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The cardiac fibroblast-targeted novel strategy for diastolic heart failure

Research Project

Project/Area Number 21590936
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionYokohama City University

Principal Investigator

YOKOYAMA Utako  横浜市立大学, 医学部, 講師 (70404994)

Co-Investigator(Kenkyū-buntansha) UECHI Masami  横浜市立大学, 医学研究科, 客員教授 (90296426)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords分子心臓病理学 / シグナル伝達 / 分子心臓病態学
Research Abstract

Activation of the renin-angiotensin-aldosterone system results in vasoconstriction, cardiac hypertrophy and fibrosis. Established arterial stiffness and cardiac dysfunction are key factors contributing to chronic heart failure. Regulation of intracellular concentrations of cyclic AMP is one of the most ubiquitous mechanisms for regulating cellular functions. In this study we showed Epac, an exchange protein activated by cAMP and a new effector molecule of cyclic AMP signaling, inhibited myocardial apoptosis and cardiac dysfunction under activation of aldosterone. Stimulation of Epac may be an alternative strategy for heart failure.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (98 results)

All 2012 2011 2010 2009 Other

All Journal Article (25 results) (of which Peer Reviewed: 24 results) Presentation (69 results) Remarks (4 results)

  • [Journal Article] Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening2012

    • Author(s)
      Ichikawa Y, Yokoyama U, Iwamoto M, Oshikawa J, Okumura S, Sato M, Yokota S, Masuda M, Asou T, Isikawa Y
    • Journal Title

      Circ J

    • NAID

      10030875150

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose Thromboxane A2 Receptor Stimulation Promotes Closure of the Rat Ductus Arteriosus with Minimal Adverse Effects2012

    • Author(s)
      Yokota T, Aida T, Ichikawa Y, Fujita T, Yokoyama U, Minamisawa S
    • Journal Title

      Pediatr Res

      Volume: (in press)

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attelluates aortic aneurysm formation2012

    • Author(s)
      Yokoyama U
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e36724-e36724

    • DOI

      10.1371/journal.pone.0036724

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells.2012

    • Author(s)
      Fukumura H, et al.
    • Journal Title

      J. Physiol. Sci.

      Volume: 62 Issue: 3 Pages: 251-257

    • DOI

      10.1007/s12576-012-0204-0

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic AMP and Epac in the regulation of tissue fibrosis2012

    • Author(s)
      Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N
    • Journal Title

      Br. J. Pharmacol

      Volume: 166(2) Issue: 2 Pages: 447-456

    • DOI

      10.1111/j.1476-5381.2012.01847.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation.2011

    • Author(s)
      Kurotani R, et al
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 22 Pages: 19682-19692

    • DOI

      10.1074/jbc.m111.239046

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Roles of Cytochrome P450 in Ischemic Heart Diseas2011

    • Author(s)
      Sato M, Yokoyama U, Fujita T, Okumura S, Ishikawa Y
    • Journal Title

      Curr Drug Metab

      Volume: 12(6) Pages: 526-532

    • URL

      http://www.benthamdirect.org/pages/content.php?CDM/2011/00000012/00000006/0002F.SGM

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Identification of transcription factor E3 (TFE3) as areceptor-independent activator of G α 16: Gene regulation by nuclear Ga subunit and it s activator.2011

    • Author(s)
      Sato M, et al
    • Journal Title

      J Biol Chem.

      Volume: 286 Issue: 20 Pages: 17766-17776

    • DOI

      10.1074/jbc.m111.219816

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus.2011

    • Author(s)
      Jin M-H, et al
    • Journal Title

      J Physiol Sci.

      Volume: 61 Issue: 3 Pages: 167-179

    • DOI

      10.1007/s12576-011-0133-3

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of transcription factor E3 (TFE3) as a receptor-independent activator of G{alpha}16 : Gene regulation by nuclear G{alpha} subunit and its activator2011

    • Author(s)
      Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y.
    • Journal Title

      J Biol Chem.

      Volume: 286(20) Pages: 1776-1776

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus.2011

    • Author(s)
      Jin MH, Yokoyama U, Sato Y, Shioda A, Jiao Q, Ishikawa Y, Minamisawa S.
    • Journal Title

      J Physiol Sci.

      Volume: 61(3) Pages: 167-179

    • NAID

      10029049952

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y
    • Journal Title

      Circ Res

      Volume: 106(12) Issue: 12 Pages: 1882-1892

    • DOI

      10.1161/circresaha.109.214924

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardial cells2010

    • Author(s)
      Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kurotani R, Sato M, Okumura S, Ishikawa Y
    • Journal Title

      J Biol Chem

      Volume: 285(31) Pages: 24248-24259

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular tone and remodeling of the ductus arteriosus2010

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y
    • Journal Title

      Journal of Smooth Muscle Research

      Volume: 46 Issue: 2 Pages: 77-87

    • DOI

      10.1540/jsmr.46.77

    • NAID

      10030687229

    • ISSN
      0916-8737, 1884-8796
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 運動誘発性発作を呈するQT延長症候群の運動負荷心電図の特徴について2010

    • Author(s)
      岩本眞理, 西澤崇, 渡部重朗, 市川泰宏, 志水直, 山口和子, 赤池徹, 横山詩子, 瀧聞浄宏, 佐近琢磨, 安井清, 柴田利満, 新村一郎, 横田俊平
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 第26巻第1号 Pages: 67-72

    • NAID

      10026281971

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice2010

    • Author(s)
      Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 298(3) Issue: 3 Pages: C450-C456

    • DOI

      10.1152/ajpcell.00077.2009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y.
    • Journal Title

      Circ Res

      Volume: 106(12) Pages: 1882-1892

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardial cells.2010

    • Author(s)
      Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kurotani R., Sato M, Okumura S, Ishikawa Y.
    • Journal Title

      J Biol Chem.

      Volume: 285(31) Pages: 24248-24259

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular tone and remodeling of the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y.
    • Journal Title

      J.Smooth Muscle Res

      Volume: 46(2) Pages: 77-87

    • NAID

      10030687229

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and Histological Evaluations of 3D-Layered Blood Vessel Constructs Prepared by Hierarchical Cell Manipulation.2010

    • Author(s)
      Matsusaki M, Kadowaki K, Adachi E, Sakura T, Yokoyama U, Ishikawa Y, Akashi M.
    • Journal Title

      J Biomater Sci Polym Ed

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-type Ca2+channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation2009

    • Author(s)
      Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S
    • Journal Title

      J Biol Chem

      Volume: 284(36) Issue: 36 Pages: 24025-24034

    • DOI

      10.1074/jbc.m109.017061

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice2009

    • Author(s)
      Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y
    • Journal Title

      Am.J.Physiol.Cell Physiol. 298(3)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects2009

    • Author(s)
      Hamanoue H, Rahayuningsih SE, Hirahara Y, Itoh J, Yokoyama U, Mizuguchi T, Saitsu H, Miyake N, Hirahara F, Matsumoto N
    • Journal Title

      Cardiol Young 19(5)

      Pages: 482-485

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-type Ca2+ channels promote oxygenation-induced closure of the ratductus arteriosus not only by vasoconstriction but also by neointima formation2009

    • Author(s)
      Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S
    • Journal Title

      J.Biol.Chem. 284

      Pages: 24025-24034

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of markers for fetal inflammatory response syndrome : fetal blood interleukin-6 and neonatal urinary beta(2)-microglobulin2009

    • Author(s)
      Nishimaki S, Sato M, An H, Shima Y, Akaike T, Yokoyama U, Yokota S
    • Journal Title

      J.Obstet Gynaecol.Res 35(3)

      Pages: 472-476

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Molecular mechanism of the regulation of vascular elastic fiber formation2012

    • Author(s)
      Yokoyama U, Shioda A, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 89th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      長野県松本文化会館,長野
    • Year and Date
      2012-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular mechanism of the regulation of vascular elastic fiber formation2012

    • Author(s)
      Yokoyama U, Shioda A, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 89^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      長野県松本文化体育館(長野県)(招待講演)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 signaling may play a role in intimal thickening that precedes atherosclerosis2012

    • Author(s)
      Kumagaya S, Yokoyama U, Iwai K, Nishihara H, Ishikawa Y, Minamisawa S
    • Organizer
      The 89^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      長野県松本文化体育館(長野県)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 3D cellular multi-layers of rat smooth muscle cells has a potential as a novel ex vivo vascular model2012

    • Author(s)
      Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
    • Organizer
      The 89^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      長野県松本文化体育館(長野県)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oxygenation-induced postnatal remodeling of the ductus arteriosus2012

    • Author(s)
      Jin MH, Yokoyama U, Ishiwata R, Minamisawa S, Ishikawa Y
    • Organizer
      The 89^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      長野県松本文化体育館(長野県)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of Phophodiesterase Type 3 Milrinone Dilate the Ductus Arteriosus without Forming Intimal Thickening2012

    • Author(s)
      Ichikawa Y, Yokoyama U, Ishikawa Y
    • Organizer
      The 89^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      長野県松本文化体育館(長野県)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of EP4 Signaling Attenuates Mouse Aortic Aneurysm Formation2012

    • Author(s)
      Yokoyama U, Jin MH, Kato Y, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 76rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡国際会議場,福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of EP4 Signaling Attenuates Mouse Aortic Aneurysm Formation2012

    • Author(s)
      Yokoyama U, Jin MH, Kato Y, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 76^<rd> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管閉鎖における低浸透圧センサーTransient Receptor Potential Melastatin 3 (TRPM3)チャネルの役割」心血管イオンチャネル・トランスポーター研究の新展開--基礎研究と臨床研究の融合--2011

    • Author(s)
      青木理加、横山詩子、市川泰広、南沢享、石川義弘
    • Organizer
      生理学研究所研究会
    • Place of Presentation
      自然科学研究機構生理学研究所(愛知県)
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管の閉鎖機序と新生児循環管理2011

    • Author(s)
      横山詩子
    • Organizer
      第9回日本周産期循環管理研究会
    • Place of Presentation
      ハーネル仙台,宮城
    • Year and Date
      2011-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管の閉鎖機序と新生児循環管理2011

    • Author(s)
      横山詩子
    • Organizer
      第9回日本周産期循環管理研究会
    • Place of Presentation
      ハーネル仙台(宮城県)(招待講演)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管収縮における出生後の血清浸透圧低下の役割2011

    • Author(s)
      青木理加、横山詩子、岩崎志穂、関和男、西巻滋、横田俊平、石川義弘
    • Organizer
      第56回日本未熟児新生児学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管の閉鎖,開存の分子メカニズムと治療開発2011

    • Author(s)
      横山詩子
    • Organizer
      横浜市立大学医学部小児科同門会
    • Place of Presentation
      ホテルプライム,神奈川
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管の閉鎖、開存の分子メカニズムと治療開発2011

    • Author(s)
      横山詩子
    • Organizer
      横浜市立大学医学部小児科同門会
    • Place of Presentation
      ホテルプラム(神奈川県)(招待講演)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管内皮細胞の遺伝子プロファイリング2011

    • Author(s)
      横田知大、劉孟佳、前川峻、加藤尚志、横山詩子、南沢享
    • Organizer
      第10回心臓血管発生研究会
    • Place of Presentation
      ホテル華の湯(福島県)
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酸素による動脈管リモデリング2011

    • Author(s)
      金美花、横山詩子、石渡遼、南沢享、石川義弘
    • Organizer
      第10回心臓血管発生研究会
    • Place of Presentation
      ホテル華の湯(福島県)
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly2011

    • Author(s)
      Yokoyama U, Kato Y, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 2^<nd> Molecular Cardiovascular Conference II
    • Place of Presentation
      キロロリゾートホテルピアノ(北海道)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胎生期から始まる血管リモデリングの分子機序2011

    • Author(s)
      横山詩子
    • Organizer
      第9回腫瘍病理学分野・探索病理学講座セミナー
    • Place of Presentation
      北海道大学医学部,北海道
    • Year and Date
      2011-09-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 胎生期から始まる血管リモデリングの分子機序2011

    • Author(s)
      横山詩子
    • Organizer
      第9回腫瘍病理学分野・探索病理学講座セミナー
    • Place of Presentation
      北海道大学医学部(北海道)(招待講演)
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 臨床から基礎医学研究へ-豊かな感受性を持とう-基礎研究者育成プロジェクト2011

    • Author(s)
      横山詩子
    • Organizer
      第1回リトリート
    • Place of Presentation
      東京大学医学部,東京
    • Year and Date
      2011-08-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 臨床から基礎医学研究へ-豊かな感受性を持とう」基礎研究者育成プロジェクト2011

    • Author(s)
      横山詩子
    • Organizer
      第1回リトリート
    • Place of Presentation
      東京大学医学部(東京都)(招待講演)
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epac1は血管障害時の内膜肥厚形成を促進する2011

    • Author(s)
      加藤優子、横山詩子、奥村敏、南沢享、佐田政隆、宮島栄治、石川義弘
    • Organizer
      第53回日本平滑筋学会
    • Place of Presentation
      ゆうぽうと(東京都)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Three dimensional cellular multi-layer technology utilized evaluation of elastic fiber formation and phenotype of rat vascular smooth muscle cells2011

    • Author(s)
      Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
    • Organizer
      The 7th Japan-China-Korea Pediatric Heat Forum
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 出生後の血清浸透圧低下は動脈管収縮を促進させる2011

    • Author(s)
      市川泰広、青木理加、横山詩子、岩本眞理、南沢享、石川義弘
    • Organizer
      第47回日本小児循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-07-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管を制御する分子メカニズム2011

    • Author(s)
      横山詩子
    • Organizer
      第1回新生児循環基礎・臨床コラボレーションカンファレンスin YOKOHAMA
    • Place of Presentation
      神奈川県立子供医療センター,神奈川
    • Year and Date
      2011-06-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管を制御する分子メカニズム2011

    • Author(s)
      横山詩子
    • Organizer
      第1回新生児循環基礎・臨床コラボレーションカンファレンスin YOKOHAMA
    • Place of Presentation
      神奈川県立子供医療センター(招待講演)
    • Year and Date
      2011-06-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管を制御する分子メカニズム2011

    • Author(s)
      横山詩子
    • Organizer
      第8回RSVJapan Global Expert Meeting
    • Place of Presentation
      東京国際フォーラム,東京
    • Year and Date
      2011-06-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管を制御する分子メカニズム2011

    • Author(s)
      横山詩子
    • Organizer
      第8回RSV Japan Global Expert Meeting
    • Place of Presentation
      東京国際フォーラム(東京都)(招待講演)
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of vascular remodeling of the ductus arteriosus2011

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      パシフィコ横浜,神奈川
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Epacl promotes vascular remodeling upon vascular injury in vivo.2011

    • Author(s)
      Kato Y, Yokoyama U, Okumura S, Minamisawa S, Sata M, Miyajima E, Ishikawa Y
    • Organizer
      The 88^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serum depletion and three-dimensional multilayer composition induce elastic fiber formation and a contractile phenotype of rat vascular smooth muscle cells.2011

    • Author(s)
      Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
    • Organizer
      The 88^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Thromnoxane A2 Receptor Stimulation Specifically Causes Closure of the Rat Ductus Arteriosus.2011

    • Author(s)
      Aida T, Yokota T, Yokoyama U, Minamisawa S
    • Organizer
      The 88^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Successful Isolation of Vascular Endothelial Cells from the Rat Ductus Arteriosus.2011

    • Author(s)
      Liu N, Yokota T, Maekawa S, Yokoyama U, Kato T, Minamisawa S.
    • Organizer
      The 88^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of vascular remodeling of the ductus arteriosus.2011

    • Author(s)
      Yokoyama U, Minamisawa S, Ishika Y.
    • Organizer
      The 88^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      横浜、パシフィコ横浜(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 炎症性メディエーターによる血管弾性線維と細胞外基質の制御2010

    • Author(s)
      横山詩子
    • Organizer
      大阪大学明石研セミナー
    • Place of Presentation
      大阪大学,大阪
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 炎症性メディエーターによる血管弾性線維と細胞外基質の制御2010

    • Author(s)
      横山詩子
    • Organizer
      大阪大学明石研セミナー
    • Place of Presentation
      大阪、大阪大学(招待講演)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly2010

    • Author(s)
      Yokoyama U, Shioda A, Kato Y, Asou T, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 84th Scientific Session, American Heart Association(AHA)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管閉鎖のメカニズム-from bench to bedside2010

    • Author(s)
      横山詩子
    • Organizer
      第6回横浜小児先端医療セミナー
    • Place of Presentation
      横浜崎陽軒,神奈川
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管閉鎖のメカニズム-from bench to bedside2010

    • Author(s)
      横山詩子
    • Organizer
      第6回横浜小児先端医療セミナー
    • Place of Presentation
      横浜、横浜崎陽軒(招待講演)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動脈管のリモデリングー酸素の役割2010

    • Author(s)
      横山詩子
    • Organizer
      小児心血管分子医学研究会
    • Place of Presentation
      シェラトングランデ・トーキョーベイホテル,千葉
    • Year and Date
      2010-07-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 動脈管のリモデリング一酸素の役割2010

    • Author(s)
      横山詩子
    • Organizer
      小児心血管分子医学研究会
    • Place of Presentation
      千葉、シェラトングランデ・トーキョーベイホテル(招待講演)
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A2010

    • Author(s)
      横山詩子
    • Organizer
      第52回日本平滑筋学会総会栗山煕賞受賞記念講演
    • Place of Presentation
      仙台市情報プラザアエル,宮城
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A.2010

    • Author(s)
      横山詩子
    • Organizer
      第52回日本平滑筋学会総会 栗山煕賞受賞記念講演
    • Place of Presentation
      仙台、仙台市情報プラザアエル(招待講演)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epac1 plays a critical role in advancing vascular remodeling after mechanoinjury in vivo2010

    • Author(s)
      Kato Y, Yokoyama U, Okumura S, Sata M, Minamisawa S, Ishikawa Y
    • Organizer
      The 74^<rd> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      国立京都国際会議場,京都
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y
    • Organizer
      The 16^<th> International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Oxygenation Promotes Migration of Smooth Muscle Cell in the Rat Ductus Arteriosus2010

    • Author(s)
      Minamisawa S, Akaike T, Yokoyama U, Iwasaki S, Ishikawa Y.
    • Organizer
      Developmental Vascular Biology Workshop IV
    • Place of Presentation
      Monterey, California
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      Yokoyama U, Minamisawa S, Katayama A, Tang T, Iwasaki S, Hammond HK, Ishikawa Y.
    • Organizer
      Developmental Vascular Biology Workshop IV
    • Place of Presentation
      Monterey, California
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly2010

    • Author(s)
      Shioda A, Yokoyama U, Kato Y, Asou T, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y.
    • Organizer
      The 33^<th> Annual Meeting of the Molecular Biological Society of Japan
    • Place of Presentation
      神戸、神戸国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly.2010

    • Author(s)
      Yokoyama U, Shioda A, Kato Y, Asou T, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y.
    • Organizer
      The 84^<th> Scientific Session, American Heart Association(AHA)
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット動脈管閉鎖における低浸透圧センサーTransient Receptor Potential Melastatin 3(TRPM3)チャネルの役割2010

    • Author(s)
      青木理加、横山詩子、岩崎志穂、西巻滋、横田俊平、石川義弘
    • Organizer
      第55回未熟児新生児学会・学術集会
    • Place of Presentation
      神戸、神戸国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット動脈管内膜肥厚におけるアデニル酸シクラーゼアイソフォームの役割の検討2010

    • Author(s)
      岩崎志穂、青木理加、西巻滋、横田俊平、南沢享、横山詩子
    • Organizer
      第46回日本周産新生児医学会
    • Place of Presentation
      神戸、神戸国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Role of Thromboxane A2 Receptor in the Rat Ductus Arteriosus as a Vasoconstrictor.2010

    • Author(s)
      Yokota T, Ozawa M, Yokoyama U, Minamisawa S
    • Organizer
      The 16^<th> International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y
    • Organizer
      The 16^<th> International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epac1 plays a critical role in advancing vascular remodeling after mechanoinjury in vivo2010

    • Author(s)
      Kato Y, Yokoyama U, Okumura S, Sata M, Minamisawa S, Ishikawa Y
    • Organizer
      The 74^<rd> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygenation from hypoxia to normoxia promotes smooth muscle cell migration in the rat ductus arteriosus2009

    • Author(s)
      南沢享, 赤池徹, 横山詩子
    • Organizer
      The 26^<th> Annual Meeting of the Japanese Section
    • Place of Presentation
      Sapporo
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御2009

    • Author(s)
      横山詩子, 南沢享, 片山綾子, 塩田亜樹, 中邨智之, 杉本幸彦, 石川義弘
    • Organizer
      第5回神奈川小児循環器研究会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管閉鎖を制御する因子の同定と新治療法開発2009

    • Author(s)
      南沢享, 横山詩子, 赤池徹, 横田知大, 小沢基
    • Organizer
      第1回成果報告シンポジウム「早稲田大学が目指す新しい医・理・工学融合研究の展開」
    • Place of Presentation
      東京
    • Year and Date
      2009-08-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] T-type calcium channels regulate smooth muscle cell migration, neointimal formation, and oxygen-induced closure in rat ductus arteriosus2009

    • Author(s)
      横田知大, 赤池徹, 小澤基, 横山詩子, 南沢享
    • Organizer
      The 1^<st> International Symposium on Biomedical Science and Engineering Waseda University High-Tech Research Center
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygenation Promotes Smooth Muscle Cell Migration in the Rat Ductus Arteriosus2009

    • Author(s)
      Minamisawa S, Akaike T, Yokoyama U, Ozawa M, Iwasaki S, Ishikawa Y
    • Organizer
      BCVS Conference-Molecular Mechanisms of Cardiovascular Diseases
    • Place of Presentation
      Nevada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygen Promoters Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus2009

    • Author(s)
      Ozawa M, Akaike T, Katayama A, Yokoyama U, Ishikawa Y, Minamisawa S
    • Organizer
      The 36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adenylyl Cyclase Type 2 and 6 Differentially Promote Vascular Tone and Remodeling in Ductus Arteriosus2009

    • Author(s)
      Katayama A, Yokoyama U, Tang T, Akaike T, Hammond HK, Minamisawa S, Ishikawa Y
    • Organizer
      The 36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胎生後期ラット動脈管におけるTRPMチャネルの発現2009

    • Author(s)
      青木理加, 横山詩子, 片山綾子, 石川義弘, 南沢享
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      福島
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維(エラスチン)形成の制御2009

    • Author(s)
      塩田亜樹, 横山詩子, 片山綾子, 南沢享, 石川義弘
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      福島
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御2009

    • Author(s)
      横山詩子, 南沢享, 片山綾子, 塩田亜樹, 中邨智之, 杉本幸彦, 石川義弘
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット動脈管における6型アデニル酸シクラーゼの内膜肥厚形成作用2009

    • Author(s)
      片山綾子, 横山詩子, 赤池徹, 南沢享, 石川義弘
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット動脈管組織におけるTRPMチャネルの発現~発達段階での大動脈組織との比較検討~2009

    • Author(s)
      青木理加, 横山詩子, 片山綾子, 石川義弘, 南沢享
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット動脈管において酸素化は平滑筋細胞遊走を促進する2009

    • Author(s)
      小澤基, 赤池徹, 横山詩子, 横田知大, 石川義弘, 南沢享
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胎生後期ラット動脈管におけるTRPMチャネルの発現~大動脈組織との比較検討~2009

    • Author(s)
      青木理加, 横山詩子, 岩崎志穂, 西巻滋, 横田俊平, 石川義弘
    • Organizer
      第54回日本未熟児新生児学会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 動脈管閉鎖の分子機序:プロスタグランジンの予期せぬ役割 Molecular Mechanisms of Closure of Dactus Arteriosus : Unexpected roles of prostaglandins2009

    • Author(s)
      南沢享, 横山詩子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiril/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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