The mechanism of non-apoptotic cardiomyocyte cell death

• Project/Area Number: 21590929
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: NISHIDA Kazuhiko 大阪大学, 大学院・歯学研究科, 講師 (90362681)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Osamu 大阪大学, 大学院・医学系研究科, 助教 (90467580)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 分子心臓病態学 / 細胞死 / シグナル伝達 / 心不全

Research Abstract

Necrotic cell death is mediated through the mitochondrial permeability transition(MPT) dependent on cyclophillin D(CypD). The aim in this study is to clarify the intracellular signalling mechanism of the cardiomyocyte cell death and progression of heart failure on the hypothesis that the signal crosstalk between apoptotic and necrotic pathways exists. We took note of CypD and apoptosis signal-regulating kinase 1(ASK1). ASK1 can bind to CypD. ASK1 is related to the CypD mediated through the MPT. The crosstalk between ASK1 and CypD may be involved in progression of heart failure.

Research Products

• [Journal Article] Calpain protects the heart from hemodynamic stress (2011)
  • Author(s): Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K.
  • Journal Title: J Biol Chem Volume: 286 Pages: 32170-32177
  • Peer Reviewed
• [Journal Article] Calpain protects the heart from hemodynamic stress (2011)
  • Author(s): Taneike M
  • Journal Title: J Blol Chem Volume: 286 Pages: 32170-32177
  • Peer Reviewed
• [Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy (2010)
  • Author(s): Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Shirasawa T, Mizushima N, Otsu K.
  • Journal Title: Autophagy Volume: 6 Pages: 600-606
  • Peer Reviewed
• [Journal Article] Activation of MTK1/ MEKK4 induces cardiomyocyte death and heart failure (2010)
  • Author(s): Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu K.
  • Journal Title: J Mol Cell Cardiol Volume: 48 Pages: 283-285
  • Peer Reviewed
• [Journal Article] Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure (2010)
  • Author(s): Mizote I
  • Journal Title: J Mol Cell Cardiol. 48 Pages: 302-309
  • Peer Reviewed
• [Journal Article] The IkappaB kinase beta/ nuclear factor kappaB signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression (2009)
  • Author(s): Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M, Otsu K.
  • Journal Title: Circ Res Volume: 105 Pages: 70-79
  • Peer Reviewed
• [Journal Article] The IκB kinase β/nuclear factor κB signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression (2009)
  • Author(s): Hikoso S
  • Journal Title: Circ Res. 105 Pages: 70-79
  • Peer Reviewed