| Project/Area Number |
21590927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Mie University |
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Principal Investigator |
YOSHIDA Kyoko (IMANAKA kyoko) 三重大学, 大学院・医学系研究科, 准教授 (00242967)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Hidetoshi 三重大学, 大学院・医学系研究科, 准教授 (00283987)
HARA Mari 三重大学, 医学部, 教務職員 (30176383)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子心臓病態学 / リモデリング / 心筋梗塞 / テネイシン / 細胞外マトリクス / 組織修復 / 間葉系幹細胞 / 細胞外マトリックス |
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| Research Abstract |
After myocardial infarction, bone marrow derived mesenchymal stem cells are recruited to the damaged lesion and could be involved in myocardial tissue repair as well as residential fibroblasts. An extracellular matrix molecule, tenascin-C synthesized by both mesencymal stem cells and residential fibroblasts may accelerate tissue repair at least partly, by up-regulation of cytokine and chemokine production and facilitating recruitment of bone marrow derived cells.
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