Therapeutic angiogenesis using adipose-derived regenerative cells

• Project/Area Number: 21590951
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya University
• Principal Investigator: SHINTANI Satoshi 名古屋大学, 大学院・医学系研究科, 講師 (20309777)
• Co-Investigator(Kenkyū-buntansha): MUROHARA Toyoaki 名古屋大学, 大学院・医学系研究科, 教授 (90299503)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 血管新生療法 / 脂肪由来間葉系前駆細胞 / リンパ管新生 / マクロファージ / 脂肪組織由来間葉系前駆細胞 / セリューションシステム / ヒト幹細胞臨床研究 / 血管新生 / 組織浮腫

Research Abstract

It has been known that adipose-derived regenerative cells(ADRCs) secrete multiple angiogenic growth factors. We reported that ADRCs implantation improve severe ischemia and seems to be a useful strategy of therapeutic angiogenesis. Next, we focused on VEGF-C that ADRCs released. ADRCs therapy increased lymphatic capillary density and significantly reduced tissue edema. We consider that BM derived M2 macrophages plays an important role in postnatal lymphangiogenesis.

Research Products

• [Journal Article] ヒト皮下脂肪組織由来間葉系前駆細胞を用いた重症虚血肢に対する血管新生療法の試み:特集:血管・心筋再生はどこまできたか[治す]PADに対する再生治療Heart Veiw (2011)
  • Author(s): 新谷理
  • Journal Title: CARDIAC PRACTICE Volume: Vol15 No.8 Pages: 90-96
• [Journal Article] ヒト皮下脂肪組織由来間葉系前駆細胞を用いた重症虚血肢に対する血管新生療法の試み (2011)
  • Author(s): 新谷理
  • Journal Title: [治す]PADに対する再生治療 Volume: 15 Pages: 90-96
• [Journal Article] Impact of as ingle intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pigmodel (2010)
  • Author(s): Kondo K, Shibata R, Unno K, Shimano M, Ishii M, Kitoh T, Shintani S, Walsh K, Ouchi N, Murohara T.
  • Journal Title: Circ Cardiovasc Interv Volume: 3(2) Pages: 166-173
  • Peer Reviewed
• [Journal Article] 血管再生療法は重症虚血肢を救えるか:CARDIAC PRACTICE (2010)
  • Author(s): 室原豊明, 新谷理, 小椋康弘, 清水優樹
  • Journal Title: CARDIAC PRACTICE Volume: Vol.21No.2 Pages: 27-34
• [Journal Article] Evidence for the the rapeuticpotential of ex vivo expanded humane do the lial progenitor cells using autologous serum (2010)
  • Author(s): Shumiya T, Shibata R, Shimizu Y, Ishii M, Kubota R, Shintani S, Murohara T.
  • Journal Title: Circ J Volume: 74(5) Pages: 1006-1013
  • Peer Reviewed
• [Journal Article] Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. (2010)
  • Author(s): Asano H
  • Journal Title: Diabetologia Volume: 53 Pages: 234-246
  • Peer Reviewed
• [Journal Article] Evidence for the therapeutic potential of ex vivo expanded human endothelial progenitor cells using autologous serum. (2010)
  • Author(s): Shumiya T
  • Journal Title: Circ J. Volume: 74 Pages: 1006-1013
  • Peer Reviewed
• [Journal Article] Impact of a single intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pig model. (2010)
  • Author(s): Kondo K
  • Journal Title: Circ Cardiovasc Interv. Volume: 3 Pages: 166-173
  • Peer Reviewed
• [Journal Article] Rationale and design of the NAGOYA HEART Study : Comparison between valsartan and amlodipine regarding morbidity and mortality in patients with hypertension and glucose intolerance. (2010)
  • Author(s): Matsushita K
  • Journal Title: J.Cardiol. Volume: 56 Pages: 111-117
  • Peer Reviewed
• [Journal Article] The number and function of circulating CD34+CD133+ progenitor cells decreased in stable coronary artery disease but not in acute myocardial infarction. (2010)
  • Author(s): Kondo T
  • Journal Title: Heart Asia Volume: 10 Pages: 20-23
  • Peer Reviewed
• [Journal Article] Optical coherence tomography images of a coronary artery an eurysm in an infarct-related artery 6 months after bare-metal stent implantation. (2010)
  • Author(s): Yoshikawa D
  • Journal Title: JACC Cardiovasc Interv. Volume: 3 Pages: 1300-1302
  • Peer Reviewed
• [Journal Article] 研修施設における禁煙化・禁煙治療実施の現状-2009年に本循環器学会禁煙推進委員会実施アンケート結果より- (2010)
  • Author(s): 新谷理
  • Journal Title: 日本循環器学会専門医誌循環器専門医 Volume: 18 Pages: 348-351
• [Journal Article] Kitagawa Y Murohara T Implantation of adipose-derived regenerative cells enhances ischemia-induces angiogenesis (2009)
  • Author(s): Kondo K, Shintani S, Shibata R, Murakami H, Murakami R, Imaizumi M.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 29 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Autologous adipose-derived regenerative cells for the rapeutic angiogenesis (2009)
  • Author(s): Murohara T, Shintani S, Kondo K.
  • Journal Title: Curr Pharm Des Volume: 15(24) Pages: 2784-2790
  • Peer Reviewed
• [Journal Article] 細胞移植によるハイブリッド血管新生療法の開発 (2009)
  • Author(s): 新谷理
  • Journal Title: 日本冠疾患学会雑誌 Volume: Vol.15 No.3 Pages: 193-197
  • NAID: 10026256844
  • Peer Reviewed
• [Journal Article] 骨髄細胞を用いた血管新生療法:循環器科 (2009)
  • Author(s): 新谷理, 室原豊明
  • Journal Title: 科学評論社 Volume: Vol.66 No4 Pages: 353-358
• [Journal Article] Implantation of adipose-derived regenerative cells enhances is chemia-induces angiogenesis. Role of SDF-1and endothelial progenitor cells. (2009)
  • Author(s): Kondo K
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 29 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Autologous adipose-derived regenerative cells for therapeutic angiogenesis. (2009)
  • Author(s): Murohara T
  • Journal Title: Curr Pharm Des. Volume: 15 Pages: 2784-2790
  • Peer Reviewed
• [Presentation] M2 macro phages contribute to postnatal lymph angiogenesis as lymphatic endothelial progenitors (2011)
  • Author(s): Shimizu Y, Shintani S, Shibata R, Izumi Y, Ogura Y, Ishii M, Murohara T.
  • Organizer: 2011 American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2011-11-14
• [Presentation] Im plantation of adipose-derived regenerative cells enhances lymph angiogenesis and improves secondary lymph edema (2011)
  • Author(s): Shimizu Y, Shintani S, Shibata R, Izumi Y, Ogura Y, Ishii M, Murohara T.
  • Organizer: 2011 American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2011-11-14
• [Presentation] M2 macrophages contribute to postnatal lymphangiogenesis as lymphatic endothelial cell progenitors (2011)
  • Author(s): Yuuki Shimizu
  • Organizer: American Heart Association
  • Place of Presentation: 米国:オーランド
  • Year and Date: 2011-11-14
• [Presentation] Implantation of adipose-derived regenerative cells enhances lymphangiogenesis and improves secondary lymphedema (2011)
  • Author(s): Yuuki Shimizu
  • Organizer: American Heart Association
  • Place of Presentation: 米国:オーランド
  • Year and Date: 2011-11-14
• [Presentation] The rape tic lymph angiogenesis with implantation of adipose-derived regenerative cells (2011)
  • Author(s): Shimizu Y, Shintani S, Shibata R, Izumi Y, Ogura Y, Ishii M, Murohara T.
  • Organizer: 2011 European Society of Cardiology
  • Place of Presentation: Paris
  • Year and Date: 2011-08-30
• [Presentation] Therapeutic lymphangiogenesis with implantation of adipose-derived regenerative cells (2011)
  • Author(s): Yuuki Shimizu
  • Organizer: European Society of Cardiology
  • Place of Presentation: フランス:パリ
  • Year and Date: 2011-08-30
• [Presentation] 皮下脂肪組織由来間葉系前駆細胞移植による血管新生療法.新たな細胞供給源を求めて (2011)
  • Author(s): 新谷理、室原豊明
  • Organizer: 第27回日本医工学治療学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2011-04-24
• [Presentation] 皮下脂肪組織由来間葉系前駆細胞移植による血管新生療法-新たな細胞供給源を求めて (2011)
  • Author(s): 新谷理
  • Organizer: 日本医工学治療学会学術大会
  • Place of Presentation: 岡山県岡山市(招待講演)
  • Year and Date: 2011-04-24
• [Presentation] Implantation of adipose-derived regenerative cells induces angiogenesis in ischemic tissue. (2010)
  • Author(s): 小椋康弘
  • Organizer: World Congress ISHR
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2010-05-13
• [Presentation] Implantation of Adipose-Derived Regenerative Cells Enhances Is chemia-induced Neovascularization. Role of SDF-1-mediated Endothelial Progenitor Cell Mobilization (2009)
  • Author(s): Shintani S, Kondo K, Kitagawa Y, Murohara T
  • Organizer: 7^<th> International Federation of Adipose Therapeutics & Science(IFATS)
  • Place of Presentation: Daegu Korea
  • Year and Date: 2009-10-16
• [Presentation] Implantation of adipose-derived regenerative cells enhances ischemia-induced neovascularization. (2009)
  • Author(s): 新谷理
  • Organizer: International Federation of Adipose Therapeutics & Science
  • Place of Presentation: Hotel Inter-Burgo (Daegu, Korea)
  • Year and Date: 2009-10-16
• [Presentation] 細胞移植による血管新生療法.新たな細胞供給源を求めて (2009)
  • Author(s): 新谷理、近藤和久、室原豊明
  • Organizer: 第30回日本動脈アフェレシス学会学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-12
• [Presentation] 細胞移植による血管新生療法-新たな細胞供給源を求めて (2009)
  • Author(s): 新谷理
  • Organizer: 日本動脈アフェレシス学会学術大会
  • Place of Presentation: 京王プラザホテル札幌(北海道)
  • Year and Date: 2009-09-12
• [Presentation] 脂肪組織由来間葉系前駆細胞移植による血管再生療法 (2009)
  • Author(s): 新谷理、近藤和久、室原豊明
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 下関
  • Year and Date: 2009-07-17
• [Presentation] 脂肪組織由来間葉系前駆細胞移植による血管再生療法 (2009)
  • Author(s): 新谷理
  • Organizer: 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 海峡メッセ下関(山口)
  • Year and Date: 2009-07-17
• [Book] 血管内皮前駆細胞とVEGF「血管再生治療」浅原孝之編 (2012)
  • Author(s): 新谷理
  • Publisher: 診断と治療社
• [Book] 血管内皮前駆細胞とVEGF「血管再生治療」 (2012)
  • Author(s): 新谷理
  • Publisher: 診断と治療社
• [Book] EarlyEPCとlate EPCとは「循環器再生医学の現状と展望」室原豊明編 (2011)
  • Author(s): 新谷理、泉雄介、室原豊明
  • Publisher: メディカルレビュー社
• [Book] 自己骨髄単核球細胞移植による血管新生療法の開発「循環器再生医学の現状と展望」室原豊明編 (2011)
  • Author(s): 新谷理、室原豊明
  • Publisher: メディカルレビュー社
• [Book] 自己骨髄単核球細胞移植による血管新生療法の開発「循環器再生医学の現状と展望」 (2011)
  • Author(s): 新谷理
  • Publisher: メディカルレビュー社
• [Book] Early EPCとlate EPCとは「循環器再生医学の現状と展望」 (2011)
  • Author(s): 新谷理
  • Publisher: メディカルレビュー社
• [Book] 重症ASOに対する血管新生療法の開発「閉塞性動脈硬化症診療マスターブック」朔啓二郎編 (2010)
  • Author(s): 新谷理、近藤和久、小椋康弘、清水優樹、室原豊明
  • Publisher: 新興医学出版社
• [Book] 閉塞性動脈硬化症診療マスターブック (2010)
  • Author(s): 新谷理
  • Total Pages: 191
  • Publisher: 新興医学出版社
• [Book] 閉塞性動脈硬化症「薬学生のための新臨床医学.症候および疾患とその治療」市田公美、細山田真編 (2009)
  • Author(s): 嶋野祐之、新谷理、室原豊明
  • Publisher: 廣川書店
• [Book] 薬学生のための新臨床医学-症候および疾患とその治療 (2009)
  • Author(s): 嶋野祐之
  • Publisher: 廣川書店