Analysis of systemic inflammation in the COPD-Cigarette smoke exposure induced inflammatory response in adipose tissue

• Project/Area Number: 21590962
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: KASAHARA Yasunori 千葉大学, 医学部・附属病院, 講師 (60343092)
• Co-Investigator(Kenkyū-buntansha): TATSUMI Koichiro 千葉大学, 大学院・医学研究院, 教授 (10207061) ; SAKAO Seiichiro 千葉大学, 医学部附属病院, 助教 (80431740)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 呼吸器病学 / 炎症 / たばこ / 慢性閉塞性肺疾患 / 環境

Research Abstract

Both cigarette smoking and obesity are well-established risk factors for atherosclerosis. Cigarette smoking (CS) results in systemic oxidant-antioxidant imbalance and a low-grade systemic inflammatory response. To clarify the effects of CS exposure on adipose tissue, we investigated the adipose tissue change by 2-week CS exposure using mice. We found accumulation of cells expressing the macrophage marker F4/80 in the adipose tissue of CS-exposed mice, accompanied by elevated expression of MCP-1 mRNA in adipocytes. These results suggest that CS induces inflammatory response to adipose tissue via different mechanisms from obesity.