Novel dendritic cell vaccine for tuberculosis with inhibition of indoleamine 2, 3-dioxygenase.

• Project/Area Number: 21590985
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUDA Takafumi 浜松医科大学, 医学部, 助教 (30291397)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Yutaro 浜松医科大学, 医学部附属病院, 助教 (60436962) ; 永田 年 浜松医科大学, 医学部, 教授 (90275024)
• Co-Investigator(Renkei-kenkyūsha): NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 樹状細胞 / ワクチン / 結核 / 細胞内寄生菌 / indoleamine 2 / 3-dioxygenase(IDO) / インドレアミン・ジオキシゲナーゼ

Research Abstract

The present study was conducted to develop a novel potent dendritic cell(DC) vaccine by inhibiting indoleamine 2, 3-dioxygenase(IDO) activity for intracellular pathogen infections, such as tuberculosis. We demonstrated that treatment with 1-methyl-L-tryptophan(1MT) decreased IL-10 production from DCs, resulting in augmentation of their antigen-presenting capacity. In addition, we also showed that serum IDO activity is a significant prognostic factor in community-acquired pneumonia and pulmonary tuberculosis.

Research Products

• [Journal Article] Serum indoleamine 2, 3-dioxygenase activity predicts prognosis of pulmonary tuberculosis (2012)
  • Author(s): Suzuki Y, Suda T, et al
  • Journal Title: Clin Vaccine Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Mouse CD11b^<high> lung dendritic cells have more potent capability to induce IgA than CD103^+lung dendritic cells in vitro (2012)
  • Author(s): Suzuki Y, Suda T, Furuhashi K, Shibata K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Nakamura H, Chida K
  • Journal Title: Am J Respir Cell Mol Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Enhancement of protective immunity against intracellular bacteria using type-1 polarized dendritic cell(DC) vaccine (2012)
  • Author(s): Kono M, Nakamura Y, Suda T, et al
  • Journal Title: Vaccine Volume: 30 Pages: 2633-2639
  • Peer Reviewed
• [Journal Article] Mouse lung CD103^+ and CD11b^<high> dendritic cells preferentially induce distinct CD4^+ T cell responses (2012)
  • Author(s): Furuhashi K, Suda T, et al
  • Journal Title: Am J Respir Cell Mol Biol Volume: 46 Pages: 165-172
  • Peer Reviewed
• [Journal Article] Mouse CD11b^<high> lung dendritic cells have more potent capability to induce IgA than CD103^+ lung dendritic cells in vitro (2012)
  • Author(s): Suzuki Y, Suda T, et al
  • Journal Title: Am J Respir Cell Mol Biol Volume: 46(In press)
  • Peer Reviewed
• [Journal Article] Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia (2012)
  • Author(s): Suzuki Y, Suda T, et al
  • Journal Title: J Infect Volume: 63 Pages: 215-221
  • Peer Reviewed
• [Journal Article] Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis (2012)
  • Author(s): Suzuki Y, Suda T, et al
  • Journal Title: Clin Vaccine Immunol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Serum activity of indoleamine 2, 3-dioxygenase predicts prognosis of community-acquired pneumonia (2011)
  • Author(s): Suzuki Y, Suda T, et al
  • Journal Title: J Infect Volume: 63 Pages: 215-121
  • Peer Reviewed
• [Journal Article] Mouse lung CD103^+and CD11b^<high> dendritic cells preferentially induce distinct CD4^+T cell responses (2011)
  • Author(s): Furuhashi K, Suda T, et al
  • Journal Title: Am J Respir Cell Mol Biol Volume: 46(2) Pages: 165-172
  • Peer Reviewed
• [Journal Article] A novel vaccine strategy to induce mycobacterial antigen-specific Th1 responses by utilizing the C-terminal domain of heat shock protein 70 (2011)
  • Author(s): Uto T, Tsujimura K, Suda T, et al
  • Journal Title: FEMS Immunol Med Microbiol Volume: 61 Pages: 189-196
  • Peer Reviewed
• [Journal Article] Enhanced anti-tumor immunity by superantigen-pulsed dendritic cells (2011)
  • Author(s): Kato M, Nakamura Y, Suda T, et al
  • Journal Title: Cancer Immunol Immunother Volume: 60 Pages: 1029-1038
  • Peer Reviewed
• [Journal Article] Expressions of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendric cells (2011)
  • Author(s): Hasegawa H, Inui N, Suda T, et al
  • Journal Title: Life Sci Volume: 89(7-8) Pages: 282-287
  • Peer Reviewed
• [Journal Article] Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis. (2010)
  • Author(s): Suda T, et al
  • Journal Title: Respir Med Volume: 104 Pages: 1204-1210
  • Peer Reviewed
• [Journal Article] Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD) (2010)
  • Author(s): Suda T, et al
  • Journal Title: Respir Med Volume: 104 Pages: 1527-1534
  • Peer Reviewed
• [Journal Article] Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer (2009)
  • Author(s): Suzuki Y, Suda T, et al
  • Journal Title: Lung Cancer Volume: 67 Pages: 361-365
  • Peer Reviewed
• [Journal Article] Mucosal vaccine using CTL epitope-pulsed dendritic cell confers protection for in tracellular pathogen (2009)
  • Author(s): Ozawa Y, Suda T, et al.
  • Journal Title: Am J Respir Cell Mol Biol 41 Pages: 440-448
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition induced by transforming growth factor-betal in mouse tracheal epithelial cells (2009)
  • Author(s): Kuroishi S, Suda T, et al.
  • Journal Title: Respirology 14 Pages: 698-703
  • Peer Reviewed
• [Journal Article] Higher sensitivity and specificity for diffusion-weighted imaging of malignant lung lesions without apparent diffusion coefficient quantification (2009)
  • Author(s): Uto T, Suda T, et al.
  • Journal Title: Radiology 252 Pages: 247-254
  • Peer Reviewed
• [Presentation] Lung CD103+ CD11b- And CD103- CDllbhigh Dendritic Cells Differentially Induce Distinct Subsets of Th Cells (2010)
  • Author(s): Suda T, et al
  • Organizer: アメリカ胸部疾患学会国際会議
  • Place of Presentation: ニューオリンズ(米国)
  • Year and Date: 2010-05-16