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Clinical application of newly developed h-chymase assay method : changes in acute coronary syndrome and association with coronary risk factors

Research Project

Project/Area Number 21590916
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionFukuoka University

Principal Investigator

URATA Hidenori  福岡大学, 医学部, 教授 (30289524)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心臓病態学 / レニン・アンジオテンシン系 / キマーゼ / アンジオテンシン変換酵素 / カテプシンG / 心血管病 / 慢性腎障害 / 急性冠動脈症候群 / キマーゼ阻害薬
Research Abstract

Chymase assay method was established using the specific chymase inhibitor with modified angiotensinI(AngI). Analysis in circulating mononuclear leukocyte(CML) of the patients post myocardial infarction(MI) revealed significant increase in acute phase(1-2 days) and the level of increase was positively correlated with the MI severity. In the analysis of stable angina patient chymase activity in CML was significantly higher in male and positively correlated with white blood cell number, c-reactive protein, HOMA index, degree of chronic kidney disease(CKD), suggesting that mild inflammatory status, glucose intolerance or CKD facilitate chymase levels in CML. In collaborative work with Ryuku University acute venous infusion of free fatty acid significantly increased serine protease dependent Ang II forming activity in CML, which was associated with endothelial dysfunction. In collaborative work with Kagawa University unilateral urethral clipping was associated with increased chymase activity only in the affected kidney and increased renal Ang IIlevels.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (45 results)

All 2012 2011 2010 2009

All Journal Article (31 results) (of which Peer Reviewed: 16 results) Presentation (14 results)

  • [Journal Article] 発症機序・病態キマーゼ2011

    • Author(s)
      浦田秀則
    • Journal Title

      高血圧ナビゲーター第3版

      Volume: 8 Pages: 86-87

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Blood glucose level and survival in streptozotocin-treated human chymase transgenic mice2011

    • Author(s)
      Rafiq. K., Sherajee. S. J., Fan. Y.-Y., Nakano.D., Hitomi. H., Nishiyama. A., Fujisawa. Y., Takahashi. Y., Matsuura. J., Hase. N., Urata. H.
    • Journal Title

      Chinese Journal of Physiology

      Volume: 54 Pages: 30-35

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prompt and sustained antihypertensive effect of a losartan-hydrochlorothiazide combination drug in hypertensive uncontrolled by angiotensin receptor blockers in the Chikushi Anti-Hypertension Trial-Preminent(CHAT-P)2011

    • Author(s)
      Shunichiro Sumi
    • Journal Title

      Therapeutic Research

      Volume: 32 Pages: 203-214

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACE阻害薬とアンジオテンシンII受容体拮抗薬高血圧における使い方2010

    • Author(s)
      林ちはる、浦田秀則
    • Journal Title

      Heart View

      Volume: 14 Pages: 90-95

    • Related Report
      2011 Final Research Report
  • [Journal Article] Inhibition of chymase protects anginst diabetes-induced oxidative stress and renal dysfunction in hamsters2010

    • Author(s)
      Maeda Y., Inoguchi T., Takei R., Sawada F., Sasaki S., Fujii M., Kobayashi K., Urata H., Nishiyama A., Takayanagi R.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] これからの高血圧治療新しい降圧薬レニン阻害薬2010

    • Author(s)
      久保田和充、浦田秀則
    • Journal Title

      最新高血圧治療学

      Volume: 8 Pages: 318-323

    • Related Report
      2011 Final Research Report
  • [Journal Article] レニン・アンジオテンシン・アルドステロン系2010

    • Author(s)
      久保田和充、浦田秀則
    • Journal Title

      medicina

      Volume: 47 Pages: 1199-1204

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] ACE阻害薬の歴史と種類2010

    • Author(s)
      松本研三、浦田秀則
    • Journal Title

      Modern physician

      Volume: 30 Pages: 377-381

    • Related Report
      2011 Final Research Report
  • [Journal Article] Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells2010

    • Author(s)
      Fujimi K, Uehara Y, Abe S, Kawamura A, Devarajan S, Miura S, Saku K, Urata H.
    • Journal Title

      Hypertension Research

      Volume: 33 Pages: 149-154

    • NAID

      10026126394

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dell' ltalia L. J., Husain A.、Mast cell chymase limits the cardiac efficacy of Ang I. converting enzyme inhibitor therapy in rodents2010

    • Author(s)
      Wei C. C., Hase N., Inoue Y., Bradley E. W., Yahiro E., Li M., Naqvi N., Powell P. C., Shi K., Takahashi Y., Saku K., Urata H.
    • Journal Title

      The Journal of clinical investigation

      Volume: 120 Pages: 1229-1239

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Free fatty acid causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells2010

    • Author(s)
      Azekoshi, Yoko ; Yasu, Takanori ; Watanabe, Saiko ; Tagawa, Tatsuya ; Abe, Satomi ; Yamakawa, Ken ; Uehara, Yoshinari ; Momomura, Shinichi ; Urata, Hidenori ; Ueda, Shinichiro
    • Journal Title

      Hypertension

      Volume: 56 Pages: 136-142

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic effects of calcium channel blockers in patients with vasospastic anjina -A meta-analysis-2010

    • Author(s)
      Kazuhiko Nishigaki
    • Journal Title

      Circulation Journal

      Volume: 74 Pages: 1943-1950

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] これからの高血圧治療 新しい降圧薬 レニン阻害薬2010

    • Author(s)
      久保田和充
    • Journal Title

      最新 高血圧治療学

      Volume: 8 Pages: 318-323

    • Related Report
      2010 Annual Research Report
  • [Journal Article] High efficacy of disopyramide in the management of ventricular fibriliation storms in a patient with brugade syndrome2010

    • Author(s)
      Syunichiro Sumi
    • Journal Title

      Pacing and Clinical Electrophysiology

      Volume: 33

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of chymase protects anginst diabetes-induced oxidative stress and renal dysfunction in hamsters2010

    • Author(s)
      Yasutaka Maeda
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACE阻害薬とアンジオテンシンII受容体拮抗薬 高血圧における使い方2010

    • Author(s)
      林ちはる
    • Journal Title

      Heart View

      Volume: 14 Pages: 90-95

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents2010

    • Author(s)
      Chih-Chang Wei
    • Journal Title

      The Journal of clinical investigation 120

      Pages: 1229-1235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effect of combination therapy comprising angiotensin II receptor blocker plus calcium channel blocker on plasma adiponectin levels2010

    • Author(s)
      Yukiko Inoue
    • Journal Title

      Clinical and experimental hypertension 32

      Pages: 21-28

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells2010

    • Author(s)
      Kanta Fujimi
    • Journal Title

      Hypertension Research 33

      Pages: 149-154

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACE阻害薬の歴史と種類2010

    • Author(s)
      松本研三
    • Journal Title

      Modern physician 30

      Pages: 377-381

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Contribution of chymase-dependent angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters2009

    • Author(s)
      Fan Y. Y., Nishiyama A., Fujisawa Y., Kobori H., Nakano D., Matsuura J., Hase N., Hitomi H., Kiyomoto H., Urata H., Kohno M.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 111 Pages: 82-90

    • NAID

      10025738725

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 話題のホルモン・受容体・酵素:最近の知見からキマーゼ2009

    • Author(s)
      浦田秀則
    • Journal Title

      Heart View

      Volume: 13 Pages: 22-27

    • Related Report
      2011 Final Research Report
  • [Journal Article] レニン阻害薬について、その可能性は?2009

    • Author(s)
      東條秀明、浦田秀則
    • Journal Title

      循環器科

      Volume: 66 Pages: 89-92

    • Related Report
      2011 Final Research Report
  • [Journal Article] レニンアンジオテンシン系と糖尿病血管合併症-病態生理-2009

    • Author(s)
      丸山誠代
    • Journal Title

      内分泌・糖尿病科

      Volume: 28 Pages: 294-300

    • Related Report
      2011 Final Research Report
  • [Journal Article] Reconstituted high-density lipoprotein attenuates postinfarction left ventricular remodeling in rats2009

    • Author(s)
      Yoshihiro Kiya
    • Journal Title

      Atherosclerosis 203

      Pages: 137-144

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Additive antihypertensive and antihypertrophic effects of long-acting Ca blockers in uncontrolled hypertensive patients with angiotensin-receptor blocker based treatment2009

    • Author(s)
      Sunao Kodama
    • Journal Title

      International heart journal 50

      Pages: 555-570

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レニン・アンジオテンシン系と糖尿病血管合併症-病態生理-2009

    • Author(s)
      丸山誠代
    • Journal Title

      内分泌・糖尿病科 28

      Pages: 294-300

    • Related Report
      2009 Annual Research Report
  • [Journal Article] レニン阻害薬について、その可能性は?2009

    • Author(s)
      東條秀明
    • Journal Title

      循環器科 66

      Pages: 89-92

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 1.話題のホルモン・受容体・酵素:最近の知見からc.キマーゼ2009

    • Author(s)
      浦田秀則
    • Journal Title

      Heart View 13

      Pages: 22-27

    • Related Report
      2009 Annual Research Report
  • [Journal Article] VI 治療に関する最新知見 薬物療法 種類別にみた降圧薬の特性と使い方(有用性・安全性)ARB 各製剤の特徴 ロサルタン2009

    • Author(s)
      角俊一郎
    • Journal Title

      高血圧 下 -日本における最新の研究動向- 臨床編 67

      Pages: 325-329

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Contribution of chymase-dependent angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters2009

    • Author(s)
      Yu-Yan Fan
    • Journal Title

      Journal of Pharmacological Sciences 111

      Pages: 82-90

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Increased angiotensin II forming chymase activity in the circulating mononuclear leukocyte associated with diastolic dysfunction detected by echocardiography2012

    • Author(s)
      Okamura K
    • Organizer
      第76回日本循環器学会総会・学術集会
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Increased angiotensin II forming chymase activity in the circulating mononuclear leukocyte associated with diastolic dysfunction detected by echocardiography2012

    • Author(s)
      Keisuke Okamura
    • Organizer
      第76回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡国際センター
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多剤併用で管理不良高血圧患者での少量HCTZの有効性:CHAT-P試験(1年目)サブ解析結果2010

    • Author(s)
      北島研
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 長時間作用型カルシウム拮抗薬4剤の本態性高血圧治療における降圧・脈拍および腎保護効果比較2010

    • Author(s)
      東條秀明
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Beneficial effect of combination therapy comprising angiotensin II receptor blocker plus calcium channel blocker on plasma adiponectin levels2010

    • Author(s)
      Kenzo Matsumoto
    • Organizer
      ISH2010 第23回国際高血圧学会
    • Place of Presentation
      Vancouver Convention Centre(Canada)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Results of an observational regional cohort study using losartan-hydrochlorothiazide combined drug in Japanese essential hypertension2010

    • Author(s)
      Kenzo Matsumoto
    • Organizer
      ISH2010 第23回国際高血圧学会
    • Place of Presentation
      Vancouver Convention Centre(Canada)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Angiotensin II forming system in various cardiovascular disease2010

    • Author(s)
      Urata H.
    • Organizer
      CSDS2010
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Angiotensin II forming system in various cardiovascular disease2010

    • Author(s)
      Hidenori Urata
    • Organizer
      CSDS2010
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Higher chymase dependent angiotensin II-forming activity in the circulating mononuclear leukocyte is a significant contributing factor for atrial fibrillation2010

    • Author(s)
      Okamura K., Inoue Y., Uehara Y., Maruyama S., Sumi S., Furuyama S., Kodama S., Andoh C., Niimura H., Tojo H., Miyoshi K., Tsuchiya Y., Miura S., Yamanouchi Y., Saku K., Urata H.
    • Organizer
      ACC 2010 59th Annual Scientific Session
    • Year and Date
      2010-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Higher chymase dependent angiotensin II-forming activity in the circulating mononuclear leukocyte is a significant contributing factor for atrial fibrillation2010

    • Author(s)
      Keisuke Okamura
    • Organizer
      ACC 2010 59th Annual Scientific Session
    • Place of Presentation
      Georgia World Congress Center
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Higher Chymase Dependent Angiotensin II-Forming Activity in the Circulating Mononuclear Leukocyte is a Significant Contributing Factor for Atrial Fibrillation2010

    • Author(s)
      Okamura K., Inoue Y., Uehara Y., Matsumoto K., Maruyama S., Sumi S., Fukuda Y., Furuyama S., Kodama S., Andoh C., Niimura H., Kubota K., Tohjoh H., Miyoshi K., Miura S., Yamanouchi Y., Saku K., Urata H.
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Year and Date
      2010-03-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Higher Chymase Dependent Angiotensin II-Forming Activity in the Circulating Mononuclear Leukocyte is a Significant Contributing Factor for A trial Fibrillation2010

    • Author(s)
      Keisuke Okamura
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Increased chymase-dependent Angiotensin II forming activity of circulating mononuclear leukocyte in patients with coronary artery disease2009

    • Author(s)
      Inoue Y., Okamura K., Ide H., Maruyama S., Sumi S., Furuyama S., Kodama S., Ando C., Niimura H., Tojo H., Miyoshi K., Yamanouchi Y., Urata H.
    • Organizer
      ESH2009 19th European Meeting on Hypertension
    • Year and Date
      2009-06-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Increased chymase-dependent Angiotensin II forming activity of circulating mononuclear leukocyte in patients with coronary artery disease2009

    • Author(s)
      Yukiko Inoue
    • Organizer
      ESH2009 19th European Meeting on Hypertension
    • Place of Presentation
      MIC, Milan Convention Center
    • Year and Date
      2009-06-14
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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