Role of SMP30 in the development of heart failure

• Project/Area Number: 21590935
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: TAKEISHI Yasuchika 福島県立医科大学, 医学部, 教授 (40272067)
• Co-Investigator(Kenkyū-buntansha): SAITOH Shu-ichi 福島県立医科大学, 医学部, 准教授 (20274962)
• Co-Investigator(Renkei-kenkyūsha): ISHIGAMI Akihito 東京都健康長寿医療センター研究所, 分子老化制御部門, 研究副部長 (50270658)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 加齢 / 心不全 / 酸化ストレス / アンジオテンシンII / アポトーシス / 遺伝子操作マウス / 老化

Research Abstract

In SMP30 knockout mice, cardiac function was more severely depressed after angiotensin II infusion compared to wild type mice. Angiotensin IIinduced increases in NADPH oxidase activity, ROS generation, c-Jun N terminal kinase activity, a ratio of Bax/Bcl, caspase activity, and numbers of TUNEL positive nuclei were greater in SMP30 knockout mice. Thus, SMP30 may have cardio-protective roles by antioxidant and anti-apoptotic effects.

Research Products

• [Journal Article] Crucial role of membrane type 1 matrix metalloproteinase(MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells (2011)
  • Author(s): Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 762-773
  • NAID: 130004845389
  • Peer Reviewed
• [Journal Article] Differential regulation of diacylglycerol kinase isoform in human failing hearts (2011)
  • Author(s): Bilim O, Shishido T, Toyama S, Suzuki S, Sasaki T, Kitahara T, Sadahiro M, Takeishi Y, Kubota I
  • Journal Title: J Cardiothorac Surg Volume: 6 Pages: 65-65
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase inhibits ventricular tachyarrhythmias in a mouse model of heart failure-roles of canonical transient receptor potential(TRPC) channels- (2011)
  • Author(s): Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M
  • Journal Title: Circ J Volume: 75 Pages: 2333-2342
  • Peer Reviewed
• [Journal Article] Involvement of membrane type 1-matrix metalloproteinase(MT1-MMP) in RAGE activation signaling pathways (2011)
  • Author(s): Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y
  • Journal Title: J Cell Physiol Volume: 226 Pages: 1554-1563
  • Peer Reviewed
• [Journal Article] Long-term clinical outcomes after deferral of percutaneous coronary intervention of intermediate coronary stenoses based on coronary pressure-derived fractional flow reserve (2011)
  • Author(s): Misaka T, Kunii H, Mizukami H, Sakamoto N, Nakazato K, Takeishi Y
  • Journal Title: J Cardiol Volume: 58 Pages: 32-37
  • NAID: 10031159571
  • Peer Reviewed
• [Journal Article] Very late stent thrombosis and neointimal plaque rupture after implantation of sirolimus-eluting stents : observations with angiography (2011)
  • Author(s): Sakamoto N, Nakazato K, Misaka T, Mizukami H, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Cardiovasc Intervent Ther Volume: 26 Pages: 263-268
  • Peer Reviewed
• [Journal Article] Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients (2011)
  • Author(s): Shikama Y, XiaoMin F, Shichishima T, Ono T, Noji H, Ikeda K, Ogawa K, Takeishi Y, Kimura J
  • Journal Title: Brit J Haematol Volume: 154 Pages: 525-527
  • Peer Reviewed
• [Journal Article] Suppressive effects of valsartan on microalbuminuria and CRP in patients with metabolic syndrome(Val-Mets) (2011)
  • Author(s): Shishido T, Konta T, Nishiyama S, Miyashita T, Miyamoto T, Takasaki S, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Clin Exp Hypertens Volume: 33 Pages: 117-123
  • Peer Reviewed
• [Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • Author(s): Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Eur J Clin Invest Volume: 41 Pages: 759-766
  • Peer Reviewed
• [Journal Article] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Shimizu T, Owada T, Nakamura Y, Iwaya S, Yamauchi H, Miyata M, Hoshino Y, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Int Heart J Volume: 52 Pages: 218-223
  • NAID: 130000971165
  • Peer Reviewed
• [Journal Article] Ezetimibe and vascular inflammation (2011)
  • Author(s): Ishibashi T, Takeishi Y
  • Journal Title: Curr Vasc Pharmacol Volume: 9 Pages: 99-108
  • Peer Reviewed
• [Journal Article] Pleiotropic effects of ARB in diabetes mellitus (2011)
  • Author(s): Saitoh S, Takeishi Y
  • Journal Title: Curr Vasc Pharmacol Volume: 9 Pages: 136-144
  • Peer Reviewed
• [Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • Author(s): Suzuki S, Takeishi Y, et al
  • Journal Title: European Journal of Clinical Investigation Volume: 41 Issue: 7 Pages: 759-766
  • DOI: 10.1111/j.1365-2362.2010.02465.x
  • Peer Reviewed
• [Journal Article] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Takeishi Y, et al
  • Journal Title: International Heart Journal Volume: 52 Pages: 218-223
  • NAID: 130000971165
  • Peer Reviewed
• [Journal Article] Crucial role of membrane type 1 matrix metalloproteinase (MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells (2011)
  • Author(s): Ando K, Takeishi Y, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 18 Pages: 762-773
  • NAID: 130004845389
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure-roles of canonical transient receptor potential (TRPC) channels- (2011)
  • Author(s): Hirose M, Takeishi Y, et al
  • Journal Title: Circulation Journal Volume: 75 Pages: 2333-2342
  • NAID: 10029459214
  • Peer Reviewed
• [Journal Article] Differential regulation of diacylglycerol kinase isoform in human failing hearts (2011)
  • Author(s): Bilim O, Takeishi Y, et al
  • Journal Title: Journal of Cardiothoracic Surgery Volume: 6 Pages: 65-65
  • Peer Reviewed
• [Journal Article] Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients (2011)
  • Author(s): Shikama Y, Takeishi Y, et al
  • Journal Title: British Journal of Haematology Volume: 154 Pages: 525-527
  • Peer Reviewed
• [Journal Article] Involvement of membrane type1-matrix metalloproteinase(MT1-MMP) in rage activation signalingpathways (2011)
  • Author(s): Kamioka M, Ishibashi T, Ohkawara H, Eguchi R, Sugimoto K, Uekita H, Matsui T, Yamagishi SI, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y.
  • Journal Title: J Cell Physiol Volume: 226(6) Issue: 6 Pages: 1554-1563
  • DOI: 10.1002/jcp.22492
  • Peer Reviewed
• [Journal Article] Long-term chnical outcomes after deferral of percutaneous coronary intervention of intermediate coronary stenoses based on coronary pressure-derived fractional flow reserve (2011)
  • Author(s): Misaka T, Takeishi Y, et al
  • Journal Title: Journal of Cardiology Volume: 58 Pages: 32-37
  • Peer Reviewed
• [Journal Article] Suppressive effects of valsartan on microalbuminuria and CRP in patients with metabolic syndrome (Val-Mets) (2011)
  • Author(s): Shishido T, Takeishi Y, et al
  • Journal Title: Clinical and Experimental Hypertension Volume: 33 Pages: 117-123
  • Peer Reviewed
• [Journal Article] Very late stent thrombosis and neointimal plaque rupture after implantation of sirolimus-eluting stents : observations with angiography, IVUS and OCT (2011)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Journal Title: Cardiovascular Intervention and Therapeutics Volume: 26 Pages: 263-268
  • Peer Reviewed
• [Journal Article] Ezetimibe and vascular inflammation (Review) (2011)
  • Author(s): Ishibashi T, Takeishi Y, et al
  • Journal Title: Current Vascular Pharmacology Volume: 9 Pages: 99-108
• [Journal Article] Pleiotropic effects of ARB in diabetes mellitus (Review) (2011)
  • Author(s): Saitoh S, Takeishi Y, et al
  • Journal Title: Current Vascular Pharmacology Volume: 9 Pages: 136-144
• [Journal Article] Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure (2010)
  • Author(s): Bilim O, Takeishi Y, Kitahara T, Ishino M, Sasaki T, Suzuki S, Shishido T, Kubota I
  • Journal Title: J Card Fail Volume: 16 Pages: 873-879
  • Peer Reviewed
• [Journal Article] Advanced glycation end product mediated matrix metallo-proteinase-9 and apoptosis via renin-angiotensin system in type 2 diabetes (2010)
  • Author(s): Ishibashi T, Kawaguchi M, Sugimoto K, Uekita H, Sakamoto N, Yokoyama K, Maruyama Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 578-589
  • NAID: 130004845318
  • Peer Reviewed
• [Journal Article] Tricuspid valvular dysplasia and its differentiation from Ebstein's anomaly (2010)
  • Author(s): Iwai-Takano M, Watanabe M, Otake H, Kobayashi A, Oikawa M, Machii H, Misaka T, Watanabe T, Takeishi Y
  • Journal Title: J Echocardiogr Volume: 8 Pages: 137-139
  • NAID: 10027703318
  • Peer Reviewed
• [Journal Article] Blockade of renin-angiotensin system attenuates advanced glycation end products-mediated signaling pathways (2010)
  • Author(s): Kamioka M, Ishibashi T, Sugimoto K, Uekita H, Nagai R, Sakamoto N, Ando K, Ohkawara H, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 590-600
  • NAID: 130004845319
  • Peer Reviewed
• [Journal Article] Metabolic regulation of coronary vascular tone : role of hydrogen peroxide, purinergic components, and angiotensin (2010)
  • Author(s): Kaneshiro T, Saitoh S, Machii H, Yamaguchi O, Ishibashi T, Maruyama Y, Takeishi Y
  • Journal Title: Eur J Pharmacol Volume: 645 Pages: 127-134
  • Peer Reviewed
• [Journal Article] Serum midkine as a predictor of cardiac events in patients with chronic heart failure (2010)
  • Author(s): Kitahara T, Shishido T, Suzuki S, Katoh S, Sasaki T, Ishino M, Nitobe J, Miyamoto T, Miyashita T, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: J Card Fail Volume: 16 Pages: 308-313
  • Peer Reviewed
• [Journal Article] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Takeishi Y
  • Journal Title: Mech Ageing Dev Volume: 131 Pages: 710-717
  • Peer Reviewed
• [Journal Article] Prognostic study of cardiac and renal events in Japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPECT : J-ACCESS 3 study design (2010)
  • Author(s): Nakamura S, Yuhei K, Hase H, Hatta T, Nishimura S, Moroi M, Nakagawa S, Kasai T, Kusuoka H, Takeishi Y, Nakajima K, Momose M, Takehana K, Nanasato M, Yoda S, Nishina H, Matsumoto N, Nishimura T
  • Journal Title: Ther Apher Dial Volume: 14 Pages: 379-385
  • Peer Reviewed
• [Journal Article] A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation (2010)
  • Author(s): Ogawa K, Ikeda K, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Hashimoto Y, Asahi K, Noji H, Ohto H, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 151-156
  • NAID: 130000419024
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation in the department of hematology (2010)
  • Author(s): Ogawa K, Noji H, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Ikeda K, Ohto H, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 107-114
  • Peer Reviewed
• [Journal Article] Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo (2010)
  • Author(s): Ohkawara H, Ishibashi T, Saitoh S, Inoue N, Sugimoto K, Kamioka M, Uekita H, Kaneshiro T, Ando K, Takuwa Y, Maruyama Y, Takeishi Y
  • Journal Title: Cardiovasc Res Volume: 88 Pages: 492-501
  • Peer Reviewed
• [Journal Article] Hydrogen peroxide generated from cardiac myocytes impacts metabolic dilation in coronary arterioles (2010)
  • Author(s): Otake A, Saitoh S, Takeishi Y
  • Journal Title: Int Heart J Volume: 51 Pages: 125-128
  • NAID: 130000250204
  • Peer Reviewed
• [Journal Article] High serum level of neopterin is a risk factor of patients with heart failure (2010)
  • Author(s): Sasaki T, Takeishi Y, Suzuki S, Niizeki T, Kitahara T, Katoh S, Ishino M, Shishido T, Kubota I
  • Journal Title: Int J Cardiol Volume: 145 Pages: 318-318
  • NAID: 120002190675
  • Peer Reviewed
• [Journal Article] Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes (2010)
  • Author(s): Shichishima T, Ikeda K, Takahashi N, Kameoka J, Tajima K, Murai K, Tamai Y, Shichishima-Nakamura A, Akutsu K, Noji H, Okamoto M, Kimura H, Harigae H, Oyamada T, Kamesaki T, Takeishi Y, Sawada K
  • Journal Title: Int J Hematol Volume: 91 Pages: 602-610
  • NAID: 10026401926
  • Peer Reviewed
• [Journal Article] The nitric oxide synthase family and left ventricular diastolic function (2010)
  • Author(s): Takeishi Y
  • Journal Title: Circ J Volume: 74 Pages: 2556-2557
  • NAID: 10027424100
  • Peer Reviewed
• [Journal Article] Survival of a refractory ventricular fibrillation by cooperative treatments (2010)
  • Author(s): Tase C, Ohno Y, Hasegawa A, Tsukada Y, Shimada J, Ikegami Y, Sakamoto N, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 139-143
  • NAID: 130000419022
  • Peer Reviewed
• [Journal Article] Flow mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome (2010)
  • Author(s): Yoshihisa A, Owada T, Hoshino Y, Miyata M, Misaka T, Sato T, Suzuki S, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishibashi T, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 115-120
  • NAID: 130000419018
  • Peer Reviewed
• [Journal Article] A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stern-cell transplantation (2010)
  • Author(s): Ogawa K, Takeishi Y, et al
  • Journal Title: Fukushima Journal of Medical Science Volume: 56 Pages: 151-156
  • Peer Reviewed
• [Journal Article] Advanced glycation end product-mediated matrix metallo-proteinase-9 and apoptosis via renin-angiotensin system in type 2 diabetes (2010)
  • Author(s): Ishibashi T, Takeishi Y, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 17 Pages: 578-589
  • NAID: 130004845318
  • Peer Reviewed
• [Journal Article] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • Author(s): Machii H, Takeishi Y, et al
  • Journal Title: Mechanisms of Ageing and Development Volume: 131 Pages: 710-717
  • Peer Reviewed
• [Journal Article] Blockade of renin-angiotensin system attenuates advanced glycation end products-mediated signaling pathways (2010)
  • Author(s): Kamioka M, Takeishi Y, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 17 Pages: 590-600
  • NAID: 130004845319
  • Peer Reviewed
• [Journal Article] Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome (2010)
  • Author(s): Yoshihisa A, Takeishi Y, et al
  • Journal Title: Fukushima Journal of Medical Science Volume: 56 Pages: 115-120
  • NAID: 130000419018
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation in the department of hematology, Fukushima Medical University (2010)
  • Author(s): Ogawa K, Takeishi Y, et al
  • Journal Title: Fukushima Journal of Medical Science Volume: 56 Pages: 107-114
  • NAID: 130000419017
  • Peer Reviewed
• [Journal Article] High serum level of neopterin is a risk factor of patients with heart failure (2010)
  • Author(s): Sasaki T, Takeishi Y, et al
  • Journal Title: International Journal of Cardiology Volume: 145 Pages: 318-318
  • NAID: 120002190675
  • Peer Reviewed
• [Journal Article] Hydrogen peroxide generated from cardiac myocytes impacts metabolic dilation in coronary arterioles (2010)
  • Author(s): Otake A, Takeishi Y, et al
  • Journal Title: International Heart Journal Volume: 51 Pages: 125-128
  • NAID: 130000250204
  • Peer Reviewed
• [Journal Article] Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes (2010)
  • Author(s): Shichishima T, Takeishi Y, et al
  • Journal Title: International Journal of Hematology Volume: 91 Pages: 602-610
  • NAID: 10026401926
  • Peer Reviewed
• [Journal Article] Metabolic regulation of coronary vascular tone : role of hydrogen peroxide, purinergic components, and angiotensin (2010)
  • Author(s): Kaneshiro T, Takeishi Y, et al
  • Journal Title: European Journal of Pharmacology Volume: 645 Pages: 127-134
  • Peer Reviewed
• [Journal Article] Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Racl pathways in vivo (2010)
  • Author(s): Ohkawara H, Takeishi Y, et al
  • Journal Title: Cardiovascular Research Volume: 88 Pages: 492-501
  • Peer Reviewed
• [Journal Article] Prognostic study of cardiac and renal events in Japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPELT : J-ACCESS 3 study design (2010)
  • Author(s): Nakamura S, Takeishi Y, et al
  • Journal Title: Therapeutic Apheresis and Dialysis Volume: 14 Pages: 379-385
  • Peer Reviewed
• [Journal Article] Serum midkine as a predictor of cardiac events in patients with chronic heart failure (2010)
  • Author(s): Kitahara T, Takeishi Y, et al
  • Journal Title: Journal of Cardiac Failure Volume: 16 Pages: 308-313
  • Peer Reviewed
• [Journal Article] Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure (2010)
  • Author(s): Bilim O, Takeishi Y, et al
  • Journal Title: Journal of Cardiac Failure Volume: 16 Pages: 873-879
  • Peer Reviewed
• [Journal Article] Survival of a refractory ventricular fibrillation by cooperative treatments (2010)
  • Author(s): Tase C, Takeishi Y, et al
  • Journal Title: Fukushima Journal of Medical Science Volume: 56 Pages: 139-143
  • NAID: 130000419022
  • Peer Reviewed
• [Journal Article] The nitric oxide synthase family and left ventricular diastolic function (2010)
  • Author(s): Takeishi Y
  • Journal Title: Circulation Journal Volume: 74 Pages: 2556-2557
  • NAID: 10027424100
  • Peer Reviewed
• [Journal Article] Tricuspid valvular dysplasia and its differentiation from Ebstein's anomaly (2010)
  • Author(s): Takano M, Takeishi Y, et al
  • Journal Title: Journal of Echocardiography Volume: 8 Pages: 137-139
  • NAID: 10027703318
  • Peer Reviewed
• [Journal Article] Factors correlated with plasma renin activity in general Japanese population (2009)
  • Author(s): Abiko H, Konta T, Hao Z, Takasaki S, Suzuki K, Ichikawa K, Ikeda A, Shibata Y, Takeishi Y, Kawata S, Kato T, Kubota I
  • Journal Title: Clin Exp Nephrol Volume: 13 Pages: 130-137
  • NAID: 10025586090
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase inhibits Gaq-induced atrial remodeling in transgenic mice (2009)
  • Author(s): Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M
  • Journal Title: Heart Rhythm Volume: 6 Pages: 78-84
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women (2009)
  • Author(s): Ichikawa K, Konta T, Emi M, Toriyama S, Takasaki S, Ikeda A, Shibata Y, Takabatake N, Takeishi Y, Kato T, Kawata S, Kubota I
  • Journal Title: Kidney Int Volume: 76 Pages: 183-189
  • Peer Reviewed
• [Journal Article] In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function (2009)
  • Author(s): Ikeda A, Konta T, Takasaki S, Hao Z, Suzuki K, Sato H, Shibata Y, Takeishi Y, Kato T, Kawata S, Kubota I
  • Journal Title: Nephrol Dial Transpl Volume: 24 Pages: 841-847
  • Peer Reviewed
• [Journal Article] Combination of conventional biomarkers for risk stratification in chronic heart failure (2009)
  • Author(s): Niizeki T, Takeishi Y, Kitahara T, Suzuki S, Sasaki T, Ishino M, Kubota I
  • Journal Title: J Cardiol Volume: 53 Pages: 179-187
  • NAID: 10025183000
  • Peer Reviewed
• [Journal Article] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits (2009)
  • Author(s): Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 16 Pages: 846-856
  • NAID: 10026144512
  • Peer Reviewed
• [Journal Article] Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+signaling pathways in endothelial cells (2009)
  • Author(s): Sakamoto N, Ishibashi T, Sugimoto K, Sawamura T, Sakamoto T, Inoue N, Saitoh S, Kamioka M, Uekita H, Ohkawara H, Suzuki K, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: J Cell Physiol Volume: 220 Pages: 706-715
  • Peer Reviewed
• [Journal Article] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells (2009)
  • Author(s): Sugimoto K, Ishibashi T, Sawamura T, Inoue N, KamiokaM, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: Cardiovasc Res Volume: 84 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Mast cells contribute to flow restoration by bone marrow cell transplantation in rats with ischemic limbs (2009)
  • Author(s): Tajima H, Iwai-Takano M, Yaoita H, Ogawa K, Yamaki T, Takeishi Y, Maruyama Y
  • Journal Title: Int Heart J Volume: 50 Pages: 247-257
  • NAID: 130000108089
  • Peer Reviewed
• [Journal Article] A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD (2009)
  • Author(s): Takabatake N, Toriyama S, Igarashi A, Tokairin Y, Takeishi Y, Konta T, Inoue S, Abe S, Shibata Y, Kubota I
  • Journal Title: Biochem Bioph Res Co Volume: 381 Pages: 554-559
  • Peer Reviewed
• [Journal Article] Regulation of coronary vascular tone via redox modulation in the α1-adrenergic-angiotensin-endothelin axis of the myocardium (2009)
  • Author(s): Yamaguchi O, Kaneshiro T, Saitoh S, Ishibashi T, Maruyama Y, Takeishi Y
  • Journal Title: Am J Physiol-Heart C Volume: 296
  • Peer Reviewed
• [Journal Article] Participation of mast cells in angiogenesis in the border zone of myocardial infarction in rats (2009)
  • Author(s): Yamaki T, Iwai-Takano M, Yaoita H, Ogawa K, Tajima H, Takeishi Y, Maruyama Y
  • Journal Title: J Med Ultrason Volume: 36 Pages: 119-127
  • NAID: 10025328115
  • Peer Reviewed
• [Journal Article] Role of Toll-like receptor mediated signaling pathway in ischemic heart (2009)
  • Author(s): Takeishi Y, Kubota I
  • Journal Title: Front Biosci Volume: 14 Pages: 2553-2558
  • Peer Reviewed
• [Journal Article] A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD (2009)
  • Author(s): Takabatake N, Takeishi Y, et al
  • Journal Title: Biochemical and Biophysical Research Communications 4 Pages: 554-559
  • Peer Reviewed
• [Journal Article] Combination of conventional biomarkers for risk stratification in chronic heart failure (2009)
  • Author(s): Niizeki T, Takeishi Y, et al
  • Journal Title: Journal of Cardiology 2 Pages: 179-187
  • NAID: 10025183000
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase ζ inhibits G α q-induced atrial remodeling in transgenic mice (2009)
  • Author(s): Hirose M, Takeishi Y, et al
  • Journal Title: Heart Rhythm 1 Pages: 78-84
  • Peer Reviewed
• [Journal Article] Factors correlated with plasma renin activity in general Japanese population (2009)
  • Author(s): Abiko H, Takeishi Y, et al
  • Journal Title: Clinical and Experimental Nephrology 2 Pages: 130-137
  • NAID: 10025586090
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Javanese women (2009)
  • Author(s): Ichikawa K, Takeishi Y, et al
  • Journal Title: Kidney International 2 Pages: 183-189
  • Peer Reviewed
• [Journal Article] In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function : the Takahata study (2009)
  • Author(s): Ikeda A, Takeishi Y, et al
  • Journal Title: Nephrology Dialysis Transplantation 3 Pages: 841-847
  • Peer Reviewed
• [Journal Article] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells (2009)
  • Author(s): Sugimoto K, Takeishi Y, et al
  • Journal Title: Cardiovascular Research 1 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Mast cells contribute to flow restoration by bone marrow cell transplantation in rats with ischemic limbs (2009)
  • Author(s): Tajima H, Takeishi Y, et al
  • Journal Title: International Heart Journal 2 Pages: 247-257
  • NAID: 130000108089
  • Peer Reviewed
• [Journal Article] Participation of mast cells in angiogenesis in the border zone of myocardial infarction in rats (2009)
  • Author(s): Yamaki T, Takeishi Y, et al
  • Journal Title: Journal of Medical Ultrasonics 3 Pages: 119-127
  • NAID: 10025328115
  • Peer Reviewed
• [Journal Article] Regulation of coronary vascular tone via redox modulation in the α 1-adrenergic-angiotensin-endothelin axis the myocardium (2009)
  • Author(s): Yamaguchi O, Takeishi Y, et al
  • Journal Title: American Journal of Physiology (Heart and Circulatory Physiology) 1
  • Peer Reviewed
• [Journal Article] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits (2009)
  • Author(s): Ohkawara H, Takeishi Y, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis 6 Pages: 846-856
  • NAID: 10026144512
  • Peer Reviewed
• [Journal Article] Role of Toll-like receptor mediated signaling pathway in ischemic heart (2009)
  • Author(s): Takeishi Y, Kubota I
  • Journal Title: Frontiers in Bioscience Jan.1 Pages: 2553-2558
  • Peer Reviewed
• [Journal Article] Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca^<2+> signaling pathways in endothelial cells (2009)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Journal Title: Journal of Cellular Physiology 3 Pages: 706-715
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 泉田次郎, 竹石恭知
  • Journal Title: みるみるマスター! 循環器ケアのトレーニングブック 100のキーワード&50のケース&250問クイズ (第1部 100のキーワードから修得する循環器ケア;KEY WORD 53 : MRI検査, KEY WORD 54 : CT検査, KEY WORD 55 : 運動負荷心電図検査, KEY WORD 56 : 電気生理検査)((株)メディカ出版) Pages: 124-131
• [Journal Article] (2009)
  • Author(s): 竹石恭知
  • Journal Title: Annual Review循環器2009 (II. 疾患の病因と病態 3. Toll-like receptorと心臓リモデリング)(中外医学社) Pages: 66-75
• [Journal Article] (2009)
  • Author(s): 鈴木均, 竹石恭知
  • Journal Title: 循環器検査のグノーティ・セアウトンー過信せず侮らず、謙虚で緻密な検査とは(3. 不整脈,失神:心臓電気生理検査で異常が出ないときは、睡眠時無呼吸症を疑え)((株)シナジー) Pages: 204-207
• [Journal Article] Maturity-dependent fractionation of neutrophil progenitors : A new method to examine in vivo expression profiles of differentiation-regulating genes
  • Author(s): Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J
  • Journal Title: Exp Hematol Volume: (in press)
  • Peer Reviewed
• [Presentation] Senescence marker protein-30 deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • Author(s): Mizukami H, Takeishi Y, et al
  • Organizer: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: Tokyo
  • Year and Date: 2011-12-03
• [Presentation] Senescence marker protein 30 inhibits angiotensin II-induced cardiac remodeling (2011)
  • Author(s): Misaka T, Takeishi Y, et al
  • Organizer: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: Tokyo
  • Year and Date: 2011-12-02
• [Presentation] Adaptive servo ventilation improves cardiac function and prognosis in chronic heart failure patients with Cheyne-Stokes respiration after cardiac resynchronization therapy (2011)
  • Author(s): Miyata M, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-16
• [Presentation] Senescence marker protein 30 inhibits angiotensin II-induced cardiac remodeling (2011)
  • Author(s): Misaka T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-16
• [Presentation] Comparisons of prognostic factors between chronic heart failure patients with and without atrial fibrillation (2011)
  • Author(s): Sato T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-16
• [Presentation] Cardiac-specific overexpression of high mobility group box 1 (HMGB1) attenuates cardiac dysfunction induced by pressure overload (2011)
  • Author(s): Funayama A, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Associaton 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-16
• [Presentation] Overnight use of adaptive servo ventilation reduces cardiac overbad and improves renal function in patients with chronic heart failure and Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-15
• [Presentation] Aging impairs endothelium-dependent dilation via thiol-oxidation in coronary arterioles in SMP 30 deficiency mice (2011)
  • Author(s): Yamada S, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-15
• [Presentation] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury (2011)
  • Author(s): Oikawa M, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-15
• [Presentation] Distinct prognostic factors in patients with chronic heart failure and chronic kidney-disease (2011)
  • Author(s): Sato T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-14
• [Presentation] Senescence marker protein-30 deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • Author(s): Mizukami H, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-14
• [Presentation] The importance of serial renal function measurements in chronic heart failure (2011)
  • Author(s): Sato T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 2011-11-14
• [Presentation] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodeling (2011)
  • Author(s): Misaka T, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-31
• [Presentation] Common carotid artery Kinking is predictor of cardiovascular events : long term follow-up study using by carotid sonography (2011)
  • Author(s): Watanabe T, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-30
• [Presentation] Non-invasive detection of vascular dysfunction in sleep apnea syndrome by cardio-ankle vascular index and flow-mediated dilatation (2011)
  • Author(s): Yoshihisa A, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-30
• [Presentation] Tenascin-C level is related to coronary plaque rupture in patients with acute coronary syndrome (2011)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-30
• [Presentation] Acute benefical impact of adaptive servo ventilation on hemodynamic data in heart failure patients with Cheyne-Stokes respiration (2011)
  • Author(s): Miyata M, Takeishi Y, et al
  • Organizer: Congress of the Euaropean Society of Cardiology 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-30
• [Presentation] Adaptive servo ventilation improves cardiac function and long term prognosis in heart failure patients with Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-08-29
• [Presentation] The relation of the decreasing rates of intrathoracic impedance and decompensated heart failure (2011)
  • Author(s): Yamada S, Takeishi Y, et al
  • Organizer: Heart Rhythm 2011, 32nd Annual Scientific Sessions
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2011-05-06
• [Presentation] The assessment of circadian variation of late potential is useful for predicting the occurrence of ventricular tachycardia in patients with dilated cardiomyopathy (2011)
  • Author(s): Kamiyama Y, Takeishi Y, et al
  • Organizer: Heart Rhythm 2011, 32nd Annual Scientific Sessions
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2011-05-06
• [Presentation] Early repolarization pattern on electrocardiogram and risk of sudden cardiac death : the circulatory risk in communities study (CIRCS) (2011)
  • Author(s): Ohira T, Takeishi Y, et al
  • Organizer: Nutrition, Physical Activity and Metabolism/Cardiovascular Disease Epidemiology and Prevention 2011 Scientific Sessions
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2011-03-24
• [Presentation] Senescence marker protein 30 inhibits angiotensin II-induced cardiac remodeling (2011)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Distinct prognostic factors in patients with chronic heart failure and chronic kidney disease (2011)
  • Author(s): Sato T, Misaka T, Ohwada T, Yamauchi H, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Overnight use of adaptive servo ventilation reduces cardiac overload and improves renal function in patients with chronic heart failure and Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Suzuki S, Miyata M, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitho S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Comparisons of prognostic factors between chronic heart failure patients with and without atrial fibrillation (2011)
  • Author(s): Sato T, Misaka T, Nakamura Y, Owada T, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Cardiac-specific overexpression of high mobility group box 1(HMGB1) attenuates cardiac dysfunction induced by pressure overload (2011)
  • Author(s): Funayama A, Netsu S, Ishino M, Otaki Y, Honda S, Hasegawa H, Kadowaki S, Narumi T, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Woo C, Abe J, Kuwahara K, Nakao K, Takeishi Y, Kubota I
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Senescence marker protein-30 deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • Author(s): Mizukami H, Saitoh S, Yamada S, Machii H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] The importance of serial renal function measurements in chronic heart failure (2011)
  • Author(s): Sato T, Nakamura Y, Shimizu T, Misaka T, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Aging impairs endothelium dependent dilation via thiol-oxidation in coronary arterioles in SMP 30 deficiency mice (2011)
  • Author(s): Yamada S, Saitoh S, Mizukami H, Machii H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Over expressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury (2011)
  • Author(s): Oikawa M, Lim S, Jeon K, Knight W, Miller C, Cai Y, Blaxall B, Abe J, Takeishi Y, Yan C
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodeling (2011)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Ishigami A, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology
  • Place of Presentation: Paris, France
• [Presentation] Senescence marker protein-30 deficiency impairs myocardium induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • Author(s): Mizukami H, Saitoh S, Yamada S, Machii H, Suzuki H, Takeishi Y
  • Organizer: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: Tokyo
• [Presentation] Clinical utility of a novel index to evaluate left ventricular relaxation using aortic regurgitant velocity (2010)
  • Author(s): Watanabe T, Takeishi Y, et al
  • Organizer: EUROECHO 2010
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2010-12-08
• [Presentation] Adaptive servo ventilation improves cardiac function and prognosis in heart failure patients with Cheyne-Stokes respiration (2010)
  • Author(s): Yoshihisa A, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] Olmesartan inhibits GTP-binding protein alpha q-induced atrial remodeling in transgenic mice (2010)
  • Author(s): Hirose M, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] Coronary flow reserve predicts cardiovascular and cerebrovascular events in patients with chronic kidney disease (2010)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] MT1-MMP controls Akt-dependent Fox01 activation in TNF-α-induced signaling pathways of endothelial cell apoptosis and haemostasis (2010)
  • Author(s): Ohkawara H, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] MT1-MMP forms a complex with Gi and regulates eNOS expression at posttranscriptional mechanism in oxidized LDL stimulated-endothelial cells (2010)
  • Author(s): Sugimoto K,, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • Author(s): Machii H, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] Intrathoracic impedance change reflects reverse left ventricular remodeling in response to cardiac resynchronization therapy in chronic heart failure (2010)
  • Author(s): Yamada S, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] Uric acid increases the incidence of ventricular arrhythmia in patients with left ventricular hypertrophy (2010)
  • Author(s): Yamada S, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] Soluble lectin-like oxidized LDL receptor-1 (LOX-1) and LOX index are useful biomarkers for vulnerable plaques (2010)
  • Author(s): Misaka T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] Anaemia and abnormal ventilatory response to exercise predict adverse clinical outcomes in chronic heart failure (2010)
  • Author(s): Sato T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2010-11-13
• [Presentation] 自然免疫と心血管病 (2010)
  • Author(s): 竹石恭知
  • Organizer: Vascular and Brain Conference
  • Place of Presentation: 大阪(特別講演)
  • Year and Date: 2010-10-30
• [Presentation] Membrane Type I Matrix Metalloproteinase (MT1-MMP) mediates thrombin-induced RhoA/Racl activation and their downstream signaling in endothelial cells (2010)
  • Author(s): Ando K, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-29
• [Presentation] LOX-1 cooperates with renin-angiotensin system in monocyte adhesion-induced redox-sensitive and Ca^<2+> signaling pathways in endothelial cells (2010)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-29
• [Presentation] Serum 8-OHdG levels predicts adverse clinical outcomes in patients with heart failure (2010)
  • Author(s): Suzuki S, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-29
• [Presentation] Coronary flow reserve predicts cardiovascular and cerebrovascular events in patients with chronic kidney disease (2010)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-29
• [Presentation] The long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2010)
  • Author(s): Suzuki S, Takeishi Y, et al
  • Organizer: Congress of the European Society of Cardiology 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-29
• [Presentation] 心不全診療にバイオマーカーを活かす (2010)
  • Author(s): 竹石恭知
  • Organizer: BHK/ARCHフォーラム
  • Place of Presentation: 名古屋(特別講演)
  • Year and Date: 2010-05-20
• [Presentation] Pivotal role of receptor for advanced glycation end products (RAGE) in hyperlipidemia-dependent atherosclerosis and molecular regulation (2010)
  • Author(s): Uekita H, Takeishi Y, et al
  • Organizer: 20th World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] The long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2010)
  • Author(s): Suzuki S, Takeishi Y, et al
  • Organizer: 20th World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] LOX-1 cooperates with renin-angiotensin system (RAS) in monocyte adhesion-induced redox-sensitive and Ca^<2+> signaling pathways in endothelial cells (ECs) (2010)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Organizer: 20th World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] Age-associated metabolic regulation in coronary vascular tone (2010)
  • Author(s): Machii H, Takeishi Y, et al
  • Organizer: 20th World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] Cardiac myocyte modulates coronary vascular tone through H2O2, ADP, and Angiotensin (2010)
  • Author(s): Machii H, Takeishi Y, et al
  • Organizer: 20th World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] Distinct prognostic factors in patients with chronic heart failure (CHF) and chronic kidney disease (CKD) (2010)
  • Author(s): Sato T, Takeishi Y, et al
  • Organizer: 20th World Congress of the International Society for Heart Research (ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Chicago, USA
• [Presentation] MT1-MMP controls Akt-dependent Fox01 activation in TNF-α-induced signaling pathways of endothelial cell apoptosis and haemostasis (2010)
  • Author(s): Ohkawara H, Ishibashi T, Ando K, Sugimoto K, Sakamoto N, Uekita H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Age-associated metabolic regulation in coronary vascular tone (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Ishibashi T, Takeishi Y
  • Organizer: 20th World Congress of the International Society for Heart Research(ISHR)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Cardiac myocyte modulates coronary vascular tone through H2O2, ADP, and Angiotensin (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Ishibashi T, Takeishi Y
  • Organizer: 20th World Congress of the International Society for Heart Research(ISHR)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Akt cooperates with membrane type 1-matrix metalloproteinase (MT1-MMP) in TNF- α -induced signaling pathways of endothelial dysfunction and haemostasis (2009)
  • Author(s): Ohkawara H, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] Metabolic regulation in coronary vascular tone : various vasodilative substances in myocardial_ischemia (2009)
  • Author(s): Kaneshiro T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] Cooperation of MT1-MMP and LOX-1 for RhoA- and Racl-dependent signaling pathways in oxidized LDL-mediated endothelial dysfunction and atherosclerosis (2009)
  • Author(s): Sugimoto K, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] Area strain by 3D wall motion tracking method is useful to detect adenosine-induced myocardial dysfunction : comparisons with 99mTc myocardial perfusion scintigraphy (2009)
  • Author(s): Kobayashi A, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] LOX-1 mediates reriin-angiotensin system (RAS)-dependent redox-sensitive and Ca^<2+> signaling pathways induced in endothelial cells by monocyte ardhesion (2009)
  • Author(s): Sakamoto N, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] High serum level of neopterin is a risk factor of patients with heart failure (2009)
  • Author(s): Sasaki T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] The long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2009)
  • Author(s): Suzuki S, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] 8-hydroxy-2'-deoxyguanosine predicts adverse clinical outcomes in patients with heart failure (2009)
  • Author(s): Suzuki S, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] Relation of serum heat shock protein 60 level to severity and prognosis in chronic heart failure (2009)
  • Author(s): Niizeki T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] High serum level of neopterin predicts cardiac events in chronic heart failure patients with preserved left ventricular systolic function (2009)
  • Author(s): Sasaki T, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] Nicorandil inhibits ventricular remodeling and arrhythmias in a mouse model of chronic heart failure (2009)
  • Author(s): Hirose M, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] Adaptive servo ventilation improves cardiac dysfunction in heart failure patients with cheyne- stokes respiration (2009)
  • Author(s): Yoshihisa A, Takeishi Y, et al
  • Organizer: Scientific Sessions of American Heart Association 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-14
• [Presentation] High-mobility group box 1 enhances angiogenesis, prevents cardiac remodeling, and improves survival after myocardial infarction in the chronicphase (2009)
  • Author(s): Takeishi Y
  • Organizer: Basic Cardiovascular Sciences Conference 2009 -Molecular Mechanisms of Cardiovascular Disease
  • Place of Presentation: Lake Las Vegas, Nevada, USA
  • Year and Date: 2009-07-20
• [Presentation] HMGB1 improves cardiac dysfunction and survival in the chronic state after MI (2009)
  • Author(s): Takeishi Y
  • Organizer: Heart Failure 2009, European Society of Cardiology
  • Place of Presentation: Nice, France
  • Year and Date: 2009-05-30
• [Book] C.慢性心不全の治療11.鉄欠乏状態の慢性心不全患者において、鉄欠乏性貧血治療薬ferric carboxymaltoseの静注は症状を改善するか? EBM循環器疾患の治療 (2012)
  • Author(s): 及川雅啓,斎藤修一,竹石恭知
  • Publisher: 中外医学社
• [Book] X不整脈12.心臓ペースメーカーの選択と植込み患者の管理循環器疾患最新の治療 (2012)
  • Author(s): 鈴木均,竹石恭知
  • Publisher: 南江堂
• [Book] 心硬化症候群症候群ハンドブック (2011)
  • Author(s): 竹石恭知
  • Total Pages: 174
  • Publisher: 中山書店
• [Book] 症候群ハンドブック心硬化症候群 (2011)
  • Author(s): 竹石恭知
  • Total Pages: 174
  • Publisher: 中山書店
• [Book] III救急外来から入院1.病態・血行動態をどのように把握するか血液マーカー徹底ガイド心不全Q & A-プレホスピタルから慢性期まで- (2010)
  • Author(s): 義久精臣,小林淳,竹石恭知
  • Publisher: 総合医学社
• [Book] I.症候編1.全身的に見られる症候チアノーゼ今日の診断指針第6版 (2010)
  • Author(s): 竹石恭知
  • Publisher: 医学書院
• [Book] 今日の診断指針 第6版(I.症候編 1.全身的に見られる症候 チアノーゼ) (2010)
  • Author(s): 竹石恭知
  • Publisher: 医学書院
• [Book] 徹底ガイド 心不全Q&A-プレホスピタルから慢性期まで(III救急外来から入院 1.病態・血行動態をどのように把握するか?血液マーカー) (2010)
  • Author(s): 義久精臣, 小林淳, 竹石恭知
  • Publisher: 総合医学社
• [Book] II.疾患の病因と病態3. Toll-like receptorと心臓リモデリングAnnual Review循環器 (2009)
  • Author(s): 竹石恭知
  • Publisher: 中外医学社
• [Book] 3.不整脈,失神:心臓電気生理検査で異常が出ないときは、睡眠時無呼吸症を疑え循環器検査のグノーティ・セアウトンー過信せず侮らず、謙虚で緻密な検査とは (2009)
  • Author(s): 鈴木均,竹石恭知
  • Publisher: シナジー