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Identification and characterization of a novel endoplasmic reticulum molecule involved in cardiomyogenic differentiation and cardiac dysfunction

Research Project

Project/Area Number 21590937
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TAKAHASHI Tomosaburo  京都府立医科大学, 医学研究科, 客員講師 (20381973)

Co-Investigator(Kenkyū-buntansha) ISODONO Koji  京都府立医科大学, 医学研究科, 助教 (50515294)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心筋細胞 / PARM-1 / 心不全 / ERストレス / 心筋細胞分化 / アポトーシス
Research Abstract

We identified PARM-1 as a novel endoplasmic reticulum(ER)-localized protein whose expression was induced by ER stress. In cardiomyocytes, knockdown of PARM-1 increased ER stress-induced apoptosis. In P19CL6 cells, overexpression of PARM-1 increased expression of BMP and phosphorylation of Smad1/5/8, resulting in acceleration of cardiomyogenic differentiation. These results indicate that PARM-1 is an ER-localized protein which plays a protective role against ER stress in postnatal cardiomyocytes, and that PARM-1 promotes cardiomyogenic differentiation through regulating the BMP-Smad signaling pathway.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 15 results) Presentation (17 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Endothelial FGF receptor signaling accelerates atherosclerosis2011

    • Author(s)
      Che J, Okigaki M, Takahashi T, Katsume A, Adachi Y, Yamaguchi S, Matsunaga S, Takeda M, Matsui A, Kishita E, Ikeda K, Yamada H, Matsubara H
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 300 Issue: 1 Pages: 154-161

    • DOI

      10.1152/ajpheart.00075.2010

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes2010

    • Author(s)
      Isodono K, Takahashi T, Imoto H, Nakanishi N, Ogata T, Asada S, Adachi A, Ueyama T, Oh H, Matsubara H
    • Journal Title

      PLoS ONE

      Volume: 5 Issue: 3 Pages: e9746-e9746

    • DOI

      10.1371/journal.pone.0009746

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo2010

    • Author(s)
      Nakagawa Y, Ikeda K, Akakabe Y, Koide M, Uraoka M, Yutaka KT, Kurimoto-Nakano R, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30 Issue: 10 Pages: 1908-1915

    • DOI

      10.1161/atvbaha.110.206185

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow AT1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1α2010

    • Author(s)
      Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Kato T, Matsui A, Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M, Matsubara H
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30 Issue: 1 Pages: 60-67

    • DOI

      10.1161/atvbaha.109.192161

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PARM-1 is an Endoplasmic Reticulum Molecule Involved in Endoplasmic Reticulum Stress-induced Apoptosis in Rat Cardiac Myocytes2010

    • Author(s)
      Isodono K, et al.
    • Journal Title

      PLoS ONE

      Volume: 5 Pages: 9746-9746

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow AT1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1a2010

    • Author(s)
      Yokoi H
    • Journal Title

      Arterioscler Thromb Vase Biol. 30

      Pages: 60-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes2010

    • Author(s)
      Isodono K
    • Journal Title

      PLoS ONE 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition2009

    • Author(s)
      Nakano-Kurimoto R, Ikeda K, Uraoka M, Nakagawa Y, Yutaka K, Koide M, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 297 Issue: 5 Pages: 1673-1684

    • DOI

      10.1152/ajpheart.00455.2009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow angiotensin AT1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells2009

    • Author(s)
      Tsubakimoto Y, Yamada H, Yokoi H, Kishida S, Takata H, Kawahito H, Matsui A, Urao N, Nozawa Y, Hirai H, Imanishi J, Ashihara E, Maekawa T, Takahashi T, Okigaki M, Matsubara H
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 29 Issue: 10 Pages: 1529-1536

    • DOI

      10.1161/atvbaha.109.187732

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of Na^+transporters at the mRNA level in rat normal and hypertrophic myocardium2009

    • Author(s)
      Yamamoto T, Shirayama T, Takahashi T, Matsubara H
    • Journal Title

      Heart Vessels

      Volume: 24 Issue: 1 Pages: 54-62

    • DOI

      10.1007/s00380-008-1071-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system2009

    • Author(s)
      Uraoka M, Ikeda K, Nakagawa Y, Koide M, Akakabe Y, Nakano-Kurimoto R, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 390 Issue: 4 Pages: 1202-1207

    • DOI

      10.1016/j.bbrc.2009.10.121

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition2009

    • Author(s)
      Nakano-Kurimoto R
    • Journal Title

      Am J Physiol Heart Circ Physiol 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow angiotensin AT1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells2009

    • Author(s)
      Tsubakimoto Y
    • Journal Title

      Arterioscler Thromb Vasc Biol. 29

      Pages: 1529-1536

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of Na(+) transporters at the mRNA level in rat normal and hypertrophic myocardium2009

    • Author(s)
      Uraoka M
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 1202-1207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition2009

    • Author(s)
      Yamamoto T
    • Journal Title

      Heart Vessels 24

      Pages: 54-62

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【虚血性心疾患診断と治療の進歩】最近の話題心臓再生医療の現状と将来2009

    • Author(s)
      竹原有史
    • Journal Title

      日本内科学会雑誌 98

      Pages: 343-350

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 【幹細胞研究の新展開】心筋幹細胞の臨床応用の可能性cardiosphereによる心筋再生医療2009

    • Author(s)
      山口真一郎
    • Journal Title

      分子心血管病 10

      Pages: 40-47

    • Related Report
      2009 Annual Research Report
  • [Presentation] NFAT5 is essential for mesodermal and cardiomyogenic differentiation through regulating the canonical Wnt pathway2011

    • Author(s)
      Adachi A, Takahashi T, Imoto H, Nakanishi N, Kangawa H, Ueyama T, Matsubara H
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] NFAT5 is Essential for Mesodermal and Cardiomyogenic Differentiation through Regulating the Canonical Wnt Pathway2010

    • Author(s)
      Adachi A
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Serglycin, a Novel Adipokine Highly Expressed in Epicardial Adipose Tissue2010

    • Author(s)
      Imoto H
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] PARM-1, a Novel Transmembrane Molecule Involved in Endoplasmic Reticulum Stress-induced Apoptosis in Cardiac Myocytes2010

    • Author(s)
      Isodono K
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] MURC induces cardiomyocyte hypertrophy through the extracellular signal-regulated kinase pathway2010

    • Author(s)
      Naito D, Ogata T, Amano K, Taniguchi T, Isodono K, Adachi A, Imoto H, Nakanishi N, Kangawa H, Takahashi T, Ueyama T, Matsubara H
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism
    • Place of Presentation
      Nara, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Bone marrow angiotensin AT1 receptor regulates differentiation of Monocyte lineage progenitors from hematopoietic stem cells2010

    • Author(s)
      Yamada H, Tsubakimoto Y, Yokoi H, Kishida S, Kato T, Kawahito H, Hirai H, Ashihara E, Maekawa T, Ikeda K, Takahashi T, Okigaki M, Matsubara H
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism
    • Place of Presentation
      Nara, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Bone marrow AT1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1α2010

    • Author(s)
      Yamada H, Tsubakimoto Y, Yokoi H, Kishida S, Kato T, Kawahito H, Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M, Matsubara H
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism
    • Place of Presentation
      Nara, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] MURC, muscle-restricted coiled-coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes2010

    • Author(s)
      Taniguchi T, Ogata T, Naito D, Nakanishi N, Miyagawa K, Amano K, Isodono K, Imoto H, Tagawa M, Takehara N, Asada S, Adachi A, Morimoto T, Takahashi T, Oh H, Ueyama T, Matsubara H
    • Organizer
      American Heart Association(米国心臓病学術会議)
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] NFAT5 is essential for mesodermal and cardiomyogenic differentiation through regulating the canonical pathway2010

    • Author(s)
      Adachi A, Takahashi T, Imoto H, Nakanishi N, Kangawa H, Ueyama T, Matsubara H
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Serglycin, a novel adipokine highly expressed in epicardial adipose tissue2010

    • Author(s)
      Imoto H, Takahashi T, Adachi A, Nakanishi N, Kangawa H, Ueyama T, Matsubara H
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] PARM-1, a novel transmembrane molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes2010

    • Author(s)
      Isodono K, Takahashi T, Imoto H, Nakanishi N, Ogata T, Asada S, Adachi A, Kangawa H, Ueyama T, Matsubara H
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] MURC induces cardiomyocyte hypertrophy through the extracellular signal-regulated kinase pathway.2010

    • Author(s)
      Naito D, et al.
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] MURC, muscle-restricted coiled-coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes.2010

    • Author(s)
      Taniguchi T, et al.
    • Organizer
      American Heart Association
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] NFAT5 is essential for mesodermal and cardiomyogenic differentiation through regulating the canonical pathway.2010

    • Author(s)
      Adachi A, et al.
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serglycin, a novel adipokine highly expressed in epicardial adipose tissue.2010

    • Author(s)
      Imoto H, et al.
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] PARM-1, a novel transmembrane molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.2010

    • Author(s)
      Isodono K, et al.
    • Organizer
      第74回日本循環器学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] Downregulation of Dicer Expression by Serum Withdrawal Sensitizes Human Endothelial Cells to Apoptosis2009

    • Author(s)
      Asada S, Takahashi T, Isodono K, Imoto H, Adachi A, Ogata T, Ueyama T, Matsubara H, Oh H
    • Organizer
      第73回日本循環器学会総会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Book] 心筋前駆・幹細胞と臨床応用の可能性、循環器再生医学の現状と展望2011

    • Author(s)
      竹原有史, 高橋知三郎, 松原弘明
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 循環器再生医学の現状と展望2011

    • Author(s)
      竹原有史、高橋知三郎、松原弘明
    • Total Pages
      234
    • Publisher
      心筋前駆・幹細胞と臨床応用の可能性
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www2.kpu-m.ac.jp/~med2/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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