Cancer antigen WT1-targeting peptide vaccine therapy for lung cancer
| Project/Area Number |
21590991
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
OKA Yoshihiro 大阪大学, 大学院・医学系研究科, 講師 (20273691)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Yoshito 大阪大学, 大学院・医学系研究科, 助教 (40452388)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | WT1 / 肺癌 / 癌免疫療法 / ペプチドワクチン / 免疫療法 / 胸腺腫 |
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| Research Abstract |
We accumulated cases with lung cancer treated by WT1 peptide vaccine. We analyzed anti-WT1 antibody in nonsmall cell lung cancer patients, which showed the existence of immune response against WT1 protein in the lung cancer. We analyzed WT1-specific CTLs in bone marrow(BM) of cancer-bearing patients, which indicated the possibility that BM had a role as a secondary lymhpoid organ in cancer immunity. We analyzed WT1 helper peptide-specific response of CD4^+ T cells, which suggested an important role of Th response in cancer immunity. We demonstrated, using a mice model, that co-administration of WT1 peptide vaccine and IFN-βwas a promising novel therapy for cancer. Biased usage of TCR BV gene families of WT1-specific CD8^+ T cells in patients with solid tumors and healthy donors was shown.
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Report
(5 results)
Research Products
(48 results)
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[Journal Article] Biased usage of T cell receptorβ-chain variable region genes of WT1(Wilms' tumor gene)-specific CD8^+ T cells in patients with solid tumors and healthy donors2012
Author(s)
Morimoto S., Oka Y., Tsuboi A., Tanaka Y., Fujiki F., Nakajima H., Hosen N., Nishida S., Nakata J., Nakae Y., Murao A., Myoui A., Enomoto T., Izumoto S., Sekimoto M., Kagawa N., Hashimoto N., Yoshimine T., Oji Y., Kumanogoh A., Sugiyama H
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Journal Title
Cancer Science
Volume: 103
Pages: 408-414
Related Report
Peer Reviewed
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[Journal Article] Enhanced tumor immunity of WT1 peptide vaccination by interferon-βadministration2012
Author(s)
Nakajima H., Oka Y., Tsuboi A., Tatsumi N., Yamamoto Y., Fujiki F., Li Z., Murao A., Morimoto S., Hosen N., Shirakata T., Nishida S., Kawase I., Isaka Y., Oji Y., Sugiyama H
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Journal Title
Vaccine
Volume: 30
Pages: 722-729
Related Report
Peer Reviewed
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[Journal Article] A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination2010
Author(s)
Fujiki F., Oka Y., Kawakatsu M., Tsuboi A., Harada Y., Hosen N., Nishida S., Shirakata T., Nakajima H., Tatsumi N., Hashimoto N., Taguchi T., Ueda S., Nonomura N., Takeda Y., Ito T., Myoui A., Izumoto Izumoto S., Maruno M., Yoshimine T., Noguchi S., Okuyama A., Kawase I., Oji Y., Sugiyama H
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Journal Title
Anticancer Research
Volume: 30
Pages: 2247-2254
Related Report
Peer Reviewed
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[Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients : an important role of bone marrow as a secondary lymhpoid organ2010
Author(s)
Murao A., Oka Y., Tsuboi A., Elisseeva O. A., Harada Y., Fujiki F., Nakajima H., Nishida S., Hosen N., Shirakata T., Hashimoto N., Myoui A., Ueda T., Takeda Y., Osaki T., Enomoto T., Yoshikawa H., Kimura T., Oji Y., Kawase I., Sugiyama H
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Journal Title
Cancer Science
Volume: 101
Pages: 848-854
Related Report
Peer Reviewed
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[Journal Article] WT1 peptide vaccine as a paradigm for" cancer antigen-derived peptide"-based immunotherapy for malignancies : Successful induction of ant-cancer effect by vaccination with a single kind of WT1 peptide2009
Author(s)
Oka Y., Tsuboi A., Fujiki F., Li Z., Nakajima H., Hosen N., Shirakata T., Nishida S., Oji Y., Kawase I., Sugiyama H
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Journal Title
Anti-Cancer Agents in Medicinal Chemistry
Volume: 9
Pages: 787-797
Related Report
Peer Reviewed
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[Journal Article] WT1 IgG antibody for early detection of non-small cell lung cancer and as its prognostic factor2009
Author(s)
Oji Y., Kitamura Y., Kamino E., Kitano A., Sawabata N., Inoue M., Mori M., Nakatsuka S-I., Sakaguchi N., Miyazaki K., Nakamura M., Fukuda I., Nakamura J., Tatsumi N., Takakuwa T., Nishida S., Shirakata T., Hosen N., Tsuboi A., Nezu R., Maeda H., Oka Y., Kawase I., Aozasa K., Okumura M., Miyoshi S., Sugiyama H
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Journal Title
International Journal of Cancer
Volume: 125
Pages: 381-387
Related Report
Peer Reviewed
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[Presentation] WT1 peptide vaccination combined with IFN-βenhances tumor rejection in a mice model2011
Author(s)
Nakajima H., Oka Y., Tsuboi A., Tatsumi N., Fujiki F., Morimoto S., Hosen N., Shirakata T., Nishida S., Oji Y., Sugiyama H
Organizer
第70回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2011-10-04
Related Report
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