Sympathetic Denervation Using Stellate Ganglia Ablation as Novel Therapeutic Approach for Cardiac Arrhythmias in Heart Failure

• Project/Area Number: 21590917
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukuoka University
• Principal Investigator: OGAWA Masahiro 福岡大学, 医学部, 准教授 (70341485)
• Co-Investigator(Kenkyū-buntansha): SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 心不全 / 不整脈 / 自律神経

Research Abstract

We clarified the causal relationship between the autonomic nervous activity and cardiac arrhythmias in heart failure. Increased sympathetic activity has important role of both the maintenance and occurrence of arrhythmias in heart failure, including atrial brady-tachycardia and prolongation of ventricular repolarization and its dispersion. After sympathetic denervation using sympathetic ganglion ablation on both sides(from second level to fourth levels of thoracic spinal cord) was applied, cardiac arrhythmias in heart failure were significantly reduced. Sympathetic denervation using stellate ganglia ablation may be useful for treatment of cardiac arrhythmias in heart failure.

Research Products

• [Journal Article] Oxidized CaMKII causes cardiac sinus node dysfunction in mice (2011)
  • Author(s): Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME.
  • Journal Title: J Clin Invest Volume: 121(8) Pages: 3277-88
  • Peer Reviewed
• [Journal Article] 自由行動下心臓自律神経活動と心電図の長期間直接同時記録:心不全合併不整脈における星状神経節アブレーションを用いた心臓交感神経遮断治療 (2011)
  • Author(s): 小川正浩
  • Journal Title: 心電図 Volume: Vol.31, No.4 Pages: 394-400
• [Journal Article] Oxidized CaMKII causes cardiac sinus node dysfunction in mice (2011)
  • Author(s): Swaminathan PD, et al
  • Journal Title: J Clin Invest Volume: 121 Pages: 3277-3288
  • Peer Reviewed
• [Journal Article] 自由行動下心臓自律神経活動と心電図の長期間直接同時記録:心不全合併不整脈における星状神経節アブレーションを用いた心臓交感神経遮断治療 (2011)
  • Author(s): 小川正浩
  • Journal Title: 日本心電学会誌心電図 Volume: 31 Pages: 394-400
• [Journal Article] Cryoablation of stellate ganglia and atrial arrhythmia in ambulatory dogs with pacing-induced heart failure (2009)
  • Author(s): Ogawa M, Tan AY, Song J, Kobayashi K, Fishbein MC, Lin SF, Chen LS, Chen PS.
  • Journal Title: Heart Rhythm Volume: 6(12) Pages: 1772-9
  • Peer Reviewed
• [Journal Article] Autonomic nervous system activity measured directly and QT interval variability in normal and pacing-induced tachycardia heart failure dogs (2009)
  • Author(s): Piccirillo G, Magri D, Ogawa M, Song J, Chong VJ, Han S, Joung B, Choi EK, Hwang S, Chen LS, Lin SF, Chen PS.
  • Journal Title: J Am Coll Cardiol Volume: 840-50
  • Peer Reviewed
• [Journal Article] What have we learned about the contribution of autonomic nervous system to human arrhythmia? (2009)
  • Author(s): Ogawa M, Zhou S, Tan AY, Fishbein MC, Lin SF, Chen LS, Chen PS.
  • Journal Title: Heart Rhythm Volume: 6(8suppl)
  • Peer Reviewed
• [Journal Article] Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure (2009)
  • Author(s): Piccirillo G, Ogawa M, Song J, Chong VJ, Joung B, Han S, Magri D, Chen LS, Lin SF, Chen PS.
  • Journal Title: Heart Rhythm Volume: 6(4) Pages: 546-52
  • Peer Reviewed
• [Journal Article] What have we learned about the contribution of autonomic nervous system to human arrhythmia? (2009)
  • Author(s): Masahiro Ogawa, et al.
  • Journal Title: Heart Rhythm 6
  • Peer Reviewed
• [Journal Article] Cryoablation of stellate ganglia and atrial arrhythmia in ambulatory dogs with pacing-induced heart failure (2009)
  • Author(s): Masahiro Ogawa, et al.
  • Journal Title: Heart Rhythm 6 Pages: 1772-1779
  • Peer Reviewed
• [Presentation] Sympathetic Denervation Using Stellate Ganglia Ablation as Novel Therapeutic Approach for Cardiac Arrhythmias in Heart Failure (2012)
  • Author(s): Ogawa M, Saku K, Chen PS(Plenary session)
  • Organizer: The 76^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-03-17
• [Presentation] Sympathetic Denervation Using Stellate Ganglia Ablation as Novel Therapeutic Approach for Cardiac Arrhythmias in Heart Failure (2012)
  • Author(s): Masahiro Ogawa, et al
  • Organizer: 第76回日本循環器学会学術総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-03-17
• [Presentation] 星状神経節アブレーションによる新しい心不全治療の試み (2010)
  • Author(s): 小川正浩, 朔啓二郎, Chen, Peng-Sheng
  • Organizer: 第27回日本心電学会学術集会(学術諮問委員会提言シンポジウム)
  • Place of Presentation: 大分
  • Year and Date: 2010-10-08
• [Presentation] 星状神経節アブレーションによる新しい心不全治療の試み (2010)
  • Author(s): 小川正浩
  • Organizer: 第27回 日本心電学会学術集会学術諮問委員会提言シンポジウム
  • Place of Presentation: 大分iichiko総合文化センター
  • Year and Date: 2010-10-08
• [Book] 自由行動下心臓自律神経活動と心電図の長期間直接同時記録:心不全合併不整脈における星状神経節アブレーションを用いた心臓交感神経遮断治療,循環器薬物治療実践シリーズX心不全に伴う不整脈の治療戦略 (2011)
  • Author(s): 小川正浩
  • Publisher: 日本心電学会学術諮問委員会(株式会社ライフメディコム)