| Project/Area Number |
21590935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
SAITOH Shu-ichi 福島県立医科大学, 医学部, 准教授 (20274962)
|
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGAMI Akihito 東京都健康長寿医療センター研究所, 分子老化制御部門, 研究副部長 (50270658)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 加齢 / 心不全 / 酸化ストレス / アンジオテンシンII / アポトーシス / 遺伝子操作マウス / 老化 |
|---|
| Research Abstract |
In SMP30 knockout mice, cardiac function was more severely depressed after angiotensin II infusion compared to wild type mice. Angiotensin IIinduced increases in NADPH oxidase activity, ROS generation, c-Jun N terminal kinase activity, a ratio of Bax/Bcl, caspase activity, and numbers of TUNEL positive nuclei were greater in SMP30 knockout mice. Thus, SMP30 may have cardio-protective roles by antioxidant and anti-apoptotic effects.
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