| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Although recent studies have suggested that cysteinyl cathepsins(Cats) participate in cell apoptosis, the Cat-related precise mechanism of in atherosclerotic plaque disruption remains poorly understood. Here, we focused to investigate the role of Cat in plaque rupture using a mouse carotid artery plaque rupture model. We have observed that CatS involves vascular smooth muscle cell apoptosis and contributes to plaque rupture. CatS is an important determination of atherosclerotic plaque composition and disruption, rendering CatS an attractive target for pharmaceutical prevention in atherosclerotic plaque vulnerability.
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