| Project/Area Number |
21590941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | BDNF / 肥満 / 食事制限 / ストレス / アディポネクチン / 心臓 / 脳 / サイトカイン / BDFN / 心筋傷害 / 食餌制限 |
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| Research Abstract |
Brain-derived neurotrophic factor(BDNF), a member of the neurotrophin family of neurotrophic factors, has important functions in the peripheral and central nervous system of vertebrates. BDNF was originally isolated from the brain, but it is also expressed in the non-neural tissues. BDNF is expressed in cardiac muscle and may modulate cardiac function. Caloric restriction(CR) is beneficial for myocardial ischemia through BDNA signaling pathway. Moreover, CR in the obesity is improves myocardial damage and is closely related with the increase of hyppocampal BDNF mRNA. However, the relation between BDNF and heart disease is controversial. My data showed that cardiac and hyppocampal expression of BDNF can be induced by food restriction in obesity and that induced BDNF signaling can be beneficial in cardiac dysfunction. Moreover, physical activity became increased by CR after 3 months.
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