Clarification of causal antigens of bronchial asthma in terms of cellular immune responses and mediators of bronchoconstriction
| Project/Area Number |
21590978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital |
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Principal Investigator |
MORI Akio 独立行政法人国立病院機構(相模原病院臨床研究センター), 臨床研究センター, 部長 (80251247)
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| Co-Investigator(Kenkyū-buntansha) |
OHTOMO Takayuki 独立行政法人国立病院機構相模原病院, 臨床研究センター, 特別研究員 (90463108)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 閉塞性肺疾患 / 気管支喘息 / アレルゲン / T細胞 / 遅発型喘息反応 / 細胞性免疫 / IL-5 / 気管支平滑筋 / アレルギー |
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| Research Abstract |
Mechanism of bronchoconstriction in nonatopic asthma is studied in the present study. T cell IL-5 production was induced in response to house dust mite or mold allergens despite lack of IgE antibodies. Upon bronchial provocation, late asthmatic response, but not immediate asthmatic response, was induced in IL-5-producing asthmatics. To delineate mechanisms of IgE-independent bronchoconstriction, T cell clones were established, and the bronchoconstriction activity of activated T cell clones was analyzed in terms of human bronchial smooth muscle cells-embedded collagen gels.
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Report
(4 results)
Research Products
(90 results)
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[Journal Article] Murine T cell-derived contractile activity for human bronchial smooth muscle cells2012
Author(s)
Abe, A., Koyama, S., Ohtomo, T., Kitamura, N., Kaminuma, O., and Mori, A.
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Journal Title
Int. Arch. Allergy Immunol
Volume: 158
Issue: Suppl. 1
Pages: 7-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th transfer model of Balb/c background2010
Author(s)
Ohtomo, T., Kaminuma, O., Yamada, J., Kitamura, N., Abe, A., Kobayashi, N., Suko, M., and Mori, A.
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Journal Title
Int. Arch. Allergy Immunol
Volume: 152
Issue: Suppl. 1
Pages: 79-82
DOI
Related Report
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