Analysis of activation mechanism of cardiac p300/GATA4 pathway during heart failure

• Project/Area Number: 21590944
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: University of Shizuoka
• Principal Investigator: MORIMOTO Tatsuya 静岡県立大学, 薬学部, 教授 (50390779)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心筋細胞肥大 / GATA4 / p300 / プロテオミクス / 転写因子 / クロマチンリモデリング因子 / Ini1 / ヒストンアセチルトランスフェラーゼ / Cdk9

Research Abstract

GATA4 forms a large complex with an intrinsic histone acetyltransferase, p300 and these factors are involved in transcriptional regulation during myocardial cell hypertrophy. Moreover, noble p300/GATA4 binding partners, Cdk9, Iin1, RbAp48, and RbAp46 form a functional complex with p300/GATA4 and suppress hypertrophic responses in cardiomyocytes.

Research Products

• [Journal Article] α1-Antitrypsin Low-Density-Lipoprotein Serves as a Marker of Smoking-Specific Oxidative Stress (2012)
  • Author(s): Hiromichi Wada
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 19 Issue: 1 Pages: 47-58
  • DOI: 10.5551/jat.9035
  • NAID: 130004721902
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes (2011)
  • Author(s): Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K
  • Journal Title: J Cell Physiol Volume: 226(1) Pages: 248-54
• [Journal Article] A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin converting enzyme inhibitor exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats (2011)
  • Author(s): Sunagawa Y, Morimoto T, Wada H, Takaya T, Katanasaka Y, Kawamura T, Yanagi S, Marui A, Sakata R, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K
  • Journal Title: Circ J Volume: 75(9) Pages: 2151-9
  • NAID: 10029339526
• [Journal Article] Innovative preparation of curcumin for Improved oral bioavailability (2011)
  • Author(s): Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya K, Fujita M, Hasegawa K, Morimoto T
  • Journal Title: Biol Pharm Bull Volume: 34(5) Pages: 660-5
  • NAID: 130000657776
• [Journal Article] Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes (2011)
  • Author(s): Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K
  • Journal Title: Journal of Cellular Physiology Volume: 226 Issue: 1 Pages: 248-254
  • DOI: 10.1002/jcp.22336
  • Peer Reviewed
• [Journal Article] Distinct characteristics of circulating vascular endothelial growth factor-A and C levels in human subjects (2011)
  • Author(s): Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K.
  • Journal Title: Pros ONE Volume: 6 Issue: 12 Pages: 29351-29351
  • DOI: 10.1371/journal.pone.0029351
  • Peer Reviewed
• [Journal Article] A Natural p300-Specific Histone Acetyltransferase Inhibitor, Curcumin, in Addition to Angiotensin-Converting Enzyme Inhibitor, Exerts Beneficial Effects on Left Ventricular Systolic Function After Myocardial Infarction in Rats (2011)
  • Author(s): Yoichi sunagawa
  • Journal Title: Circulation Journal Volume: 75 Issue: 9 Pages: 2151-2159
  • DOI: 10.1253/circj.CJ-10-1072
  • NAID: 10029339526
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Innovative Preparation of Curcumin for Improved Oral Bioavailability (2011)
  • Author(s): Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, atanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 34 Issue: 5 Pages: 660-665
  • DOI: 10.1248/bpb.34.660
  • NAID: 130000657776
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Cyclin-dependent kinsase-9 is a component of p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes (2010)
  • Author(s): Sunagawa Y, Morimoto T, Takaya T, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K
  • Journal Title: J Biol Chem Volume: 285(13) Pages: 9556-68
• [Journal Article] Aldosterone Signaling Associates with p300/GATA4 Transcriptional Pathway during Hypertrophic Responses in Cardiomyocytes (2010)
  • Author(s): Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K
  • Journal Title: Circ J Volume: 74(1) Pages: 156-62
  • NAID: 10025941604
• [Journal Article] Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts (2010)
  • Author(s): Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K
  • Journal Title: Circ J Volume: 74(4) Pages: 723-9
  • NAID: 10026472482
• [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice (2010)
  • Author(s): Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Yamanaka S, Nakahata T, Heike T
  • Journal Title: Cardiovasc Res Volume: 88(2) Pages: 314-23
• [Journal Article] Excessive apoptosis as a downstream molecular event during the development of congenital heart diseases (2010)
  • Author(s): Kaichi S, Hasegawa K, Morimoto T
  • Journal Title: Circ J Volume: 74(11) Pages: 2297-8
  • NAID: 10026972554
• [Journal Article] Hasegawa K Novel heart failure therapy targeting transcriptional pathway in cardiomyocytes by a natural compound, curcumin (2010)
  • Author(s): Morimoto T, Sunagawa Y, Fujita M
  • Journal Title: Circ J Volume: 74(6) Pages: 1059-66
• [Journal Article] Cyclin-dependent kinase-9 is a component of p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. (2010)
  • Author(s): Yoichi Sunagawa
  • Journal Title: The Journal of Biological Chemistry Volume: 285 Pages: 9556-9568
  • Peer Reviewed
• [Journal Article] Aldosterone Signaling Associates with p300/GATA4 Transcriptional Pathway during Hypertrophic Responses in Cardiomyocytes. (2010)
  • Author(s): Yoshinori Yoshida
  • Journal Title: Circulation Journal Volume: 74 Pages: 156-162
  • Peer Reviewed
• [Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. (2010)
  • Author(s): Hiromichi Wada
  • Journal Title: Atherosclerosis Volume: 208 Pages: 512-517
  • Peer Reviewed
• [Journal Article] Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts. (2010)
  • Author(s): Tomohide Takaya
  • Journal Title: Circulation Journal Volume: 74 Pages: 723-729
  • Peer Reviewed
• [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. (2010)
  • Author(s): Sinji Kaichi
  • Journal Title: Cardiovascular Research Volume: 88 Pages: 314-323
  • Peer Reviewed
• [Journal Article] Excessive apoptosis as a downstream molecular event during the development of congenital heart diseases. (2010)
  • Author(s): Sinji Kaichi
  • Journal Title: Circulation Journal Volume: 74 Pages: 2297-2298
  • Peer Reviewed
• [Journal Article] Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy. (2010)
  • Author(s): Hiromichi Wada
  • Journal Title: Heart Vessels Volume: 25 Pages: 45-50
  • Peer Reviewed
• [Journal Article] JCAD Study Investigators. Treatment effects of renin-angiotensin system inhibitor and calcium channel blocker in patients with coronary artery narrowing (from the Japanese Coronary Artery Disease Study). (2010)
  • Author(s): Masatoshi Fujita
  • Journal Title: Heart Vessels Volume: 25 Pages: 453-459
  • Peer Reviewed
• [Journal Article] Novel heart failure therapy targeting transcriptional pathway in cardiomyocytes by a natural compound, curcumin. (2010)
  • Author(s): Tatsuya Morimoto
  • Journal Title: Circulation Journal Volume: 74 Pages: 1059-1066
  • NAID: 10026474264
  • Peer Reviewed
• [Journal Article] 心不全進展増悪における心筋細胞核のアセチル化調節機構 (2010)
  • Author(s): 長谷川浩二
  • Journal Title: BIO Clinica Volume: 25(2) Pages: 84-89
• [Journal Article] 天然成分クルクミンによる新規心不全治療 (2010)
  • Author(s): 森本達也
  • Journal Title: BIO Clinica Volume: 25(3) Pages: 78-53
• [Journal Article] カレーに含まれるクルクミンの作用とその機序 (2010)
  • Author(s): 森本達也
  • Journal Title: 循環器科 Volume: Vol.67, No.2 Pages: 208-215
• [Journal Article] クルクミンによる心機能改善効果の研究 (2010)
  • Author(s): 森本達也
  • Journal Title: Anti-aging Science Volume: Vol.2, No.1 Pages: 67-71
• [Journal Article] Cyclin-dependent kinsase-9 is a component of p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes (2010)
  • Author(s): Yoichi Sunagawa
  • Journal Title: The Journal of Biological Chemistry 285 Pages: 9556-9568
  • Peer Reviewed
• [Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance (2010)
  • Author(s): Hiromichi Wada
  • Journal Title: Atherosclerosis 208 Pages: 512-517
  • Peer Reviewed
• [Journal Article] Aldosterone Signaling Associates with p300/GATA4 Transcriptional Pathway during Hypertrophic Responses in Cardiomyocytes (2010)
  • Author(s): Yoshinori Yoshida
  • Journal Title: Circulation Journal 74 Pages: 156-162
  • Peer Reviewed
• [Journal Article] Transmitral E/A ratio decreases in association with abdominal fataccumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy (2010)
  • Author(s): Hiromichi Wada
  • Journal Title: Heart Vessels 25 Pages: 45-50
  • Peer Reviewed
• [Journal Article] Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts (2010)
  • Author(s): Tomohide Takaya
  • Journal Title: Circulation Journal 25 Pages: 723-729
  • Peer Reviewed
• [Journal Article] 心不全進展増悪における心筋細胞核のアセチル化調節機構 (2010)
  • Author(s): 長谷川浩二
  • Journal Title: BIO Clinica 25(2) Pages: 84-89
• [Journal Article] カレーに含まれるクルクミンの作用とその機序 (2010)
  • Author(s): 森本達也
  • Journal Title: 循環器科 Vol.67 No.2 Pages: 208-215
• [Journal Article] クルクミンによる心機能改善効果の研究 (2010)
  • Author(s): 森本達也
  • Journal Title: Anti-aging Science Vol.2 No1 Pages: 67-71
• [Journal Article] MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells (2009)
  • Author(s): Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K
  • Journal Title: Circ J Volume: 73(8) Pages: 1397-8
  • NAID: 10025933876
• [Journal Article] MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells (2009)
  • Author(s): Tomohide Takaya
  • Journal Title: Circulation Journal 73 Pages: 1397-1398
  • Peer Reviewed
• [Journal Article] カレーの成分の一つクルクミンの心臓に対する新しい作用 (2009)
  • Author(s): 森本達也
  • Journal Title: Medical View Point Vol.30 No.4 Pages: 2-2
• [Journal Article] クルクミンによる新しい心不全治療 (2009)
  • Author(s): 森本達也
  • Journal Title: 医学のあゆみ 229 No8 Pages: 646-647
• [Journal Article] 甲状腺機能異常症と循環器疾患―不整脈・心不全 (2009)
  • Author(s): 森本達也
  • Journal Title: 綜合臨床(特集 甲状腺疾患をマスターすう) Vol.58 No7 Pages: 1577-1582
• [Journal Article] 心不全の分子標的療法の開発 (2009)
  • Author(s): 森本達也
  • Journal Title: News letter(日本心不全学会) Vol.13 No2 Pages: 10-11
• [Journal Article] 天然成分クルクミンによる新規心不全治療 (2009)
  • Author(s): 森本達也
  • Journal Title: BIO Clinica 25(3) Pages: 81-87
• [Presentation] Human SNF5/INI1, a Component of the Human SWI/SNF Chromatin Remodeling Complex, Inhibits Hypertrophic Responses by Suppressing p300/GATA4-dependent Pathways in Cardiomyocytes (2012)
  • Author(s): Yoichi Sunagawa, Yukihiro Ishibashi, Natsumi Banno, Yasufumi Katanasaka, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-17
• [Presentation] Retinoblastoma Protein (Rb)-associated Protein 48 and 46, Novel p300/GATA4-binding Partners, Inhibits Hypertrophic Responses in Cardiomyocytes (2012)
  • Author(s): Yoichi Sunagawa, Yuichi Watanabe, Hidetoshi Suzuki, Yasufumi Katanasaka, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-17
• [Presentation] Transducin Beta-like Protein 1 Suppresses Hypertrophic Responses Through Repression of p300/GATA4 Pathway in Cardiomyocytes (2012)
  • Author(s): Masatoshi Namiki, Yasufumi Katanasaka, Yoichi Sunagawa, Hidetoshi Suzuki, Sho Hirota, Yukiko Nakagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Receptor for Activated Protein Kinase C1 is a novel component of p300/GATA4 complex and required for hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Hidetoshi Suzuki, Yoichi Sunagawa, Yasufumi Katanasaka, Nobuko Okamura, Taishi Terada, Masatoshi Namiki, Yukiko Nakagawa, Akihisa Sugimoto, Hiromichi Wada, Akira Shimatsu, Takeshi Kimura, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: 第28回国際心臓研究学会(ISHR)日本部会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-02
• [Presentation] Transducin beta-like protein 1 suppresses p300/GATA4-induced hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Masatoshi Namiki, Yasufumi Katanasaka, Yoichi Sunagawa, Hidetoshi Suzuki, Sho Hirota, Taishi Terada, Yukiko Nakagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: 第28回国際心臓研究学会(ISHR)日本部会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-02
• [Presentation] SNF5/INI1 Inhibits Hypertrophic Responses by Suppressing p300/GATA4-dependent Pathways in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Sugimoto Akihisa, Yukihiro Ishibashi, Yasufumi Katanasaka, Hiromichi Wada, Akira Shimatsu, Takeshi Kimura, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-11-15
• [Presentation] Retinoblastoma Protein (Rb)-associated Protein 48 and 46 Form a Functional Complex With p300/GATA4 and Suppress Hypertrophic Responses in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-11-15
• [Presentation] Protein Arginine Methyltransferase 5 and Methylosome Protein 50 Suppressies Hypertrophic Responses in Cardiomyocytes by Inhibition of p300/GATA4 Pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-11-13
• [Presentation] A P300/GATA4 transcriptional pathway that induces the development of heart failure (2011)
  • Author(s): Tatsuya Morimoto, Koji Hasegawa
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-15
• [Presentation] Protein arginine ethyltransferase 5 suppresses hypertrophic gene transcription in rat cardiomyocytes through the inhibition of P300/GATA4 pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-15
• [Presentation] Retinoblastoma protein (Rb)-associated protein 48 and 46 are novel p300/GATA4-binding partners involved in hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: 第15回日本心不全学会学術集会会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-10-14
• [Presentation] Retinoblastoma protein (Rb)-associated protein 48 and 46 are novel p300/GATA4-binding partners involved in hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association BCVS2011
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2011-07-20
• [Presentation] Retinoblastoma protein (Rb)-associated protein 48 and 46 are novel components of p300/GATA4 complex required for hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 14 th Annual International Tronto Heart Summit
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2011-06-09
• [Presentation] Protein arginine metyltransferase 5 and methylosome protein 50 are novel component of P300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Masatoshi Fujita, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 14 th Annual International Tronto Heart Summit
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2011-06-09
• [Presentation] 新しい心不全分子標的治療 (2011)
  • Author(s): 森本達也、長谷川浩二
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] 心筋細胞肥大におけるp300/GATA4経路に対するIni1の役割 (2011)
  • Author(s): 杉本明央
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] Retinoblastoma Protein(Rb)-associated Protein 48 and 46 are Novel Components of p300/GATA4 Complex Required for Hypertrophic Responses in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 14th Annual International Tronto Heart Summit
  • Place of Presentation: Tronto, Canada
• [Presentation] Protein arginine metyltransferase 5 and methylosome protein 50 are novel component of p300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Masatoshi Fujita, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 14th Annual International Tronto Heart Summit
  • Place of Presentation: Tronto, Canada
• [Presentation] Retinoblastoma protein(Rb)-associated protein 48 and 46 are novel p300/GATA4-binding partners involved in hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association BCVS2011
  • Place of Presentation: New Orleans, USA
• [Presentation] Protein arginine metyltransferase 5 and methylosome protein 50 are novel component of p300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association BCVS2011
  • Place of Presentation: New Orleans, USA
• [Presentation] A p300/GATA4 Transcriptional Pathway that Induces the Development of Heart Failure (2011)
  • Author(s): Tatsuya Morimoto, Koji Hasegawa
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
• [Presentation] Transducin beta-like protein 1 inhibits hypertrophic responses by recruiting HDAC3 to p300/GATA4 pathways (2011)
  • Author(s): Masatoshi Namiki, Yasufumi Katanasaka, Yoichi Sunagawa, Hidetoshi Suzuki, Sho Hirota, Taishi Terada, Yukiko Nakagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
• [Presentation] Receptor for activated protein kinase C1 is a novel component of p300/GATA4 complex and suppresses hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Hidetoshi Suzuki, Yoichi Sunagawa, Yasufumi Katanasaka, Nobuko Okamura, Taishi Terada, Masatoshi Namiki, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
• [Presentation] Protein arginine ethyltransferase 5 suppresses hypertrophic gene transcription in rat cardiomyocytes through the inhibition of p300/GATA4 pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
• [Presentation] Protein Arginine Methyltransferase 5 and Methylosome Protein 50 Suppressies Hypertrophic Responses in Cardiomyocytes by Inhibition of p300/GATA4 Pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
• [Presentation] SNF5/INI1 Inhibits Hypertrophic Responses by Suppressing p300/GATA4-dependent Pathways in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Sugimoto Akihisa, Yukihiro Ishibashi, Yasufumi Katanasaka, Hiromichi Wada, Akira Shimatsu, Takeshi Kimura, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
• [Presentation] Retinoblastoma Protein(Rb)-associated Protein 48 and 46 Form a Functional Complex With p300/GATA4 and Suppress Hypertrophic Responses in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
• [Presentation] 心筋細胞肥大におけるp300/GATA4経路に対するIni1の役割 (2010)
  • Author(s): 石橋幸大
  • Organizer: 第20回日本病院薬剤師会東海ブロック学術大会・平成22年度日本薬学会東海支部例会
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-28
• [Presentation] p300/GATA4経路に対するIni1の機能 (2010)
  • Author(s): 杉本明央
  • Organizer: 第56回 日本薬学会東海支部 総会・大会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-03
• [Presentation] HDAC阻害剤(Trichostatin A)は、 Ini1によるp300/GATA4経路活性化による心筋細胞肥大抑制効果を回復しなかった (2010)
  • Author(s): 杉本明央
  • Organizer: 第122回日本薬理学会関東部会
  • Place of Presentation: 静岡
  • Year and Date: 2010-06-05
• [Presentation] 心筋細胞肥大におけるp300/GATA4経路に対するIni1の役割 (2010)
  • Author(s): 杉本明央
  • Organizer: 第10回抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] SNF5/INI1はp300/GATA4経路による心筋細胞肥大を抑制する (2010)
  • Author(s): 杉本明央
  • Organizer: 第14回日本心不全学会学術集会
  • Place of Presentation: 東京
• [Presentation] 心筋梗塞後の心不全に対するクルクミンとACE阻害薬の効果の比較検討 (2009)
  • Author(s): 桑原正和
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 津
  • Year and Date: 2009-11-23
• [Presentation] Cdk9阻害によりp300/GATA4経路活性による心筋肥大を抑制する (2009)
  • Author(s): 寺田太士
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 津
  • Year and Date: 2009-11-23
• [Presentation] 新規GATA4結合タンパク質であるCdk9はGATA4を介して心筋細胞肥大反応遺伝子のプロモーター上にリクルートされる (2009)
  • Author(s): 砂川陽一
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 津
  • Year and Date: 2009-11-23
• [Presentation] Curcumin, a Natural p300-specific Histone Acetyltransferase Inhibitor, Prevents the Development of Hypertension-induced Left Ventricular Hypertrophy in Rats (2009)
  • Author(s): Hidetoshi Suzuki
  • Organizer: 第13回 日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-30
• [Presentation] Curcumin exerts synergistic effects with ACE inhibitor during systolic function restoration after myocardial infarction in rats (2009)
  • Author(s): Shogo Kawaguchi
  • Organizer: 第13回 日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-30
• [Presentation] Novel Oral Curcumin Drug-delivery System Improves the Deterioration of Systolic Function after Rat Myocardial Infarction (2009)
  • Author(s): 砂川陽一
  • Organizer: 第13回 日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-30
• [Presentation] A Natural p300-specific HAT Inhibitor, Curcumin, Possesses Beneficial Effects in Addition to ACE Inhibitor after Rat Myocardial Infarction (2009)
  • Author(s): Tatsuya Morimoto, Yoichi Sunagawa, Hiromichi Wada, Tomohide Takaya, Shigeki Yanagi, Akihiro Sugimoto, Masaki Tsukashita, Akira Marui, Tadashi Ikeda, Masatoshi Fujita, Akira Shimatsu, Toru KitaKoji Hasegawa
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: Kyoto, Japan
• [Presentation] A natural p300-specific histone acetyltransferase inhibitor, Curcumin, can prevent the development of heart failure in addition to ACE inhibitor after myocardial infarction in rats (2009)
  • Author(s): Tatsuya Morimoto, Masatoshi Fujita, Yoichi Sunagawa, Hiromichi Wada, Tomohide Takaya, Shigeki Yanagi, Akira Marui, Tadashi Ikeda, Akira ShimatsuKoji Hasegawa
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Barcelona, Spain
• [Presentation] Curcumin exerts synergistic effects with ACE inhibitor during LV systolic function restoration after rat myocardial infarction (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Tomohide Takaya, Masatoshi Fujita, Takeshi KimuraKoji Hasegawa
  • Organizer: The 5th China-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
• [Presentation] Cdk9 kinase activity is required for p300 phosphorylation and regulate transcriptional pathway during hypertrophic responses in cardiomyocytes (2009)
  • Author(s): Taishi Terada, Tatsuya Morimoto, Yoichi Sunagawa, Masatoshi Fujita, Takeshi KimuraKoji Hasegawa
  • Organizer: The 5th China-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
• [Presentation] A natural p300-specific histone acetyltransferase inhibitor, curcumin, exerts synergistic effects with ACE inhibitor during systolic function restoration after myocardial infarction in rats (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Hiromichi Wada, Tomohide Takaya, Teruhisa Kawamura, Shigeki Yanagi, Akira Marui, Tadashi Ikeda, Ryuzo Sakata, Akira Shimatsu, Takeshi Kimura, Masatoshi FujitaKoji Hasegawa
  • Organizer: The 82th American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Novel drug-delivery system of oral curcumin that prevents the deterioration of systolic function after myocardial infarction in rats (2009)
  • Author(s): Yoichi Sunagawa, Hiroyuki Fukuda, Hiromichi Wada, Tomohide Takaya, Akira Marui, Kazuhide Uemura, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 82th American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Curcumin Prevents the Development of Hypertension-induced Left Ventricular Hypertrophy in Rats (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Teruhisa Kawamura, Tomohide Takaya, Hiromichi Wada, Kazuhide Uemura, Akira Shimatsu, Takeshi Kimura, Masatoshi FujitaKoji Hasegawa
  • Organizer: The 82th American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Heart f ailure therapy that targets nuclear signaling pathway in cardiomyocytes. from bench to bedside (2009)
  • Author(s): Tatsuya MorimotoKoji Hasegawa
  • Organizer: The 25th Annual Meeting of ISHR Japanese Section, Scientific Program
  • Place of Presentation: Sapporo, Japan
• [Presentation] A novel component of p300/GATA4 complex, Cyclin-dependent kinsase-9, is required for hypertrophic responses in cardiomyocytes (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Masatoshi FujitaKoji Hasegawa
  • Organizer: The 25th Annual Meeting of ISHR Japanese Section Scientific Program
  • Place of Presentation: Sapporo, Japan
• [Presentation] A Natural p300-specific HAT Inhibitor, Curcumin, Possesses Beneficial Effects in Addition to ACE Inhibitor after Rat Myocardial Infarction (2009)
  • Author(s): 森本達也
  • Organizer: 17^<th> Asian Pacific Congress of Cardiology(APCC)
  • Place of Presentation: Kyoto, Japan
• [Presentation] A natural p300-specific histone acetyltransferase inhibitor, Curcumin, can prevent the development of heart failure in addition to ACE inhibitor after myocardial infarction in rats (2009)
  • Author(s): 森本達也
  • Organizer: European Society of Cardiology(ESC)Congress
  • Place of Presentation: Barcelona, Spain
• [Presentation] Curcumin exerts synergistic effects with ACE inhibitor during LV systolic function restoration after rat myocardial infarction (2009)
  • Author(s): 砂川陽一
  • Organizer: The 5th China-Japan Cardiovascular Forum(CJCF)
  • Place of Presentation: Beijing, China
• [Presentation] Cdk9 kinase activity is required for p300 phosphorylation and regulate transcriptional pathway during hypertrophic responses in cardiomyocytes (2009)
  • Author(s): 寺田太士
  • Organizer: The 5th China-Japan Cardiovascular Forum(CJCF)
  • Place of Presentation: Beijing, China
• [Presentation] A natural p300-specific histone acetyltransferase inhibitor, curcumin, exerts synergistic effects with ACE inhibitor during systolic function restoration after myocardial infarction in rats (2009)
  • Author(s): 砂川陽一
  • Organizer: The 82^<th> American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Novel drug-delivery system of oral curcumin that prevents the deterioration of systolic function after myocardial infarction in rats (2009)
  • Author(s): 砂川陽一
  • Organizer: The 82^<th> American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Curcumin Prevents the Development of Hypertension-induced Left Ventricular Hypertrophy in Rats (2009)
  • Author(s): 砂川陽一
  • Organizer: The 82^<th> American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Heart failure therapy that targets nuclear signaling pathway in cardio myocytes- from bench to bedside (2009)
  • Author(s): 森本達也
  • Organizer: The 26th Annual Meeting of ISHR Japanese Section
  • Place of Presentation: Sapporo, Japan
• [Presentation] Cyclin-dependent kinsase-9, is required for hypertrophic responses in cardiomyocytes (2009)
  • Author(s): 砂川陽一
  • Organizer: The 26th Annual Meeting of ISHR Japanese Section
  • Place of Presentation: Sapporo, Japan
• [Presentation] 心筋細胞においてCdk9はGATA4を介して肥大反応遺伝子プロモーターにリクルートされる (2009)
  • Author(s): 砂川陽一
  • Organizer: 第46回日本臨床分子医学会
  • Place of Presentation: 東京
• [Presentation] 天然クルクミン2g/日は、有効な血中クルクミン濃度となる (2009)
  • Author(s): 森本達也
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
• [Presentation] Cdk9はGATA4を介して肥大反応遺伝子プロモーターにリクルートされる (2009)
  • Author(s): 砂川陽一
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
• [Presentation] Cdk9阻害はp300/GATA4経路活性化による心筋細胞肥大を抑制する (2009)
  • Author(s): 寺田太士
  • Organizer: 第13回 Molecular Cardiovascular Conference
  • Place of Presentation: 北海道
• [Remarks]