Molecular mechanism regulating mesenchymal cell dynamics during myocardial remodeling
Project/Area Number |
21590927
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Mie University |
Principal Investigator |
YOSHIDA Kyoko (IMANAKA kyoko) 三重大学, 大学院・医学系研究科, 准教授 (00242967)
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Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Hidetoshi 三重大学, 大学院・医学系研究科, 准教授 (00283987)
HARA Mari 三重大学, 医学部, 教務職員 (30176383)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 分子心臓病態学 / リモデリング / 心筋梗塞 / テネイシン / 細胞外マトリクス / 組織修復 / 間葉系幹細胞 / 細胞外マトリックス |
Research Abstract |
After myocardial infarction, bone marrow derived mesenchymal stem cells are recruited to the damaged lesion and could be involved in myocardial tissue repair as well as residential fibroblasts. An extracellular matrix molecule, tenascin-C synthesized by both mesencymal stem cells and residential fibroblasts may accelerate tissue repair at least partly, by up-regulation of cytokine and chemokine production and facilitating recruitment of bone marrow derived cells.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Toward in vivo imaging of heart disease using a radiolabeled single-chain fv fragment targeting tenascin-c2011
Author(s)
Kobayashi N, Odaka K, Uehara T, Imanaka-Yoshida K, Kato Y, Oyama H, Tadokoro H, Akizawa H, Tanada S, Hiroe M, Fukumura T, Komuro I, Arano Y, Yoshida T, Irie T.
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Journal Title
Anal Chem
Volume: 83
Pages: 9123-9130
Related Report
Peer Reviewed
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[Journal Article] Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C2011
Author(s)
Kobayashi N, Odaka K, Uehara T, Imanaka-Yoshida K, Kato Y, Oyama H, Tadokoro H, Akizawa H, Tanada S, Hiroe M, Fukumura T, Komuro I, Arano Y, Yoshida T, Irie T
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Journal Title
ANALYTICAL CHEMISTRY
Volume: 83
Issue: 23
Pages: 9123-9130
DOI
Related Report
Peer Reviewed
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[Journal Article] Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development.2011
Author(s)
Ando, K., Takahashi, M., Yamagishi, T., Miyagawa-Tomita, S., Imanaka-Yoshida, Toshimichi Yoshida, K., Nakajima, Y.
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Journal Title
Differentiation
Volume: (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells.2011
Author(s)
Nagaharu, K., Zhang, X., Yoshida, T., Katoh, D., Hanamura, N., Kozuka, Y., Ogawa, T., Shiraishi, T., Imanaka-Yoshida, K.
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Journal Title
Am J Pathol
Volume: 178
Pages: 754-763
Related Report
Peer Reviewed
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[Journal Article] Developmental defects of coronary vasculature in rat embryos administered bis-diamine.2011
Author(s)
Hanato, T., Nakagawa, M., Okamoto, N., Nishijima, S., Fujino, H., Shimada, M., Takeuchi, Y., Imanaka-Yoshida, K.
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Journal Title
Birth Defects Res B Dev Reprod Toxicol.
Volume: 92
Pages: 10-16
Related Report
Peer Reviewed
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[Journal Article] Tenascin-c may aggravate left ventricular remodeling and function after myocardial infarction in mice2010
Author(s)
Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, Hiroe M, Yoshida T, Imanaka-Yoshida K
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 298
Pages: 1072-1078
Related Report
Peer Reviewed
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[Journal Article] Tenascin-C enhances crosstalk signaling of integrin alphavbeta3/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells.2010
Author(s)
Ishigaki, T., Imanaka-Yoshida, K., Shimojo, N., Matsushima, S., Taki, W., Yoshida, T.
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Journal Title
J Cell Physiol
Volume: (Epub ahesd of prints)
Related Report
Peer Reviewed
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[Journal Article] Dynamic expression of tenascin-C after myocardial ischemia and reperfusion : assessment by 125I-anti-tenascin-C antibody imaging.2010
Author(s)
I Taki, J., Inaki, A., Wakabayashi, H., Imanaka-Yoshida K., Ogawa, K., Hiroe, M., Shiba, K., Yoshida, T., Kinuya, S.
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Journal Title
J Nucl Med.
Volume: 51
Pages: 1116-1122
Related Report
Peer Reviewed
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[Journal Article] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice2010
Author(s)
Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, Hiroe M, Yoshida T, Imanaka-Yoshida K.
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Journal Title
Am J Physiol Heart Circ Physiol 298
Related Report
Peer Reviewed
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[Journal Article] High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty : Expression of tenascin c as a possible marker for inflammation2009
Author(s)
Tsukada B, Terasaki F, Shimomura H, Otsuka K, Otsuka K, Katashima T, Fujita S, Imanaka-Yoshida K, Yoshida T, Hiroe M, Kitaura Y.
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Journal Title
Hum Pathol
Volume: 40
Pages: 1015-1022
Related Report
Peer Reviewed
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[Journal Article] Incremental prognostic values of serum tenascin-c levels with blood b-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure2009
Author(s)
Fujimoto N, Onishi K, Sato A, Terasaki F, Tsukada B, Nozato T, Yamada T, Imanaka-Yoshida K, Yoshida T, Ito M, Hiroe M
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Journal Title
J Card Fail
Volume: 15
Pages: 898-908
Related Report
Peer Reviewed
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[Journal Article] Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure2009
Author(s)
Fujimoto N, Onishi K, Sato A, Terasaki F, Tsukada B, Nozato T, Yamada T, Imanaka-Yoshida K, Yoshida T, Ito M, Hiroe M.
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Journal Title
J Card Fail 15
Pages: 898-905
Related Report
Peer Reviewed
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[Journal Article] High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty : expression of tenascin C as a possible marker for inflammation2009
Author(s)
Tsukada B, Terasaki F, Shimomura H, Otsuka K, Otsuka K, Katashima T, Fujita S, Imanaka-Yoshida K, Yoshida T, Hiroe M, Kitaura Y.
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Journal Title
Human Pathol 40
Pages: 1015-1022
Related Report
Peer Reviewed
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[Journal Article] Prognostic Value of Serum Tenascin-C Levels on Long-term Outcome After Acute Myocardial Infarction
Author(s)
Sato A, Hiroe M, Nozato T, HIkita H, Hoshi T, Kimura T, Wang Z., Sakai S., Imanaka-Yoshida K, Yoshida T, Aonuma, K
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Journal Title
J Cardiac Failure
Volume: (印刷中)
Related Report
Peer Reviewed
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[Presentation] Matricellular proteinm tenascin-C, may regulate proepi,epicardial cell function duringcoronary vessel development2011
Author(s)
Imanaka-Yoshida K, Ando K, Takahashi M, Yamagishi T, Yoshida T, Nakajima Y, Miyagawa-Tomita S
Organizer
2011 Weinstein Cardiovascular Development Conference
Place of Presentation
Cincinnati, OH, USA
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