| Project/Area Number |
21590975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
|
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| Research Institution | Nihon University |
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Principal Investigator |
GON Yasuhiro 日本大学, 医学部, 准教授 (80339316)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
RA Chisei 日本大学, 医学部, 教授 (60230851)
林 伸一 日本大学, 医学部, 助教 (20445745)
|
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Shinichi 日本大学, 医学部, 助教 (20445745)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 気道上皮 / 気管支喘息 / タイトジャンクション / 気道炎症 / 気道上皮細胞 / EGFR / 副腎皮質ステロイド / バリア機能 / 透過性 / Heregulin / ErbB1 / ErbB3 / Tight junction / 透過性バリア |
|---|
| Research Abstract |
The airway epithelial barrier provides defenses against inhaled antigens and pathogens, and alterations of epithelial barrier function have been proposed to play a significant role in the pathogenesis of chronic airway diseases. In this study, we demonstrated that EGFR positively regulates permeability barrier development through the Rac1/JNK-dependent pathway. We also found that heregulin activation of ErbB2/ErbB3 heterodimers is essential for the regulation of permeability barrier in the airway epithelial cells. We also found that glucocorticoids have an effects of improving epithelial barrier integrity.
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