New Mechanisms of the Protection against the Increase in Oxidative Stress in Hypertension
| Project/Area Number |
21590954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
UMEMOTO Seiji 山口大学, 医学部附属病院, 准教授 (90263772)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Kohichi 山口大学, 大学院・医学系研究科, 准教授 (00322248)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Oxidative stress / Toll-like receptor / Angiotensin II / Superoxide dismutase / hypertension / oxidative stress / superoxide dismutase / Toll-like reveptor |
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| Research Abstract |
Angiotensin II(AngII) increased oxidative stress and induced vascular remodeling through AngII type 1 receptor via TLR4, whereas TLR4 directly inhibited ecSOD to promote the production of oxidative stress and vascular remodeling. PPARγwas not involved in these processes.
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Report
(4 results)
Research Products
(33 results)
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[Presentation] Toll-like receptor 4 increases oxidative stress by inhibiting the upregulation of extracellular superoxide dismutase in angiotensin II-induced hypertension2009
Author(s)
Yoshino H, Umemoto S, Matsuda S, Nakashima T, Itoh S, Aoki H, YoshimuraK, Murata T, Fukai T, Matsuzaki M
Organizer
ESC Congress2009
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] Toll-like receptor 4 augments angiotensin II-inducedoxidative stress by inhibiting the upregulation of extracellular superoxide dismutase2009
Author(s)
Yoshino H, Umemoto S, Matsuda S, ItohS, Aoki H, Yoshimura K, Murata T, FukaiT, Matsuzaki M
Organizer
The American Society of Hypertension, Inc 24^<rd> Annual Scientific Meeting and Exposition
Place of Presentation
San Francisco, USA
Related Report
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