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Clarification of causal antigens of bronchial asthma in terms of cellular immune responses and mediators of bronchoconstriction

Research Project

Project/Area Number 21590978
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionClinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital

Principal Investigator

MORI Akio  独立行政法人国立病院機構(相模原病院臨床研究センター), 臨床研究センター, 部長 (80251247)

Co-Investigator(Kenkyū-buntansha) OHTOMO Takayuki  独立行政法人国立病院機構相模原病院, 臨床研究センター, 特別研究員 (90463108)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords閉塞性肺疾患 / 気管支喘息 / アレルゲン / T細胞 / 遅発型喘息反応 / 細胞性免疫 / IL-5 / 気管支平滑筋 / アレルギー
Research Abstract

Mechanism of bronchoconstriction in nonatopic asthma is studied in the present study. T cell IL-5 production was induced in response to house dust mite or mold allergens despite lack of IgE antibodies. Upon bronchial provocation, late asthmatic response, but not immediate asthmatic response, was induced in IL-5-producing asthmatics. To delineate mechanisms of IgE-independent bronchoconstriction, T cell clones were established, and the bronchoconstriction activity of activated T cell clones was analyzed in terms of human bronchial smooth muscle cells-embedded collagen gels.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (90 results)

All 2012 2011 2010 2009

All Journal Article (39 results) (of which Peer Reviewed: 22 results) Presentation (48 results) Book (3 results)

  • [Journal Article] Murine T cell-derived contractile activity for human bronchial smooth muscle cells2012

    • Author(s)
      Abe, A., Koyama, S., Ohtomo, T., Kitamura, N., Kaminuma, O., and Mori, A.
    • Journal Title

      Int. Arch. Allergy Immunol

      Volume: 158 Issue: Suppl. 1 Pages: 7-10

    • DOI

      10.1159/000337743

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective down-regulation of Th2 cell-mediated airway inflammation in mice by pharmacological intervention of CCR42012

    • Author(s)
      Kaminuma, O, et al
    • Journal Title

      Clin.Exp.Allergy

      Volume: 42 Issue: 2 Pages: 315-25

    • DOI

      10.1111/j.1365-2222.2011.03847.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obesity and aspirin intolerance are risk factors for difficult-to-treat asthma in Japanese non-atopic women2012

    • Author(s)
      Fukutomi.Y
    • Journal Title

      Clin.Exp.Allergy

      Volume: Vol.42 Issue: 5 Pages: 738-746

    • DOI

      10.1111/j.1365-2222.2011.03880.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells2012

    • Author(s)
      Kaminuma, O, et al
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of allergen-induced airway inflammation by oral immunotherapy with transgenic rice seeds independently of IgE synthesis2012

    • Author(s)
      Saeki, M, et al
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 重症喘息の病態と真菌抗原による非IgE依存性喘息反応、臨床免疫2011

    • Author(s)
      森晶夫
    • Journal Title

      アレルギー科

      Volume: 56(1) Pages: 44-50

    • URL

      http://www.kahyo.com/category/A1-MA

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo2011

    • Author(s)
      Abe A, Kaminuma O, et al
    • Journal Title

      International Archives of Allegy and Immunology

      Volume: VOL.155 Issue: Suppl. 1 Pages: 110-116

    • DOI

      10.1159/000327494

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc finger protein, multitype 1 suppresses human Th2 development via down-regulation of IL-42011

    • Author(s)
      Kitamura N, Kaminuma O, et al
    • Journal Title

      International Archives of Allegy and Immunology

      Volume: VOL.155 Issue: Suppl. 1 Pages: 53-56

    • DOI

      10.1159/000327292

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD44 is critical for airway accumulation of antigen-specific Th2 cells, but not Th1 cells, induced by antigen challenge in mice2011

    • Author(s)
      Kato S, Kaminuma O, et al
    • Journal Title

      European Journal of Immunology

      Volume: 41 Issue: 11 Pages: 3198-3207

    • DOI

      10.1002/eji.201141521

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen : induction of allergen-specific oral tolerance without bystander suppression2011

    • Author(s)
      Suzuki, K, et al
    • Journal Title

      Plant Biotech.J.

      Volume: 9 Issue: 9 Pages: 982-990

    • DOI

      10.1111/j.1467-7652.2011.00613.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein phosphatase 1 is involved in IL-2-induced IL-5 and IL-13 expression in human T cells2011

    • Author(s)
      Kaminuma, O, et al
    • Journal Title

      Genes to Cells

      Volume: (submitted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高IgE症候群2011

    • Author(s)
      森晶夫
    • Journal Title

      呼吸

      Volume: 30(2) Pages: 151-153

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 国際アレルギー学会(WAO)国際科学会議報告2011

    • Author(s)
      森晶夫
    • Journal Title

      日本アレルギー協会関東支部だより

      Volume: 9 Pages: 4-7

    • Related Report
      2011 Annual Research Report
  • [Journal Article] アレルギーをめぐるトレンド抗IgE抗体療法2011

    • Author(s)
      森晶夫
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: 9(2) Pages: 126-129

    • Related Report
      2011 Annual Research Report
  • [Journal Article] アレルギー病因論の新しい展開と重症アレルギーを特徴付けるステロイド抵抗性について2011

    • Author(s)
      森晶夫
    • Journal Title

      日本アレルギー協会アレルギー研修会主題:アレルギー診療Update~病態に基づいた合理的な治療~

      Pages: 1-10

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 重症喘息の病態と真菌抗原による非IgE依存性喘息反応2011

    • Author(s)
      森晶夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56(1) Pages: 44-50

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 重症喘息におけるステロイド治療抵抗性の機序解明とその治療法の開発2011

    • Author(s)
      森晶夫、安部暁美, ほか
    • Journal Title

      アレルギア

      Volume: 40 Pages: 96-101

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo.2011

    • Author(s)
      Abe, A, et al.
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc finger protein, multitype 1 suppresses human Th2 development via down-regulation of IL-4.2011

    • Author(s)
      Kitamura, N., et al.
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1L-5、臨床免疫・アレルギー科2011

    • Author(s)
      森晶夫
    • Journal Title

      臨床免疫・アレルギー科(特別増刊号)

      Volume: 54 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高IgE症候群2011

    • Author(s)
      森晶夫
    • Journal Title

      呼吸2010

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アレルギーをめぐるトレンド抗IgE抗体療法2011

    • Author(s)
      森晶夫
    • Journal Title

      皮膚アレルギーフロンティア2010

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th transfer model of Balb/c background2010

    • Author(s)
      Ohtomo, T., Kaminuma, O., Yamada, J., Kitamura, N., Abe, A., Kobayashi, N., Suko, M., and Mori, A.
    • Journal Title

      Int. Arch. Allergy Immunol

      Volume: 152 Issue: Suppl. 1 Pages: 79-82

    • DOI

      10.1159/000312130

    • Related Report
      2011 Final Research Report
  • [Journal Article] Eosinophils are required for the induction of bronchial hyperresponsiv eness in a Th transfer model of Balb/c background2010

    • Author(s)
      Otomo, T., et al.
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: 152 Pages: 79-82

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective down-regulation of Th2 cytokines by C-terminal binding protein 2 in human T cells.2010

    • Author(s)
      Kaminuma, F., et al.
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: 152 Pages: 18-21

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of sublingual immunotherapy on antigen-induced bronchial and nasal inflammation in mice2010

    • Author(s)
      Kaminuma, O., et al.
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: 152 Pages: 75-78

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A crucial role of sialidase Neul in hyaluronan receptor function of CD44 in T helper type 2-mediated airway inflammation of murine acute asthmatic model2010

    • Author(s)
      Katoh, S., et al.
    • Journal Title

      Clin.Exp.Immunol.

      Volume: 161 Pages: 233-241

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood.2010

    • Author(s)
      Ebisawa T., et al.
    • Journal Title

      Neurosci.Res.

      Volume: 66 Pages: 223-227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome.2010

    • Author(s)
      Seki M., et al.
    • Journal Title

      Pediatr.Int

      Volume: 52

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 真菌アレルギー最近の話題-自然免疫、獲得免疫と真菌2010

    • Author(s)
      森晶夫
    • Journal Title

      アレルギーの臨床

      Volume: 30(1) Pages: 30-32

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 重症喘息の機序とその対策2010

    • Author(s)
      森晶夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53(2) Pages: 167-173

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 国際アレルギー学会(WAO)2009報告2010

    • Author(s)
      森晶夫
    • Journal Title

      日本アレルギー協会関東支部だより

      Volume: 7 Pages: 3-5

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 炎症性メディエータとアレルギー疾患2010

    • Author(s)
      森晶夫
    • Journal Title

      Topics in Atopy

      Volume: 9(2) Pages: 37-43

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 成人喘息患者における持続的気流閉塞-臨床的見地から-2010

    • Author(s)
      福冨友馬、森晶夫, ほか
    • Journal Title

      第11回喘息リモデリング研究会、呼吸

      Volume: 29(5) Pages: 535-537

    • Related Report
      2010 Annual Research Report
  • [Journal Article] T細胞の遊走とCD442010

    • Author(s)
      神沼修、森晶夫, ほか
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53(6) Pages: 551-555

    • Related Report
      2010 Annual Research Report
  • [Journal Article] わが国の重症難治性喘息の病態と治療2010

    • Author(s)
      森晶夫、北村紀子, ほか
    • Journal Title

      第50回日本呼吸器学会学術講演会ハイライト

      Pages: 2-4

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Evaluation of cysteinyl leukotriene-induced contraction of human cultured bronchial smooth muscle cells2009

    • Author(s)
      Kitamura, N., et al.
    • Journal Title

      Int.Arch.Allergy Immunol. 149

      Pages: 83-86

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Murine Th clones confer late asthmatic response upon antigen challenge2009

    • Author(s)
      Ohtomo, T., et al.
    • Journal Title

      Int.Arch.Allergy Immunol. 149

      Pages: 2-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-bet is responsible for distorted Th2 differentiation in human peripheral CD4^<+> T cells2009

    • Author(s)
      Kaminuma, O., et al.
    • Journal Title

      J.Allergy Clin.Immunol. 123

      Pages: 813-820

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗原誘発気道内Th2細胞浸潤に対するCD44の選択的役割2011

    • Author(s)
      Kaminuma O., Mori A., ほか
    • Organizer
      2011日本免疫学会総会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗原特異的Treg細胞によるTh1、Th2およびTh17細胞依存性腸炎に対する抑制効果の検討2011

    • Author(s)
      Watanabe N., Mori A., ほか
    • Organizer
      2011日本免疫学会総会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] アスピリン喘息におけるアトピー要因2011

    • Author(s)
      三井千尋、森晶夫, ほか
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルギー性鼻炎発症におけるT細胞の役割2011

    • Author(s)
      西村友枝、森晶夫, ほか
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルギー性気管支肺真菌症と真菌感作喘息の病態におけるTh17細胞の意義に関する検討2011

    • Author(s)
      押方智也子、森晶夫, ほか
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] セツキシマブに対するIgE抗体とマダニ咬傷第2報2011

    • Author(s)
      中澤卓也、森晶夫, ほか
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト気管支平滑筋細胞ゲルを用いた気管支収縮因子の探索2011

    • Author(s)
      安部暁美、森晶夫, ほか
    • Organizer
      アレルギー・好酸球研究会2011
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] T細胞のIL-17産生に対するNFATファミリーの機能的相違2011

    • Author(s)
      神沼修、森晶夫, ほか
    • Organizer
      アレルギー・好酸球研究会2011
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 形質転換イネを用いたダニアレルギー治療米の開発2011

    • Author(s)
      佐伯真弓、森晶夫, ほか
    • Organizer
      アレルギー・好酸球研究会2011
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Risk factors and characteristics associated with uncontrolled severe asthma in patients with aspirin-exacerbated respiratory disease2011

    • Author(s)
      Mitsui, C, et al
    • Organizer
      30th Congress of the European Academy of Allergy and Clinical Immunology
    • Place of Presentation
      Istanbul
    • Year and Date
      2011-06-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 喘息大発作症例の臨床的検討2011

    • Author(s)
      関谷潔史、森晶夫, ほか
    • Organizer
      第23回日本アレルギー学会春季臨床大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] アスピリン喘息における持続的気流制限の検討2011

    • Author(s)
      三井千尋、森晶夫, ほか
    • Organizer
      第23回日本アレルギー学会春季臨床大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルギー性気管支肺アスペルギルス症(ABPA)において、発症年齢による臨床的な違いはあるのか2011

    • Author(s)
      谷本英則、森晶夫, ほか
    • Organizer
      第23回日本アレルギー学会春季臨床大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 喘息大発作症例の臨床的検討2011

    • Author(s)
      関谷潔史、森晶夫, ほか
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス喘息モデルのTh2細胞性気道炎症におけるNeulシアリダーゼの役割2011

    • Author(s)
      加藤茂樹、森晶夫, ほか
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] NSAIDs過敏喘息の難治化とCysLTs過剰産生2011

    • Author(s)
      三井千尋、森晶夫, ほか
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 環境中ダニアレルゲン量はアトピー型成人気管支喘息患者の臨床症状を反映する2011

    • Author(s)
      押方智也子、森晶夫, ほか
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルギー病因論の新しい展開と重症アレルギーを特徴付けるステロイド抵抗性について2011

    • Author(s)
      森晶夫
    • Organizer
      2011年公益財団法人日本アレルギー協会研修会「アレルギー診療Update~病態に基づいた合理的な治療~
    • Place of Presentation
      東京
    • Year and Date
      2011-03-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comparative Analysis of Steroid Sensitivity of Th cells in vitro and in vivo2011

    • Author(s)
      Mori, A, et al
    • Organizer
      30th Congress of the European Academy of Allergy and Clinical Immunology
    • Place of Presentation
      Istanbul
    • Related Report
      2011 Annual Research Report
  • [Presentation] T cell clone transfer model for steroid resistant asthma2011

    • Author(s)
      Mori, A, et al
    • Organizer
      European Respiratory Society 2011
    • Place of Presentation
      Amsterdam
    • Related Report
      2011 Annual Research Report
  • [Presentation] 難治性アレルギー疾患における真菌の役割(わが国の重症喘息の病態と真菌抗原による非IgE依存性喘息反応)2010

    • Author(s)
      森晶夫、北村紀子, ほか
    • Organizer
      第60回日本アレルギー学術秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレルギー性気管支肺アスペルギルス症とアスペルギルス感作成人喘息の臨床像とIgE抗体産生に関する検討2010

    • Author(s)
      押方智也子、森晶夫, ほか
    • Organizer
      第60回日本アレルギー学術秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 環境中ダニアレルゲン量は成人喘息患者の臨床症状を反映する-2臨床-2010

    • Author(s)
      押方智也子、森晶夫, ほか
    • Organizer
      第60回日本アレルギー学術秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 喘息が臨床的に安定しているにもかかわらず呼気NO高値の症例の経過2010

    • Author(s)
      武市清香、森晶夫, ほか
    • Organizer
      第60回日本アレルギー学術秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 喘息大発作症例の臨床的検討2010

    • Author(s)
      関谷潔史、森晶夫, ほか
    • Organizer
      第60回日本アレルギー学術秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ZFPM1/CtBP1コンプレックスはGATA-3によるTh2分化を抑制する2010

    • Author(s)
      神沼修、森晶夫, ほか
    • Organizer
      第60回日本アレルギー学術秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] NSAIDs過敏喘息の難治化とCysLTs過剰産生2010

    • Author(s)
      三井千尋、森晶夫, ほか
    • Organizer
      第60回日本アレルギー学術秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトTh1/Th2分化に対するZFPMlの役割2010

    • Author(s)
      神沼修、森晶夫, ほか
    • Organizer
      アレルギー・好酸球研究会2010
    • Place of Presentation
      東京
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] T細胞クローン移入喘息モデルによるステロイド感受性解析2010

    • Author(s)
      安部暁美、森晶夫, ほか
    • Organizer
      アレルギー・好酸球研究会2010
    • Place of Presentation
      東京
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 若年成人の喘息大発作はここ10年でどう変化したのか2010

    • Author(s)
      関谷潔史、森晶夫, ほか
    • Organizer
      第22回日本アレルギー学会春期臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] ABPA-Seropositiveの臨床的検討2010

    • Author(s)
      谷本英則、森晶夫, ほか
    • Organizer
      第22回日本アレルギー学会春期臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成人喘息患者における超極細線維フトンカバーによる環境調整の有用性に関する検討2010

    • Author(s)
      押方智也子、森晶夫, ほか
    • Organizer
      第22回日本アレルギー学会春期臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 過敏性肺炎における沈降抗体反応とイムノキャップTaの有用性2010

    • Author(s)
      齋藤明美、森晶夫, ほか
    • Organizer
      第22回日本アレルギー学会春期臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 若年成人喘息大発作入院症例における臨床的背景の検討2010

    • Author(s)
      関谷潔史、森晶夫, ほか
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成人喘息難治化因子の臨床的検討~特に性差に注目して~2010

    • Author(s)
      福冨友馬、森晶夫, ほか
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 副鼻腔炎の合併は気流制限なく臨床的に安定している喘息患者における呼気NO高値の予測因子である2010

    • Author(s)
      龍野清香、森晶夫, ほか
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] アトピー型成人喘息患者における環境中ダニアレルゲン量モニタリングの有用性の検討2010

    • Author(s)
      押方智也子、森晶夫, ほか
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] T cell-dependent bronchoconstriction in vivo and in vitro2010

    • Author(s)
      Mori A, Kitamura N, Otomo T, Abe, A., and Kaminuma O.
    • Organizer
      European Association of Allergy and Clinical Immunology 2010
    • Place of Presentation
      London
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of T cells in late phase asthmatic response2010

    • Author(s)
      Mori A, Kitamura N, Otomo T, Abe, A., and Kaminuma O.
    • Organizer
      The 8th Asia pacific Congress of Allergy, Asthma, and Clinical Immunology 2010
    • Place of Presentation
      Singapore
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of T cell-dependent bronchoconstriction using human cultured bronchial smooth muscle cells.2010

    • Author(s)
      Mori A, et al.
    • Organizer
      Collegium International Allergologicum 27th SYMPOSIUM.
    • Place of Presentation
      Ischia
    • Related Report
      2010 Annual Research Report
  • [Presentation] T cell-dependent bronchoconstriction in vivo and in vitro.2010

    • Author(s)
      Mori A, et al.
    • Organizer
      European Association of Allergy and Clinical Immunology 2010.
    • Place of Presentation
      London
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of T cells in late phase asthmatic response.2010

    • Author(s)
      Mori A, et al.
    • Organizer
      The 8th Asia Pacific Congress of Allergy, Asthma, and Clinical Immunology 2010.
    • Place of Presentation
      Singapore
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cysteinyl-Leukotriens overproduction and the asthma severity in patients with aspirin-induced asthma.2010

    • Author(s)
      Mitsui C., et al.
    • Organizer
      World Allergy Organization International Scientific Conference.
    • Place of Presentation
      Dubai
    • Related Report
      2010 Annual Research Report
  • [Presentation] 副鼻腔炎の合併は気流制限なく臨床的に安定している喘息患者における呼気NO高値の予測因子である2010

    • Author(s)
      武市清香、森晶夫, ほか
    • Organizer
      第20回国際喘息学会日本・北アジア部会プログラム
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 若年成人喘息大発作入院症例における臨床背景の変化2010

    • Author(s)
      関谷潔史、森晶夫, ほか
    • Organizer
      第20回国際喘息学会日本・北アジア部会 プログラム
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレルギー性気管支肺アスペルギルス症43例の臨床的検討2010

    • Author(s)
      谷本英則、森晶夫, ほか
    • Organizer
      第20回国際喘息学会日本・北アジア部会 プログラム
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレルギー性気管支肺アスペルギルス症(ABPA)とアスペルギルスに感作された成人喘息(FSBA)のアレルゲン特異的lgE抗体に関する比較検討2010

    • Author(s)
      押方智也子、森晶夫, ほか
    • Organizer
      第20回国際喘息学会日本・北アジア部会 プログラム
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of T cell-dependent bronchoconstriction using human cultured bronchial smooth muscle cells2009

    • Author(s)
      Mori, A., et al.
    • Organizer
      XXI World Allergy Congress
    • Place of Presentation
      Buenos Aires
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Book] アトピー型喘息と非アトピー型喘息の病態機序、第30回六甲カンファレンス2011

    • Author(s)
      森晶夫
    • Publisher
      ライフサイエンス出版
    • Related Report
      2011 Final Research Report
  • [Book] アトピー型喘息と非アトピー型喘息の病態機序、第30回六甲カンファレンス2010年における気管支喘息のすべて(森川昭廣、足立満、秋山一男、大田健、東田有智編)2011

    • Author(s)
      森晶夫
    • Total Pages
      8
    • Publisher
      ライフサイエンス出版
    • Related Report
      2011 Annual Research Report
  • [Book] 非アトピー型喘息、The 17th Symposium of Asthma in Tokyo2010

    • Author(s)
      森晶夫
    • Publisher
      ライフサイエンス出版
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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