| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In cardiomyocytes, as a long term influence of the arrhythmias, ion channels such as voltage-dependent Na^+ channel may suffer from remodeling. As a consequence of cellular calcium overload, calmodulin is highly activated to suppress TRE17 functions to deubiquitinate the channel. Although Na^+ channel synthesis was intact, channel degradation ration exceeds the protein life span, which leads the down-regulation of Na+channels in the heart as a long-term impact on the cardiac excitability.
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