarin in patients with atrial fibrillation (2011)
  • Author(s): Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L; ARISTOTLE Committees and Investigators
  • Journal Title: N Engl J Med Volume: 365 Issue: 11 Pages: 981-992
  • DOI: 10.1056/nejmoa1107039
  • Peer Reviewed
• [Journal Article] Prospective Cohort Study of Gastrointestinal Complications and Vascular Diseases in Patients Talking Aspirin : Rationale and Design of the MAGIC Study (2011)
  • Author(s): Origasa H, Goto S, Shimada K, Uchiyama S, Okada Y, Sugano K, Hiraishi H, Uemura N, Ikeda Y, on behalf of the MAGIC Investigators
  • Journal Title: Cardiovasc Drugs Ther Volume: 25 Issue: 6 Pages: 551-560
  • DOI: 10.1007/s10557-011-6328-2
  • Peer Reviewed
• [Journal Article] One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction, Stroke, and Atrial Fibrillation (2011)
  • Author(s): Goto S, Ikeda Y, Shimada K, Uchiyama S, Origasa H, Kobayashi H; The J-TRACE Investigators
  • Journal Title: Circ J Volume: 75 Pages: 2598-2604
  • Peer Reviewed
• [Journal Article] A randomized, double-blind, placebo-controlled study to evaluate the effcacy and safety of rivaroxaban in subjects with acute coronary syndrome (2011)
  • Author(s): Gibson CM, Mega JL, Burton P, Goto S, Verheugt F, Bode C, Plotnikov A, Sun X, Bruns NC, Braunwald E : Rationale and design of the Anti-Xa therapy to Lower cardiovascular events in Addition to standard therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51(ATLAS-ACS 2 TIMI 51) trial
  • Journal Title: American Heart Journal Volume: 161 Issue: 5 Pages: 815-821
  • DOI: 10.1016/j.ahj.2011.01.026
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled Phase II studies of the PAR-1 antagonist E5555 in Japanese patients with acute coronary syndrome(ACS) or high-risk coronary artery disease(CAD) (2010)
  • Author(s): Goto S, Ogawa H, Takeuchi M, Flather M, Bhatt DL
  • Journal Title: Eur Heart J Volume: 31(21) Pages: 2601-2613
  • Peer Reviewed
• [Journal Article] Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral artery (2010)
  • Author(s): Sumi, T. Yamashita, A. Matsuda, S. Goto, S. Nishihira, K. Furukoji, E. Sugimura, H. Kawahara, H. Imamura, T. Kitamura, K. Tamura, S. Asada, Y
  • Journal Title: J Thromb Haemost Volume: 8 Pages: 1394-402
  • Peer Reviewed
• [Journal Article] Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo (2010)
  • Author(s): Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, and Eto K
  • Journal Title: J Clin Invest Volume: 120 Pages: 179-90
  • Peer Reviewed
• [Journal Article] Basic Principles of Platelet Biology and Clinical Implications (2010)
  • Author(s): Angiolillo DJ, Ueno M, and Goto S
  • Journal Title: Circ J Volume: 74 Pages: 597-607
  • NAID: 10026471766
  • Peer Reviewed
• [Journal Article] Platelet thrombin receptor antagonism and atherothrombosis (2010)
  • Author(s): Angiolillo DJ, Capodanno D, and Goto S
  • Journal Title: Eur Heart J Volume: 31(1) Pages: 17-28
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled Phase II studies of the PAR-1 antagonist E5555 in Japanese patients with acute coronary syndrome (ACS) or high-risk coronary artery disease(CAD). (2010)
  • Author(s): Goto S, Ogawa H, Takeuchi M, Flather M, Bhatt DL
  • Journal Title: European Heart Journal Volume: 31 Pages: 2601-2613
  • Peer Reviewed
• [Journal Article] Y.Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral artery (2010)
  • Author(s): Sumi, T., et al., (12名の著者のうち4番目)
  • Journal Title: Journal of Thrombosis and Hemostasis Volume: 8 Pages: 1394-1402
  • Peer Reviewed
• [Journal Article] Comparative Determinants of 4-Year Cardiovascular Event Rates in Stable Outpatients at Risk of or With Atherothrombosis (2010)
  • Author(s): Bhatt DL, et al., (17名の著者のうち5番目)
  • Journal Title: JAMA Volume: 304 Pages: 1350-1357
  • Peer Reviewed
• [Journal Article] Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo. (2010)
  • Author(s): Takizawa H(17名の著者のうち10番目), Goto S, Eto K
  • Journal Title: Journal of Clinical Investigation 120 Pages: 179-190
  • Peer Reviewed
• [Journal Article] Imaging of Structural Changes in Endothelial Cells and Thrombus Formation at the Site of FeCl3-Induced Injuries in Mice Cremasteric Arteries (2009)
  • Author(s): Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H and Goto S
  • Journal Title: J Atheroscler Thromb Volume: 16(6) Pages: 807-814
  • NAID: 130004444350
  • Peer Reviewed
• [Journal Article] Important regulatory role of activated platelet-derived procoaulant activity in the propagation of thrombi formed under arteiral blood flow conditions (2009)
  • Author(s): Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S
  • Journal Title: Circ J Volume: 73 Pages: 540-548
  • Peer Reviewed
• [Journal Article] ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions (2009)
  • Author(s): Moriguchi-Goto S, Yamashita A, Tamura N, Soejima K, Takahashi M, Nakagaki T, Goto S, Asada Y
  • Journal Title: Atherosclerosis Volume: 203 Pages: 409-16
  • Peer Reviewed
• [Journal Article] Imaging of Structural Changes in Endothelial Cells and Thrombus Formation at the Site of FeC13-Induced Injuries in Mice Cremasteric Arteries (2009)
  • Author(s): Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H, Goto S.
  • Journal Title: Journal of Atherosclerosis and Thrombosis 16 Pages: 807-814
  • Peer Reviewed
• [Journal Article] Important regulatory role of activated platelet-derived procoaulant activity in the propagation of thrombi formed under arteiral blood flow conditions (2009)
  • Author(s): Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S
  • Journal Title: Circulation Journal 73 Pages: 540-548
  • Peer Reviewed
• [Presentation] Use of the CHADS2 and CHA2DS2-VASC Score in Japanese Patients with Atrial Fibrillation : A sub-analysis of the Japan Thrombosis Registryfor Atrial Fibrillation, Coronary or Cerebrovascular Events (J-TRACE) (2012)
  • Author(s): Toda E, Gregory YH Lip, Shinichiro Uchiyama S, Shimada K, Origasa H, Kobayashi H, Kawamura A, Kitagawa K, Nagao T, Ikeda Y, S.Goto
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-26
• [Presentation] Inappropriate utilization of Anticoagulation in Patients With Atrial Fibrillation : The Global Anticoagulant Registry in the FIELD (GARFIELD) Registry (2012)
  • Author(s): Gregory Lip, Jean-Pierre Bassand, David Fitzmaurice, Samuel Goldhaber, Goto S, Freek Verheugt, Alexander Turpie, Iris Mueller, Sophie Rushton-Smith, Ajay Kakkar
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-26
• [Presentation] Atopaxar and Its Effects on Markers of Platelet Activation and Inflammation : Results From the LANCELOT Program (2012)
  • Author(s): Michelle L.O'Donoghue Deepak Bhatt, Marcus Flather, Goto S, Dominick Angiolillo, Shaun Goodman, Uwe Zeymer, Philip Aylward, Gilles Montalescot, Rafal Ziecina, Fang Ren, Stephen Wiviott
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-26
• [Presentation] Long-Term Risk and Prognosis of Recurrent Cardiovascular Events in the REACH Registry (2012)
  • Author(s): Christian T.Ruff, Deepak Bhatt, Erik Ohman, Kim Eagle, Mark Alberts, Peter Wilson, Ralph D'Agostino, Amarachi A, Umez-Eronini, Charles Contant, Goto S, Philippe Steg
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-26
• [Presentation] Gender Differences in Cardiovascular Risk in Diabetic and Non-DiabeticOutpatients at Risk of or with Atherothrombosis in the REACH Registry (2012)
  • Author(s): Jacob A.Udell, Annie Nguyen, Philippe Steg, Benjamin Scirica, Kim Eagle, Erik Ohman, Goto S, Kevin Crowley, Peter Wilson, Deepak Bhatt
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-25
• [Presentation] Resistant Hypertension : A Frequent And Ominous Finding Among Hypertensive Patients With Atherothrombosis (2012)
  • Author(s): Dharam J.Kumbhani, Philippe Steg, Christopher Cannon, Kim Eagle, Kevin Crowley, Goto S, Erik Ohman, George Bakris, Todd Perlstein, Scott Kinlay, Deepak Bhatt
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-25
• [Presentation] Efficacy and Safety of Apixaban Compared with Warfarin for Stroke Prevention in Atrial Fibrillation in Patients Taking Concomitant Aspirin (2012)
  • Author(s): John H.Alexander, Renato Lopes, John McMurray, Dan Atar, Daniel Wojdyla, Philip Aylward, Steen Husted, Marco Alings, Kurt Huber, Michael Hanna, Prem Pais, Basil Lewis, Goto S, Hubert Pouleur, Philippe Steg, Freek Verheugt, Christopher Granger, Lars Wallentin
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-25
• [Presentation] Metabolic Syndrome, Diabetes Mellitus, or Both and Cardiovascular Risk in Outpatients at Risk of or with Atherothrombosis in the REACH Registry (2012)
  • Author(s): Jacob A.Udell, Philippe Steg, Benjamin Scirica, Kim Eagle, Erik Ohman, Goto S, Jang Ik Cho, Peter Wilson, Deepak Bhatt
  • Organizer: ACC.12
  • Place of Presentation: McCormick Place Convention Center
  • Year and Date: 2012-03-25
• [Presentation] Long-Term Cardiovascular Outcomes in Patients with Atrial Fibrillationand Atherothrombosis in the REACH Registry (2011)
  • Author(s): Christian T Ruff, Goto S
  • Organizer: American Heart Association 2011
  • Place of Presentation: Orange County ConventionCenter
  • Year and Date: 2011-11-14
• [Presentation] 我が国における大規模臨床試験の発展に向けて (2011)
  • Author(s): 後藤信哉
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 栃木県総合文化センター(招待講演)
  • Year and Date: 2011-10-22
• [Presentation] 教育講演:ステント後の抗血栓療法 (2011)
  • Author(s): 後藤信哉
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2011-09-23
• [Presentation] 薬剤溶出ステント後の抗血小板療法 (2011)
  • Author(s): 後藤信哉
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場(招待講演)
  • Year and Date: 2011-09-23
• [Presentation] Prospective multicentre international registry of patients newly diagnosed with atrial fibrillation at risk of stroke : the Garfield registry (2011)
  • Author(s): A.K.Kakkar, Goto S
  • Organizer: ESC Congress 2011
  • Place of Presentation: Inter Continental Paris le Grand
  • Year and Date: 2011-08-27
• [Presentation] Lower Risk of Coronary Events in Japanese Outpatients with Ischemic Stroke-Results from the Effective Vascular Event Reduction after Stroke Registry (2011)
  • Author(s): Goto S
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-08-03
• [Presentation] Future Perspective of Warfarin and Newer Generation of Oral Anticoagulants (2011)
  • Author(s): 後藤信哉
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2011-08-03
• [Presentation] Lower Risk of Coronary Events in Japanese Outpatients with Ischemic Stroke-Results from the Effective Vascular Event Reduction after Stroke Registry (2011)
  • Author(s): 後藤信哉
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-08-03
• [Presentation] ROLE OF MITOCHONDRIA IN THE PROCESS OF PLATELET ACTIVATION AND THROMBUS FORMATION UNDER BLOOD FLOW CONDITIONS (2011)
  • Author(s): Tamura N, and Goto S
  • Organizer: ISTH 2011
  • Place of Presentation: ICC京都(京都市)
  • Year and Date: 2011-07-28
• [Presentation] ROLE OF MITOCHONDRIA IN THE PROCESS OF PLATELET ACTIVATION AND THROMBUS FORMATION UNDER BLOOD FLOW CONDITIONS (2011)
  • Author(s): Tamura N, Nanazawa Y, Goto S
  • Organizer: ISTH 2011 KYOTO JAPAN
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2011-07-28
• [Presentation] DEVELOPMENT OF PLATELET CELL SIMULATOR IMPLEMENTINGTHE FUNCTION OF RELEASE REACTION (2011)
  • Author(s): Nanazawa Y, Tamura N, Goto S, Sunaga Y Koyama T, Yokota H
  • Organizer: ISTH 2011 KYOTO JAPAN
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2011-07-26
• [Presentation] Risk and benefit of anti-thrombotic therapy : Still ignore the bleeding risk? (2011)
  • Author(s): Goto S
  • Organizer: ISTH 2011
  • Place of Presentation: ICC京都(京都市)
  • Year and Date: 2011-07-25
• [Presentation] Risk and benefit of anti-thrombotic therapy : Still ignore the bleeding risk? (2011)
  • Author(s): Goto S
  • Organizer: ISTH 2011 KYOTO JAPAN
  • Place of Presentation: Kyoto International Conference Center(招待講演)
  • Year and Date: 2011-07-25
• [Presentation] J-ROCKET AF : THE SAFETY AND EFFICACY OF RIVAROXABAN FOR PREVENTION OF STROKE IN JAPANESE PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION (2011)
  • Author(s): Hori M, Matsumoto M, Tanahashi N, Momomura S, Uchiyama S, Goto S, Izumi T, Koretsune Y
  • Organizer: ISTH 2011 KYOTO JAPAN
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2011-07-25
• [Presentation] 血管内治療における抗血小板薬の役割 (2011)
  • Author(s): 後藤信哉
  • Organizer: 第10回日本頸部脳血管治療学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪市)
  • Year and Date: 2011-06-11
• [Presentation] 血管内治療における抗血小板薬の役割 (2011)
  • Author(s): 後藤信哉
  • Organizer: 第10回日本頸部脳血管治療学会
  • Place of Presentation: 千里ライフサイエンスセンター(招待講演)
  • Year and Date: 2011-06-11
• [Presentation] Aspirin or other antipletet for primary prevention (2011)
  • Author(s): Goto S
  • Organizer: The 1st Asia Pacific Congress on CONTROVERSIES TO CONSENSUS IN DIABETES, OBESITY AND HYPERTENSION
  • Place of Presentation: Kerry Hotel Pudong, Shanghai(招待講演)
  • Year and Date: 2011-06-04
• [Presentation] A Call to Action (2011)
  • Author(s): Goto S
  • Organizer: 18th Asia Pacific Congress of Cardiology
  • Place of Presentation: Kuala Lumpur ConventionCenter(招待講演)
  • Year and Date: 2011-05-05
• [Presentation] COMPUTER SIMULATION OF ARTERIAL THROMBUS FORMATION Atherosclerotic Plaque (2011)
  • Author(s): Goto S, Komai T, Kawahara H, Tajima S
  • Organizer: ACC.11
  • Place of Presentation: New Orleans
  • Year and Date: 2011-04-04
• [Presentation] Double-blind, placebo-controlled Phase II studies of the PAR-1 antagonist E5555 in Japanese patients with acute coronary syndrome(ACS)or high-risk coronary artery disease(CAD). (2010)
  • Author(s): Goto S
  • Organizer: Annual Congress of European Society of Cardiology 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-30
• [Presentation] Mechanism of Various Antiplatelet Agents and the Impact on the Bleeding Complication (2010)
  • Author(s): Goto S
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2010-03-05
• [Book] How can we avoid stroke crisis in the Asia-Pacific region? (2011)
  • Author(s): Goto S, et al
  • Publisher: Chameleon Communications International
• [Book] 抗血栓療法ハンドブック (2011)
  • Author(s): 後藤信哉
  • Publisher: 中外医学社
• [Book] そこが知りたい抗血栓療法 (2011)
  • Author(s): 後藤信哉
  • Publisher: Medical View
• [Book] How Can We Avoid a Stroke Crisis in the Asia-Pacific Region? Working Group Report : Stroke Prevention in Patients with Atrial Fibrillation (2011)
  • Author(s): Goto S, Hankey G, Hills MT, Hu D, Hu HH, Lip GY, MBE TL, Quek DK, Sim K-H, Tanahashi N, Tse H-F, Yoon B-W, Zhang S
  • Total Pages: 82
  • Publisher: Chameleon Communications International : 1-82, 2011
• [Book] そこが知りたい抗血栓療法 (2011)
  • Author(s): 後藤信哉
  • Total Pages: 259
  • Publisher: メディカルビュー
• [Book] 動脈硬化/血栓性疾患ハンドブック (2009)
  • Author(s): 後藤信哉
  • Total Pages: 208
  • Publisher: 医歯薬出版
• [Remarks]
  • URL: http://www.med.u-tokai.ac.jp/daigakuin/pdf/gotou.pdf
• [Patent(Industrial Property Rights)] 特許 (2011)
  • Inventor(s): 広渡祐史、岡本奈美、後藤信哉
  • Industrial Property Rights Holder: 東ソー株式会社/学校法人東海大学
  • Acquisition Date: 2011-03-04