Research for heart failure by regulating mitochondrial energy metabolism with p53
Project/Area Number |
21590938
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
MATOBA Satoaki 京都府立医科大学, 医学研究科, 助教 (10305576)
|
Co-Investigator(Kenkyū-buntansha) |
KANAI Eri 明治国際医療大学, 医学教育研究センター, 教授 (20372584)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | p53 / 心不全 / ミトコンドリア / エネルギー代謝 / アポトーシス |
Research Abstract |
Ischemia or hyperglycemia induced p53, SCO2(Synthesis of cytochrome c oxidase 2) and TIGAR(TP53-induced glycolysis and apoptosis regulator) in the heart. We demonstrated diabetic condition induced SCO2, which promoted cardiac lipotoxicity(Circ Heart Fail. 2012). Ischemia induced p53 and TIGAR, which inhibited glycolysis(Am J Physiol Heart Circ Physiol. 2010) and mitophagy in the myocardium(J Mol Cell Cardiol. 2012). We also found that p53/TIGAR-mediated inhibition of myocyte mitophagy was responsible for ventricular remodeling after myocardial infarction.(J Mol Cell Cardiol 2012). SCO2 heterozygote mice were protective against diabetes induced cardiomyopathy. These data indicated that regulating energy metabolism will be a novel therapeutics for heart failure.
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia2012
Author(s)
Hoshino A, Matoba S, Iwai-Kanai E, Nakamura H, Kimata M, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Ueyama T, Okigaki M, Matsubara H
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Journal Title
J Mol Cell Cardiol
Volume: 52
Pages: 175-184
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[Journal Article] p53 promotes cardiac dysfunction in diabetic mellitus due to excessive mitochondrial respiration-mediated ROS generation and lipid accumulation2012
Author(s)
Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Okigaki M, Tanaka H, Takamatsu T, Matsubara H
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Journal Title
Circ Heart Fail
Volume: 5
Pages: 106-115
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[Journal Article] 15-deoxy-δprostaglandin j(2) reduces the formation of atherosclerotic lesions in apolipoprotein e knockout mice2011
Author(s)
Seno T, Hamaguchi M, Ashihara E, Kohno M, Ishino H, Yamamoto A, Kadoya M, Nakamura K, Murakami K, Matoba S, Maekawa T, Kawahito Y
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Journal Title
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[Journal Article] p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress2010
Author(s)
Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Okigaki M, Ikeda K, Tatsumi T, Matsubara H
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 299
Pages: 1908-1916
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[Presentation] Curcumin Protect Mice Heart against Doxorubicin Induced Cardiomyopathy thorough the Induction of Autophagy2012
Author(s)
Nakaoka M, Iwai-Kanai E, Matoba S, Mita Y, Kimata M, Nakamura H, Hoshino A, Katamura M, Okawa Y, Ariyoshi M, Adachi S, Matsubara H
Organizer
第76回日本循環器病学会
Place of Presentation
福岡
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[Presentation] p53 promotes cardiac dysfunction in diabetes mellitus by excessive mitochondrial respiration and Fat/CD36 upregulation2011
Author(s)
Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Ariyoshi M, Ikeda K, Okigaki M, Matsubara H
Organizer
米国心臓病学術会議
Place of Presentation
Orlando, USA
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[Presentation] p53-mediated acceleration of mitochondrial oxygen consumption promotes lipotoxicity via SCO2 in diabetic mice2010
Author(s)
Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Tatsumi T, Matsubara H
Organizer
American Heart Association(米国心臓病学術会議)
Place of Presentation
Chicago
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[Presentation] p53-mediated decrease in ROS signal reduces mitophagy via inactivation of Bnip3 to aggravate cardiac damage after ischemic injury2010
Author(s)
Hoshino A, Matoba S, Iwai-Kanai E, Kimata M, Nakamura H, Nakaoka M, Katamura M, Okawa Y, Mita Y, Tatsumi T, Matsubara H
Organizer
American Heart Association(米国心臓病学術会議)
Place of Presentation
Chicago, USA
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