The role of soluble VEGF receptor in cardiovascular risk of metabolic syndrome and smoking
| Project/Area Number |
21590918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
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Principal Investigator |
WADA Hiromichi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 研究室長(先端医療技術開発) (20416209)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Noriko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究室長(臨床代謝栄養) (80373512)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | メタボリックシンドローム / 喫煙 / バイオマーカー / 肥満 / 脂質異常 / 動脈硬化 / 血管新生 / リンパ管新生 / トランスレーショナルリサーチ / 循環器・高血圧 / 細胞・組織 / 動物 / 臨床 / トランスレーションリサーチ |
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| Research Abstract |
The mechanisms that lead from obesity to atherosclerotic disease are not fully understood. Obesity involves angiogenesis in which vascular endothelial growth factor-A(VEGF-A) plays a key role. Soluble VEGF receptor-2(sVEGFR-2) acts as an endogenous inhibitor of VEGF-A. We demonstrated that serum levels of sVEGFR-2 are increased in sera from subjects with metabolic syndrome in association with insulin resistance. We also showed that the sVEGFR-2 level, as well as the body mass index, significantly increases after successful smoking cessation. A recent study reported that sVEGFR-2 also acts as an endogenous inhibitor of vascular endothelial growth factor-C(VEGF-C). We found that VEGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] α1-Antitrypsin-low-density-lipoprotein serves as a marker of smoking-specific oxidative stress2012
Author(s)
Wada H, Ura S, Satoh-Asahara N, Kitaoka S, Mashiba S, Akao M, Abe M, Ono K, Morimoto T, Fujita M, S himatsu A, Takahashi Y, Hasegawa K
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Journal Title
J Atheroscler Thromb
Volume: 19(1)
Pages: 47-58
NAID
Related Report
Peer Reviewed
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[Journal Article] Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects2011
Author(s)
Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Takahashi Y, Hasegawa K
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Distinct characteristics of circulating vascular endothelial growth factor-A and C levels in human subjects2011
Author(s)
Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K.
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Journal Title
Pros ONE
Volume: 6
Issue: 12
Pages: 29351-29351
DOI
Related Report
Peer Reviewed
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[Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance2010
Author(s)
Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K
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Journal Title
Atherosclerosis
Volume: 208(2)
Pages: 512-7
Related Report
Peer Reviewed
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[Presentation] Serum Levels of Vascular Endothelial Growth Factor-C are Associated with Dyslipidemia and Atheroscrelosis2012
Author(s)
Shuichi Ura, Hiromichi Wada, Sh uji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa
Organizer
第76回日本循環器学会年次集会
Place of Presentation
福岡
Year and Date
2012-03-17
Related Report
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[Presentation] α1-Antitrypsin-low-density-lipoprotein Serves as a Marker of Smoking-specific Oxidative Stress2011
Author(s)
Hiromichi Wada, Noriko Satoh-Asahara, Shuichi Ura ; Akira Yamada ; Shuji Kitaoka, Masaharu Akao, Mitsuru Abe, Koh Ono, Tatsuya Morimoto, Masatoshi Fujita, Akira Shimatsu, Yuko Takahash i, Koji Hasegawa
Organizer
第75回日本循環器学会年次集会
Place of Presentation
横浜
Year and Date
2011-08-04
Related Report
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[Presentation] Soluble VEGF Receptor-2 is a Possible Novel Indicator of Impaired An giogenesis in Metabolic Syndrom2010
Author(s)
Hiromichi Wada, Noriko Satoh, Shuji Kitaoka, Koh Ono, Tatsuya Morimoto, Teruhisa Kawamura, Tameo Nakano, Masatosh i Fujita, Toru Kita, Akira Shimatsu, Koji Hasegawa
Organizer
第74回日本循環器学会年次集会
Place of Presentation
京都
Year and Date
2010-03-07
Related Report
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