| Project/Area Number |
21590969
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
HAMADA Kaoru 奈良県立医科大学, 医学部, 教授 (80228535)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIMURA Hiroshi 奈良県立医科大学, 医学部, 教授 (20195374)
SHO Masayuki 奈良県立医科大学, 医学部, 准教授 (50364063)
SUZAKI Yasue 奈良県立医科大学, 医学部, 助教 (30382302)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 気管支喘息 / 大気汚染 / 喫煙Th2サイトカイン / エピジェネティクス / 喫煙 / 室内気(indoor-air) / 室内大気(in-door air) / ホルムアルデヒド |
|---|
| Research Abstract |
Increased incidence of asthma and other allergic diseases are the worldwide problem. Air-pollution is recognized as one of the important factor for pathogenesis of asthma. We have investigated whether exposure to air-pollution such as oil fly as, formaldehyde and tobacco smoking during pregnancy can contribute to development of asthma in the offspring. Data indicated neonatal mice from mothers exposed to pollutants before delivery could express asthma manifestation by the suboptimal sensitization. As the mechanism(s), these mice showed the persistent Th2-dominant immune profile after birth. Contribution of epigenetics to this maternal transmission or transplacental effect of asthma susceptibility should be clarified.
|
