| Project/Area Number |
21590958
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
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| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
UEMURA Shiro 奈良県立医科大学, 医学部, 准教授 (80232792)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAITO Yoshihiko 奈良県立医科大学, 医学部, 教授 (30250260)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 分子血管病態学 / 動脈硬化 / 慢性腎臓病 / 血管新生 / 遺伝子改変マウス |
|---|
| Research Abstract |
Chronic kidney disease is frequently associated with advanced atherosclerosis. We have found that placental growth factor(PlGF) and its endogenous antagonist, sFlt-1, play important role in this setting. In this study, we investigated the manifestation of sFlt-1 and ApoE double knock-out mouse, as well as the effect of recombinant sFlt-1 administration to ApoE KO mice with renal failure. Our results indicate supplemental enhancement of plasma level of sFlt-1 might be a candidate as a pharmacological intervention for advanced atherosclerosis in patients with renal dysfunction.
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