Application of sFlt-1 for the prevention of advanced atherosclerosis in chronic kidney disease
| Project/Area Number |
21590958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
UEMURA Shiro 奈良県立医科大学, 医学部, 准教授 (80232792)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Yoshihiko 奈良県立医科大学, 医学部, 教授 (30250260)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子血管病態学 / 動脈硬化 / 慢性腎臓病 / 血管新生 / 遺伝子改変マウス |
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| Research Abstract |
Chronic kidney disease is frequently associated with advanced atherosclerosis. We have found that placental growth factor(PlGF) and its endogenous antagonist, sFlt-1, play important role in this setting. In this study, we investigated the manifestation of sFlt-1 and ApoE double knock-out mouse, as well as the effect of recombinant sFlt-1 administration to ApoE KO mice with renal failure. Our results indicate supplemental enhancement of plasma level of sFlt-1 might be a candidate as a pharmacological intervention for advanced atherosclerosis in patients with renal dysfunction.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Thin-Cap Fibroatheroma and Microchannel Findings in Optical Coherence Tomography Correlate with Subsequent Progression of Coronary Atheromatous Plaques2012
Author(s)
Uemura S, Ishigami K, Soeda T, Okayama S, Sung JH, Nakagawa H, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y.
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Journal Title
Eur Heart J
Volume: 33(1)
Pages: 78-85
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[Journal Article] Diagnostic accuracy of dual-source computed tomography in the characterization of coronary atherosclerotic plaques : Comparison with intravascular optical coherence tomography2011
Author(s)
Soeda T, Uemura S, Morikawa Y, Ishigami K, Okayama S, Hee SJ, Nishida T, Onoue K, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y.
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Journal Title
Int J Cardiol
Volume: 148
Pages: 313-318
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[Journal Article] Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes Trial Investigators. Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate : subanalysis from the JPAD trial2011
Author(s)
Saito Y, Morimoto T, Ogawa H, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sugiyama S, Okada S, Akai Y.
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Journal Title
Diabetes Care
Volume: 34
Pages: 280-5
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[Journal Article] Differential effect of low-dose aspirin for primary prevention of atherosclerotic events in diabetic management : A subanalysis of the JPAD Trial.2011
Author(s)
Okada S, Morimoto T, Ogawa H, Kanauchi M, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sakuma M, Saito Y
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Journal Title
Diabetes Care
Volume: 34(6)
Pages: 1277-83
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[Journal Article] Morphological features of coronary arteries in patients with coronary spastic angina : Assessment with intracoronary optical coherence tomography2011
Author(s)
Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, Onoue K, Somekawa S, Nishida T, Takeda Y, Kawata H, Horii M, Saito Y.
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Journal Title
Int J Cardiol
Volume: 146
Pages: 334-340
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[Journal Article] Using imaging mass spectrometry to accurately diagnose Fabry's disease2010
Author(s)
Onoue K, Zaima N, Sugiura Y, Isojima T, Okayama S, Horii M, Akai Y, Uemura S, Takemura G, Sakuraba H, Sakaguchi Y, Setou M, Saito Y.
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Journal Title
Circ J
Volume: 75
Pages: 221-223
NAID
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[Presentation] Low-dose aspirin therapy in patients with type 2 diabetes mellitus coexisting renal damage : Subanalysis from the JPAD study. Late Breaking Clinical Trials 022010
Author(s)
Saito Y, Morimoto T, Ogawa H, Nakayama M, Okada S, Uemura S, Nishiura K, Soejima H, Jinnouchi H, Waki M, Doi N.
Organizer
The 74th annual meeting of the Japanese Circulation Society
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