Role of AT2 Receptor on Insulin Resistance and Adipose Tissue Dysfunction in Atherosclerotic Mouse Model
| Project/Area Number |
21590956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
IWAI Masaru 愛媛大学, 大学院・医学系研究科, 准教授 (00184854)
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Masatsugu 愛媛大学, 大学院医学系研究科, 教授 (40150338)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 動脈硬化 / アンジオテンシン / 受容体 / インスリン抵抗性 / 脂肪組織 / アンジオテンシンII / コレステロール / メタボリック症候群 / AT1受容体 / AT2受容体 / 代謝異常 / 胆汁 / 膵臓 / 炎症反応 / 酸化ストレス |
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| Research Abstract |
In the comparison with ApoEKO mice, AT2 deficient(AT2/ApoE knockout) mice showed the increase in adipose tissue weight, adipocyte size, markers for adipocyte differentiation and insulin resistance. AT2/ApoEKO mice also showed the decrease in cholesterol excretion into bile and feces. These results suggest that AT2 receptor stimulation induces improvement of adipocyte function and cholesterol metabolism and that these effects may be useful for the therapy for metabolic syndrome in the near future.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Temporary Treatment With AT1 Receptor Blocker, Valsartan, From Early Stage of Hypertension Prevented Vascular Remodeling2011
Author(s)
Inaba S, Iwai M, Furuno M, Kanno H, Senba I, Okayama H, Mogi M, Higaki J, Horiuchi M
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Journal Title
Am J Hypertens
Volume: 24(5)
Pages: 550-556
Related Report
Peer Reviewed
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[Journal Article] Prevention of Vascular Injury by Combination of an AT1 Receptor Blocker, Olmesartan, with Various Calcium Antagonists2009
Author(s)
Inaba S, Iwai M, Tomono Y, Senba I, Furuno M, Kanno H, Okayama H, Mogi M, Higaki J, Horiuchi M
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Journal Title
Am J Hypertens
Volume: 22(2)
Pages: 145-150
Related Report
Peer Reviewed
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