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The role of soluble VEGF receptor in cardiovascular risk of metabolic syndrome and smoking

Research Project

Project/Area Number 21590918
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center

Principal Investigator

WADA Hiromichi  独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 研究室長(先端医療技術開発) (20416209)

Co-Investigator(Kenkyū-buntansha) SATOH Noriko  独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究室長(臨床代謝栄養) (80373512)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsメタボリックシンドローム / 喫煙 / バイオマーカー / 肥満 / 脂質異常 / 動脈硬化 / 血管新生 / リンパ管新生 / トランスレーショナルリサーチ / 循環器・高血圧 / 細胞・組織 / 動物 / 臨床 / トランスレーションリサーチ
Research Abstract

The mechanisms that lead from obesity to atherosclerotic disease are not fully understood. Obesity involves angiogenesis in which vascular endothelial growth factor-A(VEGF-A) plays a key role. Soluble VEGF receptor-2(sVEGFR-2) acts as an endogenous inhibitor of VEGF-A. We demonstrated that serum levels of sVEGFR-2 are increased in sera from subjects with metabolic syndrome in association with insulin resistance. We also showed that the sVEGFR-2 level, as well as the body mass index, significantly increases after successful smoking cessation. A recent study reported that sVEGFR-2 also acts as an endogenous inhibitor of vascular endothelial growth factor-C(VEGF-C). We found that VEGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (46 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (37 results) Book (1 results) Remarks (2 results)

  • [Journal Article] α1-Antitrypsin-low-density-lipoprotein serves as a marker of smoking-specific oxidative stress2012

    • Author(s)
      Wada H, Ura S, Satoh-Asahara N, Kitaoka S, Mashiba S, Akao M, Abe M, Ono K, Morimoto T, Fujita M, S himatsu A, Takahashi Y, Hasegawa K
    • Journal Title

      J Atheroscler Thromb

      Volume: 19(1) Pages: 47-58

    • NAID

      130004721902

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] α1-Antitrypsin Low-Density-Lipoprotein Serves as a Marker of Smoking-Specific Oxidative Stress2012

    • Author(s)
      Hiromichi Wada
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 19 Issue: 1 Pages: 47-58

    • DOI

      10.5551/jat.9035

    • NAID

      130004721902

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects2011

    • Author(s)
      Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Takahashi Y, Hasegawa K
    • Journal Title

      PLoS ONE

      Volume: 6(12)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct characteristics of circulating vascular endothelial growth factor-A and C levels in human subjects2011

    • Author(s)
      Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K.
    • Journal Title

      Pros ONE

      Volume: 6 Issue: 12 Pages: 29351-29351

    • DOI

      10.1371/journal.pone.0029351

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance2010

    • Author(s)
      Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K
    • Journal Title

      Atherosclerosis

      Volume: 208(2) Pages: 512-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance2010

    • Author(s)
      和田啓道
    • Journal Title

      Atherosclerosis VOL.208

      Pages: 512-517

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Serum Levels of Vascular Endothelial Growth Factor-C are Associated with Dyslipidemia and Atheroscrelosis2012

    • Author(s)
      Shuichi Ura, Hiromichi Wada, Sh uji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa
    • Organizer
      第76回日本循環器学会年次集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects2011

    • Author(s)
      Hiromichi Wada
    • Organizer
      第19回血管生物医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 喫煙特異的酸化ストレスマーカーと動脈硬化性疾患2011

    • Author(s)
      和田啓道
    • Organizer
      第6回日本禁煙科学会学術総会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血清α1-Antitrypsin-LDLは喫煙と密接に関連したマーカーである2011

    • Author(s)
      和田啓道
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト血中の血管内皮増殖因子A(VEGF-A)及びC(VEGF-C)の心血管危険因子との関連2011

    • Author(s)
      和田啓道
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路(兵庫)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮増殖因子Cは動脈硬化惹起性脂質異常と関連している2011

    • Author(s)
      和田啓道
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] alpha1-Antitrypsin-low-density-lipoprotein serves as a marker of smoking-specific oxidative stress2011

    • Author(s)
      Hiromichi Wada
    • Organizer
      European Society of Cardiology Congress 2011
    • Place of Presentation
      Paris France
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Serum VEGF-C levels are elevated in metabolic syndrome subjects2011

    • Author(s)
      Hiromichi Wada
    • Organizer
      European Society of Cardiology Congress 2011
    • Place of Presentation
      Paris France
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] α1-Antitrypsin-low-density-lipoprotein Serves as a Marker of Smoking-specific Oxidative Stress2011

    • Author(s)
      Hiromichi Wada, Noriko Satoh-Asahara, Shuichi Ura ; Akira Yamada ; Shuji Kitaoka, Masaharu Akao, Mitsuru Abe, Koh Ono, Tatsuya Morimoto, Masatoshi Fujita, Akira Shimatsu, Yuko Takahash i, Koji Hasegawa
    • Organizer
      第75回日本循環器学会年次集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2011 Final Research Report
  • [Presentation] α1-Antitrypsin-low-density-lipoprotein Serves as a Marker of Smoking-specific Oxidative Stress2011

    • Author(s)
      Hiromichi Wada
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] α1-Antitrypsin-low-density-lipoprotein serves as a marker of smoking-specific oxidative stress2011

    • Author(s)
      Hiromichi Wada
    • Organizer
      第43回動脈硬化学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Serum Levels of VEGF-C are Elevated in Metabolic Syndrome Subjects in Association With Dyslipidemia and Soluble VEGF Receptor-22011

    • Author(s)
      Hiromichi Wada
    • Organizer
      第43回動脈硬化学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Serum Levels of α1-Antitrypsin-LDL are Negatively Associated with Soluble VEGF Receptor-1 in Smokers and Decrease after Successful Smoking Cessation2011

    • Author(s)
      Hiromichi Wada
    • Organizer
      The 14th Annual International Toronto Heart Summit
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 喫煙特異的酸化ストレスマーカーと動脈硬化性疾患2011

    • Author(s)
      和田啓道
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] VEGF-Cと可溶性VEGF受容体3は可溶性VEGF受容体2と関連して、メタボリックシンドローム患者血清で上昇している2011

    • Author(s)
      和田啓道
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血清α1-Antitrypsin-LDLは喫煙特異的酸化ストレスマーカーである2010

    • Author(s)
      和田啓道
    • Organizer
      第1回日本小児禁煙研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎盤由来増殖因子(PIGF)は禁煙後の内臓脂肪蓄積、インスリン抵抗性増悪の鋭敏な指標である2010

    • Author(s)
      和田啓道
    • Organizer
      第18回日本血管生物医学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮増殖因子C(VEGF-C)はメタボリックシンドロームで上昇している2010

    • Author(s)
      和田啓道
    • Organizer
      第18回日本血管生物医学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 喫煙患者における2つの異なる特徴をもつ酸化LDLマーカーによるリスク評価2010

    • Author(s)
      和田啓道
    • Organizer
      第5回日本禁煙科学会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎盤由来増殖因子(PIGF)は禁煙後の内臓脂肪蓄積、インスリン抵抗性増悪の鋭敏な指標である2010

    • Author(s)
      和田啓道
    • Organizer
      第5回日本禁煙科学会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serum Adiponectin Levels are Increased by Pathologically Induced Left Ventricular Hypertrophy2010

    • Author(s)
      Hiromichi Wada
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      シカゴ(アメリカ合衆国)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Distinct Characteristics of Two Oxidized Low-density lipoprotein Markers in Smoking Patients2010

    • Author(s)
      Hiromichi Wada
    • Organizer
      The 6th China-Japan Cardiovascular Forum
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] VEGF-C and Soluble VEGF Receptor-3 are Increased in Sera of Subjects with Metabolic Syndrome in Association with Soluble VEGF Receptor-22010

    • Author(s)
      Shuichi Ura
    • Organizer
      The 6th China-Japan Cardiovascular Forum
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Placental Growth Factor is a Sensitive Indicator of Abdominal Fat Accumulation and Increased Insulin Resistance after Smoking Cessation in Men2010

    • Author(s)
      Akira Yamada
    • Organizer
      The 6th China-Japan Cardiovascular Forum
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎盤由来増殖因子(PIGF)は禁煙後の体重増加と関連する2010

    • Author(s)
      和田啓道
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血清α1-Antitrypsin-LDLは可溶性VEGF受容体1と逆相関し、禁煙成功後に低下する2010

    • Author(s)
      和田啓道
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内皮増殖因子C(VEGF-C)はメタボリックシンドロームで上昇している2010

    • Author(s)
      和田啓道
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 健常成人における可溶性血管内皮増殖因子受容体2の血清レベルはインスリン抵抗性に規定される2010

    • Author(s)
      和田啓道
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心肥大を伴う心不全患者血清における可溶性VEGF受容体2レベルの意義2010

    • Author(s)
      和田啓道
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 左室肥大を伴う心不全患者の血清における可溶性レクチン様酸化LDLレセプター1(sLOX-1)の上昇2010

    • Author(s)
      和田啓道
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 左室重量係数は血中アディポネクチンレベルの重要な規定因子である2010

    • Author(s)
      和田啓道
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elevated Serum Levels of Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 in Chronic Heart Failure Patients with Left Ventricular Hypertrophy2010

    • Author(s)
      Hiromichi Wada
    • Organizer
      Keystone Symposia
    • Place of Presentation
      京都
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心機能正常及び慢性心不全を含むNYHAクラスの安定した循環器外来男性患者の血清adiponectinレベルは中性脂肪と左室重量係数/NT-proBNPレベルに規定される2010

    • Author(s)
      和田啓道
    • Organizer
      第1回京都循環器内科カンファレンス
    • Place of Presentation
      京都
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elevated Serum Levels of Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 in Chronic Heart Failure Patients with Left Ventricular Hypertrophy2010

    • Author(s)
      Hiromichi Wada
    • Organizer
      27th World Congress of the International Society for Heart Research
    • Place of Presentation
      京都
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 可溶性レクチン様酸化LDLレセプター1(sLOX-1)は左室肥大を伴う心不全患者の血清で上昇している2010

    • Author(s)
      和田啓道
    • Organizer
      第47回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Soluble VEGF Receptor-2 is a Possible Novel Indicator of Impaired An giogenesis in Metabolic Syndrom2010

    • Author(s)
      Hiromichi Wada, Noriko Satoh, Shuji Kitaoka, Koh Ono, Tatsuya Morimoto, Teruhisa Kawamura, Tameo Nakano, Masatosh i Fujita, Toru Kita, Akira Shimatsu, Koji Hasegawa
    • Organizer
      第74回日本循環器学会年次集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Soluble VEGF receptor-2 is a possible novel indicator of impaired angiogenesis in metabolic syndrome2010

    • Author(s)
      和田啓道
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Book] <seriesモデル動物利用マニュアル>疾患モデルの作製と利用-循環器疾患第1章 心疾患 第4節「大動脈縮窄圧負荷心肥大モデル」2010

    • Author(s)
      和田啓道
    • Publisher
      株式会社 エル・アイ・シー
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.hosp.go.jp/~kyotolan/html/guide/medicalinfo/clinicalresearch/expand/translational.html

    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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