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The establishment of therapeutic strategy for pulmonary fibrosis and pulmonary hypertension in targeting endothelial-mesenchymal transition

Research Project

Project/Area Number 21590987
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNagoya University

Principal Investigator

HASHIIMO Naozumi  名古屋大学, 医学部附属病院, 助教 (30378020)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Yoshinori  名古屋大学, 大学院・医学系研究科, 教授 (20270986)
IMAIZUMI Kazuyoshi  藤田保健衛生大学, 大学院・医学研究科, 教授 (50362257)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords呼吸器病学 / 肺線維症 / 血管内皮間葉系細胞転換 / 線維芽細胞 / 低酸素 / 血管内皮細胞
Research Abstract

Current evidence suggests that the pathogenesis of pulmonary fibrosis might be due to the heterogeneity of fibroblast origins. In this study, persistent tissue hypoxia might be involved in active fibrosis in an in vivo model of BLM-induced lung injury/fibrosis, likely due to endothelial-mesenchymal transition. These findings indicate that persistent tissue hypoxia as tissue microenvironment may promote secondary EMT and lung fibrosis. These also indicate the clue to understand the underlying mechanism of lung fibrosis, leading the new therapeutic strategy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2012 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (10 results)

  • [Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells2012

    • Author(s)
      Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, KawabeT.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417(1) Pages: 169-174

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute exacerbation of IPF following diagnostic broncho alveolar lavage procedures2012

    • Author(s)
      Sakamoto K, Taniguchi H, Kondoh Y, Wakai K, Kimura T, Kataoka K, Hashimoto N, Nishiyama O, Hasegawa Y.
    • Journal Title

      Respir Med

      Pages: 436-42

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quercetin protects against pulmonary oxidant stress via hemeoxygenase-1 induction in lung epithelial cells2012

    • Author(s)
      Yuta Hayashi, Naozumi Hashimoto, 5番目
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417 Pages: 169-174

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute exacerbation of IPF following diagnostic bronchoalveolar lavage procedures2012

    • Author(s)
      Koji Sakamoto, Naozumi Hashimoto, 7番目
    • Journal Title

      Respir Med

      Volume: 106 Pages: 436-442

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant CCL2 Greatly Attenuate Bleomycin-Induced Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor ofCCL2 Greatly Attenuate Bleomycin-Induced Lung Damage2011

    • Author(s)
      Saito S, Nakayama T, Hashimoto N, Miyata Y, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T.
    • Journal Title

      Am J Pathol

      Volume: 179(3) Pages: 1088-94

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal transition in lung cancercells2011

    • Author(s)
      Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
    • Journal Title

      Mol Carcinog

      Volume: E1 Issue: 5 Pages: 1-11

    • DOI

      10.1002/mc.20802

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinaseandc AMP-dependent mechanisms2011

    • Author(s)
      Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45(4) Pages: 684-91

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-InducedHO-1.2011

    • Author(s)
      Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 44(5) Pages: 614-20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor of CCL2 Greatl Attenuate Bleomycin-Induced Lung Damage2011

    • Author(s)
      Sigeki Saito, Naozumi Hashimoto, 3番目
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 1088-1094

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Capsaicinoids regulate airway anion transporters through Rhokinase- and cAMP-dependent mechanisms2011

    • Author(s)
      Yoshitaka Hibino, Naozumi Hashimoto, 7番目
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Pages: 684-691

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-12011

    • Author(s)
      Toshinobu Nakamura, Naozumi Hashimoto, 6番目
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 44 Pages: 614-620

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis2010

    • Author(s)
      Naozumi Hashimoto
    • Journal Title

      Am J Respir Cell Mol Blol

      Volume: 43 Pages: 161-172

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of ZEB1, a Master Epithelial-to-Mesenchymal Transition (EMT) Gene, Suppresses Anchorage-independent Cell Growth of Lung Cancer Cells2010

    • Author(s)
      Naozumi Hashimoto(8番目)
    • Journal Title

      Cancer Letters

      Volume: 296 Pages: 216-224

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterologous regulation of anion transporters by menthol in human airway epithelial cells2010

    • Author(s)
      Naozumi Hashimoto(6番目)
    • Journal Title

      Eur J Pharmacol

      Volume: 635 Pages: 204-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential Th1/Th2 chemokine expression in interstitial pneumonia2010

    • Author(s)
      Naozumi Hashimoto(4番目)
    • Journal Title

      Am J Med Sci

      Volume: 339 Pages: 41-48

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythromycin-induccd CXCR4 expression on microvascular endothelial cell2009

    • Author(s)
      Naozumi Hashimoto
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model2009

    • Author(s)
      Naozumi Hashimoto
    • Journal Title

      BMC Pulm Med 9

      Pages: 45-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Inhibition of TGFbeta induced epithelial mesenchymal transition in lung cancer by modulation of PTEN c-terminal tail2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      日本癌学会総会
    • Place of Presentation
      日本,名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of TGFbeta induced epithelial mesenchymal transition in lung cancer by modulation of PTEN c-terminal tail2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      日本癌学会総会
    • Place of Presentation
      日本、名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inspiratory capacity is a new preoperative risk predictor in the patients with lung cancer undergoing surgical resection European Respiratory Society Congress2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      オランダ、アムステルダム
    • Place of Presentation
      アムステルダム
    • Year and Date
      2011-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of Hypoxia-induced phenotype alterations through epithelial-mesenchymal transition(EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN European Respiratory Society Congress2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      オランダ、アムステルダム
    • Place of Presentation
      アムステルダム
    • Year and Date
      2011-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Inspiratory capacity is a new preoperative risk predictor in the patients with lung cancer undergoing surgical resection2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      European Respiratory Society Congress
    • Place of Presentation
      オランダ、アムステルダム
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of Hypoxia-induced phenotype alterations through epithelial-mesenchymal transition (EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      European Respiratory Society Congress
    • Place of Presentation
      オランダ、アムステルダム
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] A critical involvement of chronic obstructive pulmonary disease as a preo perative risk factor in the patients with lung cancer undergoing surgical resection2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      American Thoracic Society 2011
    • Place of Presentation
      アメリカ、デンバー
    • Year and Date
      2011-05-17
    • Related Report
      2011 Final Research Report
  • [Presentation] A critical involvement of chronic obstructive pulmonary disease as a preoperative risk factor in the patients with lung cancer undergoing surgical resection2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      American Thoracic Society 2011 International conference
    • Place of Presentation
      アメリカ、デンバー
    • Year and Date
      2011-05-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of fibrosis-related growth factors in endothelial-mesenchymal transition2010

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      2010 EB
    • Place of Presentation
      Vermont USA
    • Year and Date
      2010-08-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of fibrosis-related growth factors in endothelial-mesenchymal transition2010

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      ATS 2010 International Conference
    • Place of Presentation
      New Orleans USA
    • Year and Date
      2010-05-17
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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