| Project/Area Number |
21590942
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
KOBARA Miyuki 京都薬科大学, 薬学部, 准教授 (80275198)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATOBA Satoaki 京都府立医科大学, 医学研究科, 助教 (10305576)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 心筋細胞 / ミトファジー / 心不全 / オートファジー / 活性酸素種 / ミトコンドリア品質管理 |
|---|
| Research Abstract |
Among heart failure-related factors, metabolic inhibition and angiotensin II induce mitophagy via mitochondrial superoxide production, and imatinib, a therapeutic agent for chronic mylogenous leukemia, also induce mitophagy. The inhibition of mitophagy/autophagy exacervates myocardial injury and cardiac dysfunction.
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