The cardiac fibroblast-targeted novel strategy for diastolic heart failure

• Project/Area Number: 21590936
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yokohama City University
• Principal Investigator: YOKOYAMA Utako 横浜市立大学, 医学部, 講師 (70404994)
• Co-Investigator(Kenkyū-buntansha): UECHI Masami 横浜市立大学, 医学研究科, 客員教授 (90296426)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 分子心臓病理学 / シグナル伝達 / 分子心臓病態学

Research Abstract

Activation of the renin-angiotensin-aldosterone system results in vasoconstriction, cardiac hypertrophy and fibrosis. Established arterial stiffness and cardiac dysfunction are key factors contributing to chronic heart failure. Regulation of intracellular concentrations of cyclic AMP is one of the most ubiquitous mechanisms for regulating cellular functions. In this study we showed Epac, an exchange protein activated by cAMP and a new effector molecule of cyclic AMP signaling, inhibited myocardial apoptosis and cardiac dysfunction under activation of aldosterone. Stimulation of Epac may be an alternative strategy for heart failure.

Research Products

• [Journal Article] Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening (2012)
  • Author(s): Ichikawa Y, Yokoyama U, Iwamoto M, Oshikawa J, Okumura S, Sato M, Yokota S, Masuda M, Asou T, Isikawa Y
  • Journal Title: Circ J
  • NAID: 10030875150
  • Peer Reviewed
• [Journal Article] Low-dose Thromboxane A2 Receptor Stimulation Promotes Closure of the Rat Ductus Arteriosus with Minimal Adverse Effects (2012)
  • Author(s): Yokota T, Aida T, Ichikawa Y, Fujita T, Yokoyama U, Minamisawa S
  • Journal Title: Pediatr Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Inhibition of EP4 signaling attelluates aortic aneurysm formation (2012)
  • Author(s): Yokoyama U
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e36724-e36724
  • DOI: 10.1371/journal.pone.0036724
  • Peer Reviewed
• [Journal Article] Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells. (2012)
  • Author(s): Fukumura H, et al.
  • Journal Title: J. Physiol. Sci. Volume: 62 Issue: 3 Pages: 251-257
  • DOI: 10.1007/s12576-012-0204-0
  • Peer Reviewed
• [Journal Article] Cyclic AMP and Epac in the regulation of tissue fibrosis (2012)
  • Author(s): Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N
  • Journal Title: Br. J. Pharmacol Volume: 166(2) Issue: 2 Pages: 447-456
  • DOI: 10.1111/j.1476-5381.2012.01847.x
  • Peer Reviewed
• [Journal Article] Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation. (2011)
  • Author(s): Kurotani R, et al
  • Journal Title: J. Biol. Chem. Volume: 286 Issue: 22 Pages: 19682-19692
  • DOI: 10.1074/jbc.m111.239046
  • Peer Reviewed
• [Journal Article] The Roles of Cytochrome P450 in Ischemic Heart Diseas (2011)
  • Author(s): Sato M, Yokoyama U, Fujita T, Okumura S, Ishikawa Y
  • Journal Title: Curr Drug Metab Volume: 12(6) Pages: 526-532
  • URL: http://www.benthamdirect.org/pages/content.php?CDM/2011/00000012/00000006/0002F.SGM
• [Journal Article] Identification of transcription factor E3 (TFE3) as areceptor-independent activator of G α 16: Gene regulation by nuclear Ga subunit and it s activator. (2011)
  • Author(s): Sato M, et al
  • Journal Title: J Biol Chem. Volume: 286 Issue: 20 Pages: 17766-17776
  • DOI: 10.1074/jbc.m111.219816
  • Peer Reviewed
• [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus. (2011)
  • Author(s): Jin M-H, et al
  • Journal Title: J Physiol Sci. Volume: 61 Issue: 3 Pages: 167-179
  • DOI: 10.1007/s12576-011-0133-3
  • Peer Reviewed
• [Journal Article] Identification of transcription factor E3 (TFE3) as a receptor-independent activator of G{alpha}16 : Gene regulation by nuclear G{alpha} subunit and its activator (2011)
  • Author(s): Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y.
  • Journal Title: J Biol Chem. Volume: 286(20) Pages: 1776-1776
  • Peer Reviewed
• [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus. (2011)
  • Author(s): Jin MH, Yokoyama U, Sato Y, Shioda A, Jiao Q, Ishikawa Y, Minamisawa S.
  • Journal Title: J Physiol Sci. Volume: 61(3) Pages: 167-179
  • NAID: 10029049952
  • Peer Reviewed
• [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus (2010)
  • Author(s): Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y
  • Journal Title: Circ Res Volume: 106(12) Issue: 12 Pages: 1882-1892
  • DOI: 10.1161/circresaha.109.214924
  • Peer Reviewed
• [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardial cells (2010)
  • Author(s): Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kurotani R, Sato M, Okumura S, Ishikawa Y
  • Journal Title: J Biol Chem Volume: 285(31) Pages: 24248-24259
  • Peer Reviewed
• [Journal Article] Regulation of vascular tone and remodeling of the ductus arteriosus (2010)
  • Author(s): Yokoyama U, Minamisawa S, Ishikawa Y
  • Journal Title: Journal of Smooth Muscle Research Volume: 46 Issue: 2 Pages: 77-87
  • DOI: 10.1540/jsmr.46.77
  • NAID: 10030687229
  • ISSN: 0916-8737, 1884-8796
  • Peer Reviewed
• [Journal Article] 運動誘発性発作を呈するQT延長症候群の運動負荷心電図の特徴について (2010)
  • Author(s): 岩本眞理, 西澤崇, 渡部重朗, 市川泰宏, 志水直, 山口和子, 赤池徹, 横山詩子, 瀧聞浄宏, 佐近琢磨, 安井清, 柴田利満, 新村一郎, 横田俊平
  • Journal Title: 日本小児循環器学会雑誌 Volume: 第26巻第1号 Pages: 67-72
  • NAID: 10026281971
  • Peer Reviewed
• [Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice (2010)
  • Author(s): Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y
  • Journal Title: Am J Physiol Cell Physiol Volume: 298(3) Issue: 3 Pages: C450-C456
  • DOI: 10.1152/ajpcell.00077.2009
  • Peer Reviewed
• [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. (2010)
  • Author(s): Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y.
  • Journal Title: Circ Res Volume: 106(12) Pages: 1882-1892
  • Peer Reviewed
• [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardial cells. (2010)
  • Author(s): Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kurotani R., Sato M, Okumura S, Ishikawa Y.
  • Journal Title: J Biol Chem. Volume: 285(31) Pages: 24248-24259
  • Peer Reviewed
• [Journal Article] Regulation of vascular tone and remodeling of the ductus arteriosus. (2010)
  • Author(s): Yokoyama U, Minamisawa S, Ishikawa Y.
  • Journal Title: J.Smooth Muscle Res Volume: 46(2) Pages: 77-87
  • NAID: 10030687229
  • Peer Reviewed
• [Journal Article] Morphological and Histological Evaluations of 3D-Layered Blood Vessel Constructs Prepared by Hierarchical Cell Manipulation. (2010)
  • Author(s): Matsusaki M, Kadowaki K, Adachi E, Sakura T, Yokoyama U, Ishikawa Y, Akashi M.
  • Journal Title: J Biomater Sci Polym Ed Volume: (in press)
  • Peer Reviewed
• [Journal Article] T-type Ca2+channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation (2009)
  • Author(s): Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S
  • Journal Title: J Biol Chem Volume: 284(36) Issue: 36 Pages: 24025-24034
  • DOI: 10.1074/jbc.m109.017061
  • Peer Reviewed
• [Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice (2009)
  • Author(s): Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y
  • Journal Title: Am.J.Physiol.Cell Physiol. 298(3)
  • Peer Reviewed
• [Journal Article] Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects (2009)
  • Author(s): Hamanoue H, Rahayuningsih SE, Hirahara Y, Itoh J, Yokoyama U, Mizuguchi T, Saitsu H, Miyake N, Hirahara F, Matsumoto N
  • Journal Title: Cardiol Young 19(5) Pages: 482-485
  • Peer Reviewed
• [Journal Article] T-type Ca2+ channels promote oxygenation-induced closure of the ratductus arteriosus not only by vasoconstriction but also by neointima formation (2009)
  • Author(s): Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S
  • Journal Title: J.Biol.Chem. 284 Pages: 24025-24034
  • Peer Reviewed
• [Journal Article] Comparison of markers for fetal inflammatory response syndrome : fetal blood interleukin-6 and neonatal urinary beta(2)-microglobulin (2009)
  • Author(s): Nishimaki S, Sato M, An H, Shima Y, Akaike T, Yokoyama U, Yokota S
  • Journal Title: J.Obstet Gynaecol.Res 35(3) Pages: 472-476
  • Peer Reviewed
• [Presentation] Molecular mechanism of the regulation of vascular elastic fiber formation (2012)
  • Author(s): Yokoyama U, Shioda A, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 89th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 長野県松本文化会館,長野
  • Year and Date: 2012-03-31
• [Presentation] Molecular mechanism of the regulation of vascular elastic fiber formation (2012)
  • Author(s): Yokoyama U, Shioda A, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 89^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 長野県松本文化体育館(長野県)(招待講演)
  • Year and Date: 2012-03-31
• [Presentation] Prostaglandin E2-EP4 signaling may play a role in intimal thickening that precedes atherosclerosis (2012)
  • Author(s): Kumagaya S, Yokoyama U, Iwai K, Nishihara H, Ishikawa Y, Minamisawa S
  • Organizer: The 89^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 長野県松本文化体育館(長野県)
  • Year and Date: 2012-03-30
• [Presentation] 3D cellular multi-layers of rat smooth muscle cells has a potential as a novel ex vivo vascular model (2012)
  • Author(s): Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
  • Organizer: The 89^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 長野県松本文化体育館(長野県)
  • Year and Date: 2012-03-30
• [Presentation] Oxygenation-induced postnatal remodeling of the ductus arteriosus (2012)
  • Author(s): Jin MH, Yokoyama U, Ishiwata R, Minamisawa S, Ishikawa Y
  • Organizer: The 89^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 長野県松本文化体育館(長野県)
  • Year and Date: 2012-03-30
• [Presentation] Inhibition of Phophodiesterase Type 3 Milrinone Dilate the Ductus Arteriosus without Forming Intimal Thickening (2012)
  • Author(s): Ichikawa Y, Yokoyama U, Ishikawa Y
  • Organizer: The 89^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 長野県松本文化体育館(長野県)
  • Year and Date: 2012-03-30
• [Presentation] Inhibition of EP4 Signaling Attenuates Mouse Aortic Aneurysm Formation (2012)
  • Author(s): Yokoyama U, Jin MH, Kato Y, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 76rd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 福岡国際会議場,福岡
  • Year and Date: 2012-03-17
• [Presentation] Inhibition of EP4 Signaling Attenuates Mouse Aortic Aneurysm Formation (2012)
  • Author(s): Yokoyama U, Jin MH, Kato Y, Ishiwata R, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 76^<rd> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2012-03-17
• [Presentation] 動脈管閉鎖における低浸透圧センサーTransient Receptor Potential Melastatin 3 (TRPM3)チャネルの役割」心血管イオンチャネル・トランスポーター研究の新展開--基礎研究と臨床研究の融合-- (2011)
  • Author(s): 青木理加、横山詩子、市川泰広、南沢享、石川義弘
  • Organizer: 生理学研究所研究会
  • Place of Presentation: 自然科学研究機構生理学研究所(愛知県)
  • Year and Date: 2011-11-30
• [Presentation] 動脈管の閉鎖機序と新生児循環管理 (2011)
  • Author(s): 横山詩子
  • Organizer: 第9回日本周産期循環管理研究会
  • Place of Presentation: ハーネル仙台,宮城
  • Year and Date: 2011-11-26
• [Presentation] 動脈管の閉鎖機序と新生児循環管理 (2011)
  • Author(s): 横山詩子
  • Organizer: 第9回日本周産期循環管理研究会
  • Place of Presentation: ハーネル仙台(宮城県)(招待講演)
  • Year and Date: 2011-11-26
• [Presentation] 動脈管収縮における出生後の血清浸透圧低下の役割 (2011)
  • Author(s): 青木理加、横山詩子、岩崎志穂、関和男、西巻滋、横田俊平、石川義弘
  • Organizer: 第56回日本未熟児新生児学会学術集会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-11-14
• [Presentation] 動脈管の閉鎖,開存の分子メカニズムと治療開発 (2011)
  • Author(s): 横山詩子
  • Organizer: 横浜市立大学医学部小児科同門会
  • Place of Presentation: ホテルプライム,神奈川
  • Year and Date: 2011-11-10
• [Presentation] 動脈管の閉鎖、開存の分子メカニズムと治療開発 (2011)
  • Author(s): 横山詩子
  • Organizer: 横浜市立大学医学部小児科同門会
  • Place of Presentation: ホテルプラム(神奈川県)(招待講演)
  • Year and Date: 2011-11-10
• [Presentation] 動脈管内皮細胞の遺伝子プロファイリング (2011)
  • Author(s): 横田知大、劉孟佳、前川峻、加藤尚志、横山詩子、南沢享
  • Organizer: 第10回心臓血管発生研究会
  • Place of Presentation: ホテル華の湯(福島県)
  • Year and Date: 2011-10-08
• [Presentation] 酸素による動脈管リモデリング (2011)
  • Author(s): 金美花、横山詩子、石渡遼、南沢享、石川義弘
  • Organizer: 第10回心臓血管発生研究会
  • Place of Presentation: ホテル華の湯(福島県)
  • Year and Date: 2011-10-08
• [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly (2011)
  • Author(s): Yokoyama U, Kato Y, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 2^<nd> Molecular Cardiovascular Conference II
  • Place of Presentation: キロロリゾートホテルピアノ(北海道)
  • Year and Date: 2011-09-03
• [Presentation] 胎生期から始まる血管リモデリングの分子機序 (2011)
  • Author(s): 横山詩子
  • Organizer: 第9回腫瘍病理学分野・探索病理学講座セミナー
  • Place of Presentation: 北海道大学医学部,北海道
  • Year and Date: 2011-09-01
• [Presentation] 胎生期から始まる血管リモデリングの分子機序 (2011)
  • Author(s): 横山詩子
  • Organizer: 第9回腫瘍病理学分野・探索病理学講座セミナー
  • Place of Presentation: 北海道大学医学部(北海道)(招待講演)
  • Year and Date: 2011-09-01
• [Presentation] 臨床から基礎医学研究へ-豊かな感受性を持とう-基礎研究者育成プロジェクト (2011)
  • Author(s): 横山詩子
  • Organizer: 第1回リトリート
  • Place of Presentation: 東京大学医学部,東京
  • Year and Date: 2011-08-20
• [Presentation] 臨床から基礎医学研究へ-豊かな感受性を持とう」基礎研究者育成プロジェクト (2011)
  • Author(s): 横山詩子
  • Organizer: 第1回リトリート
  • Place of Presentation: 東京大学医学部(東京都)(招待講演)
  • Year and Date: 2011-08-20
• [Presentation] Epac1は血管障害時の内膜肥厚形成を促進する (2011)
  • Author(s): 加藤優子、横山詩子、奥村敏、南沢享、佐田政隆、宮島栄治、石川義弘
  • Organizer: 第53回日本平滑筋学会
  • Place of Presentation: ゆうぽうと(東京都)
  • Year and Date: 2011-08-04
• [Presentation] Three dimensional cellular multi-layer technology utilized evaluation of elastic fiber formation and phenotype of rat vascular smooth muscle cells (2011)
  • Author(s): Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
  • Organizer: The 7th Japan-China-Korea Pediatric Heat Forum
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2011-07-08
• [Presentation] 出生後の血清浸透圧低下は動脈管収縮を促進させる (2011)
  • Author(s): 市川泰広、青木理加、横山詩子、岩本眞理、南沢享、石川義弘
  • Organizer: 第47回日本小児循環器学会総会・学術集会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2011-07-07
• [Presentation] 動脈管を制御する分子メカニズム (2011)
  • Author(s): 横山詩子
  • Organizer: 第1回新生児循環基礎・臨床コラボレーションカンファレンスin YOKOHAMA
  • Place of Presentation: 神奈川県立子供医療センター,神奈川
  • Year and Date: 2011-06-22
• [Presentation] 動脈管を制御する分子メカニズム (2011)
  • Author(s): 横山詩子
  • Organizer: 第1回新生児循環基礎・臨床コラボレーションカンファレンスin YOKOHAMA
  • Place of Presentation: 神奈川県立子供医療センター(招待講演)
  • Year and Date: 2011-06-22
• [Presentation] 動脈管を制御する分子メカニズム (2011)
  • Author(s): 横山詩子
  • Organizer: 第8回RSVJapan Global Expert Meeting
  • Place of Presentation: 東京国際フォーラム,東京
  • Year and Date: 2011-06-18
• [Presentation] 動脈管を制御する分子メカニズム (2011)
  • Author(s): 横山詩子
  • Organizer: 第8回RSV Japan Global Expert Meeting
  • Place of Presentation: 東京国際フォーラム(東京都)(招待講演)
  • Year and Date: 2011-06-18
• [Presentation] Regulation of vascular remodeling of the ductus arteriosus (2011)
  • Author(s): Yokoyama U, Minamisawa S, Ishikawa Y
  • Organizer: The 88th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: パシフィコ横浜,神奈川
  • Year and Date: 2011-03-29
• [Presentation] Epacl promotes vascular remodeling upon vascular injury in vivo. (2011)
  • Author(s): Kato Y, Yokoyama U, Okumura S, Minamisawa S, Sata M, Miyajima E, Ishikawa Y
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] Serum depletion and three-dimensional multilayer composition induce elastic fiber formation and a contractile phenotype of rat vascular smooth muscle cells. (2011)
  • Author(s): Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] Thromnoxane A2 Receptor Stimulation Specifically Causes Closure of the Rat Ductus Arteriosus. (2011)
  • Author(s): Aida T, Yokota T, Yokoyama U, Minamisawa S
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] Successful Isolation of Vascular Endothelial Cells from the Rat Ductus Arteriosus. (2011)
  • Author(s): Liu N, Yokota T, Maekawa S, Yokoyama U, Kato T, Minamisawa S.
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] Regulation of vascular remodeling of the ductus arteriosus. (2011)
  • Author(s): Yokoyama U, Minamisawa S, Ishika Y.
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 横浜、パシフィコ横浜(招待講演)
• [Presentation] 炎症性メディエーターによる血管弾性線維と細胞外基質の制御 (2010)
  • Author(s): 横山詩子
  • Organizer: 大阪大学明石研セミナー
  • Place of Presentation: 大阪大学,大阪
  • Year and Date: 2010-12-07
• [Presentation] 炎症性メディエーターによる血管弾性線維と細胞外基質の制御 (2010)
  • Author(s): 横山詩子
  • Organizer: 大阪大学明石研セミナー
  • Place of Presentation: 大阪、大阪大学(招待講演)
  • Year and Date: 2010-12-07
• [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly (2010)
  • Author(s): Yokoyama U, Shioda A, Kato Y, Asou T, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 84th Scientific Session, American Heart Association(AHA)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-11-16
• [Presentation] 動脈管閉鎖のメカニズム-from bench to bedside (2010)
  • Author(s): 横山詩子
  • Organizer: 第6回横浜小児先端医療セミナー
  • Place of Presentation: 横浜崎陽軒,神奈川
  • Year and Date: 2010-09-03
• [Presentation] 動脈管閉鎖のメカニズム-from bench to bedside (2010)
  • Author(s): 横山詩子
  • Organizer: 第6回横浜小児先端医療セミナー
  • Place of Presentation: 横浜、横浜崎陽軒(招待講演)
  • Year and Date: 2010-09-03
• [Presentation] 動脈管のリモデリングー酸素の役割 (2010)
  • Author(s): 横山詩子
  • Organizer: 小児心血管分子医学研究会
  • Place of Presentation: シェラトングランデ・トーキョーベイホテル,千葉
  • Year and Date: 2010-07-08
• [Presentation] 動脈管のリモデリング一酸素の役割 (2010)
  • Author(s): 横山詩子
  • Organizer: 小児心血管分子医学研究会
  • Place of Presentation: 千葉、シェラトングランデ・トーキョーベイホテル(招待講演)
  • Year and Date: 2010-07-08
• [Presentation] Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A (2010)
  • Author(s): 横山詩子
  • Organizer: 第52回日本平滑筋学会総会栗山煕賞受賞記念講演
  • Place of Presentation: 仙台市情報プラザアエル,宮城
  • Year and Date: 2010-07-01
• [Presentation] Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A. (2010)
  • Author(s): 横山詩子
  • Organizer: 第52回日本平滑筋学会総会 栗山煕賞受賞記念講演
  • Place of Presentation: 仙台、仙台市情報プラザアエル(招待講演)
  • Year and Date: 2010-07-01
• [Presentation] Epac1 plays a critical role in advancing vascular remodeling after mechanoinjury in vivo (2010)
  • Author(s): Kato Y, Yokoyama U, Okumura S, Sata M, Minamisawa S, Ishikawa Y
  • Organizer: The 74^<rd> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 国立京都国際会議場,京都
  • Year and Date: 2010-03-05
• [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus (2010)
  • Author(s): Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y
  • Organizer: The 16^<th> International Vascular Biology Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] Oxygenation Promotes Migration of Smooth Muscle Cell in the Rat Ductus Arteriosus (2010)
  • Author(s): Minamisawa S, Akaike T, Yokoyama U, Iwasaki S, Ishikawa Y.
  • Organizer: Developmental Vascular Biology Workshop IV
  • Place of Presentation: Monterey, California
• [Presentation] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus (2010)
  • Author(s): Yokoyama U, Minamisawa S, Katayama A, Tang T, Iwasaki S, Hammond HK, Ishikawa Y.
  • Organizer: Developmental Vascular Biology Workshop IV
  • Place of Presentation: Monterey, California
• [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly (2010)
  • Author(s): Shioda A, Yokoyama U, Kato Y, Asou T, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y.
  • Organizer: The 33^<th> Annual Meeting of the Molecular Biological Society of Japan
  • Place of Presentation: 神戸、神戸国際会議場
• [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly. (2010)
  • Author(s): Yokoyama U, Shioda A, Kato Y, Asou T, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y.
  • Organizer: The 84^<th> Scientific Session, American Heart Association(AHA)
  • Place of Presentation: Chicago, USA
• [Presentation] ラット動脈管閉鎖における低浸透圧センサーTransient Receptor Potential Melastatin 3(TRPM3)チャネルの役割 (2010)
  • Author(s): 青木理加、横山詩子、岩崎志穂、西巻滋、横田俊平、石川義弘
  • Organizer: 第55回未熟児新生児学会・学術集会
  • Place of Presentation: 神戸、神戸国際会議場
• [Presentation] ラット動脈管内膜肥厚におけるアデニル酸シクラーゼアイソフォームの役割の検討 (2010)
  • Author(s): 岩崎志穂、青木理加、西巻滋、横田俊平、南沢享、横山詩子
  • Organizer: 第46回日本周産新生児医学会
  • Place of Presentation: 神戸、神戸国際会議場
• [Presentation] A Role of Thromboxane A2 Receptor in the Rat Ductus Arteriosus as a Vasoconstrictor. (2010)
  • Author(s): Yokota T, Ozawa M, Yokoyama U, Minamisawa S
  • Organizer: The 16^<th> International Vascular Biology Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. (2010)
  • Author(s): Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y
  • Organizer: The 16^<th> International Vascular Biology Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] Epac1 plays a critical role in advancing vascular remodeling after mechanoinjury in vivo (2010)
  • Author(s): Kato Y, Yokoyama U, Okumura S, Sata M, Minamisawa S, Ishikawa Y
  • Organizer: The 74^<rd> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Kyoto
• [Presentation] Oxygenation from hypoxia to normoxia promotes smooth muscle cell migration in the rat ductus arteriosus (2009)
  • Author(s): 南沢享, 赤池徹, 横山詩子
  • Organizer: The 26^<th> Annual Meeting of the Japanese Section
  • Place of Presentation: Sapporo
  • Year and Date: 2009-12-05
• [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御 (2009)
  • Author(s): 横山詩子, 南沢享, 片山綾子, 塩田亜樹, 中邨智之, 杉本幸彦, 石川義弘
  • Organizer: 第5回神奈川小児循環器研究会
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-26
• [Presentation] 血管閉鎖を制御する因子の同定と新治療法開発 (2009)
  • Author(s): 南沢享, 横山詩子, 赤池徹, 横田知大, 小沢基
  • Organizer: 第1回成果報告シンポジウム「早稲田大学が目指す新しい医・理・工学融合研究の展開」
  • Place of Presentation: 東京
  • Year and Date: 2009-08-20
• [Presentation] T-type calcium channels regulate smooth muscle cell migration, neointimal formation, and oxygen-induced closure in rat ductus arteriosus (2009)
  • Author(s): 横田知大, 赤池徹, 小澤基, 横山詩子, 南沢享
  • Organizer: The 1^<st> International Symposium on Biomedical Science and Engineering Waseda University High-Tech Research Center
  • Place of Presentation: Tokyo
  • Year and Date: 2009-07-18
• [Presentation] Oxygenation Promotes Smooth Muscle Cell Migration in the Rat Ductus Arteriosus (2009)
  • Author(s): Minamisawa S, Akaike T, Yokoyama U, Ozawa M, Iwasaki S, Ishikawa Y
  • Organizer: BCVS Conference-Molecular Mechanisms of Cardiovascular Diseases
  • Place of Presentation: Nevada
• [Presentation] Oxygen Promoters Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus (2009)
  • Author(s): Ozawa M, Akaike T, Katayama A, Yokoyama U, Ishikawa Y, Minamisawa S
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Adenylyl Cyclase Type 2 and 6 Differentially Promote Vascular Tone and Remodeling in Ductus Arteriosus (2009)
  • Author(s): Katayama A, Yokoyama U, Tang T, Akaike T, Hammond HK, Minamisawa S, Ishikawa Y
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] 胎生後期ラット動脈管におけるTRPMチャネルの発現 (2009)
  • Author(s): 青木理加, 横山詩子, 片山綾子, 石川義弘, 南沢享
  • Organizer: 心臓血管発生研究会
  • Place of Presentation: 福島
• [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維(エラスチン)形成の制御 (2009)
  • Author(s): 塩田亜樹, 横山詩子, 片山綾子, 南沢享, 石川義弘
  • Organizer: 心臓血管発生研究会
  • Place of Presentation: 福島
• [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御 (2009)
  • Author(s): 横山詩子, 南沢享, 片山綾子, 塩田亜樹, 中邨智之, 杉本幸彦, 石川義弘
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
• [Presentation] ラット動脈管における6型アデニル酸シクラーゼの内膜肥厚形成作用 (2009)
  • Author(s): 片山綾子, 横山詩子, 赤池徹, 南沢享, 石川義弘
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
• [Presentation] ラット動脈管組織におけるTRPMチャネルの発現～発達段階での大動脈組織との比較検討～ (2009)
  • Author(s): 青木理加, 横山詩子, 片山綾子, 石川義弘, 南沢享
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
• [Presentation] ラット動脈管において酸素化は平滑筋細胞遊走を促進する (2009)
  • Author(s): 小澤基, 赤池徹, 横山詩子, 横田知大, 石川義弘, 南沢享
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
• [Presentation] 胎生後期ラット動脈管におけるTRPMチャネルの発現～大動脈組織との比較検討～ (2009)
  • Author(s): 青木理加, 横山詩子, 岩崎志穂, 西巻滋, 横田俊平, 石川義弘
  • Organizer: 第54回日本未熟児新生児学会・学術集会
  • Place of Presentation: 横浜
• [Presentation] 動脈管閉鎖の分子機序:プロスタグランジンの予期せぬ役割 Molecular Mechanisms of Closure of Dactus Arteriosus : Unexpected roles of prostaglandins (2009)
  • Author(s): 南沢享, 横山詩子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Remarks]
• [Remarks]
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• [Remarks]
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  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/index.html