| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In the comparison with ApoEKO mice, AT2 deficient(AT2/ApoE knockout) mice showed the increase in adipose tissue weight, adipocyte size, markers for adipocyte differentiation and insulin resistance. AT2/ApoEKO mice also showed the decrease in cholesterol excretion into bile and feces. These results suggest that AT2 receptor stimulation induces improvement of adipocyte function and cholesterol metabolism and that these effects may be useful for the therapy for metabolic syndrome in the near future.
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