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Immunologic Mechanisms in Acute Coronary Syndrome through TRAIL/DR5 pathway

Research Project

Project/Area Number 21590912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Women's Medical University

Principal Investigator

SATO Kayoko  東京女子医科大学, 医学部, 助教 (20246482)

Co-Investigator(Kenkyū-buntansha) SAWABE Motoji  地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター (30196331)
Co-Investigator(Renkei-kenkyūsha) HAGIWARA Nobuhisa  東京女子医科大学, 医学部, 教授 (00180802)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords急性冠症候群 / 免疫・炎症 / アポトーシス / 動脈硬化 / 接着分子
Research Abstract

Development of atherosclerosis and unstable plaque, which cause acute coronary syndrome(ACS), are highly associated with chronic inflammation and immunological mechanisms. In this study we found that, (1) in unstable plaque, there are abundant TRAIL-positive CD4 T cells, DR5-positive vascular smooth muscle cells and endothelial cells, and apoptosis of target cells induced through the TRAIL/DR5 pathway, (2) inflammatory cytokine TNFαproduced by CD4 T cells increase DR5 and destabilizes plaque, (3) monitoring of soluble TRAIL in peripheral blood is a potential immunological biomarker for assessing plaque stability and disease severity.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (87 results)

All 2012 2011 2010 2009 Other

All Journal Article (28 results) (of which Peer Reviewed: 20 results) Presentation (50 results) Book (8 results) Remarks (1 results)

  • [Journal Article] PSGL-1-expressing CD4 T cells induce endothelial cell apoptosis in perimenopausal women2012

    • Author(s)
      Gomita K, Sato K, Yoshida M, Hagiwara N
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 19(3) Pages: 227-236

    • NAID

      130004444592

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis : A pathological study of 1503 consecutive autopsy cases2012

    • Author(s)
      Ikeda S, Tanaka N, Arai T, Chida K, Muramatsu M, Sawabe M
    • Journal Title

      Atherosclerosis

      Volume: 221(2)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PSGL-1-Expressing CD4 T Cells Induce Endothelial Cell Apoptosis in Perimenopausal Women2012

    • Author(s)
      Gomita K, Sato K, et al
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 19 Issue: 3 Pages: 227-236

    • DOI

      10.5551/jat.9399

    • NAID

      130004444592

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis : A pathological study of 1503 consecutive autopsy cases2012

    • Author(s)
      Ikeda S, Sawabe M, et al
    • Journal Title

      Atherosclerosis

      Volume: 221 Issue: 2 Pages: 221-221

    • DOI

      10.1016/j.atherosclerosis.2012.01.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動脈硬化と免疫異常2011

    • Author(s)
      佐藤加代子
    • Journal Title

      総合臨床(特集)

      Volume: 60(10) Pages: 2005-2009

    • Related Report
      2011 Final Research Report
  • [Journal Article] 急性冠症候群とT細胞2011

    • Author(s)
      佐藤加代子
    • Journal Title

      循環器内科

      Volume: 69(6) Pages: 627-634

    • NAID

      40018927324

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 私が推する2010年のこの1報2011

    • Author(s)
      佐藤加代子
    • Journal Title

      血管糖尿病

    • Related Report
      2011 Final Research Report
  • [Journal Article] 炎症細胞(マクロファージ, T細胞,樹状細胞)と糖尿病性血管障害2011

    • Author(s)
      佐藤加代子
    • Journal Title

      血管糖尿病

      Pages: 21-25

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations2011

    • Author(s)
      Yamada Y, Sawabe M, Jang Y
    • Journal Title

      Atherosclerosis

      Volume: 215(1) Pages: 145-152

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly : an autopsy study of 1, 536 patients2011

    • Author(s)
      Sawabe M, Tanaka M, Tanaka N
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(2) Pages: 166-175

    • NAID

      130004444492

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age is a major pathobiological determinant of aortic dilatation : a large autopsy study of community deaths2011

    • Author(s)
      Sawabe M, Hamamatsu A, Chida K, Mieno MN, Ozawa T
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(2) Pages: 157-165

    • NAID

      130004444491

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema2011

    • Author(s)
      Yamada M, Sawabe M, et al
    • Journal Title

      Journal of human genetics

      Volume: 56 Issue: 12 Pages: 857-60

    • DOI

      10.1038/jhg.2011.118

    • NAID

      10030662015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age is a major pathobiological determinant of aortic dilatation : a large autopsy study of community deaths2011

    • Author(s)
      Sawabe M, et al
    • Journal Title

      Journal of atherosclerosis and thrombosis

      Volume: 18 Pages: 157-65

    • NAID

      130004444491

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly : an autopsy study of 1,536 patients2011

    • Author(s)
      Sawabe M, et al
    • Journal Title

      Journal of atherosclerosis and thrombosis

      Volume: 18 Pages: 166-75

    • NAID

      130004444492

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations2011

    • Author(s)
      Yoshiji Yamada, Tamotsu Nishida, Sahoko Ichihara, Motoji Sawabe, Noriyuki Fuku, Yutaka Nishigaki, Yukitoshi Aoyagi, Masashi Tanaka, Yoshinori Fujiwara, Hiroto Yoshida, Shoji Shinkai, Kei Satoh, Kimihiko Kato, Tetsuo Fujimaki, Kiyoshi Yokoi, Mitsutoshi Oguri, Tetsuro Yoshida, Sachiro Watanabe, Yoshinori Nozawa, Aki Hasegawa, Toshio Kojima, Bok-Ghee Han, Younjin Ahn, Meehee Lee, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang
    • Journal Title

      Atherosclerosis

      Volume: 215 Issue: 1 Pages: 145-152

    • DOI

      10.1016/j.atherosclerosis.2010.12.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動脈硬化と免疫異常2011

    • Author(s)
      佐藤加代子
    • Journal Title

      総合臨床

      Volume: 60 Pages: 2005-9

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Mitochondrial haplogroups a and m7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly : an autopsy study of 1, 536 patients.2011

    • Author(s)
      Motoji Sawabe, et al.
    • Journal Title

      J Atheroscler Thromb

      Volume: 18 Pages: 166-175

    • NAID

      130004444492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age is a Major Pathobiological Determinant of Aortic Dilatation : A Large Autopsy Study of Community Deaths.2011

    • Author(s)
      Motoji Sawabe, et al.
    • Journal Title

      J Atheroscler Thromb

      Volume: 18 Pages: 157-165

    • NAID

      130004444491

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in east Asian populations.2011

    • Author(s)
      Yamada Y, Sawabe M, et al.
    • Journal Title

      Atherosclerosis

      Volume: 215 Pages: 145-152

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute coronary syndrome2010

    • Author(s)
      Sato K, Nuki T, Gomita K, Weyand CM, Hagiwara N
    • Journal Title

      Atherosclerosis

      Volume: 213(1) Pages: 33-39

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular aging : from molecular mechanism to clinical significance2010

    • Author(s)
      Sawabe M
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Suppl 1 Pages: 213-220

    • NAID

      10027274057

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute coronary syndrome.2010

    • Author(s)
      Kayoko Sato, et al.
    • Journal Title

      Atherosclerosis

      Volume: 213 Pages: 33-39

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular aging : from molecular mechanism to clinical significance.2010

    • Author(s)
      Motoji Sawabe
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Suppl 1

    • NAID

      10027274057

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 大動脈加齢性中膜変性症の病理2010

    • Author(s)
      沢辺元司
    • Journal Title

      日本老年医学会雑誌

      Volume: 47 Pages: 202-205

    • NAID

      10026895340

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute coronary syndrome2010

    • Author(s)
      Kayoko Sato
    • Journal Title

      Atherosclerosis in press(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 女性の大血管・小血管障害予防戦略を考える-中高年~高齢期にわたる最適な降圧治療とは-2009

    • Author(s)
      佐藤加代子
    • Journal Title

      血圧

      Volume: 16, suppl. 3 Pages: 83-90

    • Related Report
      2011 Final Research Report
  • [Journal Article] High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction : a path analysis using a large number of autopsy cases2009

    • Author(s)
      Sawabe M, Tanaka N, Matsushita S
    • Journal Title

      Heart

      Volume: 95(24) Pages: 1997-2002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smoking confers a MTHFR 677C> T genotype-dependent risk for systemic atherosclerosis : results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital2009

    • Author(s)
      Sawabe M, Arai T, Muramatsu M
    • Journal Title

      J Atheroscler Thromb

      Volume: 16(2) Pages: 91-104

    • NAID

      10025765030

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] PSGL-1 Expressing CD4^+T-cells in Acute Coronary Syndrome2012

    • Author(s)
      Kayoko Sato, Keiko Gomita, Atsuko Futase, Fumiaki Mori, Motoji Sawabe, Nobuhisa Hagiwara
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      Sydney
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] CD4 T Cell Dysfunction in Perimenopausal Women2012

    • Author(s)
      Kayoko Sato
    • Organizer
      第76回日本循環器学会総会, Circulation J
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] INFγ and IL-17-Producing T-Cells Contribute to the Microalbuminuria with the Dysfunction of Podocytes2012

    • Author(s)
      Takashi Saito, Kayoko Sato, Keiko Gomita, Atsuko Futase, Atsushi Suzuki, Keiko Uchida, Kosaku Nitta, Nobuhisa Hagiwara
    • Organizer
      第76回日本循環器学会総会, Circulation J
    • Place of Presentation
      Fuluoka
    • Year and Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] INFγ and IL-17-Producing T-Cells Contribute to the Microalbuminuria with the Dysfunction of Podocytes2012

    • Author(s)
      Saito T, Sato K, et al
    • Organizer
      第76回日本循環器学会総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] CD4 T Cell Dysfunction in Perimenopausal Women2012

    • Author(s)
      Sato K, et al
    • Organizer
      第76回日本循環器学会総会(Symposium)
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 女性におけるPSGL-1発現CD4T細胞による血管内皮細胞障害の検討2012

    • Author(s)
      佐藤加代子, 五味田敬子, 萩原誠久
    • Organizer
      第5回日本性差医学会・医療学会,学術集会記録
    • Place of Presentation
      東京
    • Year and Date
      2012-02-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 女性におけるPSGL-1発現CD4 T細胞による血管内皮細胞障害の検討2012

    • Author(s)
      佐藤加代子, 等
    • Organizer
      第5回日本性差医学会・医療学会
    • Place of Presentation
      弥生記念講堂(東京都)(優秀演題賞)
    • Year and Date
      2012-02-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Th1 and Th17 T cells contribute albuminuria with the dysfunction of podocytes2011

    • Author(s)
      Atsuko Futase, Kayoko Sato, Keiko Gomita, Reiko Honda, Keiko Uchida, Kosaku Nitta, Nobuhisa Hagiwara
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Th1 and Th17 T cells contribute albuminuria with the dysfunction of podocytes2011

    • Author(s)
      Futase A, Sato K, et al
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京ステーションカンファレンス(東京都)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] T cells contribute to the microalbuminuria in atherosclerotic model mouse2011

    • Author(s)
      Kayoko Sato, Keiko Gomita, Atsuko Futase, Keiko Uchida, Kosaku Nitta, Nobuhisa Hagiwara
    • Organizer
      日本免疫学会総会・学術集会記録
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] T cells contribute to the microalbuminuria in atherosclerotic model mouse2011

    • Author(s)
      Sao K, et al
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] PSGL-1 Expressing CD4 T cells Contribute Plaque Instability in ACS2011

    • Author(s)
      Kayoko Sato, Keiko Gomita, Atsuko Futase, Fumiaki Mori, Motoji Sawabe, Nobuhisa Hagiwara
    • Organizer
      2011 Scientific Session of American Heart Association, Circulation
    • Place of Presentation
      Orland
    • Year and Date
      2011-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] PSGL-1 Expressing CD4 T cells Contribute Plaque Instability in ACS2011

    • Author(s)
      Sato K, Sawabe M, et al
    • Organizer
      2011 Scientific Session of American Heart Association
    • Place of Presentation
      Orland (Florida)
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] PSGL-1 expressing CD4 T cells in plaque instability2011

    • Author(s)
      Gomita K, Sato K, Sawabe M, et al
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-08-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] PSGL-1 expressing CD4 T cells in plaque instability2011

    • Author(s)
      Keiko Gomita, Kayoko Sato, Noriko Kikuchi, Suguru Matsumoto, Kim Ahsung, Michiaki Higashitani, Fumiaki Mori, Motoji Sawabe, Nobuhisa Hagiwara
    • Organizer
      第75回日本循環器学会総会, Circulation J
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Th1 T cells and Th17 cells contribute to the microalbuminuria in apolipoprotein E-deficient mice2011

    • Author(s)
      Keiko Gomita, Kayoko Sato, Keiko Uchida, Teiko Ohashi, Nobuhisa Hagiwara
    • Organizer
      第75回日本循環器学会総会, Circulation J
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of T cells in Essential Hypertension2011

    • Author(s)
      Ahsung Kim, Kayoko Sato, Suguru Matsumoto, Keiko Gomita, Nobuhisa Hagiwara
    • Organizer
      第75回日本循環器学会総会, Circulation J
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Th1 T cells and Th17 cells contribute to the microalbuminuria in apolipoprotein E-deficient mice2011

    • Author(s)
      Gomita K, Sato K, et al
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of T cells in Essential Hypertension2011

    • Author(s)
      Ahsung Kim, Kayoko Sato, et al
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of CD4 T cells in the vulnerable plaque formation2010

    • Author(s)
      Kayoko Sato
    • Organizer
      第18回血管生物医学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of CD4 T cells in the vulnerable plaque formation.2010

    • Author(s)
      Kayoko Sato
    • Organizer
      第18回血管生物医学会
    • Place of Presentation
      梅田スカイビル(大阪)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of PSGL-1 expressing CD4 T cells in plaque instability2010

    • Author(s)
      Keiko Gomita, Kayoko Sato, Michiaki Higashitani, Fumiaki Mori, Motoji Sawabe, Nobuhisa Hagiwara
    • Organizer
      2010 Scientific Session of American Heart Association, Circulation
    • Place of Presentation
      Chicago
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of PSGL-1 expressing CD4 T cells in plaque instability.2010

    • Author(s)
      Keiko Gomita, Kayoko Sato
    • Organizer
      2010 Scientific Session of American Heart Association
    • Place of Presentation
      McCormick Place(Chicago)
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] PSGL-1-expressing CD4 T cells induce endothelial apoptosis in perimenopausal women2010

    • Author(s)
      Keiko Gomita, Kayoko Sato, Masayuki Yoshida, Nobuhisa Hagiwara
    • Organizer
      14^<th> International Congress of Immunology, International Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-23
    • Related Report
      2011 Final Research Report
  • [Presentation] TRAIL-expressing CD4 T cell induce endothelial apoptosis in perimenopausal women2010

    • Author(s)
      Noriko Kikuchi, Kayoko Sato, Keiko Gomita, Nobuhisa Hagiwara
    • Organizer
      第42回日本動脈硬化学会総会・学術集会,日本動脈硬化学会総会プログラム・抄録集
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of PSGL-1-expressing CD4 T cells in perimenopausal women2010

    • Author(s)
      Keiko Gomita, Kayoko Sato, Masayuki Yoshida, Nobuhisa Hagiwara
    • Organizer
      第42回日本動脈硬化学会総会・学術集会,日本動脈硬化学会総会プログラム・抄録集
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Statins Protect In-stent Restenosis in Patients with High Adiponectin by Improving the LDL to HDL Cholesterol Ratio2010

    • Author(s)
      Suguru Matsumoto, Kayoko Sato, Kazutaka Kitamura, Ahsung Kim, Keiko Gomita, Nobuhisa Hagiwara
    • Organizer
      第42回日本動脈硬化学会総会・学術集会,日本動脈硬化学会総会プログラム・抄録集
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Activation of T cells in hypertension2010

    • Author(s)
      Ahsung Kim, Kayoko Sato, Suguru Matsumoto, Noriko Kikuchi, Keiko Gomita, Nobuhisa Hagiwara
    • Organizer
      第42回日本動脈硬化学会総会・学術集会,日本動脈硬化学会総会プログラム・抄録集
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of PSGL-1-expressing CD4 T cells in perimenopausal women.2010

    • Author(s)
      Keiko Gomita, Kayoko Sato
    • Organizer
      第42回日本動脈硬化学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] TRAIL-expressing CD4 T cell induce endothelial apaptosis in perimenop ausal women.2010

    • Author(s)
      Noriko Kikuchi, Kayoko Sato
    • Organizer
      第42回日本動脈硬化学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adtivation of T cells in hypertension2010

    • Author(s)
      Ahsung Kim, Kayoko Sato
    • Organizer
      第42回日本動脈硬化学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stating Protect In-stent Restenosis in Patients with High Adiponectin by Improving the LDL to HDL Cholesterol Ratio.2010

    • Author(s)
      Suguru Matsumoto, Kayoko Sato
    • Organizer
      第42回日本動脈硬化学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] PSGL-1-expressing CD4 T cells induce endothelial apoptosis in perimen opausal women.2010

    • Author(s)
      Keiko Gomita, Kayoko Sato
    • Organizer
      14^<th>International Congress of Immunology
    • Place of Presentation
      Kobe International Exhibition Hall(Kobe)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Age-related degeneration and loss of smooth muscle cells in the inner and middle layers of thoracic descending aorta.2010

    • Author(s)
      Sawabe Motoji
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic polymarphisms of SLC22A3-LPAL2-LPA gene cluster hasdirect and indrect effects on coronary atherosclerosis and coronaryheart disease2010

    • Author(s)
      Sawabe Motoji
    • Organizer
      Human Genome Meeting 2010
    • Place of Presentation
      Montpellier, France
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 更年期女性におけるT細胞による血管内皮細胞障害2010

    • Author(s)
      五味田敬子, 佐藤加代子, 吉田雅幸, 萩原誠久
    • Organizer
      第47回日本臨床分子医学会,日本臨床医学会学術総会プログラム
    • Place of Presentation
      東京
    • Year and Date
      2010-05-10
    • Related Report
      2011 Final Research Report
  • [Presentation] T細胞による急性冠症候群発症にかかわる粥腫不安定化機序2010

    • Author(s)
      佐藤加代子
    • Organizer
      第10回Cardiovascular Frontier Conference(Symposium)
    • Place of Presentation
      東京
    • Year and Date
      2010-05-03
    • Related Report
      2011 Final Research Report
  • [Presentation] SLC22A3-LPAL2-LPA領域の遺伝子多型は血清Lipoprotein(a)値、冠動脈疾患、脳血管疾患と有意な関連を示す2010

    • Author(s)
      沢辺元司
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 更年期女性におけるT細胞による血管内皮細胞障害2010

    • Author(s)
      五味田敬子、佐藤加代子
    • Organizer
      第47回日本臨床分子医学会
    • Place of Presentation
      朝日ホール(東京)
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of PSGL-1 expressing CD4 T Cells in Acute Coronary Syndrome2010

    • Author(s)
      Keiko Gomita, Kayoko Sato, Noriko Kikuchi, Nobuhisa Hagiwara
    • Organizer
      第74回日本循環器学会総会, Circulation J
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Pitavastatin prevents Atherosclerotic Plaque Development via Inhibition of TRAIL Expression on CD4 T Cells2010

    • Author(s)
      Kayoko Sato, Keiko Gomita, Nobuhisa Hagiwara
    • Organizer
      第74回日本循環器学会総会, Circulation J
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] CD4 T Cell Dysfunction in Perimenopausal Women : The Mechanism of Acceleration of Atherosclerosis2010

    • Author(s)
      Noriko Kikuchi, Kayoko Sato, Keiko Gomita, Nobuhisa Hagiwara
    • Organizer
      第74回日本循環器学会総会, Circulation J
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Pitavastatin prevents Atherosclerotic Plaque Development via Inhibition of TRAIL Expression on CD4 T Cells.2010

    • Author(s)
      Kayoko Sato
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD4 T Cell Dysfunction in Perimenopausal Women : The Mechanism of Acceleration of Atherosclerosis.2010

    • Author(s)
      Noriko Kikuchi
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of PSGL-1 Expressing CD4 T Cells in Vulnerable Plaque2009

    • Author(s)
      Keiko Gomita, Kayoko Sato, Motoji Sawabe, Nobuhisa Hagiwara
    • Organizer
      日本免疫学会総会・学術集会記録
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Pitavastatin has Anti-atherosclerotic Effects via Inhibition of TRAIL Expression on CD4 T Cells2009

    • Author(s)
      Kayoko Sato, Keiko gomita, Nobuhisa Hagiwara
    • Organizer
      2009 Scientific Session of American Heart Association, Circulation(George L Duff Memolial Lecture : Inflammation and Atherosclerosis)
    • Place of Presentation
      Orland
    • Year and Date
      2009-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Pitavastatin has Anti-atherosclerotic Effects via Inhibition of TRAIL Expression on CD4 T Cells.2009

    • Author(s)
      Kayoko Sato
    • Organizer
      2009 Scientific Session of American Heart Association
    • Place of Presentation
      Orland
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of T cells in Vulnerable Plaque2009

    • Author(s)
      Kayoko Sato, Nobuhisa Hagiwara
    • Organizer
      The 7th Japan-Korea Joint Symposium on Vascular Biology
    • Place of Presentation
      Seoul
    • Year and Date
      2009-08-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of T cells in Vulnerable Plaque.2009

    • Author(s)
      Kayoko Sato
    • Organizer
      The 7th Japan-Korea Joint Symposium on Vascular Biology (Symposium, 招待講演)
    • Place of Presentation
      Seoul
    • Year and Date
      2009-08-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] PSGL-1 is a key molecule for plaque stability in acute coronary syndrome2009

    • Author(s)
      Keiko Gomita, Kayoko Sato, Kazutaka Kitamura, Motoji Sawabe, Nobuhisa Hagiwara
    • Organizer
      XV International Symposium on Atherosclerosis
    • Place of Presentation
      Boston
    • Year and Date
      2009-06-16
    • Related Report
      2011 Final Research Report
  • [Book] 血管生物医学事典第5章20 STAT2011

    • Author(s)
      佐藤加代子
    • Publisher
      朝倉出版
    • Related Report
      2011 Final Research Report
  • [Book] 血管生物医学事典第6章25血管疾患と獲得免疫2011

    • Author(s)
      佐藤加代子
    • Publisher
      朝倉出版
    • Related Report
      2011 Final Research Report
  • [Book] 私が推する2010年のこの1報2011

    • Author(s)
      佐藤加代子
    • Publisher
      フジメディカル出版
    • Related Report
      2011 Final Research Report
  • [Book] 炎症細胞(マクロファージ, T細胞,樹状細胞)と糖尿病性血管障害2011

    • Author(s)
      佐藤加代子
    • Related Report
      2011 Final Research Report
  • [Book] 血管生物医学事典第5章20STAT 391-42011

    • Author(s)
      佐藤靖史, 森田育男, 高倉伸幸, 小室一成監修, 第5章20佐藤加代子
    • Total Pages
      500
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report
  • [Book] 血管生物医学事典第6章25血管疾患と獲得免疫467-92011

    • Author(s)
      佐藤靖史, 森田育男, 高倉伸幸, 小室一成監修, 第6章50佐藤加代子
    • Total Pages
      500
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report
  • [Book] 血管糖尿病2011私が推する2010年のこの1報C32011

    • Author(s)
      佐田正隆, 下村伊一郎, 野出孝一, 綿田裕孝編, 佐藤加代子
    • Total Pages
      330
    • Publisher
      フジメディカル出版
    • Related Report
      2011 Annual Research Report
  • [Book] 血管糖尿病2011炎症細胞(マクロファージ,T細胞,樹状細胞)と糖尿病性血管障害2011

    • Author(s)
      佐田正隆, 下村伊一郎, 野出孝一, 綿田裕孝編, 佐藤加代子
    • Total Pages
      330
    • Publisher
      フジメディカル出版
    • Related Report
      2011 Annual Research Report
  • [Remarks] 病理解剖コラボレーション事業

    • URL

      http://www1.tmghig.jp/pathology-d/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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