|Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Both cigarette smoking and obesity are well-established risk factors for atherosclerosis. Cigarette smoking (CS) results in systemic oxidant-antioxidant imbalance and a low-grade systemic inflammatory response. To clarify the effects of CS exposure on adipose tissue, we investigated the adipose tissue change by 2-week CS exposure using mice. We found accumulation of cells expressing the macrophage marker F4/80 in the adipose tissue of CS-exposed mice, accompanied by elevated expression of MCP-1 mRNA in adipocytes. These results suggest that CS induces inflammatory response to adipose tissue via different mechanisms from obesity.