| Project/Area Number |
21590959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUYAMA Tohru 兵庫医科大学, 医学部, 教授 (70273670)
KAWABATA Masaaki 兵庫医科大学, 医学部, 非常勤講師 (70411999)
NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | メタボリックシンドローム / 鉄代謝 / 多血症 / インスリン抵抗性 / 高血圧 / 鉄 / 貧血 / メタボリックシンドローム. / nitrosative stress / 低酸素 / 貯蔵鉄 / 糖尿病性腎症 / 酸化ストレス / ピモニダゾール / レニン・アンジオテンシン系 |
|---|
| Research Abstract |
High body iron levels are found in type 2 diabetes mellitus(DM). Iron excess leads to tissue injury through free radical formation. We investigated the effect of iron restriction on diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty(OLETF) rats, a model of type 2 DM. In OLETF given high salt-high fat diet, iron restriction reduced systolic blood pressure, urinary excretion of protein and renal glomerular injury. Iron restriction suppressed oxidative stress and renin-angiotensin system in the kidney and attenuated renal hypoxia in the HFS+IR group compared to the HFS group. Iron restriction may be beneficial in prevention of nephropathy in type 2 DM.
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