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Role of splicing variants in heart failure

Research Project

Project/Area Number 21590945
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

ASAKURA Masanori  独立行政法人国立循環器病研究センター, 臨床研究部, 室長 (80443505)

Co-Investigator(Kenkyū-buntansha) KITAKAZE Masafumi  独立行政法人国立循環器病研究センター, 臨床研究部, 部長 (20294069)
Co-Investigator(Renkei-kenkyūsha) ASANUMA Hiroshi  京都府立医科大学, 大学院・医学研究科循環器内科学, 准教授 (20416217)
TAKASHIMA Seiji  大阪大学, 大学院・医学系研究科分子心血管医学, 特任准教授 (90379272)
MINAMINO Tetsuo  大阪大学, 大学院・医学系研究科循環器内科学, 講師 (30379234)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords循環器・高血圧 / マイクロアレイ / 遺伝子 / 心不全 / スプライシング
Research Abstract

Number of patients with chronic heart failure is increasing in Japan. It is important to detect novel targets for heart failure. Alternative splicing is known to play important roles in the regulations of several diseases such as cancer and neurodegenerative diseases. However, the role of alternative splicing in the pathogenesis of heart failure remains unclear. In this study, we analyzed global expression levels of splicing variants in heart failure using exon arrays. We identified 46 genes with significant changes in splicing pattern but without changes in expression level. Out of 46 candidate genes responsible for heart failure, we narrowed our focus to Mtus1 gene. Our functional analyses revealed that Mtus1A variant is a novel inhibitory factor for cardiac hypertrophy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Identification of Genes related to Heart Failure Using Global Gene Expression Profiling of Human Failing Myocardium2010

    • Author(s)
      Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamasaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 393(1) Pages: 55-60

    • Related Report
      2011 Final Research Report
  • [Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.2010

    • Author(s)
      Sawada T, et al.
    • Journal Title

      J Mol Cell Cardiol.

      Volume: 48 Pages: 1280-1289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A histamine H(2) receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.2010

    • Author(s)
      Takahama H, et al.
    • Journal Title

      Basic Res Cardiol.

      Volume: 105 Pages: 787-794

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Genes related to Heart Failure Using Global Gene Expression Profiling of Human Failing Myocardium.2010

    • Author(s)
      Min KD., et al.
    • Journal Title

      Biochem Biophys Res Commun. 393

      Pages: 55-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global gene expression profiling in the failing myocardium.2009

    • Author(s)
      Asakura M., et al.
    • Journal Title

      Circ J. 73

      Pages: 1568-1576

    • NAID

      10025934403

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metformin Prevents Progression of Heart Failure in Dogs ; Roles of AMP-activated Protein Kinase.2009

    • Author(s)
      Sasaki H., et al.
    • Journal Title

      Circulation 119

      Pages: 2568-2577

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] A Novel approach using exon array technique identifies Mtus1 as a new heart failure-related gene2011

    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] A Novel approach using exon array technique identifies Mtusl as a new heart failure-related gene2011

    • Author(s)
      Ito S., et al
    • Organizer
      European Society of Cardiology Congress 2011
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-08-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋症および重症心不全における遺伝子プロファイルの研究2010

    • Author(s)
      朝倉正紀
    • Organizer
      第14回日本心不全学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Book] 拡張型心筋症「心不全」2010

    • Author(s)
      朝倉正紀, ほか
    • Total Pages
      5
    • Publisher
      羊土社(所収)
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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